Movement Disorders Clinical Practice最新文献

筛选
英文 中文
Dyskinetic Movement Disorder in Congenital Methemoglobinemia Type II. 先天性高铁血红蛋白血症 II 型的运动失调症。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.1002/mdc3.14207
Balamurugan Nagarajan, Pradeep Kumar Gunasekaran, Kiran Anand, Yashovardhan Kaushal, Arushi Gahlot Saini
{"title":"Dyskinetic Movement Disorder in Congenital Methemoglobinemia Type II.","authors":"Balamurugan Nagarajan, Pradeep Kumar Gunasekaran, Kiran Anand, Yashovardhan Kaushal, Arushi Gahlot Saini","doi":"10.1002/mdc3.14207","DOIUrl":"10.1002/mdc3.14207","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1451-1453"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
α-Methylacyl-CoA Racemase Deficiency in a Patient with Ataxia, Spasticity, and Segmental Dystonia. 共济失调、痉挛和节段性肌张力障碍患者体内的α-甲基酰-CoA Racemase 缺乏症
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1002/mdc3.14176
Ronak Rashedi, Mathias Gelderblom, Lisa Prilop, Maxim Bester, Tobias B Haack, Simone Zittel
{"title":"α-Methylacyl-CoA Racemase Deficiency in a Patient with Ataxia, Spasticity, and Segmental Dystonia.","authors":"Ronak Rashedi, Mathias Gelderblom, Lisa Prilop, Maxim Bester, Tobias B Haack, Simone Zittel","doi":"10.1002/mdc3.14176","DOIUrl":"10.1002/mdc3.14176","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1458-1461"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter? 帕金森病患者脑深部刺激后的生活质量:目标是否重要?
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1002/mdc3.14199
Sandra Murcia Carretero, Katrin Petermann, Ines Debove, Deborah Amstutz, Mário Sousa, Julia Waskönig, Andreas Antonios Diamantaras, Gerd Tinkhauser, Andreas Nowacki, Claudio Pollo, Michael Schuepbach, Paul Krack, Martin Lenard Lachenmayer
{"title":"Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter?","authors":"Sandra Murcia Carretero, Katrin Petermann, Ines Debove, Deborah Amstutz, Mário Sousa, Julia Waskönig, Andreas Antonios Diamantaras, Gerd Tinkhauser, Andreas Nowacki, Claudio Pollo, Michael Schuepbach, Paul Krack, Martin Lenard Lachenmayer","doi":"10.1002/mdc3.14199","DOIUrl":"10.1002/mdc3.14199","url":null,"abstract":"<p><strong>Background: </strong>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an accepted therapy for Parkinson's disease (PD) with disabling motor complications. For elderly patients with poorer cognition and postural instability, GPi has been proposed as the preferable DBS target based on expert opinion, arguing GPi-DBS may be less complicated by depression, apathy, worsened verbal fluency, and executive dysfunction, resulting in greater improvement in quality of life (QoL). However, data supporting such patient-tailored approach are lacking.</p><p><strong>Objectives: </strong>The aims were to analyze whether the DBS target influences QoL in a PD cohort and a matched subgroup of frail patients with poor cognitive status and reduced postural stability, and whether other factors affect the QoL outcomes.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed a single-center cohort of 138 PD patients who received bilateral STN-DBS (117) or GPi-DBS (21) using the mentioned approach for target selection. All patients underwent standardized clinical evaluations of motor- and nonmotor signs as well as QoL before and 1 year after surgery.</p><p><strong>Results: </strong>DBS of both targets improved motor signs, dyskinesias, and pain. QoL improved without significant difference between the targets, but with a trend for greater improvement across all QoL domains in favor of the STN, even in an STN subgroup matched to the GPi group.</p><p><strong>Conclusion: </strong>Our results contradict the prevailing belief that GPi-DBS is superior in frail PD patients with cognitive decline and postural instability, questioning the proposed patient-tailored approach of DBS target selection. Further studies are needed for a data-driven approach.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1379-1387"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis. α-突触核蛋白病神经精神症状的性别差异:系统回顾与元分析》。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI: 10.1002/mdc3.14227
Vincent Couture, Jean-François Carmel, Katerine Rousseau, Geneviève Létourneau, Doris Clerc, Philippe Huot, Marie-France Forget, Quoc Dinh Nguyen, Richard Camicioli, Philippe Desmarais
