Natural Product Communications最新文献_第2页

Potential Antihyperglycemic Effects of Adzuki (Vigna angularis) Polyphenols on Mice and Caco-2 Cells 红木（Vigna angularis）多酚对小鼠和 Caco-2 细胞的潜在降血糖作用

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241271734

Kenji Kuriya, Masahide Osumi, Mana Ishihara, Masahiro Nishio, Hirotaka Katsuzaki, Junpei Sono, Masahiro Nakamura, Hayato Umekawa

{"title":"Potential Antihyperglycemic Effects of Adzuki (Vigna angularis) Polyphenols on Mice and Caco-2 Cells","authors":"Kenji Kuriya, Masahide Osumi, Mana Ishihara, Masahiro Nishio, Hirotaka Katsuzaki, Junpei Sono, Masahiro Nakamura, Hayato Umekawa","doi":"10.1177/1934578x241271734","DOIUrl":"https://doi.org/10.1177/1934578x241271734","url":null,"abstract":"Background/PurposeSome health-beneficial foods, including adzuki beans ( Vigna angularis), can show antihyperglycemic effects. Adzuki bean-derived polyphenols, such as (+)-catechin 7- O- β-d-glucopyranoside (C7G) and (+)-epicatechin 7- O- β-d-glucopyranoside (E7G), could be potential inhibitors of α-amylase and α-glucosidase, however, few studies of the activity of adzuki polyphenols have been performed in vivo. Thus, we evaluated the antihyperglycemic effects of crude adzuki bean extract containing polyphenols (ABP), and purified C7G or E7G using mice and Caco-2 cells.MethodsSix-week-old male ICR mice were orally administered ABP (100 or 250 mg/kg), C7G or E7G (15 or 40 mg/kg), and sucrose (2 g/kg). Blood samples were taken from the lateral tail vein to measure the blood glucose levels at various times over 0–120 min. Cultured caco-2 cells, an intestinal model, were treated with ABP, C7G, or E7G. The glucose concentration in the medium was measured to examine the activity of α-glucosidase.ResultsAdministration of adzuki polyphenols decreased blood glucose levels, especially E7G administration significantly showed antihyperglycemic effects in vivo. In Caco-2 cells, α-glucosidase activity was significantly decreased by ABP, C7G, or E7G addition in a dose-dependent manner without cytotoxicity.ConclusionThese results suggest that C7G and E7G in adzuki bean extract inhibited sucrose-degrading enzymes to elicit antihyperglycemic effects in vivo, which supports the results of previous studies using adzuki beans, and may contribute to health promotion.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"78 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abutilon theophrasti Medic.: A Review of its Traditional Uses, Phytochemistry, Pharmacology, and Pharmacokinetics Abutilon theophrasti Medic.：传统用途、植物化学、药理学和药代动力学综述

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241257380

Lu Li, Linnuo Pang, Fei Chen, Luming Zhang, Fen Zhou, Rongrong Li, Han Yan

引用次数: 0

Compositional Analysis and Network Pharmacological Strategy for the Treatment of Diabetic Kidney Disease by Shengjiang Powder Based on UHPLC-Q-TOF-MS 基于 UHPLC-Q-TOF-MS 的生姜粉成分分析及治疗糖尿病肾病的网络药理学策略

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241277543

Yongzhi Yin, Lu Yang, Ke Zhang, Silin Yu, Jinfa Liao, Jinhui Wang

{"title":"Compositional Analysis and Network Pharmacological Strategy for the Treatment of Diabetic Kidney Disease by Shengjiang Powder Based on UHPLC-Q-TOF-MS","authors":"Yongzhi Yin, Lu Yang, Ke Zhang, Silin Yu, Jinfa Liao, Jinhui Wang","doi":"10.1177/1934578x241277543","DOIUrl":"https://doi.org/10.1177/1934578x241277543","url":null,"abstract":"Objective: Shengjiang Powder (SJP) is a traditional Chinese medicine compound formula commonly used in the treatment of diabetic kidney disease (DKD). However, its material basis and mechanism of action are still unclear. Methods: In this study, the aqueous extract of SJP was obtained by aqueous decoction method, and the in vivo and in vitro constituents of SJP were analysed by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS), and a network pharmacological strategy was established in conjunction with molecular docking in order to investigate the mechanism of action of SJP in the treatment of DKD. Results: The results identified 162 components, of which 28 could be absorbed into the blood and exert therapeutic effects in vivo. The main active ingredients were CT-1, CT-2, CT-7, BJC-2, and BJC-5, and the main targets in vivo were related to AKT1, MAPK1, MAPK3, MAPK8, and MAPK14, which could exert their therapeutic effects through the PI3K-Akt signaling pathway, Insulin resistance, and AGE-RAGE signaling pathway in diabetic complications, etc Conclusion: The present study adopts a comprehensive analytical strategy to reveal the pharmacodynamic material basis and mechanism of action of SJP in the treatment of DKD, and to provide a scientific basis for its clinical application.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"23 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cimifugin Improves Motor Function Through Suppression of the NLRP3 Inflammasome in an Animal Model of Parkinson's Disease Cimifugin 通过抑制帕金森病动物模型中的 NLRP3 炎症体改善运动功能

