Movement Disorders Clinical Practice最新文献_第10页

Representational Disparities in the Enrollment of Parkinson's Disease Clinical Trials. 帕金森病临床试验入组的代表性差异

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-17 DOI: 10.1002/mdc3.70009

Chia-Chen Tsai, Brendan Tao, Vallen Lin, Jaden Lo, Suhangi Brahmbhatt, Carmen Kalo, Connie Marras, Faisal Khosa

引用次数: 0

Decision-making trends in therapeutic interventions for multiple system atrophy: a 24-year retrospective study. 多系统萎缩治疗干预的决策趋势：一项24年回顾性研究。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-14 DOI: 10.1002/mdc3.70000

Katsuya Nishida, Kento Sakashita, Naonobu Futamura

{"title":"Decision-making trends in therapeutic interventions for multiple system atrophy: a 24-year retrospective study.","authors":"Katsuya Nishida, Kento Sakashita, Naonobu Futamura","doi":"10.1002/mdc3.70000","DOIUrl":"https://doi.org/10.1002/mdc3.70000","url":null,"abstract":"Background: Managing multiple system atrophy (MSA) is challenging. While invasive interventions for amyotrophic lateral sclerosis are well-studied, those for MSA remain less explored.Objectives: To explore factors influencing treatment choices and trends in advanced-stage MSA.Methods: A retrospective cohort study analyzed 128 MSA patients at Hyogo Chuo National Hospital, Japan, from 2000 to 2024, focusing on treatment period and age at onset.Results: Tracheostomy invasive ventilation (TIV) decreased after 2014 (26.9% vs. 9.2%; P = 0.023). TIV-treated patients remained similarly young before and after 2014 (age at onset 52.7 vs. 54.5 years; P = 0.659) and tracheostomy was chosen by younger patients after 2014 (58.3 vs. 51.5 years; P < 0.001). Conversely, enteral nutrition increased in older patients (57.4 vs. 62.9 years; P = 0.011).Conclusions: In Japanese MSA, preferences for invasive treatments shifted, with younger patients favoring TIV and tracheostomy, while older patients preferred less invasive options, emphasizing personalized care.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Memoriam C. Warren Olanow (1941-2024). 纪念c·沃伦·奥拉诺（1941-2024）

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-13 DOI: 10.1002/mdc3.14351

Victor S C Fung, Kailash P Bhatia, David J Burn, Christopher G Goetz, Mark Hallett, Joseph Jankovic, Karl Kieburtz, Christine Klein, Jeffrey H Kordower, Anthony E Lang, Marcelo Merello, Matthew B Stern, A Jon Stoessl, Philip D Thompson

引用次数: 0

Autoimmune "Atypical" Atypical Parkinsonism: Anti-GABA_B Receptor Encephalitis Presenting as a Reversible Mimic of Progressive Supranuclear Palsy. 自身免疫性“非典型”非典型帕金森病：抗gabab受体脑炎表现为进行性核上性麻痹的可逆模拟。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-12 DOI: 10.1002/mdc3.70003

Farsana Mustafa, Chaithra Rajanna, Ayush Agarwal, Ajay Garg, Achal Kumar Srivastava, Anita Mahadevan, Divyani Garg

引用次数: 0

Movement Disorders in Hereditary Cerebellar Ataxia. 遗传性小脑共济失调的运动障碍。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-12 DOI: 10.1002/mdc3.14358

Joana Damásio, Sara Costa, João Moura, Mariana Santos, Carolina Lemos, Alexandre Mendes, Jorge Oliveira, José Barros, Jorge Sequeiros

{"title":"Movement Disorders in Hereditary Cerebellar Ataxia.","authors":"Joana Damásio, Sara Costa, João Moura, Mariana Santos, Carolina Lemos, Alexandre Mendes, Jorge Oliveira, José Barros, Jorge Sequeiros","doi":"10.1002/mdc3.14358","DOIUrl":"https://doi.org/10.1002/mdc3.14358","url":null,"abstract":"Background: Hereditary cerebellar ataxia (HCA) represents a complex group of disorders, with a wide spectrum of neurological symptoms. Among these, non-ataxia movement disorders (MD) have been increasingly acknowledged, with variable frequency across different forms.Objectives: To characterize the type and frequency of MD in patients with HCA. To identify factors associated with MD and analyze their impact on disability.Methods: We conducted a prospective study starting in 2017, with annual visits according to a structured protocol. Patients were selected from the study database and their clinical and genetic features analyzed.Results: The cohort comprised 193 symptomatic patients. Machado-Joseph disease (MJD, also SCA3 or ATX-ATXN3) and cerebellar ataxia, neuropathy and vestibular areflexia syndrome (ATX-RFC1) were the most common autosomal dominant (AD) or recessive forms, with a frequency of 14.0% and 15.0%, respectively. MD were present in 95 (54.4%), with dystonia being the most common (49.2%). Tremor was identified in 10.9%, Parkinsonism in 4.1% and chorea in 3.6% patients. Myoclonus and tics were rare (2.6% and 0.5%). The presence of MD was associated with AD inheritance and ATXN3. MD, regardless of type, correlated with higher SARA score at baseline, increased fall frequency, confinement to wheelchair, and earlier occurrence of falls and of permanent use of walking aid.Conclusions: Movement disorders, particularly dystonia, were common in our cohort. This highlights the possible role of the cerebellum in MD, but also extra-cerebellar involvement in some HCA. Presence of MD significantly worsened motor disability, highlighting the need for strategies of early identification and tailored management.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Equal Distress and Less Hope in Parkinson's Disease Patients Compared to Brain Tumors Patients. 帕金森氏症患者与脑肿瘤患者的痛苦相同，希望更少。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-12 DOI: 10.1002/mdc3.14355