{"title":"Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis.","authors":"Vincent Couture, Jean-François Carmel, Katerine Rousseau, Geneviève Létourneau, Doris Clerc, Philippe Huot, Marie-France Forget, Quoc Dinh Nguyen, Richard Camicioli, Philippe Desmarais","doi":"10.1002/mdc3.14227","DOIUrl":"10.1002/mdc3.14227","url":null,"abstract":"<p><strong>Background: </strong>Alpha-synucleinopathies, such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. Neuropsychiatric symptoms (NPS) are common early and late manifestations of these disorders.</p><p><strong>Objectives: </strong>We aimed to describe sex differences in NPS across alpha-synucleinopathies.</p><p><strong>Methods: </strong>We searched Web of Science Core collection databases to identify observational studies published between January 1, 2000, and June 1, 2022, reporting the prevalence or severity of NPS among individuals with a diagnosis of PD, PDD, or DLB. Prevalence and severity were pooled for each NPS according to sex using random-effects models.</p><p><strong>Results: </strong>Two-hundred-and-forty studies, representing 796,026 participants (45% females), were included in the meta-analysis. Female sex was associated with a higher prevalence of anxiety (OR = 1.60 [95% CI: 1.40, 1.82]), depression (OR = 1.56 [1.45, 1.67]), fatigue (OR = 1.21 [1.02, 1.43]), and psychotic symptoms (OR = 1.26 [1.14, 1.40]) and more severe anxiety (g = 1.35 [95% CI: 0.58, 2.13]), depression (g = 1.57 [1.05, 2.08]), and fatigue (g = 0.86 [0.41, 1.32]), while male sex was associated with a higher prevalence of apathy (OR = 0.77 [0.63, 0.93]), impulse control disorders (OR = 0.67 [0.55, 0.82]), REM sleep behavior disorder (OR = 0.54 [0.42, 0.70]), hypersomnolence (OR = 0.67 [0.56, 0.80]), and suicide (OR = 0.30 [0.20, 0.44]).</p><p><strong>Conclusions: </strong>NPS have different prevalences and severities in alpha-synucleinopathies according to sex. These findings support consideration of sex in the elaboration of clinical tools.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1335-1344"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Family History in Parkinson's Disease: A National Cross-Sectional Study. 帕金森病的家族史:全国横断面研究
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-09-13 DOI: 10.1002/mdc3.14206
Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo, Maria Antonietta Volontè, Laura Cacciaguerra, Andrea Pilotto, Alessandro Padovani, Cristoforo Comi, Luca Magistrelli, Franco Valzania, Francesco Cavallieri, Laura Avanzino, Roberta Marchese, Mariachiara Sensi, Giorgia Carroli, Roberto Eleopra, Roberto Cilia, Francesca Spagnolo, Alessandro Tessitore, Rosa De Micco, Roberto Ceravolo, Giovanni Palermo, Maria Chiara Malaguti, Leonardo Lopiano, Pierluigi Tocco, Chiara Sorbera, Michele Tinazzi, Andrea Ciammola, Donatella Ottaviani, Enza Maria Valente, Alberto Albanese, Fabio Blandini, Margherita Canesi, Angelo Antonini, Miryam Carecchio, Vincenza Fetoni, Carlo Colosimo, Daniele Volpe, Nicola Tambasco, Giovanni Cossu, Mario Zappia, Alessio Di Fonzo
{"title":"Family History in Parkinson's Disease: A National Cross-Sectional Study.","authors":"Federica Arienti, Giovanni Casazza, Giulia Franco, Giulia Lazzeri, Edoardo Monfrini, Alessandro Di Maio, Roberto Erro, Paolo Barone, Filippo Tamma, Elena Caputo, Maria Antonietta Volontè, Laura Cacciaguerra, Andrea Pilotto, Alessandro Padovani, Cristoforo Comi, Luca Magistrelli, Franco Valzania, Francesco Cavallieri, Laura Avanzino, Roberta Marchese, Mariachiara Sensi, Giorgia Carroli, Roberto Eleopra, Roberto Cilia, Francesca Spagnolo, Alessandro Tessitore, Rosa De Micco, Roberto Ceravolo, Giovanni Palermo, Maria Chiara Malaguti, Leonardo Lopiano, Pierluigi Tocco, Chiara Sorbera, Michele Tinazzi, Andrea Ciammola, Donatella Ottaviani, Enza Maria Valente, Alberto Albanese, Fabio Blandini, Margherita Canesi, Angelo Antonini, Miryam Carecchio, Vincenza Fetoni, Carlo Colosimo, Daniele Volpe, Nicola Tambasco, Giovanni Cossu, Mario Zappia, Alessio Di Fonzo","doi":"10.1002/mdc3.14206","DOIUrl":"10.1002/mdc3.14206","url":null,"abstract":"<p><strong>Background: </strong>Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.