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241265938

Ji Yun Lee, Min Jae Kim, Byung Tae Choi, Young Ju Yun, Seo-Yeon Lee, Hwa Kyoung Shin

{"title":"Cimifugin Improves Motor Function Through Suppression of the NLRP3 Inflammasome in an Animal Model of Parkinson's Disease","authors":"Ji Yun Lee, Min Jae Kim, Byung Tae Choi, Young Ju Yun, Seo-Yeon Lee, Hwa Kyoung Shin","doi":"10.1177/1934578x241265938","DOIUrl":"https://doi.org/10.1177/1934578x241265938","url":null,"abstract":"Objective: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons and persistent neuroinflammation in the substantia nigra (SN), triggering a dopamine deficiency that can lead to movement disorders. Neuroinflammation is a common feature of aging brains and neurodegenerative diseases. Inflammasome-related neuroinflammation is involved in the progression of PD. Methods: The effects of cimifugin was investigated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Cimifugin is one of the main components of Saposhnikovia divaricata (Turcz.) Schischkin. Behavioral tests, such as the rotarod, pole, and traction tests, were conducted to measure the recovery effects of Parkinson-related motor deficiencies. Results: Our analyses showed that cimifugin treatment mitigates motor dysfunction in a dose-dependent manner. In addition, cimifugin conferred neuroprotection by increasing the survival of dopaminergic neurons, as measured by tyrosine hydroxylase immunostaining. Neuroinflammation was reduced by cimifugin by inhibiting NLR family pyrin domain-containing 3 (NLRP3)/caspase-1/interleukin 1β signaling in the MPTP-insulted SN. Moreover, monosodium urate crystals, an NLRP3 agonist, reversed cimifugin-induced improvement in motor function in the PD model. Conclusion: These results suggest that cimifugin administration is a potential therapeutic strategy for mitigating PD.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"9 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Logic Gates Derived from Fluorescent Natural Products 荧光天然产物衍生的分子逻辑门

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241262897

Nicola’ Agius, David C. Magri

引用次数: 0

A Systematic Review of Medicinal Plants and Their Compounds Validated as Agents for the Management of Sickle Cell Disease 对经证实可作为镰状细胞病治疗药物的药用植物及其化合物的系统回顾

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241265889

Isaac Kingsley Amponsah, Denzel Opoku-Kwabi, Francis Ackah Armah, John Nii Addotey, Bernard Kofi Turkson, Emmanuel Quaye Kontoh

{"title":"A Systematic Review of Medicinal Plants and Their Compounds Validated as Agents for the Management of Sickle Cell Disease","authors":"Isaac Kingsley Amponsah, Denzel Opoku-Kwabi, Francis Ackah Armah, John Nii Addotey, Bernard Kofi Turkson, Emmanuel Quaye Kontoh","doi":"10.1177/1934578x241265889","DOIUrl":"https://doi.org/10.1177/1934578x241265889","url":null,"abstract":"Some plants used in traditional medicine to manage sickle cell disease have been validated pharmacologically to ascertain their anti-sickling properties. However, there is no global systematic review of the evidence in support of their use for sickle cell management. This research aimed to conduct a systematic review of the pharmacological evidence to highlight species, genera, and some phytochemicals which could be primed for novel anti-sickling medications. The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines were used. Articles in English, published from 2000 to 2022 were included in the analysis. The literature search covered 411 publications of which 82 were found to be eligible. More than half (53.65%) of the articles were published from 2016 to 2022. Anti-sickling research from Africa accounted for 86.58% of the publications, with more than half coming from Nigeria, 12.20% from Asia and only 1.22% from Europe. The Fabaceae, Euphorbiaceae, and Annonaceae were the top three plant families whereas Zanthoxylum and Terminalia were the most reported genera. Carica papaya and Terminalia catappa were the most reported species. Sickling reversal ( n = 33/82) and hemoglobin polymerization studies ( n = 29/82) were the most reported assays. Benzoic acid derivatives, butyl stearate, ellagic acid derivatives, and some pentacyclic triterpenoids were the only plant derived compounds validated for anti-sickling activities. A total of 117 plant species with anti-sickling activities were documented. Studies on secondary metabolites with anti-sickling properties to serve as scaffolds for novel drug development for sickle cell management were limited.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"88 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Analysis and Biological Activities of Various Parts of Securidaca longipedunculata From South Africa 南非 Securidaca longipedunculata 不同部位的化学分析和生物活性

