Natural Product Communications最新文献

{"title":"Analysis of Potential Factors Influencing Baicalin Content in <i>Scutellaria baicalensis</i> from Different Regions","authors":"Chaonan Yang, Xue Yu, Yintao Zhao, Yan Liu","doi":"10.1177/1934578x251337612","DOIUrl":"https://doi.org/10.1177/1934578x251337612","url":null,"abstract":"Objective: This study explored the effects of climatic and soil factors on baicalin accumulation in Scutellaria baicalensis , aiming to compare baicalin content and antibacterial efficacy across regions and optimize cultivation practices. Methods: S. baicalensis samples were collected from three production areas in Shanxi, Inner Mongolia, and Hebei. Baicalin and total protein contents were measured, and sample differences were explored. The soil microbial community composition was determined, and climatic and soil factors were analyzed. Results: Baicalin content was the highest in S. baicalensis from Hebei, with no significant difference in the total protein content. The most effective antibacterial effect was achieved with a 100 mg/mL concentration of Hebei S. baicalensis solution. Baicalin content was positively correlated with annual average temperature, precipitation, and relative humidity and negatively correlated with annual average sunshine hours and wind speed. Shanxi's rhizosphere soil contained higher levels of total nitrogen, carbon, sulfur, nitrate, and nitrite compared to the other regions. The S0134 terrestrial group and Longimicrobiaceae were positively associated with baicalin content. Conclusion: S. baicalensis from Hebei exhibited superior quality, influenced by ecological factors. In order to improve the cultivation effect, the quality of Scutellaria baicalensis can be improved by selecting planting areas with suitable acidity and alkalinity, adjusting the ratio of nitrogen, phosphorus, potassium and other fertilizers moderately during cultivation, adjusting the appropriate amount of water, and fully utilizing the accumulation of active compounds in medicinal plants by rhizosphere microorganisms.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Natural Herbal Extracts Liposomal Loaded Hybrid Hydrogel for Skin Improvement and Repair","authors":"Di Zhang, Ning Tian, Yonggang Guo, Ying Liu, Guang Sun, Rui Jiang, Xiaoyu He, Lizhi Xiao, Jiqiang Mi, Yi Liu, Wei Zheng, Yingnan Jiang","doi":"10.1177/1934578x251332366","DOIUrl":"https://doi.org/10.1177/1934578x251332366","url":null,"abstract":"Background: Hydrogel dressings have the advantages of continuous moisturizing, good permeability, antibacterial and biocompatibility, and can be used as an expecting material for skin improvement and protection. Among natural herbal extracts, ginseng extract exhibits various excellent skin care activities, including antioxidant, anti-inflammatory, brightening, and anti-aging effects. In order to better deliver active substances- ginseng extract to the skin and play an important role in protecting human skin, a novel multifunctional ginseng extract liposome-loaded hybrid hydrogel (GS-LPs@Hy) was prepared. Methods: First, the optimal reaction ratio of liposomes encapsulating natural ginseng extract (GS-LPs) was determined by measuring the encapsulation rate of the active substance and the proliferation of skin cells. Transmission electron microscopy (TEM), dynamic light scattering (DLS) measurement and fourier transform infrared spectroscopy (FTIR) showed that the natural ginseng extracts (GS) were successfully encapsulated in the liposomes. Results: GS-LPs exhibited a relatively uniform particle size distribution, with electronegative. In vitro release experiment and stability test showed that the GS-LPs had good stability and could release active substances stably for a long time. Then by testing the compressibility, rheological properties, moisturizing rate, antibacterial properties and the ability to promote cells proliferation of the hybrid hydrogels under different reaction conditions, the prepared GS-LPs@Hy had the optimal mechanical properties, moisturizing properties and antibacterial properties. And in vitro experiments showed the GS-LPs@Hy had certain proliferative activity on human immortalized epidermal (Hacat) cells and skin fibroblast (HDF-α) cells, inhibited the melanin production in mouse melanoma cells and had a good scavenging rate against 2,2-diphenyl-1-pyridylhydrazine free radical (DPPH). The in vivo animal skin damage model displayed that the GS-LPs@Hy had a certain whitening and repair effect on UV damaged skin. Conclusion: GS-LPs@Hy