Movement Disorders Clinical Practice最新文献

{"title":"Not So Smooth Sailing: FIG4-Related Disease Is a Differential Diagnosis of Rapid Onset Dystonia-Parkinsonism.","authors":"Matthew Julian Georgiades, Duncan Wilson, Maria Garcia, Robert Boland-Freitas, Hugo Morales-Briceño, Neil Mahant, Victor Shue Chung Fung, Andrew Martin","doi":"10.1002/mdc3.70049","DOIUrl":"https://doi.org/10.1002/mdc3.70049","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Principles of Cognitive Behavioral Therapy to Treat Anxiety in Parkinson's Disease.","authors":"Alice Cronin-Golomb, Bradley McDaniels, Soania Mathur, Gregory M Pontone, Gretchen O Reynolds, Indu Subramanian","doi":"10.1002/mdc3.70056","DOIUrl":"https://doi.org/10.1002/mdc3.70056","url":null,"abstract":"<p><p>Anxiety significantly affects persons with Parkinson's disease (PwP), often emerging in the prodromal phase before the onset of symptoms and persisting throughout the disease's course. It is among the most disabling, stigmatizing, and under-recognized symptoms of Parkinson's disease (PD). Consequently, it is critical to provide tools that can be universally applied and that are accessible to help all PwP live better. This article discusses the nature of anxiety in PwP, how to identify it, and how to treat it across stages of the disease. We highlight cognitive behavioral therapy (CBT), a type of psychotherapy in widespread use for anxiety and depression in general and increasingly used in PwP. The neurologist can apply the basic principles of CBT. The principles can be used by clinicians who are treating PwP globally, as they require no pharmacological intervention and minimal resources. As the disease progresses, a multidisciplinary team may be preferable to address the complex challenges that PD presents, including anxiety. The focus is on a patient-centered approach, providing compassion, hope, and resources to optimize the mental and physical well-being of PwP. Empowering PwP fosters self-agency and can significantly improve quality of life.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The Machine Will See You Now\": A Clinician's Perspective on Artificial \"Intelligence\" In Clinical Care.","authors":"Abhimanyu Mahajan, Andrew J Lees","doi":"10.1002/mdc3.70054","DOIUrl":"https://doi.org/10.1002/mdc3.70054","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Emergent Vocal Tremor in a Patient with Parkinson's Disease.","authors":"Takeharu Tsuboi, Yasuhiro Tanaka, Kosuke Kobayasi, Rina Hashimoto, Yoko Ito, Naoki Nishio, Takashi Tsuboi, Michihiko Sone, Masahisa Katsuno, Ikuko Aiba","doi":"10.1002/mdc3.70043","DOIUrl":"https://doi.org/10.1002/mdc3.70043","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education Level and Huntington's Disease Progression: A Retrospective Cohort Analysis in Western China.","authors":"Sirui Zhang, Yangfan Cheng, Lingyu Zhang, Yuanzheng Ma, Jiajia Fu, Tianmi Yang, Jieqiang Xia, Chunyu Li, Jean-Marc Burgunder, Huifang Shang","doi":"10.1002/mdc3.70047","DOIUrl":"https://doi.org/10.1002/mdc3.70047","url":null,"abstract":"<p><strong>Background: </strong>Identifying the effect of modifiable socio-environmental factors on Huntington's disease (HD) symptoms onset and progression is of great value. The role of educational attainment in HD clinical characteristics has not been elucidated.</p><p><strong>Objectives: </strong>To clarify the effect of education attainment on the age of motor symptoms onset and clinical progression of HD patients from Western China.</p><p><strong>Methods: </strong>A total of 244 adult-onset Chinese HD patients were included in the analysis. Linear regression, Kaplan-Meier analysis, and Cox regression analysis were conducted to assess the effect of education on the disease progression in HD.</p><p><strong>Results: </strong>Higher education level was significantly associated with slower decline in cognitive performance, as indicated by the Symbol Digit Modality Test (β = 0.339 [95% CI, 0.047, 0.632], p = 0.026), while it exhibited no association with the progression of other symptoms.</p><p><strong>Conclusions: </strong>The present findings suggest that education attainment is associated with a milder cognitive decline in Chinese HD patients.