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241261018

Kamogelo Shai, Zahra Battal Hassan, Segolo Lebelo, Jones Wilfred Ng’ambi, Monnye Mabelebele, Nthabiseng Amenda Sebola

{"title":"Chemical Analysis and Biological Activities of Various Parts of Securidaca longipedunculata From South Africa","authors":"Kamogelo Shai, Zahra Battal Hassan, Segolo Lebelo, Jones Wilfred Ng’ambi, Monnye Mabelebele, Nthabiseng Amenda Sebola","doi":"10.1177/1934578x241261018","DOIUrl":"https://doi.org/10.1177/1934578x241261018","url":null,"abstract":"ObjectiveThe objective of our study was to investigate the chemical composition and the biological activities of different parts of Securidaca longipedunculata from South Africa.MethodologiesThe chemical analysis methods, including chromatography and spectroscopy, were employed to identify the diverse array of compounds present in the roots, leaves, and stems of S longipedunculata.ResultsThe proximate analysis revealed that the leaf extracts had higher ( P < .05) crude protein, gross energy, and ether extract contents when compared to the stem bark and the root bark. A similar trend was observed with the mineral analysis where copper, iron, magnesium, and zinc were in abundance in the leaves. Concurrently, bioassays reveal significant biological activities, such as antioxidant, antimicrobial, and anti-inflammatory properties, associated with these plant parts. The extracts demonstrated high lipid peroxidation inhibitory activity at the concentration of 250 μg/mL, with the highest percentage inhibition of 94% recorded in the dark leaf extract, followed by 92% and 73% at the concentrations of 125 and 62.5 μg/mL, respectively. The antimicrobial analysis revealed that the root bark extract was active against Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis with the average minimum inhibitory concentration of 1.67 mg/mL (dark type) and 0.63 mg/mL (light type).ConclusionOur findings emphasize the medicinal potential of S longipedunculata and underscore the importance of understanding its chemical makeup in explaining its therapeutic effects. This research provides valuable insights into the pharmacological properties of S longipedunculata, offering a foundation for further exploration in drug development and natural product discovery.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"42 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory Mechanism of the Oregano Essential Oil on the Growth and Biofilm Formation of Streptococcus mutans 牛至精油对变异链球菌生长和生物膜形成的抑制机制

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241266699

Kegang Wu, Yuqiang Huang, Tong Zhang, Xianghua Chai, Xuejuan Duan

{"title":"Inhibitory Mechanism of the Oregano Essential Oil on the Growth and Biofilm Formation of Streptococcus mutans","authors":"Kegang Wu, Yuqiang Huang, Tong Zhang, Xianghua Chai, Xuejuan Duan","doi":"10.1177/1934578x241266699","DOIUrl":"https://doi.org/10.1177/1934578x241266699","url":null,"abstract":"Objective: The objective was to determine the in vitro antibacterial effect of the Oregano essential oil (OEO) on Streptococcus mutans ( S mutans) and to explore the anti-biofilm effect and mechanism of OEO. Methods: The in vitro antibacterial susceptibility of OEO was detected by the growth curve and colony-forming unit (CFU) counting method. Confocal laser scanning microscope (CLSM) and crystal violet assay were used to explore the anti-biofilm activity of OEO, and the anti-biofilm mechanism was explored from the aspects of extracellular polysaccharides (EPS) synthesis, acidoid, and extracellular DNA changes. OEO was characterized using a gas chromatography-mass spectrometer and cytotoxicity was tested using a cell counting Kit-8 assay. Results: The minimum inhibitory concentration of OEO was 0.25 mg/mL, and the CFU showed the ability of OEO to kill planktonic bacteria. Scanning electron microscopy and CLSM showed that OEO could hinder the development of biofilms, harm bacteria, and eliminate mature biofilms by changing EPS synthesis and pH value. Carvacrol in OEO played a major role in biological antibacterial activity. OEO had low cytotoxicity and good biocompatibility. Conclusions: OEO had excellent antibacterial and anti-biofilm effects on the key virulence traits of S mutans, indicating potential prospects in preventing dental caries.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"53 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Corilagin on Alcoholic Liver Injury 柯里拉京对酒精性肝损伤的保护作用

