Movement Disorders Clinical Practice最新文献

{"title":"Integrating Digital and Ancillary Technologies in the Modern Clinical Evaluation of Chorea.","authors":"Gerard Saranza, Chin-Hsien Lin","doi":"10.1002/mdc3.70238","DOIUrl":"https://doi.org/10.1002/mdc3.70238","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous Apomorphine Infusion Initiation Is Associated with Impulse Control Disorder Attenuation in Advanced Parkinson's Disease Patients: Insights from the French NS-Park Cohort.","authors":"Clément Desjardins, Paulo André Dias Bastos, Aymeric Lanore, Christine Brefel-Courbon, Isabelle Benatru, Caroline Giordana, Anne Doe de Maindreville, Giovanni Castelnovo, Philippe Remy, Luc Defebvre, Claire Thiriez, Stéphane Prange, Jean-Luc Houeto, Alexandra Samier Foubert, Fabienne Ory-Magne, Raquel Pinhero Barbosa, Nathalie Bertille, Jean-Christophe Corvol, Olivier Rascol, Margherita Fabbri","doi":"10.1002/mdc3.70240","DOIUrl":"https://doi.org/10.1002/mdc3.70240","url":null,"abstract":"<p><strong>Background: </strong>Impulse control disorders (ICD) are common non-motor complications in Parkinson's disease (PD), particularly in patients receiving oral dopamine agonists (DA). Continuous subcutaneous apomorphine infusion (CSAI) is a device-aided therapy for advanced PD, but its effects on ICD remain underexplored in real-world settings.</p><p><strong>Objectives: </strong>To assess the impact of CSAI initiation on ICD prevalence and severity in a large real-world PD cohort and to compare ICD evolution in CSAI-treated patients versus orally-treated controls.</p><p><strong>Methods: </strong>We analyzed data from the national prospective observational NS-Park cohort, selecting patients with documented ICD status before and after CSAI initiation. Changes in ICD prevalence and severity based on the MDS-UPDRS sub-item 1.6 were assessed using paired statistical tests, with additional sensitivity analyses based on time-restricted sub-cohorts (considering 60-, 24- and 12-months follow-up). A matched case-control analysis and a propensity score matching were used to compare CSAI-treated patients to orally-treated PD patients.</p><p><strong>Results: </strong>149 patients were included in the analysis. Before CSAI initiation, slight and mild/severe ICDs were present in 17% and 5% of the patients, respectively. After CSAI starting, ICD prevalence significantly decreased from 22% to 13%, (P = 0.003). These improvements were consistent across different time windows, despite an overall increase in DA levodopa-equivalent dose, with no associated mood worsening (up to 24-month follow-up). CSAI was associated with longitudinal ICD reduction, contrasting with the stable or worsening ICD trajectory in orally-treated controls, though trajectories were not statistically different.</p><p><strong>Conclusions: </strong>The presented findings of our real-life cohort suggest that ICD tend to improve following CSAI initiation in patients with PD, likely due to a reduction of oral DA or the effect of continuous dopaminergic stimulation provided by the pump. While this observation is clinically relevant, it should be interpreted with caution given the study's observational design and the limitations inherent to using MDS-UPDRS sub-items for ICD assessment.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Tremor-Assisted Eating Devices: A Comparative Study of Usability and Patient Preference in Essential Tremor.","authors":"Kian Adabi, William Ondo","doi":"10.1002/mdc3.70229","DOIUrl":"https://doi.org/10.1002/mdc3.70229","url":null,"abstract":"<p><strong>Background: </strong>A number of adaptive devices are marketed and sold to patients with tremor; however, there is essentially no published data on their efficacy.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the objective efficacy and subjective preferences of 6 commercially available adaptive eating devices for patients with tremor.</p><p><strong>Methods: </strong>We compared six devices (Gyenno Spoon, Tremelo, a weighted spoon, S'up Spoon, Steady Spoon, and Eli Spoon) and a regular \"control\" spoon using an objective eating test. We measured the percentage of successfully transferred couscous to a cup adjacent to the subject's mouth and recorded relative patient preferences.