is a multifunctional hybrid hydrogel comprised of polyvinyl alcohol (PVA), gelatin (Gel), hyaluronic acid (HA) and carboxymethyl chitosan (SCS) loaded with a large number of liposomes containing natural active ingredients. GS-LPs@Hy can continuously and slowly release highly active GS-LPs to the skin's surface. Based on the amphiphilic nature of liposomes, GS-LPs could effectively penetrate deep into the skin and be absorbed by cells in the epidermis and dermis due to their nanoscale size and surface properties. It would maximize the skincare efficacy of natural active substances within skin cells. This material not only provides a new approach for skincare products but also highlights the potential application value of natural herbal components in skin repair and health maintenance.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Chemical Composition of Cumin (Cuminum cyminum L.) Analyzed by UPLC-Q-Orbitrap MS and GC-MS","authors":"Yanqiu Bai, Qier Mu, Junni Qi, Chula Sa","doi":"10.1177/1934578x251328280","DOIUrl":"https://doi.org/10.1177/1934578x251328280","url":null,"abstract":"Objective: Cumin ( Cuminum cyminum L.) is an important spice widely used as a functional food and in traditional Chinese medicine. However, its chemical constituents have not been systematically reported. This study aimed to identify and analyze the chemical composition of its aqueous extracts and volatile oils. Methods: The chemical composition of cumin was systematically analyzed using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-Orbitrap-MS) and gas chromatography-mass spectrometry (GC-MS). Results: A total of 102 compounds were identified in cumin. Of these, 62 were found in the aqueous extract, including 10 flavonoids, 7 phenylpropanoids, 5 terpenoids, 4 alkaloids, 7 organic acids, 8 fatty acids, 8 amino acids, 2 glycosides, and 10 other components. In addition, 40 compounds were characterized in the volatile oil, accounting for 98.70% of the total volatile content. These compounds include monoterpenes, sesquiterpenes, alkanes, alcohols, aldehydes, phenols, ketones, and alkylbenzenes. Conclusion: These findings expand our understanding of the chemical composition of cumin and provide a foundation for elucidating its pharmacodynamic properties.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC-MS and Chemometric Contrastive Analysis of the Essential Oils from the Leaves of <i>Chimonanthus salicifolius</i> S.Y.Hu and <i>Chimonanthus nitens</i> Oliv. in China","authors":"Yamin Wang, Yanzhen Hu, Xiaoqun He, Xusheng Huang, Di Zhang, Cui Hu, Jiawei Xu, Xue Li","doi":"10.1177/1934578x251333914","DOIUrl":"https://doi.org/10.1177/1934578x251333914","url":null,"abstract":"Background/Objective: Chimonanthus salicifolius S.Y.Hu ( C. salicifolius ) is one of the most important herbs in She nationality of China. For the similar appearance of C. salicifolius and Chimonanthus nitens Oliv. ( C. nitens ), they are often used in confusion in folk. In order to preliminarily estimate whether C. salicifolius is the pharmaceutical base source of C. nitens , in this study, the essential oil components of C. salicifolius and C. nitens from different locations in China were analyzed for the first time. Methods: The essential oil components of C. salicifolius and C. nitens from different locations in China were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Results: The two essential oils contained 67 and 71 compounds, respectively, and with 18 common components. The primary components of volatile oil of C. salicifolius were eucalyptol, linalool, caryophyllene, δ -cadinene and limonene, while those of C. nitens were eucalyptol, linalool, 2-bornanone and α -terpineol. PLS-DA and HCA were performed on 18 common main components. The C. salicifolius species sources (L1 and L2) were in a cluster, the C. salicifolius species sources (L3) and the C. nitens species sources (S1-S3) were in another cluster. The differential substances of the two clusters were eucalyptol, linalool, caryophyllene, 2-bornanone, limonene and α -terpineol. In the cell experiment, the essential oils of C. salicifoliu s and C. nitens exerted evident anti-inflammatory effects. Conclusions: Our work indicated that there were similarity in types, contents and anti-inflammatory effects of essential oil of C. salicifoliu s and C. nitens from different germplasm resources. This study determined preliminarily that C. salicifolius could be used as the medicinal base of source of C. nitens .","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Angelica