Movement Disorders Clinical Practice最新文献

Subcutaneous Foslevodopa as Rescue Therapy for Abrupt Interruption of Oral Dopaminergic Treatment in Parkinson's Disease. 帕金森病患者口服多巴胺能治疗突然中断时，皮下Foslevodopa作为抢救疗法。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-24 DOI: 10.1002/mdc3.70253

Fabienne Ory-Magne, Jean Luc Houeto, Margherita Fabbri

引用次数: 0

Profile of People With Parkinson's Disease Treated With a Device-Aided Therapy in Spain. A Comparative Multicenter Observational Study. 在西班牙用器械辅助疗法治疗帕金森病患者的概况一项多中心比较观察研究。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-24 DOI: 10.1002/mdc3.70239

Diego Santos-García, Ángela Solleiro, Guillermo González-Ortega, Pablo Mir, Nuria López-Ariztegui, Rocío García Ramos, Inés Legarda, Anna Planas-Ballvé, Deborah Alonso-Modino, Pilar Sánchez-Alonso, Iria Cabo, Marta Blázquez-Estrada, Álvaro Sánchez-Ferro

{"title":"Profile of People With Parkinson's Disease Treated With a Device-Aided Therapy in Spain. A Comparative Multicenter Observational Study.","authors":"Diego Santos-García, Ángela Solleiro, Guillermo González-Ortega, Pablo Mir, Nuria López-Ariztegui, Rocío García Ramos, Inés Legarda, Anna Planas-Ballvé, Deborah Alonso-Modino, Pilar Sánchez-Alonso, Iria Cabo, Marta Blázquez-Estrada, Álvaro Sánchez-Ferro","doi":"10.1002/mdc3.70239","DOIUrl":"https://doi.org/10.1002/mdc3.70239","url":null,"abstract":"Background and objective: New device-aided therapies (DATs) have emerged to treat people with Parkinson's disease (PwP). Our aim was to know which DATs were indicated by the neurologist and to compare the characteristics of the patients treated under real clinical practice in Spain in the year 2024.Patients and methods: Data collected in the DATs-PD GETM Spanish Registry were used (REDCap). This is a descriptive, observational, prospective, multicenter, clinical registry with progressive inclusion of PwP treated with a DAT in daily clinical practice conditions in more than 40 centers from Spain for 10 years. For this proposal, only data from visit V1 (indication of DAT) were analyzed, but no follow-up data. All patients with information on DAT received until 31/DEC/2024 were included.Results: A total of 313 PD patients (66.7 ± 9.6 years old at V2; 61.7% males) were treated with a DAT. The most frequent DAT was subcutaneous foslevodopa/foscarbidopa (fLD/fCD) (47%) followed by deep brain stimulation (DBS) (20.1%) and continuous subcutaneous apomorphine infusion (CSAI) (19.8%). Up to 23.6% had received at least one previous DAT and 47% an on-demand therapy. Differences in age, time with fluctuations and other aspects (motor status, quality of life or activities of daily living among others) were observed between different DAT groups. Specifically, patients treated with DBS were younger and had less advanced disease, whereas those who received LECIG were the most affected.Conclusion: Subcutaneous therapies and DBS were the most frequent DATs (86.9%) implemented in Spain in 2024. Profile differences were detected between DAT types.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumefactive Virchow-Robin Spaces as a Cause of Secondary Parkinsonism. 肿瘤性Virchow-Robin间隙是继发性帕金森病的病因。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-24 DOI: 10.1002/mdc3.70250

Arnout Bruggeman, Jelle Vandersteene, Patrick Santens

引用次数: 0

Progressive Supranuclear Palsy and Normal Pressure Hydrocephalus: Can Neuroimaging Solve this Mysterious Diagnostic Overlap? 进行性核上性麻痹和常压性脑积水：神经影像学能解决这一神秘的诊断重叠吗？

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-22 DOI: 10.1002/mdc3.70256

Shabab Alotaibi, Alfonso Fasano

引用次数: 0

Addressing Variability and Bridging the Gap in Parkinson's Disease Care: A Call to Action. 解决可变性和弥合差距在帕金森病的护理：呼吁采取行动。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-22 DOI: 10.1002/mdc3.70255

Daniel G Di Luca, Ali Shalash

引用次数: 0

Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy. 基底前脑容量预测前驱突触核蛋白病的疾病转化。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-22 DOI: 10.1002/mdc3.70242

Lachlan Churchill, Ajay Konuri, Anna Ignatavicius, Jack Anderson, Simon J G Lewis, Elie Matar

