Movement Disorders Clinical Practice最新文献

{"title":"Amantadine Can Treat Blepharospasm in Levodopa Peak-Dose Dyskinesia.","authors":"Francisco de Assis Aquino Gondim, Rodrigo Fagundes da Rosa, Francisco Duque de Paiva Giudice Junior, João Pedro de Oliveira Gouveia Marcotti, Ítalo Ramon de Araújo","doi":"10.1002/mdc3.70220","DOIUrl":"https://doi.org/10.1002/mdc3.70220","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jerky Dystonic Unsteady Limb following High Frequency Focused Ultrasound Thalamotomy.","authors":"Abdalmalik Bin Khunayfir, Lahiru N Wimalasena, Faical Isbaine, Stewart A Factor, Nicholas AuYong, Richa Tripathi","doi":"10.1002/mdc3.70230","DOIUrl":"https://doi.org/10.1002/mdc3.70230","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers.","authors":"Nabila Dahodwala, Theodore Kapogiannis, Amanda Cruz, James C Beck, Thomas L Davis, Hongliang Liu, Sheng Luo, Anna Naito, Marilyn Neault, Miriam R Rafferty, Adolfo Ramirez-Zamora, Connie Marras","doi":"10.1002/mdc3.70232","DOIUrl":"https://doi.org/10.1002/mdc3.70232","url":null,"abstract":"<p><strong>Background: </strong>Real-world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data.</p><p><strong>Objectives: </strong>We sought to identify treatment patterns and test how treatment changed in response to (1) falling, (2) worsening disease, and (3) worsening quality of life across PD specialized centers.</p><p><strong>Methods: </strong>We used the Parkinson Outcomes Project data collected from 2010 to 2023 across 31 international PD specialized centers. Demographic and clinical characteristics were collected annually and included medication use, physical therapy referral, psychologist or psychiatrist care, and deep brain stimulation (DBS) surgery. Treatment practice variation was described by center and in response to outcomes (self-reported falls, higher Hoehn and Yahr stage, worse emotional and mobility subscale scores on quality-of-life scale).</p><p><strong>Results: </strong>A total of 12,664 participants were analyzed. Treatment practices varied substantially across centers with the use of levodopa in the first 5 years of disease ranging from 59.3% to 94.6% and physical therapy referral ranging from 13% to 71%. At ≥ 5 years of disease, DBS rates varied from 2% to 41%. After a fall, individuals were more likely to be referred for physical therapy (β: 0.44, 95% confidence interval [CI]: 0.36, 0.52), and mental health services were recommended after a decline in emotional subscores (β: 1.74, 95% CI: 1.50, 1.98). However, there was no change in levodopa-equivalent daily dose after worsening mobility subscores (β: -29.97, 95% CI: -76.67, 16.73).</p><p><strong>Conclusions: </strong>These results highlight the large variability in PD practice across specialty centers and the importance of establishing best practice guidelines. Understanding the drivers of this variability is an essential next step.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opicapone in Parkinson's Disease on Levodopa-Carbidopa Intestinal Gel Treatment: A Pilot, Randomized Study.","authors":"Fabiana Colucci, Andrea Gozzi, Pietro Antenucci, Ilaria Casetta, Lorenza Maistrello, Annibale Antonioni, Emanuela Maria Raho, Ginevra Tecilla, Jay Guido Capone, Mariachiara Sensi","doi":"10.1002/mdc3.70231","DOIUrl":"https://doi.org/10.1002/mdc3.70231","url":null,"abstract":"<p><strong>Background: </strong>Levodopa-carbidopa intestinal gel infusion (LCIG) is an effective therapy for advanced Parkinson's disease (PD). Opicapone (OPC) is an enzyme inhibitor that enhances the bioavailability of levodopa in the brain.</p><p><strong>Objectives: </strong>This study evaluates the effect of Opicapone addition in PD-LCIG patients, assessing its impact on motor fluctuations and dyskinesias. Secondly, the study analyses the impact of OPC on non-motor symptoms, LCIG dosage, and peripheral neuropathy.</p><p><strong>Methods: </strong>In this pilot study, 22 PD patients on LCIG were randomized to receive OPC or not, based on persistent or reemergent fluctuations. The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Unified Dyskinesia Rating Scale (UDysRS), Montreal Cognitive Assessment (MoCA), electroneurography (ENG), LCIG doses, homocysteine, vitamin B12, and folic acid levels were measured at baseline (T0) and after 12 months (T1).</p><p><strong>Results: </strong>Eleven patients added OPC (addOPC group), while 11 maintained standard treatment (nOPC group). At baseline, both groups had similar disease duration and severity. At T1, the addOPC group showed significant: (i) improvement in motor fluctuations evaluated by the MDS-UPDRS part IV; (ii) reduction in dyskinesias (UDyRS); (iii) decrease in LCIG infusion rate; (iv) improvement in motor and non-motor symptoms (MDS-UPDRS parts I-III); (v) increase in Vitamin B12. No significant differences were observed in the ENG data, and no serious adverse events occurred. Four addOPC patients (36%) discontinued OPC after 15 ± 2 months, mainly due to hallucinations.</p><p><strong>Conclusions: </strong>OPC addition appeared well tolerated and beneficial in reducing motor fluctuations, dyskinesia, and LCIG dose. Randomized controlled trials are needed to confirm these findings.