Movement Disorders Clinical Practice最新文献

{"title":"Hemi-Chorea in Anti-GQ1b Syndrome: Expanding the Movement Disorder Spectrum.","authors":"Ashutosh Gupta","doi":"10.1002/mdc3.70691","DOIUrl":"10.1002/mdc3.70691","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2614-2616"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Management and Resiliency Training in People with Parkinson's Disease and their Care Partners.","authors":"Carine W Maurer, Sandra Skinner, Vera N Kulikov, Adam Gonzalez","doi":"10.1002/mdc3.70676","DOIUrl":"10.1002/mdc3.70676","url":null,"abstract":"<p><strong>Background: </strong>People with Parkinson's disease (PwP) and their care partners experience stress and mental health concerns that affect quality of life and illness management. Mind-body interventions may facilitate adaptive coping and improve quality of life in PwP and their care partners.</p><p><strong>Objectives: </strong>To evaluate the feasibility, acceptability and potential benefits of a telehealth delivered stress management and resilience building intervention for PwP and their care partners.</p><p><strong>Methods: </strong>PwP (n = 32) and their care partners (n = 17) enrolled in an adapted 8-week group mind-body telehealth Stress Management and Resilience Training (SMART) Program for PwP and their care partners (SMART-PD). Participants completed self-report measures on quality of life, health promoting lifestyle behaviors, anxiety, depression, and care partner burden at baseline and at program completion. Thematic analysis of post-intervention participant feedback was also performed.</p><p><strong>Results: </strong>87% PwP and 88% care partners completed the program. Among PwP, there was a significant improvement in depression (P < 0.001) and anxiety (P = 0.026) scores, as well as quality of life (P < 0.001) and health promoting lifestyle behaviors (P < 0.001) scores. Among care partners, there was a significant improvement in caregiver burden (P = 0.04) and depression (P = 0.028) scores.</p><p><strong>Conclusion: </strong>SMART-PD is a feasible, acceptable and promising intervention to address quality of life, depression, anxiety and health promoting lifestyle behaviors in PwP, as well as caregiver burden in their care partners.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2509-2516"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio-Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease.","authors":"Gabriele Imbalzano, Elisa Montanaro, Martina Giacchero, Claudia Ledda, Alberto Romagnolo, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti","doi":"10.1002/mdc3.70661","DOIUrl":"10.1002/mdc3.70661","url":null,"abstract":"<p><strong>Background: </strong>Socio-occupational functioning in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) is not fully captured by standard motor and quality-of-life scales.</p><p><strong>Objectives: </strong>To characterize patient-reported socio-occupational functioning after STN-DBS and explore associated clinical and demographic factors.</p><p><strong>Methods: </strong>Thirty-four PD patients were assessed 9-18 months postoperatively using a semi-structured interview covering socio-occupational domains. A composite mean score (Q_mean) was computed as a descriptive index, with clinical associations explored using univariate screening and multivariate linear regression.</p><p><strong>Results: </strong>The Q_mean score following STN-DBS was 7.66 ± 0.86 (range 6.00-9.57). In exploratory multivariate analysis, female sex (n = 7) was associated with higher functioning (P = 0.003), whereas GBA variants (n = 5) with lower functioning (P = 0.007).</p><p><strong>Discussion: </strong>Perceived socio-occupational functioning was overall satisfactory at postoperative assessment, with limited association with conventional motor/neuropsychiatric measures, and greater association with individual factors such as sex and genetic background. These exploratory findings support inclusion of socio-occupational perspectives in DBS outcome evaluation.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2546-2551"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Intervention for Posthyperglycemic Hemiballismus: Illustrative Case and Literature Review.","authors":"Racheed Mani, Tiffany Kim, Thomas Kim, Chiemeka Uwakwe, Camelia Yuejiao Zheng, Sima Mofakham, Eltonnelle James, Charles Mikell, Guy Schwartz","doi":"10.1002/mdc3.70728","DOIUrl":"10.1002/mdc3.70728","url":null,"abstract":"<p><strong>Background: </strong>Hemiballismus/hemichorea can manifest as a systemic sequala of severe hyperglycemia. This typically resolves with optimal glycemic control supplemented by neuroleptic agents. However, in a subset of patients, this hyperkinetic movement disorder may persist despite maximal medical management.</p><p><strong>Cases: </strong>We present a 70-year-old man with type 2 diabetes mellitus (DM) who presented with 6 months of right-sided hemiballismus/hemichorea that started after a previous episode of nonketotic hyperglycemia. Despite optimal glucose control and the administration of several neuroleptic agents, his symptoms failed to resolve. He underwent left-sided deep brain stimulation (DBS) to the globus pallidus internus (GPi), with subsequent improvement in his hyperkinetic movements.