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241257089

Xudan Li, Xuan Li, Yuan Deng, Lianghua Chen, Zhizhong Zheng, Yanlin Ming

{"title":"Protective Effect of Corilagin on Alcoholic Liver Injury","authors":"Xudan Li, Xuan Li, Yuan Deng, Lianghua Chen, Zhizhong Zheng, Yanlin Ming","doi":"10.1177/1934578x241257089","DOIUrl":"https://doi.org/10.1177/1934578x241257089","url":null,"abstract":"ObjectivesThe herbal product corilagin is renowned for its liver-protecting benefits and antioxidant properties. However, the protective role of corilagin in alcoholic liver injury remains unexplored. The objective of this study is to delve into the protective effects of corilagin on alcoholic liver injury, both in HepG2 cells and a mouse model.MethodsTo assess the antioxidant capacity of corilagin in vitro, DPPH and ABTS assays were conducted. HepG2 cells were pretreated with 800 mM ethanol for 24 hours, followed by corilagin treatment for another 24 hours, to evaluate its liver-protecting activity. For in vivo studies, ICR mice, with and without corilagin treatment, were given ethanol for 4 weeks to induce alcoholic liver injury. At the end of the study, serum and liver tissue samples were collected to analyze liver function, enzymatic antioxidants, reactive oxygen species (ROS) levels, alcohol dehydrogenase, and liver tissue histology.ResultsThe findings reveal that corilagin exhibits remarkable free radical scavenging ability and alleviates alcohol-induced cell damage in vitro. In vivo, corilagin significantly reduced liver index and serum levels of aminotransferase aspartate, alanine transaminase, total cholesterol, and triglyceride in mice with alcoholic liver injury. Additionally, corilagin decreased ROS levels in liver tissue and increased the activities of antioxidant enzymes CAT, SOD, and GSH-Px. GSH content increased, while lipid peroxide MDA decreased in liver tissue.ConclusionOur data strongly suggests that corilagin possesses protective effects on alcoholic liver injury, both in vitro and in vivo, which is likely attributed to its exceptional antioxidant capacity. In summary, corilagin holds promise as a potential preventive or therapeutic agent for alcoholic liver injury.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"14 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glochidion Species: A Review on Phytochemistry and Pharmacology Glochidion Species：植物化学和药理学综述

IF 1.8 4区医学

Natural Product Communications Pub Date : 2024-09-10 DOI: 10.1177/1934578x241276962

Nguyen Ngoc Linh, Nguyen Quang Hop, Phi Thi Tuyet Nhung, Pham Thi Bich Dao, Vu Quoc Manh, Ty Viet Pham, Ninh The Son

{"title":"Glochidion Species: A Review on Phytochemistry and Pharmacology","authors":"Nguyen Ngoc Linh, Nguyen Quang Hop, Phi Thi Tuyet Nhung, Pham Thi Bich Dao, Vu Quoc Manh, Ty Viet Pham, Ninh The Son","doi":"10.1177/1934578x241276962","DOIUrl":"https://doi.org/10.1177/1934578x241276962","url":null,"abstract":"ObjectivesThe genus Glochidion (the family Phyllanthaceae) is used for various medicinal purposes, such as dysentery, diarrhea, cough, and skin protection. A review of phytochemical and pharmacological aspects for this remains unavailable. The current study tends to sum up a detailed list of phytochemicals, and their role in biological examinations.MethodsReferences in English were obtained by an extensive search across various electronic data sources, encompassing Web of Science, PubMed, Google Scholar, and Science Direct. The “Sci-Finder” was also utilized to find references and revise chemical structures. Referenced documents have been gathered from the 1960s to date. It also noted that Glochidion, phytochemistry, and pharmacology are likely the keywords to seek for references.ResultsOver 240 naturally occurring phytochemicals were isolated and identified from various Glochidion tissues, including terpenoids, sterols, saponins, lignans, flavonoids, mono-phenols, megastigmanes, butenolides, glycosides, alkaloids, cyanogens, tocopherols, fatty acids, and others. Three naturally occurring triterpenoids glochidonol, glochidiol, and glochidone are the likely characteristic metabolites, being isolated frequently. Glochidion crude extracts and their isolated compounds have been demonstrated as potential agents in various pharmacological targets, such as cytotoxicity, antioxidant, antiinflammation, and neuron and liver protection.ConclusionSeveral isolates acted as promising agents in pharmacological assays. The anticancer mechanisms of various triterpenoids and saponins, especially new and potential compounds, are expected. Pharmacological advancements to enhance the efficacies of Glochidion constituents, such as synergistic combinations and nano-drug formulations, are encouraged.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"222 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0