NanotechnologyPub Date : 2025-05-21DOI: 10.1088/1361-6528/addb53
Elsa Pérez-Martín, Tomas Gonzalez, Héctor Sánchez Martín, Ignacio Iniguez de la Torre, Javier Mateos
{"title":"Photoresponse of asymmetric planar GaN-based nanodiodes at low temperature.","authors":"Elsa Pérez-Martín, Tomas Gonzalez, Héctor Sánchez Martín, Ignacio Iniguez de la Torre, Javier Mateos","doi":"10.1088/1361-6528/addb53","DOIUrl":"https://doi.org/10.1088/1361-6528/addb53","url":null,"abstract":"<p><p>The direct gap of GaN (3.4 eV) and the existence of surface states (either on the top of the AlGaN layer or at the sidewalls of etched trenches) affecting the conductivity in AlGaN/GaN-based nanodiodes result in a strong photodetector performance. This paper analyzes the link between the
modifications of the surface states occupation and the optoelectronic response of such self-switching diodes (SSDs) with measurements performed in a temperature range of 70-300K using a violet laser which covers most of the energies located at the GaN bandgap. The test device consisted of an SSD with a single channel, 1 μm long and 80nm wide. The measurements revealed a notable photoresponse, taking values of 140mA/W at 100 K, which decrease considerably to 20mA/W at 300K because of the thermal discharge of the surface states. The results obtained evidence the key role played by the illumination-induced modulation of the surface states occupation in the significant photoresponse provided by the SSDs.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NCCD: A unique combination of MOF-scaffolded stable luminescent copper nanoclusters (Cu NCs) and carbon dots (Cdots) as a potent antimicrobial agent against Pseudomonas aeruginosa.","authors":"Ayush Amod, Shraddha Singh, Rubina Lawrence, Ananya Anurag Anurag Anand, Sneha Ranjan, Sangeeta Singh, Amaresh Kumar Sahoo, Sintu Kumar Samanta","doi":"10.1088/1361-6528/addacd","DOIUrl":"https://doi.org/10.1088/1361-6528/addacd","url":null,"abstract":"<p><p>Bacterial biofilm infections cause huge cases of morbidity and mortality globally. Cells in bacterial biofilms can easily overcome host immune response and become resistant to conventional antibiotics. Hence, the concurrent issues of biofilm infections demand the urgent development of new therapeutic strategies other than the conventional antibiotic treatment. Herein, we have developed an exclusive combination of fluorescent copper nanoclusters (Cu NCs) with biocompatible and bactericidal fluorescent carbon dots (Cdots) coined as nanocluster-carbon dots (NCCD) as a wide-range antibacterial and antibiofilm agent against Gram-negative Escherichia coli and Gram-positive Bacillus subtilis. Interestingly, NCCD was found effective even against the pathogenic strain of Pseudomonas aeruginosa. CuNCs showed a MIC90 value of 20 ± 2, 7.5 ± 2, and 10 ± 3 µg mL-1 against E. coli, P. aeruginosa and B. subtilis respectively while Cdots showed a MIC90 value of 200 ± 5 and 160 ± 2, against E. coli and B. subtilis respectively. NCCD inhibited the biofilm production in B. subtilis and P. aeruginosa to 40.27% and 68.10%, respectively and that of reduced the mass of established biofilm to 53.09% and 68.43%, respectively. The antibiofilm activity of NCCD was found to increase considerably in combination with biofilm-degrading enzymes like α-amylase and/or DNase. The acidic microenvironment and presence of chelating enzymes in biofilm considerably lower the antibiofilm activity of antibiotics. However, a significant increase in the susceptibility of the biofilm to antibiotics was observed in presence of NCCD. The loss of cell membrane permeability was found to be one of the probable causes of cell death by NCCD. Further, it was demonstrated that NCCD-mediated biofilm degradation may be due to the regulation of bacterial chemotaxis leading to transition of cells from biofilm to planktonic state. Thus, it is conceivable that NCCD could be a potent agent against various antibiotic-resistant bacterial biofilm infections.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-20DOI: 10.1088/1361-6528/addacf
Shivam Sharma, Mohd Faizee, Abir De Sarkar
{"title":"Current exploration of topological materials for futuristic electronics.","authors":"Shivam Sharma, Mohd Faizee, Abir De Sarkar","doi":"10.1088/1361-6528/addacf","DOIUrl":"https://doi.org/10.1088/1361-6528/addacf","url":null,"abstract":"<p><p>We offer a pedagogical review of a new class of quantum materials with non-trivial topological properties, which hold significant promise for future electronic applications. Recent advances in the development of topological materials have spurred exciting progress in areas such as spintronics, valleytronics, photonics, superconductivity, and magnetoelectronics. In this review, we explore both the fundamental physics and the practical applications driving these developments. We begin by discussing several phenomena in spintronics that emerge from novel topological phases, such as spin-orbit torque, skyrmions, and magnetic 
proximity effects at interfaces. Next, we examine valley photonics, a field characterized by unique 
valley-selective physics, which influences both the bulk topology and bulk-boundary correspondence 
in valley photonic topological phases, setting them apart from other photonic topological phases. 
