Movement Disorders Clinical Practice最新文献_第4页

Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension. 侧位丘脑下刺激治疗帕金森病的轴向功能障碍：探索性结果和开放标签扩展。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-13 DOI: 10.1002/mdc3.14188

Karlo J Lizarraga, Bhairavei Gnanamanogaran, Tameem M Al-Ozzi, Melanie Cohn, George Tomlinson, Alexandre Boutet, Gavin J B Elias, Jürgen Germann, Derrick Soh, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Connie Marras, William D Hutchison, Andres M Lozano, Anthony E Lang, Alfonso Fasano

{"title":"Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension.","authors":"Karlo J Lizarraga, Bhairavei Gnanamanogaran, Tameem M Al-Ozzi, Melanie Cohn, George Tomlinson, Alexandre Boutet, Gavin J B Elias, Jürgen Germann, Derrick Soh, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Connie Marras, William D Hutchison, Andres M Lozano, Anthony E Lang, Alfonso Fasano","doi":"10.1002/mdc3.14188","DOIUrl":"https://doi.org/10.1002/mdc3.14188","url":null,"abstract":"Background: A randomized trial suggested that reducing left-sided subthalamic stimulation amplitude could improve axial dysfunction.Objectives: To explore open-label tolerability and associations between trial outcomes and asymmetry data.Methods: We collected adverse events in trial participants treated with open-label lateralized settings for ≥3 months. We explored associations between trial outcomes, location of stimulation and motor asymmetry.Results: 14/17 participants tolerated unilateral amplitude reduction (left-sided = 10, right-sided = 4). Two hundred eighty-four left-sided and 1113 right-sided stimulated voxels were associated with faster gait velocity, 81 left-sided and 22 right-sided stimulated voxels were associated with slower gait velocity. Amplitude reduction contralateral to shorter step length was associated with 2.4-point reduction in axial MDS-UPDRS. Reduction contralateral to longer step length was associated with 10-point increase in MDS-UPDRS.Conclusions: Left-sided amplitude reduction is potentially more tolerable than right-sided amplitude reduction. Right-sided more than left-sided stimulation could be associated with faster gait velocity. Shortened step length might reflect contralateral overstimulation.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α-Methylacyl-CoA Racemase Deficiency in a Patient with Ataxia, Spasticity, and Segmental Dystonia. 共济失调、痉挛和节段性肌张力障碍患者体内的α-甲基酰-CoA Racemase 缺乏症

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-12 DOI: 10.1002/mdc3.14176

Ronak Rashedi, Mathias Gelderblom, Lisa Prilop, Maxim Bester, Tobias B Haack, Simone Zittel

引用次数: 0

Long-Term Outcomes of GPi Deep Brain Stimulation in a Child with Glutaric Aciduria Type 1 (GA1). 1 型戊二酸尿症 (GA1) 患儿接受 GPi 脑深部刺激的长期疗效。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-12 DOI: 10.1002/mdc3.14185

Almudena Chacón, Olga Mateo-Sierra, Javier Ricardo Pérez-Sánchez, Beatriz De la Casa-Fages, Francisco Grandas, Pedro De Castro, Concepción Miranda

引用次数: 0

Striking Efficacy of Pallidal Deep Brain Stimulation in a Patient with Predominant Abductor Laryngeal Dystonia: A Case Report. 苍白球深部脑刺激对优势性喉内收肌张力障碍患者的显著疗效：病例报告。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-12 DOI: 10.1002/mdc3.14189

Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Hiroshi Omae, Kaito Suzuki, Taku Matsuda, Hiroshi Koyama, Emi Ishitani, Yuishin Izumi, Yasushi Takagi

引用次数: 0

Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease. 快速眼动睡眠期间的快速眼动可区分帕金森病和帕金森综合症

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-07 DOI: 10.1002/mdc3.14187

Claudio Togni, Sandra Carpinelli, Philipp O Valko, Christopher Bockisch, Daniel Waldvogel, Esther Werth, Konrad P Weber, Yulia Valko