</p><p><strong>Objectives: </strong>We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).</p><p><strong>Methods: </strong>A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.</p><p><strong>Results: </strong>Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.</p><p><strong>Conclusions: </strong>fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1434-1440"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orthostatic Hypotension and Risk of Mild Cognitive Impairment and Dementia in Parkinson's Disease. 帕金森病患者的直立性低血压与轻度认知功能障碍和痴呆症的风险。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI: 10.1002/mdc3.14179
Ylva Hivand Hiorth, Jörn Schulz, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves
{"title":"Orthostatic Hypotension and Risk of Mild Cognitive Impairment and Dementia in Parkinson's Disease.","authors":"Ylva Hivand Hiorth, Jörn Schulz, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves","doi":"10.1002/mdc3.14179","DOIUrl":"10.1002/mdc3.14179","url":null,"abstract":"<p><strong>Background: </strong>Orthostatic hypotension (OH) is a common condition in Parkinson's disease (PD) with a possible link to cognitive decline.</p><p><strong>Objective: </strong>The aim was to explore the association between OH and PD-associated mild cognitive impairment (PD-MCI) and dementia (PDD) over 9 years in a population-based incident PD cohort.</p><p><strong>Methods: </strong>We prospectively followed up patients from PD diagnosis with serial blood pressure measurements, clinical examinations, and neuropsychological assessments. We defined OH using (1) consensus-based criteria and (2) clinically significant OH by mean arterial pressure (MAP) in standing position ≤75 mmHg. PD-MCI and PDD were diagnosed according to acknowledged criteria. We applied generalized estimating equations models to investigate associations between OH measurements and cognitive impairment over time. Weibull accelerated failure time regression models were used to study if early OH (≤3 years of PD diagnosis) accelerates the time to incident PD-MCI and PDD.</p><p><strong>Results: </strong>Of 186 enrolled patients, consensus-based OH affected 68.8%, clinically significant OH 33.9%, PD-MCI 60.8%, and PDD 31.2%. Consensus-based OH was associated with PD-MCI (odds ratio [OR]: 2.04, 95% confidence interval: 1.44-2.90, P < 0.001), whereas clinically significant OH was associated with both PD-MCI (OR: 1.95, 1.11-3.43, P = 0.020) and PDD (OR: 3.66, 1.95-6.86, P < 0.001). Early clinically significant OH, but not early consensus-based OH, reduced time to incident PD-MCI by 54% (P = 0.021) and time to PDD by 44% (P = 0.003) independently of potential confounders, including supine hypertension and cardiovascular disease.</p><p><strong>Conclusions: </strong>MAP in standing position emerged as a stronger predictor of cognitive decline than OH determined using consensus-based criteria. These findings have implications for both research and clinical practice.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1365-1372"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early- to Mid-Stage Parkinson's Disease Modification Trials. 探索在帕金森病早中期改良试验中使用多巴胺转运体纹状体结合率的分析方法。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-22 DOI: 10.1002/mdc3.14191
Nirosen Vijiaratnam, Christine Girges, Dilan Athauda, Alexa King, Grace Auld, Rachel McComish, Kashfia Chowdhury, Simon Skene, Kate Maclagan, Kallol Ray Chaudhuri, Vincenzo Libri, John Dickson, Thomas Foltynie
{"title":"Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early- to Mid-Stage Parkinson's Disease Modification Trials.","authors":"Nirosen Vijiaratnam, Christine Girges, Dilan Athauda, Alexa King, Grace Auld, Rachel McComish, Kashfia Chowdhury, Simon Skene, Kate Maclagan, Kallol Ray Chaudhuri, Vincenzo Libri, John Dickson, Thomas Foltynie","doi":"10.1002/mdc3.14191","DOIUrl":"10.1002/mdc3.14191","url":null,"abstract":"<p><strong>Background: </strong>The dopamine transporter striatal binding ratio (DAT SBR) has been used as an outcome measure in Parkinson's disease (PD) trials of potential disease-modifying therapies; however, both patient characteristics and analysis approach potentially complicate its interpretation.