</p><p><strong>Literature review: </strong>We document 7 cases in the literature of posthyperglycemic chorea-ballism (PHGCB) treated with either pallidal or thalamic DBS or pallidotomy. The procedures were safe and well tolerated, and all patients demonstrated clinical improvement following surgery.</p><p><strong>Conclusion: </strong>PHGCB represents a rare but serious complication of DM. There is a subset of patients who fail to respond to maximal medical therapy. Our illustrative case and review demonstrate that these patients may benefit from neurosurgical intervention. Further studies with long-term follow-up are warranted to substantiate the value of surgical approaches for medically refractory diabetic striatopathy.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2586-2593"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodopa/Carbidopa Intestinal Gel (LCIG) Treatment in a Patient with Parkinson's Disease and Hemophilia A.","authors":"Petra Havránková, Jana Mašková, Ivan Vonke, Markéta Volfová, Barbora Křupková, Lukáš Kunc, Petra Štofaniková, Anna Rezková, Jana Vondráková, Robert Jech","doi":"10.1002/mdc3.70628","DOIUrl":"10.1002/mdc3.70628","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2621-2622"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altitude-Related Midbrain Syndrome after Ventriculo-Peritoneal Shunt for Racemose Neurocysticercosis.","authors":"Timothy D McWilliams, Betsy S Hanampa-Colquehuanca, Isabel Camargo-Salazar, Karlo J Lizarraga","doi":"10.1002/mdc3.70631","DOIUrl":"10.1002/mdc3.70631","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2623-2625"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at Onset Predicts Motor and Non-motor Severity in Cervical Dystonia.","authors":"Shameer Rafee, Laura Williams, Sean O'Riordan, Michael Hutchinson, Conor Fearon","doi":"10.1002/mdc3.70658","DOIUrl":"10.1002/mdc3.70658","url":null,"abstract":"<p><strong>Background: </strong>Cervical dystonia (CD) is the most common focal dystonia and shows significant heterogeneity in both motor and non-motor symptoms. Although motor symptoms typically prompt clinical presentation, non-motor features are the principal determinants of quality of life. Previous efforts to classify CD have focused on selected motor and non-motor clinical characteristics, suggesting distinct subtypes with potential prognostic implications.</p><p><strong>Objective: </strong>We employed cluster analysis to identify phenotypic subgroups within a large CD population with detailed motor and non-motor assessments.</p><p><strong>Methods: </strong>Adult patients with idiopathic isolated CD were included. Data were collected across five domains using validated instruments: motor severity (TWSTRS2-Severity), quality of life (CDIP-58 total and EQ-5D-5L utility index), disability (TWSTRS2-Disability), pain (TWSTRS2-Pain), and psychiatric symptoms (HADS-Total). Hierarchical cluster analysis using Ward's linkage method was performed to identify phenotypic subgroups.</p><p><strong>Results: </strong>201 CD patients (67% female) were included for analysis. Median age was 62 years. Hierarchical cluster analysis identified two distinct phenotypic subgroups (Clusters A and B). Cluster A patients (n = 78) demonstrated significantly earlier disease onset (35 vs 48 years) and greater symptom burden across all variables (p < 0.001) when compared with Cluster B (n = 123). The largest between-cluster differences were observed for CDIP-58, HADS-Total, and TWSTRS2-Pain. Motor severity showed a smaller effect size, suggesting non-motor features more strongly distinguish these phenotypes.</p><p><strong>Conclusion: </strong>Hierarchical cluster analysis identified two distinct CD phenotypes: an earlier onset high-burden subgroup and later onset low-burden subgroup. These clusters were primarily distinguished by non-motor features (quality of life, mood, pain, and disability). Our findings highlight age at onset as a key determinant of CD phenotype.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2453-2457"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GJA1^R148Q Variant Independently Cause Spastic Paraparesis or Interact with Other Pathogenic Variants?","authors":"Yanqing Shi, Tongfei Liu, Min Zhong","doi":"10.1002/mdc3.70668","DOIUrl":"10.1002/mdc3.70668","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2651-2652"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral GPi Deep Brain Stimulation for Severe Speech-Induced Dystonic Dysfluency: A Phenotype at the Stuttering-Dystonia Interface.","authors":"Shivam Om Mittal, Yasmin Abdelmajid, Tanmoy Maiti","doi":"10.1002/mdc3.70648","DOIUrl":"10.1002/mdc3.70648","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2606-2609"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Loop: Reflections on the ADAPT-PD Trial and the Road Ahead.","authors":"Elisabeth Nguyen, Camila C Aquino","doi":"10.1002/mdc3.70737","DOIUrl":"10.1002/mdc3.70737","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"2437-2438"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}