Simone D'Souza, Esther Tekampe, Marco Skardelly, Stephan Zipfel, Martin Teufel, Björn Falkenburger

引用次数: 0

Assessing Eligibility for Apomorphine Therapy in Parkinson's Disease: The Telemonitoring Potential. 评估阿波啡治疗帕金森病的资格：远程监测潜力。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-11 DOI: 10.1002/mdc3.14345

Alagaratnam Niruban, Vaclav Dostal, Abigail Mutimer, Konstantinos Tsamis, Spyridon Kontaxis, Nicholas Kostikis, Foivos Kanellos, Adamantios Ntanis, George Rigas, Spyridon Konitsiotis

{"title":"Assessing Eligibility for Apomorphine Therapy in Parkinson's Disease: The Telemonitoring Potential.","authors":"Alagaratnam Niruban, Vaclav Dostal, Abigail Mutimer, Konstantinos Tsamis, Spyridon Kontaxis, Nicholas Kostikis, Foivos Kanellos, Adamantios Ntanis, George Rigas, Spyridon Konitsiotis","doi":"10.1002/mdc3.14345","DOIUrl":"https://doi.org/10.1002/mdc3.14345","url":null,"abstract":"Background: Although there are established guidelines for the selection of suitable candidates, objective and timely referral for the use of apomorphine remains challenging.Objectives: This research examined how telemonitoring may facilitate referrals for continuous subcutaneous apomorphine infusion in Parkinson's disease (PD).Methods: A Blind Rater and a multi-disciplinary team (MDT) including an expert PD nurse, neurologist, and geriatrician determined apomorphine pump treatment eligibility for 20 patients with PD. The MDT considered telemonitoring data and physical examination to determine eligibility. The Blind Rater used only telemonitoring data (PDMonitor®) to evaluate eligibility.Results: The results show that using wearable sensors to determine appropriateness of apomorphine pump treatment is similar to a complete method that combines objective motor symptom monitoring with clinical evaluation. The MDT and blind rater had a 0.89 Cohen's kappa coefficient, which suggests high rate of agreement. The best-performing objective metric for differentiating patients who were recommended (APO) from those non-recommended (non-APO) for apomorphine pump therapy, was the device-reported percentage of time in the \"ON\" state, which takes into consideration the \"OFF\" and dyskinesia time. The APO group had lower values in this metric and could be differentiated from the non-APO group accurately (85%).Conclusions: Using telemonitoring to determine eligibility for apomorphine therapy might improve evaluation and treatment in patients with PD and, therefore help improve their quality of life.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterior Subthalamic Area Deep Brain Stimulation Combined with Spinal Cord Stimulation in a Patient with Spinocerebellar Ataxia Type 12. 丘脑后底区深部脑刺激联合脊髓刺激治疗脊髓小脑共济失调1例。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-10 DOI: 10.1002/mdc3.14356

Ruinan Shen, Zhuofan Zhou, Zhengyu Lin, Peng Huang, Yixin Pan, Dianyou Li, Yiwen Wu

引用次数: 0

Family with BCL11B Related Dystonia and Movement Disorders. 家族与BCL11B相关的肌张力障碍和运动障碍。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-10 DOI: 10.1002/mdc3.14357

Jaclyn M Martindale, Leah Chapman, Virginia Lane, Audrey Hunt, Jennifer E Harmon, Lia K Thibodaux, Lubna Jafri, Aubrey Hite, Jessica Tate, Linda Nicolotti, Michael S Okun

引用次数: 0

Improvement of Motor Function in SLC39A8-Related Ataxia Through Manganese Supplementation: A Therapeutic Insight. 通过补充锰改善slc39a8相关共济失调的运动功能：一种治疗见解。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-02-09 DOI: 10.1002/mdc3.70001

Denise Maria Meneses Cury Portela, Thiago Gonçalves Guimarães, Sandra Tuany Alves de Morais, Natália Rebeca Alves de Araújo, Luana Larisse de Sousa Araújo, Vinicius Santana Vasconcelos, Gustavo Sousa Noleto, Patricia Maria da Costa Braga, Sarah Teixeira Camargos

引用次数: 0