Natural Product Communications最新文献

{"title":"Panax Ginseng Root Extract Exhibits Antioxidant and Anti-Inflammatory Properties by Diminishing Oxidative Stress Levels and Modulating the NF-κB Signaling Pathway at Both the Cellular and Tissue Levels in the Skin","authors":"Bo-Zheng Zhang, Haoyang Yu, Chao-Fan Tian, Ming‐Lung Yu, Yun Ha Lee, Zhi Xiong","doi":"10.1177/1934578x251364582","DOIUrl":"https://doi.org/10.1177/1934578x251364582","url":null,"abstract":"Background Panax ginseng root extract (PGRE), rich in bioactive ginsenosides, has been widely recognized for its potential health benefits. However, its skincare efficacy, particularly in anti-inflammatory and antioxidant activities, remains to be fully elucidated. Objectives This study aimed to evaluate the skincare efficacy of PGRE using primary keratinocytes and a 3D human epidermal model (EpiKutis ® ), focusing on its anti-inflammatory, antioxidant, and barrier repair mechanisms. Methods The cytotoxicity of PGRE was assessed at a concentration of 50 μg/mL, and its anti-inflammatory effects were evaluated by measuring the suppression of IL-1α, PGE2, and NF-κB activation. The antioxidant activity of PGRE was tested under 4-HNE-induced oxidative stress by quantifying reactive oxygen species (ROS) reduction. Additionally, the modulation of the NF-κB signaling pathway was investigated to understand its role in mitigating inflammatory feedback loops. Results PGRE at 50 μg/mL showed no cytotoxicity (>80% cell viability) and demonstrated potent anti-inflammatory effects by suppressing IL-1α (34.17%), PGE2 (20.70%), and NF-κB activation (43.65%). Under oxidative stress conditions, PGRE significantly reduced ROS levels by 51.6%, highlighting its strong anti-carbonylation activity. Furthermore, PGRE effectively modulated the NF-κB signaling pathway, mitigating inflammatory feedback loops and underscoring its multitarget mechanism in anti-inflammatory and antioxidant activities. Conclusion PGRE exhibits significant anti-inflammatory and antioxidant properties, making it a promising natural ingredient for anti-aging and anti-inflammatory skincare formulations. These findings suggest that PGRE could play a vital role in barrier repair and inflammation modulation. Further clinical studies are warranted to validate these in vitro results and to explore the role of NF-κB in PGRE's anti-inflammatory and barrier repair mechanisms.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://journals.sagepub.com/doi/pdf/10.1177/1934578X251364582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatilomic Signatures and Antioxidant Activities of red Mandarin ( <i>Citrus reticulata</i> ‘Dahongpao’) Essential Oils from Peel, Flower, and Leaf","authors":"Wenling Zhang, Haibing Zhang, Xingyu Chen, Teng Liu, Tingting Feng, Peipei Zhu, Qingyu Nie","doi":"10.1177/1934578x251382350","DOIUrl":"https://doi.org/10.1177/1934578x251382350","url":null,"abstract":"Objective Citrus reticulata cv. ‘Dahongpao’ is an ancient Chinese cultivar whose by-products, peel, flower, and leaf remain underexplored. This study aimed to conduct a comprehensive comparative characterization of the volatilomic profiles, odor-active signatures, and antioxidant activities of the essential oils (EOs) extracted from these three tissues to establish a scientific basis for their differentiated valorization. Methods Essential oils were obtained from the three tissues using ultrasound-assisted hydrodistillation. The volatile metabolomes were analyzed using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry. Antioxidant capacities were evaluated using spectrophotometric assays to determine total phenolic content, ferric reducing antioxidant power, and scavenging activities against superoxide and hydroxyl radicals. Results A total of 985 volatile metabolites were identified, dominated by terpenoids (25.99%), esters (15.63%), and heterocyclic compounds (9.44%). Tissue-specific chemical signatures were observed: peel EOs were enriched in terpenoids such as α-citral and (1α,3β,4β)-p-menthane-3,8-diol; flower EOs accumulated oxygenated monoterpene like linalool and nerolidol; leaf EOs were characterized by green-note aldehydes and alcohols, including (Z)-3-hexen-1-ol and phytol. Antioxidant profiling revealed functional divergence: leaf EO showed the highest superoxide scavenging, flower EO exhibited the strongest hydroxyl radical scavenging and reducing power, while peel EO had the highest total phenolic content. Differential metabolite analysis highlighted extensive divergence, with 834 metabolites differing between peel and flower EOs (815 upregulated in peel). Notably, 2-Methoxy-3,5-dimethylpyrazine, a potent odorant with a 0.4 ppb threshold was significantly enriched in peel EO, along with high-impact volatiles like α-citral, 2,4-decadienal, and 2-octanol acetate. Conclusion Red mandarin tissues possess distinct metabolite architectures. The peel is a rich reservoir of phenolics and high-impact odorants, making it a prime candidate for the food and fragrance industries. The flower and leaf EOs harbor unique aromatic and bioactive traits suitable for specialized nutraceutical or cosmetic applications. These findings strongly support the differentiated, value-added utilization of all three by-products.