Finally, we highlight recent progress in magnetoelectronics, including the study of axion 
insulators and the topological magnetoelectric effect, both observed in various topological 
insulators. Through this review, we aim to shed light on the transformative potential of these 
materials in shaping the future of electronic and photonic technologies.
.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-20DOI: 10.1088/1361-6528/add6ad
Jiahao Su, Tingyuan Yan, Xiankang Zhang, Tingxuan Yan, Zhixiang Wang
{"title":"Tumor microenvironment-responsive diagnosis and treatment of integrated drug-loaded CdTe quantum dots for treatment tumors.","authors":"Jiahao Su, Tingyuan Yan, Xiankang Zhang, Tingxuan Yan, Zhixiang Wang","doi":"10.1088/1361-6528/add6ad","DOIUrl":"10.1088/1361-6528/add6ad","url":null,"abstract":"<p><p>The acidic tumor microenvironment is a common feature of tumors, and boric acid-functionalized quantum dots (BA-QDs) exhibit pH-sensitive boron affinity effects and fluorescence emission characteristics. In this study, CdTe QDs were prepared using the water phase synthesis method. Additionally, BA-QDs were prepared by modifying QDs with 4-mercaptophenylboric acid. Hesperetin, baicalein, quercetin, and other model drugs were used, with QDs and BA-QDs serving as carriers, to create a drug-loaded system of QDs with tumor microenvironment-responsive drug release performance. The physical and chemical properties were characterized using dynamic light scattering (DLS), Fourier transform infrared spectroscopy, transmission electron microscopy, x-ray diffraction, etc. Our findings showed that the synthesis of drug-loaded QDs with a uniform particle size was successful. The experiments involved studying the adsorption kinetics of the QDs and the degree of dissolution of the drug-loaded QDs<i>in vitro</i>. BA-QDs exhibited pH-responsive drug release and fluorescence emission properties.<i>In vitro</i>cell experiments were conducted to examine the uptake and imaging effects of QDs and BA-QDs at the cell level. The results showed that both QDs and BA-QDs exhibited effective imaging at the cell level. Moreover, the three drug-loaded BA-QDs inhibited HepG2 cancer cells by about 80%, indicating a significant inhibitory effect on cancer cells. Here, we developed a universal new technology for tumor diagnosis and treatment, provided innovative approaches for targeted cancer diagnosis and treatment, and broadened the application scope of nanofluorescence technology.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-20DOI: 10.1088/1361-6528/addaca
Caixia Wang, Chengkui Qiao, Fajun Tian, Ruxia Chen, Linlin Guo, Tao Pang, Jun Li, Rongli Pang, Hanzhong Xie
{"title":"Carbon dots derived from citric acid/glucose for optimizing the retention of propamocarb in reversed-phase chromatography column.","authors":"Caixia Wang, Chengkui Qiao, Fajun Tian, Ruxia Chen, Linlin Guo, Tao Pang, Jun Li, Rongli Pang, Hanzhong Xie","doi":"10.1088/1361-6528/addaca","DOIUrl":"https://doi.org/10.1088/1361-6528/addaca","url":null,"abstract":"<p><p>Carbon dots (CDs) have been widely used in the detection of pesticide residues in foods owning to their easy surface functionalization, adjustable characteristic, stable photoluminescence properties, and high water solubility. Because CDs have variety of functional groups that could achieve multiple retention mechanisms when it as functional ligands for silica gels-based stationary-phases. However, there have no CDs to optimize the retention of propamocarb (PM) in liquid chromatography based on the adsorption capacity of CDs. In this work, a new CDs (NM-CDs) was obtained by a simple hydrothermal method via using citric acid and glucose as two carbon sources. The analysis results of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for 0.001-0.1 μg/mL PM that showed excellent retention from 0.9-2.4 min to 0.7-1.4 min, and a single chromatographic peak when added NM-CDs. At the same time, NM-CDs improved the signal-to-noise ratio and stabilized the mass spectrum for PM. Thus, the addition of NM-CDs has improved the efficiency of the chromatographic process, and the stability and sensitivity of detection concentration PM in the C18 chromatography column. Meanwhile, the excellent results were also revealed in the detection of PM with pesticide multiresidue and complex matrix, which has provided an effective implementation for CDs to detect pesticide residues in food at separation science.