sinensis</i> and <i>Ligusticum sinense ‘Chuanxiong’</i> Leaf Essential Oils Promote Hair Growth without Acute Toxicity","authors":"Li Ma, Michelle Pi, Zhuqing Dai, Yuexing Zhu, Wencui Wang, Haicheng Yang, Lei Yao","doi":"10.1177/1934578x251333902","DOIUrl":"https://doi.org/10.1177/1934578x251333902","url":null,"abstract":"Background Rhizome Angelica sinensis and Ligusticum sinense ‘chuanxiong’ are the main medicinal herbs used in traditional Chinese or Asian medicine to treat alopecia likely associated with their expertise in invigorating blood circulation. However, the effects of the volatile essential oils present in their aboveground parts are unclear. Objective To evaluate the general safety of essential oils from A. sinensis and L. sinense ‘chuanxiong’ leaves and evaluate their hair grow promoting effect on model mice and cells of dehydrotestosterone-induced androgenetic alopecia. Methods Essential oil safety was evaluated based on acute oral/dermal/eye irritation toxicity tests on laboratory animals. Essential oils (5%, 3% and 1%) were topically applied to model mice with dehydrotestosterone-induced androgenetic alopecia for 28 days. They (50-200 mg/L) were appended to the monoculture of model cells of dehydrotestosterone-induced androgenetic alopecia for 48 h. Results Both essential oils showed no acute toxicity. Mice dorsal skin indicated faster hair regrowth initiated by essential oils than by 3% minoxidil. Histological analysis shows that both essential oils increased the follicle number and dermal thickness in mice treated with dehydrotestosterone, with 1% A. sinensis and 3% L. sinense ‘chuanxiong’ essential oils performing the best. The 1% A. sinensis and 3% L. sinense ‘chuanxiong’ essential oils exhibited an average number of hair follicles (pcs/field of view) of 69.73 and 70.13, respectively, which were significantly larger than that of the model (14.80) and minoxidil (36.53) treated mice. Both essential oils significantly reversed the dehydrotestosterone-induced inhibition of secretion of hair growth promotors, the vascular endothelial growth factor and keratinocyte growth factor, in cultured cells. Conclusion A. sinensis and L. sinense ‘chuanxiong’ essential oils may act as safe and effective adjuvant agents in aromatherapy and cosmetics to treat human hair loss.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Characterization and Anti-Inflammatory Activity of <i>Ailanthus altissima</i> Flavonoids: Optimization of Extraction Process and Mechanistic Insights","authors":"Yu Liu, Yong Yan, Hongjuan Zhang, Xingxu Zhao, Yong Zhang","doi":"10.1177/1934578x251336282","DOIUrl":"https://doi.org/10.1177/1934578x251336282","url":null,"abstract":"Objectives Chronic inflammation drives numerous pathologies, necessitating novel therapeutics from natural sources. This study aimed to characterize the anti-inflammatory potential of Ailanthus altissima Swingle-derived total flavonoids (ASF), a traditional East Asian remedy, and establish its pharmacological foundation for treating cytokine-mediated inflammatory diseases. Methods ASF's anti-inflammatory activity was evaluated in LPS-stimulated RAW 264.7 macrophages, measuring nitric oxide (NO), reactive oxygen species (ROS), and cytokines (TNF-α, IL-1β). LC-MS identified ASF constituents, while network pharmacology predicted interactions with inflammation targets (NF-κB, MAPK pathways). Extraction parameters were optimized via Box-Behnken design response surface methodology (RSM). Dose-response assays assessed ASF's suppression of inflammatory mediators. Results LC-MS identified 43 major ASF constituents. Network pharmacology revealed ASF's multi-target interactions with NF-κB and MAPK signaling. RSM optimization achieved a 10.4146% flavonoid yield. ASF dose-dependently inhibited NO by 68.2% (200 μg/mL, p &lt; 0.01 versus LPS) and suppressed ROS/cytokines, demonstrating flavonoid-consistent structure-activity relationships. Conclusion ASF exhibits multi-target anti-inflammatory effects via NF-κB/MAPK modulation and mediator suppression, validating its traditional use. These findings support ASF's development as a phytopharmaceutical for cytokine-driven pathologies.