Movement Disorders Clinical Practice最新文献_第5页

Effect of Early Levodopa Treatment on Mortality in People with Parkinson's Disease. 早期左旋多巴治疗对帕金森病患者死亡率的影响。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-02 DOI: 10.1002/mdc3.14174

Amir H Talebi, Sirwan K L Darweesh, Bas R Bloem, Ioan G Bucur, Tom Heskes

{"title":"Effect of Early Levodopa Treatment on Mortality in People with Parkinson's Disease.","authors":"Amir H Talebi, Sirwan K L Darweesh, Bas R Bloem, Ioan G Bucur, Tom Heskes","doi":"10.1002/mdc3.14174","DOIUrl":"https://doi.org/10.1002/mdc3.14174","url":null,"abstract":"Background: The ideal timing for initiating levodopa in newly diagnosed people with Parkinson's disease (PD) is uncertain due to limited data on the long-term effects of levodopa.Objective: The aim was to investigate whether early levodopa initiation postpones mortality (primary outcome), the requirement of device-aided therapies, and the incidence of PD-related complications, such as fall-induced injuries.Methods: Using nationwide claims data from Dutch hospitals (2012-2020), we grouped newly diagnosed PD individuals as \"early initiators\" (initiating levodopa within 2 years of diagnosis) or \"nonearly initiators.\" We used the national death registry to assess mortality and health-care claims to assess PD-related complications and device-aided therapies. We used marginal structural models to compare mortality and device-aided therapy rates between groups, and a Poisson regression model to compare PD-related complication rates.Results: Among 29,943 newly diagnosed PD individuals (mean age at diagnosis: 71.6, 38.5% female), there were 24,847 early and 5096 nonearly levodopa initiators. Over a median 4.25 years, 8109 (27.1%) died. The causal risk ratio for mortality was 1.04 (95% confidence interval [CI] 0.92-1.19) for early versus nonearly initiators. The risk ratio of receiving any device-aided therapy was 3.19 (95% CI 2.56-5.80). No association was observed with incidence of PD-related complications (incidence rate ratio: 1.00, 95% CI 0.96-1.05).Conclusions: Early levodopa initiation in PD does neither postpone nor accelerate mortality or PD-related complications, nor does it precipitate earlier occurrence of PD-related complications or mortality. However, we cannot exclude that the results were influenced by residual confounding due to unmeasured risk factors of mortality.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pallidal and Thalamic Deep Brain Stimulation in the Treatment of Unilateral Dystonia: A Prospective Assessment. 苍白球和丘脑深部脑刺激治疗单侧肌张力障碍：前瞻性评估

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-02 DOI: 10.1002/mdc3.14184

Juan Manuel Altamirano, Karla Salinas-Barboza

{"title":"Pallidal and Thalamic Deep Brain Stimulation in the Treatment of Unilateral Dystonia: A Prospective Assessment.","authors":"Juan Manuel Altamirano, Karla Salinas-Barboza","doi":"10.1002/mdc3.14184","DOIUrl":"https://doi.org/10.1002/mdc3.14184","url":null,"abstract":"Background: The complexities of unilateral dystonia have led to exploring simultaneous (dual) globus pallidus internus (GPi) and motor ventral thalamus (Vim/Vop) deep brain stimulation (DBS), yet detailed assessments are lacking.Objectives: To assess the efficacy of GPi, Vim/Vop, and dual DBS in unilateral dystonia.Methods: Three patients with unilateral dystonia (two idiopathic, one acquired), implanted with two DBS electrodes targeting ipsilateral Vim/Vop and GPi, were included. Three stimulation modalities were assessed. First, one electrode was activated, then the other, and finally, both electrodes were activated simultaneously.Results: DBS yielded substantial symptomatic reductions in all three evaluated stimulation modalities. Patients exhibited varying responses regarding quality-of-life and depressive symptoms. Treatment satisfaction didn't align with clinical improvements, potentially affected by unrealistic expectations.Conclusions: This study contributes critical insights into GPi, Vim/Vop and simultaneous stimulation for unilateral dystonia. The safety of the procedure underscores the promise of this approach.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended Phenotype of PEX11B Pathogenic Variants: Ataxia, Tremor, and Dystonia Due to a Novel C.2T > G Variant. PEX11B 致病变异体的扩展表型：新型 C.2T > G 变异导致共济失调、震颤和肌张力障碍。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-02 DOI: 10.1002/mdc3.14178