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease.","authors":"Daniel G Di Luca, Carolina Ramirez-Gomez, Brendan Santyr, Marco Fumagalli, Jürgen Germann, Suneil K Kalia, Andres M Lozano, Alfonso Fasano","doi":"10.1002/mdc3.70042","DOIUrl":"https://doi.org/10.1002/mdc3.70042","url":null,"abstract":"<p><strong>Background: </strong>The magnitude and factors associated with levodopa equivalent daily dose (LEDD) reduction in deep brain stimulation (DBS) of the globus pallidus interna (GPi) for Parkinson's Disease (PD) remain unclear.</p><p><strong>Objective: </strong>To investigate LEDD reduction in GPi DBS and its correlation with anatomical/clinical characteristics.</p><p><strong>Methods: </strong>A consecutive cohort of 74 patients who had undergone GPi DBS was analyzed. Regression and probabilistic efficacy mapping were performed to evaluate factors predicting LEDD reduction.</p><p><strong>Results: </strong>32.4% of GPi individuals experienced significant LEDD reduction (>30%). Anteromedial GPi stimulation was associated with higher LEDD reduction.</p><p><strong>Conclusion: </strong>Anteromedial stimulation of the GPi appears to be associated with medication reduction, challenging the idea that GPi DBS is ineffective at reducing LEDD. Further prospective study will be needed to validate these findings.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless Legs Syndrome and Impulsive Decision-Making: Impact of Symptom Severity, Chronotype and Interoception.","authors":"Giacomo Carollo, Riccardo Quinci, Gloria Pompea Mingolla, Angela Sandri, Michele Tinazzi, Elena Antelmi","doi":"10.1002/mdc3.70040","DOIUrl":"https://doi.org/10.1002/mdc3.70040","url":null,"abstract":"<p><strong>Background: </strong>Restless Legs Syndrome (RLS) is a neurological disorder reported to be associated with impulsivity and impairments in interoception and emotional regulation. However, limited research has explored the combined influence of RLS severity, psychological factors, and chronotype on impulsive decision-making and risk-taking behavior in RLS patients.</p><p><strong>Objectives: </strong>To assess impulsive-decision making and its modulation by RLS severity, chronotype, and psychological factors (including interoception, anxiety, alexithymia, and sleep quality) in RLS patients compared to healthy controls (HC).</p><p><strong>Methods: </strong>A case-control study was conducted with 20 RLS patients and 20 age- and sex-matched HC. Participants completed a series of questionnaires measuring interoception, anxiety, alexithymia, sleep quality, and chronotype, followed by a temporal discounting task to assess impulsivity. Statistical analyses included Mann-Whitney U tests, Spearman's rank correlations, and multiple regression analysis.</p><p><strong>Results: </strong>No significant differences in impulsive decision-making were observed between groups. RLS patients exhibited higher levels of depression and alexithymia, along with lower scores on interoceptive awareness compared to HC. However, within the RLS group, greater symptoms' severity, poorer sleep quality, and higher anxiety were positively correlated with increased impulsivity. Regression analysis showed that the MAIA-2-Not Distracting sub-scale was a significant predictor of impulsivity in RLS patients.</p><p><strong>Conclusions: </strong>Interoceptive deficits, particularly difficulties in ignoring bodily sensations, play a central role in impulsive decision-making in RLS patients. These findings highlight the importance of targeting interoception, emotional regulation, and sleep quality in therapeutic interventions for RLS. Further research with larger samples is needed to confirm these relationships.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of N-Acetyl-l-Leucine in Niemann-Pick Disease Type C: A Critical Perspective.","authors":"Gala Lopez, Carla Holgado","doi":"10.1002/mdc3.70041","DOIUrl":"https://doi.org/10.1002/mdc3.70041","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Manifestations in Parkinson's Disease Using a Validated Arabic Version of Gastrointestinal Dysfunction Scale: A Multicenter Study.","authors":"Ali Soliman Shalash, Marwa Yassien Badr, Yara Salah, Shimaa Elgamal, Shaimaa Ahmed Elaidy, Eman Abdel-Mageed Elhamrawy, Hayam Abdel-Tawab, Eman Hamid, Ehab Ahmed El-Seidy, Noha Lotfy Dawood","doi":"10.1002/mdc3.70005","DOIUrl":"https://doi.org/10.1002/mdc3.70005","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal symptoms (GIS) contribute to the morbidity of Parkinson's disease (PD), with limited specific assessment tools.