{"title":"Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease.","authors":"Claudio Togni, Sandra Carpinelli, Philipp O Valko, Christopher Bockisch, Daniel Waldvogel, Esther Werth, Konrad P Weber, Yulia Valko","doi":"10.1002/mdc3.14187","DOIUrl":"https://doi.org/10.1002/mdc3.14187","url":null,"abstract":"Background: Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.Objectives: The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD) and 12 healthy controls.Methods: Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.Results: Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.Conclusion: Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnic Differences in Atypical Parkinsonism-is South Asian PSP Different? 非典型帕金森病的种族差异--南亚帕金森病是否与众不同？

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-07 DOI: 10.1002/mdc3.14182

Bettina Balint, Shermyn Neo, Francesca Magrinelli, Eoin Mulroy, Anna Latorre, Maria Stamelou, Huw R Morris, Amit Batla, Kailash P Bhatia

{"title":"Ethnic Differences in Atypical Parkinsonism-is South Asian PSP Different?","authors":"Bettina Balint, Shermyn Neo, Francesca Magrinelli, Eoin Mulroy, Anna Latorre, Maria Stamelou, Huw R Morris, Amit Batla, Kailash P Bhatia","doi":"10.1002/mdc3.14182","DOIUrl":"https://doi.org/10.1002/mdc3.14182","url":null,"abstract":"Background: Progressive supranuclear palsy (PSP) is a progressive atypical parkinsonian condition that results in severe disability. There are few studies of PSP in patients of non-white European ancestry.Objectives: We aim to perform deep phenotyping in a South Asian PSP cohort to uncover possible ethnic differences in disease characteristics.Methods: Consecutive PSP patients had their clinical records reviewed for clinical features operationalized in the Movement Disorder Society (MDS)-PSP diagnostic criteria and relevant investigations, including imaging and genetic tests. Clinical variables were summarized by descriptive statistics and Kaplan-Meier curves were generated for survival analysis.Results: Twenty-seven patients, comprising Indians (78%), Pakistanis (11%) and Sri Lankans (11%) were included. Mean age of symptom onset was 63.8 ± 7.0 years and 22% of patients had an early age of onset (<60 years). The most common presenting symptom was parkinsonism (56%), followed by cognitive dysfunction (37%), falls (33%) and dysarthria (26%). The predominance types at final review were distributed across PSP-RS (67%), PSP-PGF (15%), PSP-P (15%) and PSP-F (4%). Atypical clinical features like cerebellar signs (33%), REM-sleep behavior disorder (RBD) (55%), visual hallucinations (22%), and a family history of parkinsonism (20%) were evident in a proportion of patients.Conclusions: We present a South Asian cohort of PSP patients with a higher than previously reported percentages of early-onset disease, family history and atypical clinical manifestations. These patients do not fit easily into the PSP phenotypes defined by the current MDS criteria. Dedicated clinicopathological and genetic tests are needed in this population to dissect the pathogenesis of clinically-defined PSP.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthostatic Hypotension and Risk of Mild Cognitive Impairment and Dementia in Parkinson's Disease. 帕金森病患者的直立性低血压与轻度认知功能障碍和痴呆症的风险。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-06 DOI: 10.1002/mdc3.14179

Ylva Hivand Hiorth, Jörn Schulz, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves

{"title":"Orthostatic Hypotension and Risk of Mild Cognitive Impairment and Dementia in Parkinson's Disease.","authors":"Ylva Hivand Hiorth, Jörn Schulz, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves","doi":"10.1002/mdc3.14179","DOIUrl":"https://doi.org/10.1002/mdc3.14179","url":null,"abstract":"Background: Orthostatic hypotension (OH) is a common condition in Parkinson's disease (PD) with a possible link to cognitive decline.Objective: The aim was to explore the association between OH and PD-associated mild cognitive impairment (PD-MCI) and dementia (PDD) over 9 years in a population-based incident PD cohort.Methods: We prospectively followed up patients from PD diagnosis with serial blood pressure measurements, clinical examinations, and neuropsychological assessments. We defined OH using (1) consensus-based criteria and (2) clinically significant OH by mean arterial pressure (MAP) in standing position ≤75 mmHg. PD-MCI and PDD were diagnosed according to acknowledged criteria. We applied generalized estimating equations models to investigate associations between OH measurements and cognitive impairment over time. Weibull accelerated failure time regression models were used to study if early OH (≤3 years of PD diagnosis) accelerates the time to incident PD-MCI and PDD.Results: Of 186 enrolled patients, consensus-based OH affected 68.8%, clinically significant OH 33.9%, PD-MCI 60.8%, and PDD 31.2%. Consensus-based OH was associated with PD-MCI (odds ratio [OR]: 2.04, 95% confidence interval: 1.44-2.90, P < 0.001), whereas clinically significant OH was associated with both PD-MCI (OR: 1.95, 1.11-3.43, P = 0.020) and PDD (OR: 3.66, 1.95-6.86, P < 0.001). Early clinically significant OH, but not early consensus-based OH, reduced time to incident PD-MCI by 54% (P = 0.021) and time to PDD by 44% (P = 0.003) independently of potential confounders, including supine hypertension and cardiovascular disease.Conclusions: MAP in standing position emerged as a stronger predictor of cognitive decline than OH determined using consensus-based criteria. These findings have implications for both research and clinical practice.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular Leukoencephalopathy Associated Chorea Due to A Heterozygous Htra 1 Variant: Novel Presentation of Cadasil Type II. Htra 1杂合子变异导致的血管性白质脑病相关性舞蹈症：卡达希尔 II 型的新表现。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-06 DOI: 10.1002/mdc3.14186

Alina Nazir, Ali Zafar, Edward Jones, Muhammad Awan

引用次数: 0

Vibrotactile Foot Device for Freezing of Gait in Parkinson's Disease: A Pilot Study. 振动触觉足部装置治疗帕金森病步态冻结：一项试点研究

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-02 DOI: 10.1002/mdc3.14177

Shanshan Cen, Jinghong Ma, Hong Sun, Hui Zhang, Yuan Li, Wei Mao, Erhe Xu, Shanshan Mei, Jagadish K Chhetri, Zheng Ruan, Hui Wang, Kailiang Wang, Piu Chan

{"title":"Vibrotactile Foot Device for Freezing of Gait in Parkinson's Disease: A Pilot Study.","authors":"Shanshan Cen, Jinghong Ma, Hong Sun, Hui Zhang, Yuan Li, Wei Mao, Erhe Xu, Shanshan Mei, Jagadish K Chhetri, Zheng Ruan, Hui Wang, Kailiang Wang, Piu Chan","doi":"10.1002/mdc3.14177","DOIUrl":"https://doi.org/10.1002/mdc3.14177","url":null,"abstract":"Background: Vibrotactile stimulation has been studied in its efficacy of reducing freezing of gait (FOG) in patients with Parkinson's disease (PD). However, the results are still controversial. We evaluated the efficacy of a newly developed vibrotactile foot device on freezing severity and gait measures in PD patients with FOG.Objective: To evaluate the efficacy of vibrotactile foot device on PD patients with FOG.Methods: Thirty-three PD patients with FOG were examined during their \"off\" medication state. The efficacy of the vibrotactile foot device was evaluated using a gait protocol comprising walking trials with vibrotactile stimulation \"off\" and \"on.\" Walking trials were videotaped for the offline rating by two movement disorder specialists. The Opal inertial sensor unit (128 Hz; Mobility Lab; APDM Inc., Portland, OR, USA) was used for quantitative gait analysis.Results: The results demonstrated 33.1% reduction in number of FOG episodes (P < 0.001) and 32.6% reduction of freezing episodes (P < 0.001). Quantitative gait analysis showed a significant increase in step length (P = 0.033). A moderate negative correlation was observed between the change of percent time frozen and age (r = -0.415, P = 0.016). 73% of participants reported minimal to substantial improvement in walking with this vibrating stimulation delivered by the vibrotactile foot device.Conclusions: The vibrotactile foot device is an efficient device that could significantly reduce freezing severity and provide gait regulation to patients with PD experiencing frequent freezing. It could potentially be used in the home environment for improving the quality of life.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Dopamine Dancer: The Value of Holistic Autotherapy in Parkinson's Disease. 多巴胺舞者：整体自体疗法在帕金森病中的价值。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-02 DOI: 10.1002/mdc3.14166

Anne Hellevik, Karin Wirdefeldt, A J Lees

引用次数: 0