Movement Disorders Clinical Practice最新文献_第6页

Unraveling Hormonal Influence of Menstrual Cycle in a Young Patient with LRRK2-Parkinson's Disease. 揭示激素对年轻lrrk2 -帕金森病患者月经周期的影响

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-21 DOI: 10.1002/mdc3.14337

Francisca Ferreira, Carolina Correia, Carolina Soares

引用次数: 0

Mood Lability Induced by Pallidal Deep Brain Stimulation in a Patient with Meige Syndrome. Meige综合征患者苍白质深部脑刺激所致情绪不稳定。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-21 DOI: 10.1002/mdc3.14332

Kai Grimm, Alessandro Gulberti, Wolfgang Hamel, Monika Pötter-Nerger, Carsten Buhmann, Christian K E Moll, Simone Zittel

引用次数: 0

The World's Oldest Description of Oromandibular Dystonia. 世界上最古老的口腔张力障碍描述。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-21 DOI: 10.1002/mdc3.14342

Kazuya Yoshida

引用次数: 0

Rural Environment as a Risk Factor for the Age at Onset of Machado-Joseph Disease. 农村环境是马查多-约瑟夫病发病年龄的一个危险因素。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-20 DOI: 10.1002/mdc3.14338

Ana Carolina Martins, Gabriel Vasata Furtado, Jordânia Dos Santos Pinheiro, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim

{"title":"Rural Environment as a Risk Factor for the Age at Onset of Machado-Joseph Disease.","authors":"Ana Carolina Martins, Gabriel Vasata Furtado, Jordânia Dos Santos Pinheiro, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim","doi":"10.1002/mdc3.14338","DOIUrl":"https://doi.org/10.1002/mdc3.14338","url":null,"abstract":"Background: Machado-Joseph disease (SCA3/MJD) is a neurodegenerative condition caused by a dominant expansion of a CAG repeat (CAGexp). Most of the variability in the age at onset of symptoms (AO) remains unexplained, and environmental influences were scarcely studied.Objective: The objective was to test if AO of SCA3/MJD carriers can be associated with markers of the rural environment, such as demographic density (DeD), proportion of rural population (PRP), and the consumption of untreated well water (CWW).Methods: Symptomatic subjects from Rio Grande do Sul, Brazil, diagnosed between 1999 and 2017, and living in the same municipalities where they were born, were included, provided their CAGexp and AO were available, and the residual AO (RAO) could be estimated. DeD, PRP, and CWW were obtained from the Brazilian Census of 2010. Participants were stratified in high versus low DeD, PRP, and CWW groups, and their RAOs were compared for a P < 0.05.Results: A total of 188 subjects were studied. The mean (SD) RAOs of subjects from low and high DeD groups were -1.90 (6.98) and -0.11 (6.20) (P = 0.046); from low and high PRP groups were -0.12 (6.20) and -1.90 (6.99) (P = 0.046); and from low and high CWW groups were -0.11 (6.04) and -1.89 (7.11) (P = 0.034).Conclusions: AO of SCA3/MJD carriers was earlier in groups related to rural life. Our evidence suggests the presence of a risk factor in the rural environment, for earlier onset of symptoms in SCA3/MJD.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Open-Label, Non-randomized, Drug-Repurposing Study to Explore the Clinical Effects of Angiotensin II Type 1 (AT1) Receptor Antagonists on Anxiety and Depression in Parkinson's Disease. 一项开放标签、非随机、药物再利用的研究，探讨血管紧张素II型1 （AT1）受体拮抗剂对帕金森病焦虑和抑郁的临床影响。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-18 DOI: 10.1002/mdc3.14326

Sofia Bordet, Lina Grasso, Lucas Udovin, Guenson Chevalier, Matilde Otero-Losada, Francisco Capani, Santiago Perez-Lloret

{"title":"An Open-Label, Non-randomized, Drug-Repurposing Study to Explore the Clinical Effects of Angiotensin II Type 1 (AT1) Receptor Antagonists on Anxiety and Depression in Parkinson's Disease.","authors":"Sofia Bordet, Lina Grasso, Lucas Udovin, Guenson Chevalier, Matilde Otero-Losada, Francisco Capani, Santiago Perez-Lloret","doi":"10.1002/mdc3.14326","DOIUrl":"https://doi.org/10.1002/mdc3.14326","url":null,"abstract":"Background: The cerebral Renin-Angiotensin System might have a role in anxiety and depression development.Objective: We explored the effects of Angiotensin II Type 1 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACE-Is) on anxiety and depression in Parkinson's Disease (PD).Methods: Four hundred and twenty-three newly diagnosed drug-naïve PD patients were evaluated using the State-Trait Anxiety Inventory (STAI) and Geriatric Depression Scale (GDS-15) tests and were monitored at baseline and for up to 3 years.Results: Twelve patients were treated with ARBs and 42 with ACE-Is. ARB-treated patients had lower anxiety STAI scores than those on ACE-Is or drug-free at baseline (17.2 ± 1.3 vs. 21.3 ± 1.3, or 23.8 ± 0.5, respectively, P = 0.021) and during the follow-up (P < 0.01). Depression scores were unaffected by any of the drugs throughout the study.Conclusion: This small sample of ARB-treated PD patients displayed lower levels of anxiety. Randomized clinical trials are warranted.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Niemann-Pick Type C Disease: From Variant of Uncertain Significance to Pathogenic Variant. 尼曼-匹克C型病：从意义不确定的变异到致病变异。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-18 DOI: 10.1002/mdc3.14340

