Molecular Biology Research Communications最新文献_第9页

Novel RNA extraction method from human tears. 从人泪液中提取RNA的新方法。

IF 1.6

Molecular Biology Research Communications Pub Date : 2022-01-01 DOI: 10.22099/mbrc.2022.45266.1801

Mahintaj Dara, Azam Habibi, Negar Azarpira, Mehdi Dianatpour, Mahmood Nejabat, Amir Khosravi, Nader Tanideh

引用次数: 0

Investigation and confirmation of differentially expressed miRNAs, as well as target gene prediction in papillary thyroid cancer, with a special emphasis on the autophagy signaling pathway. 甲状腺乳头状癌中差异表达mirna及靶基因预测的研究与确认，重点关注自噬信号通路。

IF 1.6

Molecular Biology Research Communications Pub Date : 2022-01-01 DOI: 10.22099/mbrc.2022.43844.1751

Mojtaba Zehtabi, Zahra Akbarpour, Sepehr Valizadeh, Yousef Roosta, Amir Mahdi Khamaneh, Mortaza Raeisi

{"title":"Investigation and confirmation of differentially expressed miRNAs, as well as target gene prediction in papillary thyroid cancer, with a special emphasis on the autophagy signaling pathway.","authors":"Mojtaba Zehtabi, Zahra Akbarpour, Sepehr Valizadeh, Yousef Roosta, Amir Mahdi Khamaneh, Mortaza Raeisi","doi":"10.22099/mbrc.2022.43844.1751","DOIUrl":"https://doi.org/10.22099/mbrc.2022.43844.1751","url":null,"abstract":"Papillary thyroid carcinoma (PTC) is the most common endocrine cancer. However, the role of biomechanics in the development and progression of PTC is obscure. The microarray dataset GSE104005 was examined to identify important microRNAs (miRNAs or miRs) and their probable roles in the carcinogenesis of PTC. The gene expression omnibus (GEO) database was used to obtain the data. R was used to access the differentially expressed miRNAs (DEMs) and genes (DEGs). The multiMiR software was used to predict DEM targets. To validate the top DEMs and DEGs, thirty tissue samples were obtained from PTC patients who had their thyroids removed and compared with 30 normal samples. The total RNA content of the tumor and corresponding non-tumoral adjacent samples were purified and converted to cDNA. Expression levels of top dysregulated miRNAs and their target and predicted DEG were evaluated using the RT-qPCR method. miR-182 and miR-183 were top upregulated miRs and miR-30d was the most downregulated miR among DEMs. Furthermore, FOXO1 which was shown to be targeted by aforementioned miRNAs, was the most downregulated genes among other DEGs. 10 hub nodes were detected by PPI construction. PTEN was the hub node with highest score. The in vitro gene expression analysis was also showed the same expression pattern in tissues. Significant increase in miR-182-5p and miR-183-5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"11 4","pages":"173-181"},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10707067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A phenotypic and molecular investigation of biofilm formation in clinical samples of Pseudomonas aeruginosa. 铜绿假单胞菌临床样品生物膜形成的表型和分子研究。

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-12-01 DOI: 10.22099/mbrc.2021.41708.1673

Leila Dolatshah, Mohammad Tabatabaei

{"title":"A phenotypic and molecular investigation of biofilm formation in clinical samples of Pseudomonas aeruginosa.","authors":"Leila Dolatshah, Mohammad Tabatabaei","doi":"10.22099/mbrc.2021.41708.1673","DOIUrl":"https://doi.org/10.22099/mbrc.2021.41708.1673","url":null,"abstract":"Pseudomonas aeruginosa is identified as a versatile opportunistic microorganism with metabolic diversity contributing to a wide range of health burdens, especially in immunocompromised patients. This bacterium is the cause of 10 to 20% of nosocomial infections. In this study, we evaluated the phenotypic characterizations of biofilm formation in P. aeruginosa clinical isolates using micro-titer plate assay. Indeed, we estimated the prevalence of QS (rhlI, rhlR, rhlAB, lasB, lasI, lasR, aprA) and virulence genes (pslA and cupA) by PCR. The results showed that among 69% of the isolates forming biofilm, 9% were strong biofilm producers, whereas 13% and 47% of isolates produced moderate and low amounts of biofilm, respectively. All isolates possessed cupA and seven QS genes (rhlI, rhlR, rhlAB, lasB, lasI, lasR, aprA), while 92% of the isolates possessed the pslA gene. Identification of these genes and their association with biofilm formation can be advantageous in adopting therapeutic methods.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 4","pages":"157-163"},"PeriodicalIF":1.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and comparison of physiochemical properties, mutations and glycosylation patterns between RNA polymerase and membrane protein of SARS-CoV and SARS-CoV-2. SARS-CoV和SARS-CoV-2 RNA聚合酶和膜蛋白的理化性质、突变和糖基化模式分析与比较