</p><p><strong>Objective: </strong>The aim was to explore how well DAT SBR reflects PD motor severity across different striatal subregions and the relationship to disease duration, and side of onset.</p><p><strong>Methods: </strong>DAT SBR for the anterior and posterior putamen and caudate in both hemispheres was obtained using validated automated quantitative software on baseline scans of 132 patients recruited for the Exenatide PD2 and PD3 trials. Associations between mean and lateralized SBR subregions (posterior and anterior putamen and caudate) and summed and lateralized motor characteristics were explored using regression analysis. Analyses were repeated considering disease duration and limiting analysis to the less-affected hemisphere.</p><p><strong>Results: </strong>Lateralized bradykinesia was most consistently associated with the loss of DAT uptake in the contralateral anterior putamen. There was much higher variance in the posterior putamen, and in all regions in those with longer duration disease, although bradykinesia remained robustly associated with anterior putaminal DAT uptake even in longer-duration patients. Restricting analyses to the less-affected side did not usefully reduce the variance compared to the overall cohort.</p><p><strong>Conclusion: </strong>These data suggest that DAT SBR could be a useful biomarker in disease-modifying trials, but a focus on anterior striatal subregions and incorporating disease duration into analyses may improve its utility.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1345-1354"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise Habits in People with Parkinson's: A Multinational Survey. 帕金森病患者的运动习惯:一项跨国调查。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1002/mdc3.14197
Priya Jagota, Phanupong Phutrakool, Nitish Kamble, Thuong Huyen Thi Dang, Zakiyah Aldaajani, Taku Hatano, Deva Kumar Hoskere Sreenivasa, Telugu Tripura, Prashanth Lingappa Kukkle, Beomseok Jeon, Noriko Nishikawa, Yutaka Oji, Tai Ngoc Tran, Frandy Susatia, Margherita Fabbri, Clémence Leung, Araceli Alonso Canovas, Walaa A Kamel, Pramod Kumar Pal, Kempaiah Rakesh, Muneer Abu Snineh, Parnsiri Chairangsaris, Praween Lolekha, Roland Dominic G Jamora, Norlinah Mohamed Ibrahim, Siti Hajar Mat Desa, Ai Huey Tan, Tzi Shin Toh, Mona Obaid, Victor S C Fung, Anthony Lang, Chin-Hsien Lin, Wafa Regragui, Naima Bouslam, Roongroj Bhidayasiri
{"title":"Exercise Habits in People with Parkinson's: A Multinational Survey.","authors":"Priya Jagota, Phanupong Phutrakool, Nitish Kamble, Thuong Huyen Thi Dang, Zakiyah Aldaajani, Taku Hatano, Deva Kumar Hoskere Sreenivasa, Telugu Tripura, Prashanth Lingappa Kukkle, Beomseok Jeon, Noriko Nishikawa, Yutaka Oji, Tai Ngoc Tran, Frandy Susatia, Margherita Fabbri, Clémence Leung, Araceli Alonso Canovas, Walaa A Kamel, Pramod Kumar Pal, Kempaiah Rakesh, Muneer Abu Snineh, Parnsiri Chairangsaris, Praween Lolekha, Roland Dominic G Jamora, Norlinah Mohamed Ibrahim, Siti Hajar Mat Desa, Ai Huey Tan, Tzi Shin Toh, Mona Obaid, Victor S C Fung, Anthony Lang, Chin-Hsien Lin, Wafa Regragui, Naima Bouslam, Roongroj Bhidayasiri","doi":"10.1002/mdc3.14197","DOIUrl":"10.1002/mdc3.14197","url":null,"abstract":"<p><strong>Background: </strong>Exercise has been demonstrated to result in improvements in physical function, cognition, and quality of life in People with Parkinson's (PwP) but its adoption is variable.</p><p><strong>Objectives: </strong>To investigate exercise preferences, levels, influencing factors among a diverse Parkinson's disease (PD) population, to understand exercise adoption patterns and plan informed interventions.</p><p><strong>Methods: </strong>A cross-sectional survey collected data through online platforms and paper-based methods. The Exercise Index (ExI) calculated exercise level based on frequency and duration.