.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural regulation of VS4 cathodes for enhanced aqueous zinc-ion battery performance.","authors":"Jintao Liu, Fangfang Wu, Yuxi Wang, Junkang Zhang, Jing Zhao, Wenxian Liu, Wenhui Shi, Xiehong Cao","doi":"10.1088/1361-6528/addac9","DOIUrl":"https://doi.org/10.1088/1361-6528/addac9","url":null,"abstract":"<p><p>VS4 has garnered significant attentions in aqueous zinc ion batteries (AZIBs) due to its unique structural features and high theoretical capacity. Unfortunately, the volumetric changes and sluggish kinetics of VS4 during the electrochemical process often lead to material degradation and structural collapse, thereby limiting the performance of AZIBs. To address these challenges, we propose a structural engineering strategy for VS4 to regulate its microstructure through a simple hydrothermal method. This approach enhances the number of active sites and facilitates the diffusion of Zn2+ ions, thereby improving the electrochemical performance of VS4 in AZIBs. The AZIBs using VS4 flower (F-VS4) as the cathode material exhibit significantly enhanced electrochemical performance. The electrochemical reaction mechanism of F-VS4 is further elucidated by ex-situ XRD and XPS measurements. This work represents a significant step forward in the development of vanadium sulfide-based cathodes for AZIBs, offering a promising strategy to enhance their electrochemical performance and stability.
.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-20DOI: 10.1088/1361-6528/addace
Océane Capelle, Gaelle Amiri, Corinne Sartel, Said Said Hassani, Alain Lusson, Jean-Pierre Hermier, Stéphanie Buil, Vincent Sallet, A Delteil
{"title":"Red and infrared colour centres in zinc oxide epitaxial nanowires.","authors":"Océane Capelle, Gaelle Amiri, Corinne Sartel, Said Said Hassani, Alain Lusson, Jean-Pierre Hermier, Stéphanie Buil, Vincent Sallet, A Delteil","doi":"10.1088/1361-6528/addace","DOIUrl":"https://doi.org/10.1088/1361-6528/addace","url":null,"abstract":"<p><p>The integration of quantum emitters in semiconductor nanowires offers appealing prospects for quantum optics and quantum information applications. Here, we study the visible emission from metal-organic vapour phase epitaxy (MOVPE) zinc oxide nanowires. We show that the nanowires frequently incorporate native red-emitting colour centres at about 650~nm, in the form of small ensembles exhibiting photon antibunching, down to individual emitters. Additional post-treatment can yield modification of the number and the optical properties of the emitters, as well as generate near-infrared emitters (~780nm). Our results could be used for the realisation of guided quantum sources deterministically integrated in hybrid devices.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-20DOI: 10.1088/1361-6528/addacb
Ibtisam Hammad Abbasi, Tom Albrow-Owen, Faris Abualnaja, Ralf Mouthaan, Peter J Christopher, Jennifer Wong-Leung, Jack Allen Alexander-Webber, Hannah J Joyce, Teja Potočnik, Hark Hoe Tan, Chennupati Jagadish
{"title":"InAs nanowire transistor pairs as NMOS inverters.","authors":"Ibtisam Hammad Abbasi, Tom Albrow-Owen, Faris Abualnaja, Ralf Mouthaan, Peter J Christopher, Jennifer Wong-Leung, Jack Allen Alexander-Webber, Hannah J Joyce, Teja Potočnik, Hark Hoe Tan, Chennupati Jagadish","doi":"10.1088/1361-6528/addacb","DOIUrl":"https://doi.org/10.1088/1361-6528/addacb","url":null,"abstract":"<p><p>III-V semiconductor nanowires have the potential to play a key role in compact and flexible electronic devices for low-power applications. Here, we integrate pairs of InAs nanowires in an inverter configuration for NMOS logic circuit applications. By controlling the nanowire diameter and channel length with a combination of growth and device design, we can control the threshold voltage of each transistor of the device. Smaller diameter (<50 nm) nanowires operate in enhancement mode whereas larger diameters operate in depletion mode. Using these controllable transistor characteristics we fabricate inverter circuits with pairs of nanowires. We optimise the inverter voltage transfer characteristics by controlling the channel and gate geometries and by reducing the gate dielectric thickness. The gate length determines the inverter's switching voltage, which can be made symmetric about zero volts. The optimised inverter device can achieve a full rail-to-rail output voltage swing and switching ratio of 99.3%, with an RC-limited frequency response. The gain value and extracted high and low noise margins of 42% and 32%, respectively, satisfy the requirements for the inverter to be used in cascaded logic circuits.