</p><p><strong>Results: </strong>The mean percentages of successful transfer, in descending order of success, were as follows: S'up Spoon (93.6%), Gyenno Spoon (88.9%), weighted spoon (80.7%), Tremelo (78.0%), Steady Spoon (78.9%), control (74.3%), and Eli Spoon (67.6%). Subjective preferences ranked from best to worst based on average ranking were as follows: weighted spoon, S'up Spoon, Gyenno Spoon, Tremelo, control, Steady Spoon, and Eli Spoon.</p><p><strong>Conclusion: </strong>Overall, simple strategies, including a deeper bowl and heavier spoon, outperformed more complicated counterweight/actuator devices.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crab Walk-Like Gait in CSF1R-Related Leukoencephalopathy.","authors":"Pedro Fraiman, Raphael Pinheiro Camurugy da Hora, Orlando Graziani Povoas Barsottini, José Luiz Pedroso, Alberto J Espay","doi":"10.1002/mdc3.70227","DOIUrl":"https://doi.org/10.1002/mdc3.70227","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observed and Patient-Perceived Information Provision When Diagnosed With Parkinson's Disease.","authors":"Elisabeth Kurpershoek, Marij A Hillen, Mark H B Huisman, Machiel Pleizier, Annemarie Vlaar, Jeroen Blankevoort, Evelien Zoons, Dareia Selina Roos, Marianne de Visser, Rob M A de Bie, Joke M Dijk","doi":"10.1002/mdc3.70206","DOIUrl":"https://doi.org/10.1002/mdc3.70206","url":null,"abstract":"<p><strong>Background: </strong>People with Parkinson's disease (PD) perceive to receive insufficient disease-specific information after diagnosis, whereas clinicians report providing all relevant information.</p><p><strong>Objectives: </strong>The objectives were to examine the information actually provided by clinicians during diagnostic consultations and its relations with background characteristics, information needs, and the perception and evaluation of provided information.</p><p><strong>Methods: </strong>This prospective observational longitudinal study combined data from questionnaires and recorded diagnostic consultations at 6 neurology outpatient clinics in the Netherlands. Recordings were systematically coded for duration and extensiveness of information regarding diagnosis, treatment, disease course, and information gathering. Patients and companions completed questionnaires assessing preferred and perceived amount of information, and satisfaction with information (all ranges 1 [low] to 5 [high]).</p><p><strong>Results: </strong>Total consultation time (N = 50 patients and N = 30 companions) was 48.0 ± 19.4 (mean ± SD) minutes of which 12 ± 7 minutes were dedicated to information provision. Most time was spent on the theme \"treatment\" (6.9 ± 4.3 minutes) and least on \"disease course\" (1.4 ± 1.7 minutes). Neither duration nor extensiveness of provided information was related to patients' generally high information preference (score 4.4 ± 0.7). Patients and their companions perceived a fair amount of information given (score 2.8 ± 0.9) and were quite satisfied (score 3.4 ± 0.9). Nonetheless, one-third of patients expressed a desire for more information, specifically concerning the course of PD.</p><p><strong>Conclusion: </strong>During diagnostic consultations for PD, clinicians primarily focused on treatment-related information. Although patients were generally satisfied, information needs concerning the implications of PD for their future lives were not met for all patients.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amantadine Can Treat Blepharospasm in Levodopa Peak-Dose Dyskinesia.","authors":"Francisco de Assis Aquino Gondim, Rodrigo Fagundes da Rosa, Francisco Duque de Paiva Giudice Junior, João Pedro de Oliveira Gouveia Marcotti, Ítalo Ramon de Araújo","doi":"10.1002/mdc3.70220","DOIUrl":"https://doi.org/10.1002/mdc3.70220","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jerky Dystonic Unsteady Limb following High Frequency Focused Ultrasound Thalamotomy.","authors":"Abdalmalik Bin Khunayfir, Lahiru N Wimalasena, Faical Isbaine, Stewart A Factor, Nicholas AuYong, Richa Tripathi","doi":"10.1002/mdc3.70230","DOIUrl":"https://doi.org/10.1002/mdc3.70230","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers.","authors":"Nabila Dahodwala, Theodore Kapogiannis, Amanda Cruz, James C Beck, Thomas L Davis, Hongliang Liu, Sheng Luo, Anna Naito, Marilyn Neault, Miriam R Rafferty, Adolfo Ramirez-Zamora, Connie Marras","doi":"10.1002/mdc3.70232","DOIUrl":"https://doi.org/10.1002/mdc3.70232","url":null,"abstract":"<p><strong>Background: </strong>Real-world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data.