Movement Disorders Clinical Practice最新文献

{"title":"Ocular Motor Abnormalities in Functional Neurological Disorder: A Video-Oculography Study.","authors":"Aude Sangare, Astrid de Liège, Bertrand Gaymard, Sophie Rivaud-Péchoux, Cécilia Bonnet, Evžen Růžička, Jaromír May, Tereza Serranová, Francine Mesrati, Emmanuel Roze, Marie Vidailhet, Céline Louapre, Lionel Naccache, Béatrice Garcin","doi":"10.1002/mdc3.70394","DOIUrl":"https://doi.org/10.1002/mdc3.70394","url":null,"abstract":"<p><strong>Background: </strong>Functional neurological disorders (FND) can include various sensory, motor or cognitive symptoms. Eye movement recordings, measured through video-oculography, could serve as biomarkers for characterizing these dysfunctions in FND.</p><p><strong>Objective: </strong>To identify oculomotor patterns that may help to support a positive diagnosis of FND.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of video-oculography recordings performed between 2011 and 2023 in 149 patients with FND, focusing on horizontal and vertical prosaccades, smooth pursuit, and antisaccades. These data were compared with those obtained from 132 age and gender-matched healthy volunteers and 43 patients diagnosed with multiple sclerosis (MS).</p><p><strong>Results: </strong>FND patients exhibited significantly increased mean saccade latencies in both horizontal and vertical prosaccade tasks compared to controls (t-test, P < 0.0001). Additionally, variability in horizontal and upward saccade latency was substantially greater in the FND group than in the control and MS groups (P < 0.0001). Vertical saccades in FND patients were hypometric (P < 0.0001) with increased variability of upward saccade amplitude (P < 0.0001). Both MS and FND patients had higher antisaccade error rates than controls (P < 0.0001).</p><p><strong>Conclusion: </strong>These findings suggest that video oculography may be useful in understanding the pathophysiology of FND and highlight its potential as a complementary tool to support diagnostic reasoning in complex clinical presentations.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Movement Disorder Perspectives at MCT8 Deficiency: A Case Series of Three Colombian Patients With Allan Herndon Dudley Syndrome\".","authors":"","doi":"10.1002/mdc3.70387","DOIUrl":"https://doi.org/10.1002/mdc3.70387","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Pathology: α-Synuclein Homeostasis and Three Principles to Guide Research.","authors":"Alberto J Espay, Andrew J Lees","doi":"10.1002/mdc3.70400","DOIUrl":"https://doi.org/10.1002/mdc3.70400","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Holistic Wellness Prescription for Parkinson's Disease: Evidence-Based Perspectives and Unmet Needs.","authors":"Indu Subramanian, Lucia Ricciardi, Anette Schrag, Silke Appel-Cresswell, Sushma Kola, Josefa M Domingos, Barbara A Pickut, Nabila Dahodwala, Abdoulaye Bocoum, Cristian Falup-Pecurariu, Gila Bronner, Gregory M Pontone, Laurie K Mischley, Nélida S Garretto, Nicola Modugno, Rachel Dolhun, Tissa Wijeratne, Victoria Tull, Bradley McDaniels, K Ray Chaudhuri","doi":"10.1002/mdc3.70381","DOIUrl":"https://doi.org/10.1002/mdc3.70381","url":null,"abstract":"<p><strong>Background: </strong>In modern medicine the concept of wellness is often accompanied by various misconceptions arising from several factors, including a lack of clear definitions, the commercialization of wellness, and prevailing biases and stereotypes.</p><p><strong>Method: </strong>Although wellness has been successfully integrated into the management of conditions like cardiovascular disease, diabetes, and cancer, it has yet to be widely applied in the field of neurology. The World Federation of Neurology, American Academy of Neurology, European Academy of Neurology, and the World Health Organization (WHO) have adopted a formal definition of brain health that emphasizes the proactive role of lifestyle choices in modifying outcomes for neurological diseases, which closely aligns with the wellness approach. This shift has been further reinforced by WHO's adoption of the Intersectoral Global Action Plan on epilepsy and other neurological disorders (2022-2031), which seeks to improve access to treatment and care while promoting brain health across the lifespan. The global push for brain health highlights the need for a structured approach to wellness in neurological conditions such as Parkinson's disease (PD).</p><p><strong>Results/conclusion: </strong>This critical review, conducted by a multidisciplinary task force commissioned by the International Parkinson and Movement Disorder Society, aims to provide the current evidence base on wellness in PD, identify existing gaps in knowledge, and propose a framework to integrate wellness into the holistic care of individuals with PD.