Lucas Bruno Rezende, Caroline Nogueira Aguiar, Jesus Mística Ventura Balbino, Débora Palma Maia, Ricardo Horta Maciel, Sarah Teixeira Camargos, Francisco Cardoso

引用次数: 0

Elevated Cerebrospinal Fluid α-Synuclein Seeding Activity Predicts Central Lewy Body Diseases. 脑脊液α-突触核蛋白种子活性升高预测中枢路易体疾病。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-16 DOI: 10.1002/mdc3.14333

David S Goldstein, Parvez Alam, Patti Sullivan, Courtney Holmes, Janna Gelsomino, Andrew G Hughson, Byron Caughey

{"title":"Elevated Cerebrospinal Fluid α-Synuclein Seeding Activity Predicts Central Lewy Body Diseases.","authors":"David S Goldstein, Parvez Alam, Patti Sullivan, Courtney Holmes, Janna Gelsomino, Andrew G Hughson, Byron Caughey","doi":"10.1002/mdc3.14333","DOIUrl":"https://doi.org/10.1002/mdc3.14333","url":null,"abstract":"Background: Cerebrospinal fluid (CSF) α-synuclein seeding activity (SSA) via a seed amplification assay might predict central Lewy body diseases (LBD) in at-risk individuals.Objective: The aim was to assess CSF SSA in a prospective, longitudinal study.Methods: Participants self-reported risk factors were genetics, olfactory dysfunction, dream enactment behavior, orthostatic intolerance, or hypotension; individuals who had ≥3 confirmed risk factors underwent CSF sampling and were followed for up to 7.5 years. Participants who developed a central LBD (LBD+) were compared to those who did not. Quadruplicate SSA areas under the curve (AUC) were averaged.Results: Of 11 subjects with average AUCs above 500,000 units, 7 (64%) developed a central LBD compared to 1 of 20 (5%), with AUCs below the cutoff value (P = 0.0011 by log-rank test). Conversely, 7 of 8 (88%) LBD+ participants had elevated initial AUCs.Conclusions: Increased CSF SSA predicts central LBDs. Individuals who develop a central LBD have elevated initial SSA AUCs.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinsonian presentation in a child with Anti-NMDAR Encephalitis. 抗nmdar脑炎患儿帕金森表现。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-16 DOI: 10.1002/mdc3.14336

Saurabh Agarwal, Kandha Kumar, Ashna Kumar, Sarbesh Tiwari, Lokesh Saini

引用次数: 0

Protracted Presentation of Anti-LGI 1 Encephalitis Associated with Prostate Cancer: A Case Report. 与前列腺癌相关的抗 LGI 1 脑炎的长期表现：病例报告。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-15 DOI: 10.1002/mdc3.14334

Talyta Grippe, Peter Tai, Adrian Budhram, Robert Chen, Anthony E Lang

引用次数: 0

Alternative Deep Brain Stimulation Targets in the Treatment of Isolated Dystonic Syndromes: A Multicenter Experience-Based Survey. 替代性脑深部刺激治疗孤立性肌张力障碍综合征：一项多中心经验调查。

IF 2.6 4区医学

Movement Disorders Clinical Practice Pub Date : 2025-01-13 DOI: 10.1002/mdc3.14324

Laura Cif, Patricia Limousin, Zohra Souei, Marwan Hariz, Joachim K Krauss

{"title":"Alternative Deep Brain Stimulation Targets in the Treatment of Isolated Dystonic Syndromes: A Multicenter Experience-Based Survey.","authors":"Laura Cif, Patricia Limousin, Zohra Souei, Marwan Hariz, Joachim K Krauss","doi":"10.1002/mdc3.14324","DOIUrl":"https://doi.org/10.1002/mdc3.14324","url":null,"abstract":"Background: The globus pallidus internus (GPi) is the traditional evidence-based deep brain stimulation (DBS) target for treating dystonia. Although patients with isolated \"primary\" dystonia respond best to GPi-DBS, some are primary or secondary nonresponders (improvement <25%), showing variability in clinical response.Objective: The aim was to survey current practices regarding alternative DBS targets for isolated dystonia patients with focus on nonresponders to GPi-DBS.Methods: A 42-question survey was emailed and distributed during a DBS conference to clinicians involved in DBS for dystonia. The survey covered (1) use of alternative DBS targets as primary or rescue options, (2) target selection based on dystonia phenomenology, (3) experience with secondary nonresponders to GPi-DBS, and (4) management of patients with additional DBS leads.Results: The response rate was 53.8%, including neurologists and neurosurgeons from 28 DBS centers in 13 countries; 89% of neurologists and 86% of neurosurgeons used alternative DBS targets to GPi, with subthalamic nucleus being the most common initial or rescue alternative to GPi. Patients with additional tremor received DBS in the ventral intermediate nucleus or caudal zona incerta. Individual experience ranged from 5 to 25 patients. Most patients were still receiving dual target stimulation at the last follow-up.Conclusions: We show that more than 85% of surveyed clinicians use alternative DBS targets, mostly in some isolated dystonia patients not adequately responsive to GPi-DBS. More knowledge is needed to evaluate outcomes in alternative targets and establish the best strategies for managing insufficient GPi-DBS response in dystonia patients with diverse phenomenology. Our article contributes to establishing a clearer time frame and criteria for defining nonresponders in dystonia patients undergoing DBS.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0