</p><p><strong>Objectives: </strong>We sought to identify treatment patterns and test how treatment changed in response to (1) falling, (2) worsening disease, and (3) worsening quality of life across PD specialized centers.</p><p><strong>Methods: </strong>We used the Parkinson Outcomes Project data collected from 2010 to 2023 across 31 international PD specialized centers. Demographic and clinical characteristics were collected annually and included medication use, physical therapy referral, psychologist or psychiatrist care, and deep brain stimulation (DBS) surgery. Treatment practice variation was described by center and in response to outcomes (self-reported falls, higher Hoehn and Yahr stage, worse emotional and mobility subscale scores on quality-of-life scale).</p><p><strong>Results: </strong>A total of 12,664 participants were analyzed. Treatment practices varied substantially across centers with the use of levodopa in the first 5 years of disease ranging from 59.3% to 94.6% and physical therapy referral ranging from 13% to 71%. At ≥ 5 years of disease, DBS rates varied from 2% to 41%. After a fall, individuals were more likely to be referred for physical therapy (β: 0.44, 95% confidence interval [CI]: 0.36, 0.52), and mental health services were recommended after a decline in emotional subscores (β: 1.74, 95% CI: 1.50, 1.98). However, there was no change in levodopa-equivalent daily dose after worsening mobility subscores (β: -29.97, 95% CI: -76.67, 16.73).</p><p><strong>Conclusions: </strong>These results highlight the large variability in PD practice across specialty centers and the importance of establishing best practice guidelines. Understanding the drivers of this variability is an essential next step.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opicapone in Parkinson's Disease on Levodopa-Carbidopa Intestinal Gel Treatment: A Pilot, Randomized Study.","authors":"Fabiana Colucci, Andrea Gozzi, Pietro Antenucci, Ilaria Casetta, Lorenza Maistrello, Annibale Antonioni, Emanuela Maria Raho, Ginevra Tecilla, Jay Guido Capone, Mariachiara Sensi","doi":"10.1002/mdc3.70231","DOIUrl":"https://doi.org/10.1002/mdc3.70231","url":null,"abstract":"<p><strong>Background: </strong>Levodopa-carbidopa intestinal gel infusion (LCIG) is an effective therapy for advanced Parkinson's disease (PD). Opicapone (OPC) is an enzyme inhibitor that enhances the bioavailability of levodopa in the brain.</p><p><strong>Objectives: </strong>This study evaluates the effect of Opicapone addition in PD-LCIG patients, assessing its impact on motor fluctuations and dyskinesias. Secondly, the study analyses the impact of OPC on non-motor symptoms, LCIG dosage, and peripheral neuropathy.</p><p><strong>Methods: </strong>In this pilot study, 22 PD patients on LCIG were randomized to receive OPC or not, based on persistent or reemergent fluctuations. The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Unified Dyskinesia Rating Scale (UDysRS), Montreal Cognitive Assessment (MoCA), electroneurography (ENG), LCIG doses, homocysteine, vitamin B12, and folic acid levels were measured at baseline (T0) and after 12 months (T1).</p><p><strong>Results: </strong>Eleven patients added OPC (addOPC group), while 11 maintained standard treatment (nOPC group). At baseline, both groups had similar disease duration and severity. At T1, the addOPC group showed significant: (i) improvement in motor fluctuations evaluated by the MDS-UPDRS part IV; (ii) reduction in dyskinesias (UDyRS); (iii) decrease in LCIG infusion rate; (iv) improvement in motor and non-motor symptoms (MDS-UPDRS parts I-III); (v) increase in Vitamin B12. No significant differences were observed in the ENG data, and no serious adverse events occurred. Four addOPC patients (36%) discontinued OPC after 15 ± 2 months, mainly due to hallucinations.</p><p><strong>Conclusions: </strong>OPC addition appeared well tolerated and beneficial in reducing motor fluctuations, dyskinesia, and LCIG dose. Randomized controlled trials are needed to confirm these findings.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involuntary Eye Movements as a Clue to Diagnosis.","authors":"Victor Rebelo Procaci, Raphael Pinheiro Camurugy da Hora, Thiago Yoshinaga Tonholo Silva, Orlando Graziani Povoas Barsottini, José Luiz Pedroso","doi":"10.1002/mdc3.70233","DOIUrl":"https://doi.org/10.1002/mdc3.70233","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}