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-12-01 DOI: 10.22099/mbrc.2021.42187.1692

Mandana Behbahani, Parisa Rabiei, Hassan Mohabatkar

{"title":"Analysis and comparison of physiochemical properties, mutations and glycosylation patterns between RNA polymerase and membrane protein of SARS-CoV and SARS-CoV-2.","authors":"Mandana Behbahani, Parisa Rabiei, Hassan Mohabatkar","doi":"10.22099/mbrc.2021.42187.1692","DOIUrl":"10.22099/mbrc.2021.42187.1692","url":null,"abstract":"SARS-CoV-2 is a member of β-genus of the coronavirus subfamily, alongside the virus that causes SARS (Severe Acute Respiratory Syndrome). As implied by their names, SARS-CoV-2 and SARS-CoV genome sequences have close kinship (about 79% genomic sequence similarity). In the current research, sequence-based physiochemical properties of RNA polymerase and membrane glycoprotein of SARS-CoV-2 and SARS-CoV were compared. In addition, impacts of substitution mutations on stability and glycosylation patterns of these proteins were studied. In comparison of physiochemical features of membrane and RNA polymerase proteins, only instability index of membrane protein was difference between SARS-CoV and SARS-CoV-2. Mutation analysis showed increase in stability of RNA polymerase and decrease in stability of membrane protein in SARS-CoV-2. Glycosylation pattern analysis showed glycosylation enhancement in both membrane and RNA polymerase proteins of SARS-CoV-2 in comparison to SARS-CoV. In conclusion, more glycosylation and stability of SARS-CoV-2 RNA polymerase could be one of the reasons of high pathogenicity property and host immune system evasion of SARS-CoV-2.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 4","pages":"171-178"},"PeriodicalIF":1.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tissue expression of MMP-9, TIMP-1, RECK, and miR338-3p in prostate gland: can it predict cancer? 前列腺组织中MMP-9、TIMP-1、RECK和miR338-3p的表达:能否预测癌症?

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-12-01 DOI: 10.22099/mbrc.2021.40912.1646

Rodolfo Pacheco de Moraes, Ruan Pimenta, Fernando Noboru Cabral Mori, Gabriel Arantes Dos Santos, Nayara Izabel Viana, Vanessa Ribeiro Guimarães, Juliana Alves de Camargo, Katia Ramos Moreira Leite, Miguel Srougi, William Carlos Nahas, Sabrina T Reis

{"title":"Tissue expression of MMP-9, TIMP-1, RECK, and miR338-3p in prostate gland: can it predict cancer?","authors":"Rodolfo Pacheco de Moraes, Ruan Pimenta, Fernando Noboru Cabral Mori, Gabriel Arantes Dos Santos, Nayara Izabel Viana, Vanessa Ribeiro Guimarães, Juliana Alves de Camargo, Katia Ramos Moreira Leite, Miguel Srougi, William Carlos Nahas, Sabrina T Reis","doi":"10.22099/mbrc.2021.40912.1646","DOIUrl":"https://doi.org/10.22099/mbrc.2021.40912.1646","url":null,"abstract":"Prostate cancer is the most frequent malignancy affecting men worldwide. Due to the low sensitivity and specificity of the prostate-specific antigen test and the digital rectal exam as screening modalities, several alternatives are being studied. This study aimed to evaluate the application of MMP-9 and its regulators (TIMP-1, RECK, and miR-338-3p) as diagnostic and prognostic indicators of prostate cancer. A total of 134 randomly selected patients under investigation for prostate cancer submitted to a transrectal ultrasound-guided prostate biopsy were enrolled in the study; of these, 61 were positive for the disease (cases), and 73 were negative (control group). The tissue samples were further analyzed by gene and miR-338-3p expression analysis using qRT-PCR (one randomly selected fragment of each patient). Approximately 58% of the patients with prostate cancer presented MMP9 upregulation, while 73%, 65%, and 69% downregulated IMP-1, RECK, and miR-338-3p, respectively. MiR-338-3p was expressed at lower levels in patients with PSA concentrations exceeding 20 ng/mL (p=0.045) and abnormal DRE (p=0.006), while the RECK was more expressed in patients with abnormal DRE (p=0.01). We found that most patients with prostate cancer overexpressed MMP-9; on the other hand, most of them underexpressed TIMP-1, RECK, and miR-338-3p. MiR-338-3p presented as a possible predictor of poor prognosis. Further studies are warranted to evaluate these biomarkers as prognosis factors better.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 4","pages":"149-156"},"PeriodicalIF":1.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Investigation of p16 protein expression and its association with histopathologic parameters in breast cancer. 乳腺癌中p16蛋白表达及其与组织病理参数关系的研究。