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147894042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the Inhibitory Effect of Bergenia purpurascens Water Extract on COVID-19 XBB1.5 Variant and Its Blocking ACE2 Mechanism","authors":"Yongxia Shi, Xiaoning Sun, Zhaoxia Yu, Dalan Dai, Hongyu Guo, Lijuan Mei, Jun Dai, Lei Jiang","doi":"10.1177/1934578x251327922","DOIUrl":"https://doi.org/10.1177/1934578x251327922","url":null,"abstract":"Objective Bergenia purpurascens , a medicinal herb indigenous to southwestern China, has garnered interest for its potential therapeutic properties. This study investigates the herb's water extract's capacity to interfere with the interaction between the COVID-19 S1 Receptor Binding Domain (RBD) and the ACE2 receptor, a critical step in the virus's infection process. Methods Quality standards for the Bergenia purpurascens extract were established to ensure consistency. The extract's efficacy was assessed using a Vero-E6 cell infection model to inhibit live virus infection of the COVID-19 XBB1.5 variant. Surface Plasmon Resonance (SPR) was employed to explore the mechanism of action. The extract's composition was further analyzed using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS), with active compounds identified through a combination of in silico screening and actual activity testing. Results The water extract of Bergenia purpurascens demonstrated significant inhibitory activity against the COVID-19 XBB1.5 variant, with stability and high potency, reflected by an IC50 value of 0.037 mg/mL. The selectivity index for the antiviral effect is approximately 9. The extract's composition was predominantly Phenylpropanoids and Carbohydrates, accounting for over 60% of the total. Interestingly, a majority of the high-content compounds were inactive, while the low-content compounds, exemplified by Ellagic acid, showed synergistic activity. The extract's inhibitory mechanism was characterized as a non-specific inhibition of ACE2 with a steady-state binding affinity (KD) of 7.9 × 10 −7 M. Conclusions The study concludes that the water extract of Bergenia purpurascens is a promising, cost-effective non-specific ACE2 inhibitor with potential applications in COVID-19 therapy. The identification of active compounds and the elucidation of its inhibitory mechanism provide a foundation for further research and development of this traditional medicinal herb in combating viral infections.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Insights into the Antimicrobial Mechanism of Chelerythrine Against Methicillin-Resistant <i>Staphylococcus aureus</i>","authors":"Jianhua Liao, Chunyan Meng, Chaodan Shao, Dongli Yu, Y. F. Wang","doi":"10.1177/1934578x251330198","DOIUrl":"https://doi.org/10.1177/1934578x251330198","url":null,"abstract":"Background Methicillin-resistant Staphylococcus aureus (MRSA) is a major global health threat, causing infections that are difficult to treat due to resistance to standard antibiotics. The high mortality rates and limited treatment options for MRSA underscore the urgent need for novel therapeutic agents. Chelerythrine, a natural alkaloid, has shown potent antimicrobial activity against MRSA. However, the molecular mechanisms underlying its antibacterial effects, particularly its impact on bacterial proteomes, remain poorly understood. This study investigates chelerythrine's antibacterial efficacy and its time-dependent effects on the MRSA proteome to uncover key metabolic pathways targeted by this compound. Methods The minimum inhibitory concentration (MIC) of chelerythrine was determined using a microdilution method. Proteomic changes were analyzed by label-free quantitative mass spectrometry at 30, 60, and 120 min post-exposure. Fuzzy C-means (FCM) clustering was employed to identify protein expression patterns. Results Chelerythrine exhibited with a MIC of 19.54 mg/L against MRSA, with dose-dependent growth inhibition. Proteomic analysis identified 1037 proteins, with 447, 340, and 265 proteins showing significant changes at 30, 60, and 120 min, respectively. FCM clustering revealed three protein clusters, with Cluster 3 (36 proteins) showing specific downregulation under chelerythrine treatment. Gene Ontology (GO) and KEGG analyses indicated enrichment in metabolic pathways, particularly glycolysis, the tricarboxylic acid cycle, and arginine catabolism, highlighting chelerythrine's effect on bacterial energy production. Conclusion Chelerythrine disrupts key metabolic pathways in MRSA, particularly those involved in energy production and amino acid metabolism, suggesting its potential as an antimicrobial agent.