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging therapeutic strategies and opportunities in targeting protein pathways for breast cancer treatment: a critical review.","authors":"Panneerselvam Theivendren, Parasuraman Pavadai, Selvaraj Kunjiappan, Kaveena Ravi, Natarajan Kiruthiga, Kumarappan Chidamabaram, Shanmugarathinam Alagarsamy, Nagireddy Bhuvan Reddy","doi":"10.1088/1361-6528/add6ae","DOIUrl":"10.1088/1361-6528/add6ae","url":null,"abstract":"<p><p>Understanding breast cancer at a molecular level is essential for developing effective treatments due to its significant impact on women's mortality rates globally. Targeted medicines focus on specific proteins crucial to breast cancer progression, offering a promising treatment avenue. These proteins, often overexpressed or mutated in cancer cells, are vital for cell proliferation, division, and survival. Targeted drugs aim to inhibit these proteins, halting disease progression and sparing non-cancerous cells, which reduces side effects and improves patient quality of life. Key proteins in breast cancer treatment include HER2 (human epidermal growth factor receptor 2), ER (estrogen receptor), and PR (progesterone receptor). Drugs like Trastuzumab target HER2 to impede tumor growth in HER2-positive cancers, while hormone therapies targeting ER and PR improve outcomes for hormone receptor-positive cancers. Examining proteins such as EGFR, HER2/Neu, and ER reveals their roles in cancer pathways, with pathways like PI3K/Akt/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin) and MAPK (mitogen-activated protein kinase) being crucial targets for therapies, potentially revolutionizing breast cancer treatment.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NanotechnologyPub Date : 2025-05-19DOI: 10.1088/1361-6528/add5fe
Neha Soni, Ranu Nayak
{"title":"Emerging advancements in ecofriendly nanosorbent technology accompanied with natural fillers: a systematic review.","authors":"Neha Soni, Ranu Nayak","doi":"10.1088/1361-6528/add5fe","DOIUrl":"10.1088/1361-6528/add5fe","url":null,"abstract":"<p><p>Increasing incidence of oil spills due to maritime transportation and improper disposal of refinery waste has caused severe damage to marine ecosystems. Various traditional technologies have been developed to mitigate oil pollution. However, these methods require high-cost and complex multi-step treatments that limits their large-scale applicability. Sorbent-based remediation, particularly porous polymeric sorbents (synthetic and natural), has emerged as a promising strategy for oil spill cleanup. Synthetic polymeric sorbents exhibit high oil sorption capacities, but their non-biodegradability raises ecological concerns. Consequently, research has shifted toward nature-friendly biodegradable polymeric sorbents. Despite their environmental benefits, these sorbents often suffer from inherent hydrophilicity, limited oil selectivity, and low mechanical strength, that restricts their long-term performance. To enhance the oil selectivity and water repellency of biodegradable sorbents, various surface modification strategies have been explored. Chemical surface modifications with hydrophobic materials such as, CNTs, graphene oxide, and fluoroalkanes have proven to be effective in improving the water repellency, but raises concerns regarding toxicity and environmental safety. Recent advancements focus on integrating natural fillers, biomimetic surface engineering, and functional biocompatible coatings to achieve superior oil-water separation performance, while maintaining environmental safety. This review systematically analyzes time-based evolution and advancements in biodegradable polymeric nanosorbents, emphasizing their fabrication techniques, biocompatible surface modifications, and integration of natural fillers for enhanced oil-water separation. A comprehensive literature search was conducted across multiple electronic databases (Web of Science, ScienceDirect, PubMed, and Google Scholar), covering studies published from 2015 to 2024. Studies were selected based on keyword searches and reference mining to ensure comprehensive coverage of relevant developments in the field. By providing a comparative analysis of key performance metrics and identifying research gaps, this review highlights the potential of natural fillers and biomimetic strategies using bio-sources for developing next-generation superhydrophobic nanosorbents.</p>","PeriodicalId":19035,"journal":{"name":"Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}