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Motor OFF in Parkinson's Disease.","authors":"Shreyashi Jha, Mandar S Jog","doi":"10.1002/mdc3.70388","DOIUrl":"https://doi.org/10.1002/mdc3.70388","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freezing of Gait in Parkinson's Disease: Don't Leave Patients in the Dark!","authors":"Franka Goossens, Gijs Vissers, Bastiaan R Bloem, Sirwan Darweesh, Jorik Nonnekes","doi":"10.1002/mdc3.70401","DOIUrl":"https://doi.org/10.1002/mdc3.70401","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental and Multifocal Isolated Dystonias: Similarities and Differences.","authors":"Hyder A Jinnah, Vittorio Velucci, Daniele Belvisi, Gamze Kilic-Berkmen, Joel S Perlmutter, Laura J Wright, Christine Klein, Jeanne S Feuerstein, Steven Bellows, Joseph Jankovic, Cynthia Comella, Richard L Barbano, Aparna Wagle Shukla, Stephen G Reich, Mark S LeDoux, Alberto J Espay, Kevin R Duque, Florence C F Chang, Victor S C Fung, Sarah Pirio-Richardson, Carmen Terranova, Emile S Moukheiber, Sarah Idrissi, Barbara Vitucci, Susan H Fox, Samuel Frank, Natividad Stover, Brian D Berman, Rachel Saunders-Pullman, William G Ondo, Christopher L Groth, Marcello Esposito, Laura Avanzino, Francesco Bono, Roberto Erro, Marcello Mario Mascia, Antonella Muroni, Alfredo Berardelli, Giovanni Defazio","doi":"10.1002/mdc3.70390","DOIUrl":"https://doi.org/10.1002/mdc3.70390","url":null,"abstract":"<p><strong>Background: </strong>Whether the traditional distinction between segmental and multifocal dystonia is clinically or scientifically useful remains unclear.</p><p><strong>Objective: </strong>To evaluate whether idiopathic isolated adult-onset segmental and multifocal dystonia can be differentiated based on clinical features other than the contiguity of affected body regions.</p><p><strong>Methods: </strong>We compared data on segmental and multifocal dystonia from two large dystonia databases established in the USA and Italy that used similar criteria for patient recruitment and assessment.</p><p><strong>Results: </strong>Compared to segmental dystonia, multifocal dystonia was characterized by a higher proportion of men, a younger age at dystonia onset, a greater frequency of upper limb dystonia, and a lower frequency of cranial dystonia at both onset and last examination. Segmental and multifocal dystonia had a similar frequency of alleviating maneuvers, non-motor eye symptoms in blepharospasm, and neck pain and tremor in cervical dystonia. Although the initial spread pattern from focal to segmental or multifocal appeared faster in the segmental dystonia group, adjusting the analysis for the initial body site involved revealed no significant differences between the two groups. Segmental and multifocal dystonia starting in the same body site showed similar age, sex, and spread characteristics. The observed differences and similarities were consistent across both independent databases.</p><p><strong>Conclusions: </strong>Segmental and multifocal dystonia share differences and similarities. The observed differences may reflect a difference in the predominant site of dystonia onset. From a clinical perspective, therefore, the segmental/multifocal distinction is probably not valuable in the dystonia classification scheme, although further data may be needed from a pathophysiological perspective.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huntington's Disease and Huntington's Disease-like 2 (HDL2) in Martinique.","authors":"Ignacio Antolin-Sanfeliz, Anna-Gaelle Giguet-Valard, Sophie Duclos, Cécile Cazeneuve, Chloé Angelini, Aïssatou Signaté, Russell L Margolis, Cyril Goizet, Rémi Bellance","doi":"10.1002/mdc3.70379","DOIUrl":"https://doi.org/10.1002/mdc3.70379","url":null,"abstract":"<p><strong>Background: </strong>Huntington's Disease-like 2 (HDL2), caused by a CAG repeat expansion in JPH3, closely resembles HD. All reported HDL2 patients to date have some African ancestry. While both disorders exist in the Caribbean, their relative frequency and clinical characteristics remain largely unknown.</p><p><strong>Objectives: </strong>To characterize HD and HDL2 patients in Martinique.</p><p><strong>Methods: </strong>We retrospectively analyzed all HD and HDL2 patients evaluated over 20 years at a single neurology center in Martinique, collecting longitudinal clinical features, UHDRS scores, and repeat lengths.</p><p><strong>Results: </strong>In Martinique, combined HD and HDL2 minimum prevalence was 7.77/100,000. We ascertained 24 HD individuals, from 16 pedigrees, and 18 HDL2 individuals, from two pedigrees, one being the most extensive HDL2 pedigree yet reported. Because most HDL2 patients belong to a single large pedigree, the data must be interpreted with caution as familial clustering may introduce bias. HDL2 cases were predominantly male (83% vs. 45% in HD). Motor symptoms were the most frequent initial manifestation in both. Repeat length negatively correlated with estimated onset age in both diseases. Longitudinal motor (UHDRS-TMS) and functional capacity (UHDRS-TFC) scores in HDL2 revealed progressive worsening similar to HD. Inter- and intra-familial clinical and genetic heterogeneity was obvious in both diseases. Anticipation was not exclusively reserved to paternal transmissions in HDL2.</p><p><strong>Conclusions: </strong>HDL2 is nearly as prevalent as HD in Martinique. The study reinforces the similarities between HD and HDL2 in genotype-phenotype correlation and disease course, while highlighting heterogeneity and germline instability in HDL2. Interpretation is limited by the small number of HDL2 families.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to GPi-DBS in a Case of EIF2AK2-Associated Early-Onset Generalized Dystonia.","authors":"Sara Radmard, Kathryn Yang, Darius Ebrahimi-Fakhari","doi":"10.1002/mdc3.70395","DOIUrl":"https://doi.org/10.1002/mdc3.70395","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Report of Putaminal Cysts in the Familial Series of Dystonia Associated with Salla Disease-the Phenotype Expanded.","authors":"Esther Macken, Antoinette O'Connor, Noel Fanning, Brian J Sweeney, Diana A Olszewska","doi":"10.1002/mdc3.70392","DOIUrl":"https://doi.org/10.1002/mdc3.70392","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}