</p><p><strong>Results: </strong>Of 2976 PwP, 40.6% exercised regularly, 38.3% occasionally, and 21.2% did not exercise. The overall mean ExI was 18.99 ± 12.37. Factors associated with high exercise levels included exercising in groups (ExI 24-26), weightlifting (ExI 27 (highest)), using muscle-building equipment (ExI 25-26), and exercising at home following an app (ExI 26). A positive trend between ExI and varied exercise groups, locations, types, and equipment was observed. No expected benefit from exercise achieved the lowest ExI (8). Having at least two exercise-promoting factors, a bachelor's degree or higher, receiving exercise advice at initial visits, and aged ≤40 years at PD onset were strong predictors of exercise (adjust OR = 7.814; 6.981; 4.170; 3.565). Falls and \"other\" most troublesome PD symptoms were negative predictors (aOR = 0.359; 0.466). Barriers to exercise did not predict the odds of exercise.</p><p><strong>Conclusions: </strong>The study shows that PwP's exercise behavior is influenced by their exercise belief, age at PD onset, doctor's advice at initial visits, education level, symptoms, and exercise-promoting factors. High exercise levels were associated with certain types of exercises and exercising in groups.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1396-1409"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease. 左旋多巴等效日剂量:帕金森病的地域差异和现实生活模块。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI: 10.1002/mdc3.14200
Prashanth Lingappa Kukkle, Lorraine V Kalia, Ahsan Habib, Priya Jagota, Rajeev Ojha, Rukmini Mridula Kandadai, Soaham Desai, Manjula Caldera, Darshana Sirisena, Divyani Garg, Tiago A Mestre, Rosy Neupane, Suppata Maytharakcheep, Kanyawat Sanyawut, Rupam Borgohain
{"title":"Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease.","authors":"Prashanth Lingappa Kukkle, Lorraine V Kalia, Ahsan Habib, Priya Jagota, Rajeev Ojha, Rukmini Mridula Kandadai, Soaham Desai, Manjula Caldera, Darshana Sirisena, Divyani Garg, Tiago A Mestre, Rosy Neupane, Suppata Maytharakcheep, Kanyawat Sanyawut, Rupam Borgohain","doi":"10.1002/mdc3.14200","DOIUrl":"10.1002/mdc3.14200","url":null,"abstract":"<p><strong>Background: </strong>The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness.</p><p><strong>Objective: </strong>To assess updated LEDD conversion factors in capturing the newer therapies in PD and therapy modules in different geographical cohorts.</p><p><strong>Methods: </strong>Data were sourced from 10 Centers from 6 countries representing 2 different continents. The study compared the LEDD conversion factors proposed by Tomlinson et al and Jost et al, alongside investigating demographic disparities.</p><p><strong>Results: </strong>The analysis involved 2943 subjects; 87% (n = 2577) met the UK Brain Bank criteria for PD. The LEDD differed significantly across methodologies (Tomlinson vs. Jost, 598 mg vs 610 mg, P < 0.0001). Geographical disparities highlighted variations in PD onset age (P < 0.0001). Jost and Tomlinson's calculations demonstrated consistency within but significant differences across countries (P < 0.0001).Age at onset revealed statistically significant differences in LEDD requirements (P < 0.0001), which were particularly higher in 21-50 years (718 mg vs 566 mg). This subgroup also demonstrated increased usage of non-Levodopa therapies (P < 0.0001). Men exhibited higher total LEDD (P = 0.001). 34% reported dyskinesia, associated with higher LEDD (756 mg, P < 0.0001). Surgically treated patients also had higher LEDD (P < 0.0001) and a significant difference between Jost and Tomlinson dosages (761 mg vs716mg) reflecting the incorporation of newer therapeutic molecules.</p><p><strong>Conclusion: </strong>This analysis delineates the importance of updated LEDD algorithms and intricacies in the landscape of PD treatment, underscored by geographical, age-related, and gender-specific variations, in real-life management scenarios.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1388-1395"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic Depression Screening in Parkinson's Disease: Progress and Challenges. 帕金森病系统性抑郁筛查:进展与挑战。
IF 2.6 4区 医学
Movement Disorders Clinical Practice Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI: 10.1002/mdc3.14211
Jui-Man Chang, Lien-Chung Wei
{"title":"Systematic Depression Screening in Parkinson's Disease: Progress and Challenges.","authors":"Jui-Man Chang, Lien-Chung Wei","doi":"10.1002/mdc3.14211","DOIUrl":"10.1002/mdc3.14211","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1468-1469"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信