Franclo Henning, Kireshnee Naidu, Christopher J Record, Natalia Dominik, Jana Vandrovcova, Frans Lubbe, Marli Dercksen, Lindsay A Wilson, Francois Van Der Westhuizen, Mary M Reilly, Henry Houlden, Michael G Hanna, Jonathan Carr

引用次数: 0

Dengue Fever Associated Opsoclonus Myoclonus Ataxia Syndrome. 登革热相关性肌阵挛共济失调综合征

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1002/mdc3.14126

Anand Kumar, Ibrahim Hussain, Varun Kumar Singh, Deepika Joshi

引用次数: 0

Directional Deep Brain Stimulation Programming: Is the Segment Clearly Identifiable and Stable Over Time? 定向脑深部刺激编程：分段是否清晰可辨且长期稳定？

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-06-09 DOI: 10.1002/mdc3.14120

Jessica A Karl, Jessica M Joyce, Bichun Ouyang, Chandler E Gill, Leo Verhagen Metman

{"title":"Directional Deep Brain Stimulation Programming: Is the Segment Clearly Identifiable and Stable Over Time?","authors":"Jessica A Karl, Jessica M Joyce, Bichun Ouyang, Chandler E Gill, Leo Verhagen Metman","doi":"10.1002/mdc3.14120","DOIUrl":"10.1002/mdc3.14120","url":null,"abstract":"Background: In our early experience programming directional deep brain stimulation (d-DBS) in PD, we found the optimal directional segment changed over time in some patients. To determine the frequency/reasons for this we examined whether (1) different programmers would identify the same segment as \"optimal\"; and (2) the same programmer would select the same \"optimal\" segment over time. We hypothesized there would be a moderately high level of agreement on optimal electrode selection between different assessors and repeated assessments by the same evaluator.Methods: This was a prospective, double-blind investigation evaluating the reliability and stability of programming d-DBS. Each patient underwent a mono-polar survey four times (2 time points by 2 separate assessors). The primary aim was the inter-rater agreement of selecting the optimal electrode at 1 and 6 months. The secondary aim was to determine the intra-rater agreement of selecting the optimal electrode from 1 to 6 months.Results: Twenty-one patients were enrolled. There was fair inter-rater agreement at 1 month and moderate at 6 months. There was minimal intra-rater agreement between 1 and 6 months.Discussion: The data refuted our hypothesis. Potential reasons for low agreement include (1) the arduous/subjective nature of identifying the optimal electrode in d-DBS systems, especially in well-placed electrodes; and/or (2) acute changes to the location of stimulation delivery offering temporary improvement in symptoms. Key takeaways gathered were it may, (1) behoove the programmer to explore different electrode montages after a period of time; and (2) be more efficient to review the directional electrode montage only when dictated by clinical symptoms/disease progression.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation for Functional Dystonia: Cases and Review of the Literature. 功能性肌张力障碍的康复治疗：病例和文献综述。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-06-09 DOI: 10.1002/mdc3.14121

Priti Gros, Haseel Bhatt, Gabriela S Gilmour, Sarah C Lidstone

{"title":"Rehabilitation for Functional Dystonia: Cases and Review of the Literature.","authors":"Priti Gros, Haseel Bhatt, Gabriela S Gilmour, Sarah C Lidstone","doi":"10.1002/mdc3.14121","DOIUrl":"10.1002/mdc3.14121","url":null,"abstract":"Background: Functional dystonia (FD) is a common subtype of functional movement disorder. FD can be readily diagnosed based on positive signs and is potentially treatable with rehabilitation. Despite this, clinical outcomes remain variable and a gold standard approach to treatment is lacking.Cases: Here we present four cases of axial and limb functional dystonia who were treated with integrated rehabilitation and improved. The therapy approach and clinical outcomes are described, including videos.Literature review: A literature review evaluated the published treatment strategies for the treatment of functional dystonia. Out of 338 articles, 25 were eligible for review and included mainly case reports and case series. Most patients received more than one treatment modality. Non-invasive therapies, commonly physiotherapy and psychological approaches were mostly associated with positive outcomes. Multiple treatments commonly used in dystonia were used, including botulinum toxin injections, pharmacotherapy and surgery, leading to variable outcomes.Conclusion: Therapy should be personalized to the clinical presentation. In challenging cases, initiation of a multidisciplinary approach may provide benefit regardless of etiology. Pharmacotherapy should be used judiciously, and surgical therapy should be avoided.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin. 肉毒杆菌毒素难治性面肌痉挛老年患者的减压手术。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.1002/mdc3.14064