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involuntary Eye Movements as a Clue to Diagnosis.","authors":"Victor Rebelo Procaci, Raphael Pinheiro Camurugy da Hora, Thiago Yoshinaga Tonholo Silva, Orlando Graziani Povoas Barsottini, José Luiz Pedroso","doi":"10.1002/mdc3.70233","DOIUrl":"https://doi.org/10.1002/mdc3.70233","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: \"An Insight into Long-Term Outcomes in a Parkinson's Disease Minor Phenomena Cohort\".","authors":"Ruth B Schneider, Miriam T Weber, Anneliese T Elmer, Karlo J Lizarraga, Irene H Richard, Michael P McDermott","doi":"10.1002/mdc3.70217","DOIUrl":"https://doi.org/10.1002/mdc3.70217","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Week Video- and Home-Based Training Program for People with Ataxia: A Pilot Randomized Controlled Trial.","authors":"Clara Rentz, Alisha Reinhardt, Naomi Jung, Vignesh Vanchinathan, Jutta Peterburs, Heike Jacobi, Dagmar Timmann, Andreas Thieme, Doris Brötz, Christian Bellebaum, Alfons Schnitzler, Katrin Amunts, Martina Minnerop","doi":"10.1002/mdc3.70225","DOIUrl":"https://doi.org/10.1002/mdc3.70225","url":null,"abstract":"<p><strong>Background: </strong>Gait and balance impairment is a disabling clinical feature in people with degenerative cerebellar ataxia.</p><p><strong>Objectives: </strong>We performed a rater-blinded, parallel 3-arm randomized controlled trial with delayed-start-design (exploratory proof-of-concept study) to assess whether, compared to control, people with mild/moderate hereditary ataxia benefit from additional video-based training with different frequencies, and how clinical characteristics interact with training success.</p><p><strong>Methods: </strong>Digital gait/balance measures were assessed before and after a three-week video-based training program at home (Train20: 4 × 20min/week, n = 11; Train40: 2 × 40min/week, n = 11; control: standard medical care, n = 10). Group differences at baseline and changes over time were assessed using ANOVA. Linear mixed models were conducted to examine the influence of clinical variables on outcomes over time. Further exploratory analyses were performed using intraclass correlation coefficients (ICC), and paired t-tests within each group.</p><p><strong>Results: </strong>All variables showed good to excellent test-retest reliability (ICC ≥0.69). No significant interactions between group and measurement time were found for clinical or gait/balance variables (p ≥ 0.338). However, participants with higher initial disease severity, greater impairment in activities of daily living, and better well-being showed significant improvements in feet-together stance (p = 0.04), normal (p = 0.01), and backward gait (p = 0.03). Exploratory analyses showed improvement only in Train40.</p><p><strong>Conclusions: </strong>Although the protocol did not lead to general improvements in people with mild/moderate ataxia, irrespective of training frequency, those with higher initial disease severity, higher functional impairment, and better mental well-being showed significant benefits. Greater attention should be given to the impact of well-being to enhance motor training outcomes. Longer, less frequent sessions may offer greater potential for improvement.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Changes in Pre-ataxic Spinocerebellar Ataxias: A Scoping Review.","authors":"Renata Barreto Tenorio, Andressa Aline Vieira, Hélio Afonso Ghizoni Teive, Carlos Henrique Ferreira Camargo","doi":"10.1002/mdc3.70215","DOIUrl":"https://doi.org/10.1002/mdc3.70215","url":null,"abstract":"<p><strong>Background: </strong>Although traditionally recognized for motor impairment, evidence suggests that cognitive deficits may emerge before ataxia onset in autosomal dominant spinocerebellar ataxias (SCA), particularly in nucleotide repeat expansion SCAs (NRE-SCAs). However, the nature and extent of these early cognitive changes and cognition disorders remain unclear.</p><p><strong>Objective: </strong>This scoping review maps existing evidence on cognitive alterations in pre-ataxic NRE-SCAs, focusing on affected cognitive domains, assessment tools, and early biomarkers.</p><p><strong>Methods: </strong>A comprehensive search in PubMed, EMBASE, and CINAHL was performed in accordance with Joanna Briggs Institute guidelines. Studies were included if they assessed cognitive function in genetically confirmed pre-ataxic NRE-SCA individuals using neuropsychological tests, imaging, or biomarkers. Data extraction comprised study design, cognitive domains assessed, and key findings.</p><p><strong>Results: </strong>Thirteen studies met inclusion criteria, examining pre-ataxic individuals with SCA1, SCA2, SCA3, and SCA36. Executive dysfunction, particularly in cognitive flexibility, inhibitory control, and working memory, was the most frequent finding, assessed using the Trail Making Test, Stroop Test, and phonemic fluency tasks. Processing speed deficits were also commonly reported. Pre-ataxic SCA2 exhibited the most consistent impairments, whereas findings in pre-ataxic SCA1 and pre-ataxic SCA3 were variable. Neuroimaging studies revealed early cerebellar microstructural changes linked to cognitive dysfunction.</p><p><strong>Conclusion: </strong>Cognitive impairments may precede motor symptoms in NRE-SCAs, particularly SCA2. However, methodological heterogeneity and small sample sizes limit definitive conclusions. Standardized assessments and longitudinal studies are needed to clarify cognitive decline trajectories and their potential as early biomarkers.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Long-Term Outcomes in a Parkinson's Disease Minor Phenomena Cohort.","authors":"Leroy D'Souza, Maanini Singhvi, C S Pranav Bhat, Siri P B, Niharika B R","doi":"10.1002/mdc3.70212","DOIUrl":"https://doi.org/10.1002/mdc3.70212","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palatal-Lingual-Facial Myoclonus Due to Acute Cortical Infarction in JAK2V617F Positive Myelodysplastic Syndrome.","authors":"Matilde Sassani, Di Liang, Amrit-Deep Samra","doi":"10.1002/mdc3.70234","DOIUrl":"https://doi.org/10.1002/mdc3.70234","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}