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-12-01 DOI: 10.22099/mbrc.2021.41691.1671

Siamak Naji-Haddadi, Daniel Elieh-Ali-Komi, Saeid Aghayan, Rahim Asghari, Javad Rasouli

{"title":"Investigation of p16 protein expression and its association with histopathologic parameters in breast cancer.","authors":"Siamak Naji-Haddadi, Daniel Elieh-Ali-Komi, Saeid Aghayan, Rahim Asghari, Javad Rasouli","doi":"10.22099/mbrc.2021.41691.1671","DOIUrl":"https://doi.org/10.22099/mbrc.2021.41691.1671","url":null,"abstract":"We investigated the association between p16 expression and histopathologic parameters including size, neural and vascular invasion, and lymph node involvement in breast cancer. 58 specimens from patients with different grades of breast cancer were included. Hematoxylin and eosin and immunohistochemistry staining for p16 was performed. 5 patients (8.6%) had grade I, 23 (39.7%) had grade II, and 30 (51.7%) had grade III breast cancer. Assessment of the tumor size showed that 5 (8.6%) tumors had a size of ≤2cm, 29 (50%) were between 2-5 cm and 24 (41.4%) had a size of ≥5cm. Moreover, 45 (77.6%) of the included patients had axillary lymph node involvement. Investigation of association between p16 positivity with pathological parameters in three groups with positivity to p16 (1-25%, 26-75%, >75%) showed that there was no association between p16 positivity and other parameters including histologic score (p=0.44), tumor size (p=0.77), neural invasion (p=0.79), perivascular invasion (p=0.98) and the number of involved LNs (p=0.49). From the group including eight patients with >75% p16 positivity, seven (87.5%) were found with neural invasion and two (25%) with perivascular invasion. P16 positivity was not associated with size, neural and vascular invasion, and LN involvement in breast cancer.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 4","pages":"165-170"},"PeriodicalIF":1.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39750399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fission yeast Ase1^PRC1 is required for the G₂-microtubule damage response. 裂变酵母Ase1PRC1是g2微管损伤反应所必需的。

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-12-01 DOI: 10.22099/mbrc.2021.41001.1650

Rose M Doss, Sindi Xhunga, Dorothy Klimczak, Molly Cameron, Jordan Verlare, Tom D Wolkow

{"title":"Fission yeast Ase1PRC1 is required for the G2-microtubule damage response.","authors":"Rose M Doss, Sindi Xhunga, Dorothy Klimczak, Molly Cameron, Jordan Verlare, Tom D Wolkow","doi":"10.22099/mbrc.2021.41001.1650","DOIUrl":"https://doi.org/10.22099/mbrc.2021.41001.1650","url":null,"abstract":"Schizosaccharomyces pombe delays entry into mitosis following G2 microtubule damage. This pathway is dependent on Rad26ATRIP, the regulatory subunit of the Rad26ATRIP/Rad3ATR DNA damage response (DDR) complex. However, this G2 microtubule damage response pathway acts independently of the G2 DNA damage checkpoint pathway. To identify other proteins in this G2 microtubule damage pathway, we previously screened a cDNA overexpression library for genes that rescued the sensitivity of rad26Δ cells to the microtubule poison thiabendazole. A partial cDNA fragment encoding only the C-terminal regulatory region of the microtubule bundling protein Ase1 PRC1 was isolated. This fragment lacks the Ase1PRC1 dimerization and microtubule binding domains and retains the conserved C-terminal unstructured regulatory region. Here, we report that ase1Δ cells fail to delay entry into mitosis following G2 microtubule damage. Microscopy revealed that Rad26ATRIP foci localized alongside Ase1PRC1 filaments, although we suggest that this is related to microtubule-dependent double strand break mobility that facilitates homologous recombination events. Indeed, we report that the DNA repair protein Rad52 co-localizes with Rad26ATRIP at these foci, and that localization of Rad26ATRIP to these foci depends on a Rad26ATRIP N-terminal region containing a checkpoint recruitment domain. To our knowledge, this is the first report implicating Ase1PRC1 in regulation of the G2/M transition.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 4","pages":"179-188"},"PeriodicalIF":1.6,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39573397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19. MiR-200c-3p表达可能与COVID-19患者临床病程恶化有关。

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-09-01 DOI: 10.22099/mbrc.2021.40555.1631