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Effects of Seabuckthorn oil on Scopolamine Induced PC12 Cell Damage and APP/PS1 Mice","authors":"Dongliang Yang, Song Zhang, Duo Wang, Qiulin Yue, Chen Zhao, Xin Sun, Kunlun Li, Baojun Li, Le Su, Yang Zhang, Lin Zhao","doi":"10.1177/1934578x251329127","DOIUrl":"https://doi.org/10.1177/1934578x251329127","url":null,"abstract":"Objective Cognitive dysfunction is common in neurodegenerative diseases. Sea buckthorn oil (SBO) has anti-inflammatory and antioxidant properties. So, we want to investigate the effect of SBO on reducing scopolamine-induced oxidative stress, inflammation, and cholinergic changes in PC12 cells, and its impact on ameliorating cognitive dysfunction in APP/SP1 mice. The purpose of this study is to prove that SBO has a positive effect on cognitive dysfunction. Method In vitro, the effect of SBO on scopolamine-induced PC12 cells damage is evaluated using the 3- (4,5-dimethylthiazol-2-yl) −2,5-diphenyltetrazolium bromide (MTT) method. Levels of various biochemical markers were also examined by enzyme-linked immunosorbent assay (ELISA), including acetylcholinesterase (AChE), and acetylcholine (ACh). As well as examining the inflammatory factors: interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6). The oxidative stress of cell was detected using reactive oxygen species (ROS) staining. In addition, we detected catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), which are indicators of oxidative stress (OS) in vitro experiments. Moreover, the detection of Nrf2/HO-1 molecules and inflammatory cytokines released by reverse transcription-polymerase chain reaction (RT-PCR) and western blot. In vivo, the memory behavior is evaluated using the Morris water maze(MWM) and step-down test. Result SBO showed a significant reduction of AChE activities and increased the viability of scopolamine-treated PC12 cells. Meanwhile, SBO increases the level of GSH-Px, SOD, CAT activities, and ACh, and decreases the level of TNF-α, IL-1β, and IL-6. Moreover, increasing the expression of the Nrf2/HO-1 pathway. SBO has shortened the swimming time to the platform, and increased the exploration time of the target quadrant and the number of times it crosses the platform. Meanwhile, it reduced the number of errors in the step-down test. Conclusion SBO has a protective effect against scopolamine-induced PC12 cell injury and a favorable impact on improving cognitive impairment in APP/PS1 mice. Therefore, SBO may have clinical applications in the treatment of cognitive impairment.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and Antibacterial Activities of <i>Pteris vittata</i> L. Extracts from Metalliferous Soils: Correlations with Phenolic Compounds","authors":"Phuong Nhung Nguyen, Ngoc Lien Nguyen, Hai Nam Pham, Phuong Nguyen, Nguyễn Thị Kiều Oanh","doi":"10.1177/1934578x251322868","DOIUrl":"https://doi.org/10.1177/1934578x251322868","url":null,"abstract":"Objectives Pteris vittata L. is one of the hyperaccumulator plants that can grow in heavy metal-contaminated soil. This plant may tolerate metal stress through different mechanisms, eg, by producing a wide range of secondary metabolites. These compounds play an essential role in physiological function and can also serve as rich sources of chemicals for health benefit purposes. This study aims to determine the phytochemicals of plant extracts and the relationship between these profiles with pharmacological properties to predict active agents and their interaction. Methods The total phenolic and total flavonoid contents were measured by colorimetric assays, while the widely targeted metabolomics was applied to reveal leaf and root P. vittata metabolome. In parallel, the antioxidant and antibacterial effects of these extracts were determined by ABTS scavenging and micro-broth dilution methods. Multivariate analysis, ie, Partial Least Square Regression, calculated the correlation between metabolites and bioactivities. Results The results showed the significant content of phenolics and flavonoids in plants collected from mining soils of Thai Nguyen province, Vietnam, and their potential ABTS scavenging activity. Additionally, the plant's metabolome characterized 82 compounds, mainly secondary metabolites. The multivariate analysis indicated the positive correlation among quercetin derivatives and bioactivity, suggesting the contribution of their combination, not individually, to the antibacterial effect of P. vittata. Conclusion Hyperaccumulators in metalliferous soils are potential reservoirs for exploring the antibacterial agents against multi-drug resistant strains, and this effect may be exerted by additive or synergistic mechanisms of action of multiple compounds.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}