{"title":"Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy.","authors":"Lachlan Churchill, Ajay Konuri, Anna Ignatavicius, Jack Anderson, Simon J G Lewis, Elie Matar","doi":"10.1002/mdc3.70242","DOIUrl":"https://doi.org/10.1002/mdc3.70242","url":null,"abstract":"Background: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The basal forebrain (BF), a key cholinergic structure, is a site of known pathology in later stages of Lewy body disorders. Although bilateral BF atrophy has been linked to cognitive decline in iRBD, its potential role in predicting phenoconversion to PD and DLB remains unclear.Objectives: The aims were to examine BF gray matter volume differences between iRBD patients and healthy controls, and evaluate their utility as predictors of phenoconversion to PD or DLB. Exploratory post hoc analyses were also conducted to explore the lateral-specific effects of BF atrophy in relation to disease conversion.Methods: We assessed 41 participants with polysomnography-confirmed iRBD and 38 healthy controls using baseline T1-weighted magnetic resonance imaging (MRI) and longitudinal clinical assessments. Gray matter volumes of the left and right BF were compared between groups. Cox proportional hazards models examined baseline BF volumes as predictors of phenoconversion risk to PD and DLB.Results: Although no significant group differences in BF volume were found, lower BF volume was associated with poorer global cognition in iRBD. Bilateral BF atrophy predicted increased risk of phenoconversion to either PD or DLB. An exploratory post hoc analysis revealed that left BF atrophy specifically predicted conversion to DLB, whereas right BF volume did not.Conclusion: Bilateral BF atrophy may represent an early biomarker of phenoconversion in iRBD, with left-sided atrophy potentially indicating increased risk for DLB. These findings highlight the prognostic value of BF degeneration in prodromal synucleinopathies.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Video Urodynamic Study in Patients with Parkinson's Disease and Multiple System Atrophy. 帕金森氏病合并多系统萎缩患者的视频尿动力学研究。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-22 DOI: 10.1002/mdc3.70246

Hyun Sik Yoon, Seung Ho Jeon, Han-Joon Kim, Seung-June Oh

{"title":"Video Urodynamic Study in Patients with Parkinson's Disease and Multiple System Atrophy.","authors":"Hyun Sik Yoon, Seung Ho Jeon, Han-Joon Kim, Seung-June Oh","doi":"10.1002/mdc3.70246","DOIUrl":"https://doi.org/10.1002/mdc3.70246","url":null,"abstract":"Background: Most studies have analyzed the urodynamic characteristics of patients with Parkinson's disease (PD) and multiple system atrophy (MSA) using conventional urodynamic studies.Objectives: This study investigated the urodynamic characteristics of both diseases using video urodynamic study (VUDS).Methods: VUDS results from November 2004 to September 2020 were retrospectively analyzed at Seoul National University Hospital. The VUDS findings in patients with PD and those with MSA were compared. Movement disorder specialists diagnosed patients with PD and MSA.Results: A total of 709 patients, comprising 364 PD (260 men, 104 women) and 345 MSA (215 men, 130 women) cases, were identified. Patients with MSA had a significantly younger age at onset, lower maximum flow rate (Qmax), larger postvoid residual volume, higher rate of poor bladder compliance, higher prevalence of urinary incontinence, and lower detrusor pressure at Qmax than those with PD. Among the fluoroscopic findings of VUDS, patients with MSA had a higher rate of incompetent bladder neck (18.8% vs. 4.7%, P < 0.001), bladder trabeculation (33.0% vs. 17.0%, P < 0.001), and vesicoureteral reflux (2.9% vs. 0.5%, P = 0.019) than those with PD. In VUDS performed in patients without urinary incontinence in conventional urodynamic study, an incompetent bladder neck was found in 14.6% of patients with MSA and 3.3% of patients with PD (P < 0.001).Conclusions: Our results demonstrate that VUDS can provide additional information on bladder urethral dysfunction, particularly regarding the risk of upper urinary tract damage and bladder neck status in patients with PD and MSA.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paroxysmal Dyskinesia with a Novel Variant in the Histone 3 Family 3B (H3-3B) Gene. 组蛋白3家族3B （H3-3B）基因新变异的阵发性运动障碍

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-22 DOI: 10.1002/mdc3.70236

Gianluca D'Onofrio, Sebastien Perreault, Grant Mitchell, Inge A Meijer

引用次数: 0

The Benefit of Exclusive Nocturnal Levodopa-Carbidopa Intestinal Infusion for Severe Refractory Sleep Behavior Disorder in Parkinson's Disease. 单独夜间左旋多巴-卡比多巴肠道输注治疗帕金森病严重难治性睡眠行为障碍的益处

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-18 DOI: 10.1002/mdc3.70237

María Rivera-Sánchez, Antonio Sánchez-Rodríguez, Leire Manrique, María Sierra, Isabel González-Aramburu, María Victoria Sánchez-Peláez, Marián Martínez, Anjana López-Delgado, Jon Infante

引用次数: 0

Cannabidiol Intervention for Non-Epileptic Myoclonus in Angelman Syndrome: A Case Report. 大麻二酚干预Angelman综合征非癫痫性肌阵挛1例。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-07-18 DOI: 10.1002/mdc3.70223

Cyrus Cheung, Siddharth Selvakumar, Moosa Arif, Eric Zhao, Chathuri Senanayake, Katherine Mackenzie

引用次数: 0