Margaret Tugend, Christina M Ulane, Kevin Patel, Raymond F Sekula

{"title":"Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin.","authors":"Margaret Tugend, Christina M Ulane, Kevin Patel, Raymond F Sekula","doi":"10.1002/mdc3.14064","DOIUrl":"10.1002/mdc3.14064","url":null,"abstract":"Background: Botulinum toxin is an effective treatment for hemifacial spasm in elderly patients. However, some patients do not tolerate the side effects and frequency of botulinum toxin treatments.Objectives: The purpose of this study was to evaluate the characteristics and outcomes of a cohort of elderly patients referred by neurologists for surgical decompression of the facial nerve following botulinum toxin treatment.Methods: In a prospective cohort study, logistic regression was used to detect potential predictors of spasm-freedom after surgical decompression of the facial nerve in elderly patients that received ≤8 and >8 botulinum toxin treatments for hemifacial spasm before surgery. Age, sex, side, preoperative symptom duration, and preoperative botulinum toxin treatment were assessed as potential predictors of spasm-freedom at last follow-up.Results: Of 76 elderly patients with hemifacial spasm treated with botulinum toxin and microvascular decompression, with at least 2-years of follow-up (median, 44.5 months), 84.2% were spasm-free at last follow-up. Age (P = 0.38), sex (P = 0.59), side (P = 0.15), preoperative symptom duration (P = 0.7), and number of preoperative botulinum toxin treatments (P = 0.3) were not predictors of long-term spasm-freedom. Permanent ipsilateral hearing loss was the most frequent complication (3.9%).Conclusion: This study provides evidence that elderly patients can undergo botulinum toxin treatment for hemifacial spasm without compromising their likelihood of achieving spasm-freedom with future surgical decompression. Therefore, surgical decompression of the facial nerve is an effective therapy for elderly patients with hemifacial spasm refractory to botulinum toxin.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elimination of STN stimulation-induced dyskinesias with VIM-DBS. 通过 VIM-DBS 消除 STN 刺激引起的运动障碍。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1002/mdc3.14123

Deepal Shah-Zamora, Jessica Karl, John Pearce, Leo Verhagen Metman

引用次数: 0

Correction to "The Prevalence of Parkinson Disease in Ukraine". 更正 "乌克兰帕金森病患病率"。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI: 10.1002/mdc3.14141

引用次数: 0

Mitochondrial Parkinsonism: A Practical Guide to Genes and Clinical Diagnosis. 线粒体帕金森病：基因与临床诊断实用指南》。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI: 10.1002/mdc3.14148

Piervito Lopriore, Giovanni Palermo, Adriana Meli, Gabriele Bellini, Elena Benevento, Vincenzo Montano, Gabriele Siciliano, Michelangelo Mancuso, Roberto Ceravolo

{"title":"Mitochondrial Parkinsonism: A Practical Guide to Genes and Clinical Diagnosis.","authors":"Piervito Lopriore, Giovanni Palermo, Adriana Meli, Gabriele Bellini, Elena Benevento, Vincenzo Montano, Gabriele Siciliano, Michelangelo Mancuso, Roberto Ceravolo","doi":"10.1002/mdc3.14148","DOIUrl":"10.1002/mdc3.14148","url":null,"abstract":"Background: Primary mitochondrial diseases (PMDs) are the most common inborn errors of energy metabolism, with a combined prevalence of 1 in 4300. They can result from mutations in either nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). These disorders are multisystemic and mainly affect high energy-demanding tissues, such as muscle and the central nervous system (CNS). Among many clinical features of CNS involvement, parkinsonism is one of the most common movement disorders in PMDs.Methods: This review provides a pragmatic educational overview of the most recent advances in the field of mitochondrial parkinsonism, from pathophysiology and genetic etiologies to phenotype and diagnosis.Results: mtDNA maintenance and mitochondrial dynamics alterations represent the principal mechanisms underlying mitochondrial parkinsonism. It can be present in isolation, alongside other movement disorders or, more commonly, as part of a multisystemic phenotype. Mutations in several nuclear-encoded genes (ie, POLG, TWNK, SPG7, and OPA1) and, more rarely, mtDNA mutations, are responsible for mitochondrial parkinsonism. Progressive external opthalmoplegia and optic atrophy may guide genetic etiology identification.Conclusion: A comprehensive deep-phenotyping approach is needed to reach a diagnosis of mitochondrial parkinsonism, which lacks distinctive clinical features and exemplifies the intricate genotype-phenotype interplay of PMDs.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0