Ruan Pimenta, Nayara I Viana, Gabriel A Dos Santos, Patrícia Candido, Vanessa R Guimarães, Poliana Romão, Iran A Silva, Juliana A de Camargo, Diná M Hatanaka, Paula G S Queiroz, Alexandre Teruya, Leandro Echenique, Bruno A M P Besen, Katia R M Leite, Victor Srougi, Miguel Srougi, Sabrina T Reis

{"title":"MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19.","authors":"Ruan Pimenta, Nayara I Viana, Gabriel A Dos Santos, Patrícia Candido, Vanessa R Guimarães, Poliana Romão, Iran A Silva, Juliana A de Camargo, Diná M Hatanaka, Paula G S Queiroz, Alexandre Teruya, Leandro Echenique, Bruno A M P Besen, Katia R M Leite, Victor Srougi, Miguel Srougi, Sabrina T Reis","doi":"10.22099/mbrc.2021.40555.1631","DOIUrl":"https://doi.org/10.22099/mbrc.2021.40555.1631","url":null,"abstract":"COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It is speculated that microRNAs may play a crucial role in host cells after infection by SARS-CoV-2. Thus, our study aimed to analyze the expression of miR-200c-3p in saliva samples from patients with COVID-19. One handred eleven samples from patients with COVID-19 were divided into 4 groups. Group I: 39 patients negative for Covid-19; Group II: 37 positive and symptomatic patients, with no indication of hospitalization; Group III: 21 patients with respiratory disorders (hospitalized); Group IV: 14 patients with severe conditions (oxygen therapy). The expression levels of miR-200c-3p were determined using qPCR. We found greater expression of miR-200c-3p in patients in group IV (p<0.0001), and also verified that patients aged ≥42 years had a higher expression of this miR (p=0.013). Logistic regression analysis revealed that the expression of miR-200c-3p and systemic arterial hypertension are factors independently associated with patients in group IV (p<0.0001). Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 3","pages":"141-147"},"PeriodicalIF":1.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39379463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe? 端粒锌指相关蛋白(TZAP)在癌症生物学中的作用:是敌是友?

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-09-01 DOI: 10.22099/mbrc.2021.40106.1607

Gabriel Arantes Dos Santos, Nayara Izabel Viana, Ruan Pimenta, Juliana Alves de Camargo, Sabrina T Reis, Katia Ramos Moreira Leite, Miguel Srougi

{"title":"Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe?","authors":"Gabriel Arantes Dos Santos, Nayara Izabel Viana, Ruan Pimenta, Juliana Alves de Camargo, Sabrina T Reis, Katia Ramos Moreira Leite, Miguel Srougi","doi":"10.22099/mbrc.2021.40106.1607","DOIUrl":"https://doi.org/10.22099/mbrc.2021.40106.1607","url":null,"abstract":"The new identified protein telomeric zinc-finger associated protein (TZAP) is a negative regulator of telomere length. Since telomere length and telomere maintenance mechanisms are essential to cancer progression, TZAP is considered a new player in cancer biology. Here we aimed to analyze TZAP using the Cancer Genome Atlas data in a Pan-Cancer approach. We gathering data from TCGA Pan-Cancer studies utilizing cBioPortal, GEPIA and UALCAN. In total we analyzed 33 types of cancer (n=9664) and their respective controls (n=711). TZAP is transcribed in all cancers but less than 5% of all tumors show any somatic changes. TZAP was downregulated in kidney chromophobe carcinoma, and upregulated in esophageal cancer, head and neck squamous cell carcinomas, kidney renal clear cell carcinoma and in liver hepatocellular carcinoma. Globally, TZAP expression is related to favorable prognosis, associated to better overall and disease-free survival. Looking to specific tumors, TZAP expression has a dual behavior. Its downregulation is associated with poor prognosis in cervical squamous cell carcinoma, in kidney renal clear cell carcinoma, kidney papillary cell carcinoma, lung adenocarcinoma and pancreas adenocarcinoma. On the contrary, in adrenocortical carcinoma, colon and rectal cancer, brain lower grade glioma and prostate adenocarcinoma the upregulation of TZAP is related with poor prognosis. TZAP expression has a positive correlation with TRF1 and TRF2 in normal tissue but not in cancer. Our analyses indicate that TZAP has an important role in oncology and may be considered as a potential biomarker.","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"10 3","pages":"121-129"},"PeriodicalIF":1.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340314/pdf/mbrc-10-121.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39380917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prokaryotic expression of chimeric GFP-hFc protein as a potential immune-based tool. 嵌合GFP-hFc蛋白的原核表达作为潜在的免疫工具。

IF 1.6

Molecular Biology Research Communications Pub Date : 2021-09-01 DOI: 10.22099/mbrc.2021.39728.1588

Thanh-Tan Nguyen, Hai-Vy Vo-Nguyen, Hieu Tran-Van

引用次数: 2