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minor Non-Cytotoxic Enantiomeric Constituents from the Leaves of <i>Morus alba</i>","authors":"Jie Xu, Yanfang Yang, Qianqian Li, Ziyi Dong, Yaoyang Guo, Zhansheng Jiang","doi":"10.1177/1934578x251385042","DOIUrl":"https://doi.org/10.1177/1934578x251385042","url":null,"abstract":"Objectives The current work aimed to isolate and identify new interesting small-molecule natural products from the leaves of a well-known medicinal plant Morus alba . Methods The ethanol extract of M. alba leaves was partitioned between EtOAc and water, and the EtOAc soluble part was fractionated by macroporous resin column chromatograph (CC) eluted with gradient EtOH. The 80% EtOH eluate was subject to silica gel, reversed phase C 18 , MCI gel and Sephadex LH-20 CC and finally purified by HPLC to afford four minor compounds 1–4 , and the racemic 1 and 2 were further separated by chiral columns. Structural elucidation of these isolates was achieved via spectroscopic means especially HR-ESIMS and NMR, with the absolute configurations of new compounds assigned by ECD analyses. The cytotoxic screening was performed by MTT assay. Results A pair of new quinone enantiomers ( 1a / 1b ), a pair of new stilbenoid enantiomers ( 2a / 2b ), a known prenyl stilbenoid ( 3 ) and a known dihydrochalcone ( 4 ) were isolated and structurally characterized from the leaves of M. alba . They did not show significant cytotoxicity against MDA-MB231, A549, Hela and 4T1 tumor cell lines. Conclusions The M. alba leaves represent a rich source of new natural products, and the currently obtained constituents did not exert obvious growth inhibitory activity against the tested tumor cell lines. The bioactivities of the new isolates deserve further exploration in the future.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xiaozheng Decoction Inhibits Bladder Cancer Progression by Regulating the miR-21/SMAD7 Signaling Axis","authors":"Gang Yang, Xiaoyu Zhu, Changxiao Ye, Yi Wu, Fangze Tao, Yanchao Xu, Jin Zhao, Ting Huang, Wei Wu, Xuelai Yin","doi":"10.1177/1934578x251358955","DOIUrl":"https://doi.org/10.1177/1934578x251358955","url":null,"abstract":"Background Bladder cancer (BCa) is the most common malignant tumor of the urinary system, and there remains an urgent need for more effective therapeutic strategies. Xiaozheng Decoction has been reported to prevent postoperative recurrence of BCa; however, its specific pharmacological effects and molecular mechanisms remain inadequately defined. Objective This study aimed to investigate the inhibitory effects of Xiaozheng Decoction on BCa progression and elucidate its underlying molecular targets. Methods CCK-8, colony formation, as well as FCM assays showed the effects on bladder cancer cell growth. Transwell assays showed the effects on cell motility. qPCR as well as Immunoblot assays showed the effects on miR-21/ SMAD7 axis. Luciferase activity assay, quantification PCR, and Immunoblot assays showed the effects on the interact between miR-21 and SMAD7. Tumor growth assays were performed in mice. Results The results demonstrated that Xiaozheng Decoction suppressed the growth and induced apoptosis of BCa cells, and also significantly reduced their cell migration. Mechanistically, Xiaozheng Decoction could downregulate the expression of miR-21 and its downstream target SMAD7. Further analysis confirmed that miR-21 directly binds to and suppresses SMAD7 expression. In vivo experiments showed that Xiaozheng Decoction also inhibited tumor growth in a xenograft model of BCa. Conculsion Taken together, these findings indicate that Xiaozheng Decoction exerts anti-tumor effects in BCa by modulating the miR-21/SMAD7 signaling axis, thereby suppressing both proliferation and migration of BCa cells.