</p><p><strong>Objective: </strong>This multicenter study aimed to translate and validate the Gastrointestinal Dysfunction Scale for PD (GIDS-PD) into an Arabic version and to investigate the characteristics of GIS and its correlates.</p><p><strong>Methods: </strong>A total of 162 patients with PD and 165 age- and sex-matched healthy controls were assessed using the GIDS-PD. Arabic version was assessed for test-retest reliability, construct validity, convert validity, and floor or ceiling effects. Patients were assessed also using the International Parkinson and Movement Disorders Society-Unified Parkinson's Disease Rating Scale, Non-motor Symptoms Scale, and Parkinson's Disease Questionnaire-39.</p><p><strong>Results: </strong>The Arabic version of the GIDS-PD exhibited proper convergent validity, inter- and intrarater consistency, and an acceptable ceiling effect. Compared to controls, patients exhibited significantly higher frequency of all GIDS-PD items: difficulty in passing stools (86.42%), experiencing hard stools (65%), sensation of incomplete evacuation (75.93%), abdominal pain (69.14%), abnormal increase in passing stools (50.62%), abdominal distention (85.19%), involuntary weight loss (48.77%), difficulty in swallowing (64.81%), excessive salivation (68.52%), heartburn (82.10%), and nausea (43.83%). GISs were correlated to disease duration, motor and nonmotor severity, motor complications, and poorer quality of life (QoL). Predictors of the GIDS-PD included disease stage, motor severity, nonmotor burden, age, and dopaminergic daily dosage.</p><p><strong>Conclusion: </strong>This multicenter study provided a validated Arabic version of GIDS-PD and demonstrated the high frequency of different GISs; their high correlation with motor severity, nonmotor burden, dopaminergic dosage, and age; and their negative impact on QoL, implying the importance of their assessment and management.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to Myoclonus Dystonia Syndrome: A European Reference Network Survey.","authors":"María I Vanegas, Anna Marcé-Grau, Ana Cazurro-Gutiérrez, Feline Hamami, Elze R Timmers, Anne Weißbach, Marina A J Tijssen, Victoria González, Lucía Dougherty-de Miguel, Marina Martin, Monika Benson, Carola Reinhard, Belén Pérez-Dueñas","doi":"10.1002/mdc3.70028","DOIUrl":"https://doi.org/10.1002/mdc3.70028","url":null,"abstract":"<p><strong>Background: </strong>Myoclonus-dystonia syndrome (MDS) is a genetic movement disorder with childhood-onset, most frequently caused by SGCE defects.</p><p><strong>Objective: </strong>To evaluate the diagnostic and treatment strategies in MDS used by experts from the European Reference Network for rare neurological diseases (ERN-RND), and to assess the diagnosis and management experience in patients with MDS.</p><p><strong>Methods: </strong>Two different questionnaires were distributed: one among neurologists from ERN-RND, and another among patients and families with SGCE-related MDS.</p><p><strong>Results: </strong>Twenty-nine adult and child neurologists from 14 countries, and 84 patients and caregivers from 12 countries, replied to the surveys. All the patients included in the analysis had SGCE-related MDS. The mean age was 30.8 years (SD 19,9; range 3-75). Sixty-nine percent of patients were diagnosed in childhood and 70% had a positive family history. Most participants suffered from predominant upper body myoclonus and focal/segmental dystonia, hindering daily activities in 80% of patients, such as handwriting, drinking, feeding, walking and speech. Botulinum toxin and DBS were effective options for managing movement disorders compared to pharmacological treatments. However, neither of these therapies were applied optimally. We found deficiencies in recognition and management of academic difficulties, and a high unemployment rate. Despite all but one patient reported psychiatric symptoms such as anxiety, depression or OCD, there was a lack of formal psychiatric evaluations.</p><p><strong>Conclusions: </strong>SGCE-MDS is a well-known neurological disorder among movement disorder specialists in Europe. Offering a multidisciplinary approach that tackles both movement disorders and neuropsychiatric comorbidities could enhance the diagnosis and treatment of patients with SGCE-MDS.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}