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Chemical Constituents of Tibetan Medicine <i>Synotis solidaginea</i> and Effects of SS-2 on Melanoma Cells","authors":"Longwei Fang, Zhen Ni, Yanglei Shen, Feng Gao, La Yang, Nanling Liu, Zhuoma Duoji, Zhuoma Dongzhi, Wangdui Suolang, Zhuoma Basang","doi":"10.1177/1934578x251372421","DOIUrl":"https://doi.org/10.1177/1934578x251372421","url":null,"abstract":"Objective To study the chemical constituents of Synotis solidaginea (SS) from Tibet. In our previous research, it was found that the extract of Synotis solidaginea stems has potential inhibitory activity against the proliferation of melanoma cells. Therefore, we hope to separate, extract and structurally identify the extracts of Synotis solidaginea stems, and determine the main components that exert potential inhibitory activity on the proliferation of melanoma cells. Methods The compounds were separated and purified using silica gel, polyamide, reversed phase C18 column chromatography, and preparative high performance liquid chromatography. The structure of each compound was identified based on the spectral data and literature comparisons. To verify the inhibitory activity of each component against melanoma cells, cell and enzyme assay were conducted. Results A total of 7 compounds were isolated from the dichloromethane extract of Synotis solidaginea . The irimofen lactone structure compound SS-1 and SS-5 were isolated from Synotis solidaginea for the first time. Among these, irimofin sesquiterpenoid compound SS-2 exhibited strong inhibitory activity against B16F10 of melanoma cells. Meanwhile, the iremorphene sesquiterpenoid SS-2 exhibited significant tyrosinase inhibitory activity, and the docking results explained the mechanism of its action. Discussion Solidaginea has laid the foundation for the prevention and treatment of melanoma with the active ingredients of Tibetan medicine.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining UPLC-Q-TOF-MS/MS with Network Pharmacology and Molecular Docking to Explore the Potential Mechanism of Yin-Qiao-Qing-Re Tablets in Treating Fever","authors":"Zerong Cai, Pei Liu, Wenjun Liu, Mengyu Qian, Liang Cao, Yumei Hu, Zhenzhong Wang","doi":"10.1177/1934578x251359862","DOIUrl":"https://doi.org/10.1177/1934578x251359862","url":null,"abstract":"Objective Yin-Qiao-Qing-Re Tablets (YQT) are clinically used for the treatment of wind-heat type common cold. However, YQT is composed of nine herbs, containing complex and multiple chemical components, and the metabolism of YQT in vivo lacks a more in-depth study. Methods In this study, based on targeted and non-targeted UPLC-Q-TOF-MS/MS data analyzing strategy, the prototypes and metabolites of YQT in normal rats were systematically studied for the first time, and the metabolic pattern of its chemical components was summarized. Finally, to identify the target and signaling pathway of YQT in the treatment of fever, the prototypes in plasma were analyzed through network pharmacology and molecular docking. Results A total of 238 components, including 39 prototypes and 198 metabolites, were identified from drug-containing plasma, urine and feces. The metabolic pathways of flavonoids, phenylethanols, organic acids, lignans and alkaloids in the TCM compound were summarized. The main metabolic reactions included one-phase metabolism (dehydroxylation, demethylation, dehydration, deglycosylation, hydrogenation) and two-phase metabolism (methylation, hydroxylation, glucuronidation, sulfation, alanine binding). Network pharmacology predicted 112 key targets for YQT treatment of fever, and KEGG enrichment analysis yielded 163 pathways. The molecular docking results indicated that there is good affinity between the core targets and the key compound molecules. Conclusion This study provides a rapid qualitative analysis of the prototypes and metabolites of YQT in rats, revealing its potential active ingredients and mechanism of action in the treatment of fever. Furthermore, it provides a solid database for the subsequent pharmacokinetic and pharmacodynamic studies of YQT, promoting the further clinical application of this marketed drug.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Composition, Insecticidal Activity and Action Mode of <i>Artemisia scoparia</i> Methanolic Extracts on <i>Aedes albopictus</i>","authors":"Wenjiao Li, Yiyang Zhu, Qiwei Xuan, Xiangyu Zhu, Hanwen Miao, Yufang Zhang, Yi Cui, Shengliang Liao, Zhaojun Sheng, Zhongze Lin","doi":"10.1177/1934578x251348383","DOIUrl":"https://doi.org/10.1177/1934578x251348383","url":null,"abstract":"Objectives To identify new active compounds with mosquito larvicidal properties from natural products, the larvicidal activity of several traditional Chinese medicinal herbs extracts against Aedes albopictus (Diptera: Culicidae) was screened. Methods The ultrasonic-assisted extraction method was employed to process seven Chinese medicinal herbs. Subsequently, the extractums were fractionated using solvents with varying polarities and identify the extract phase exhibiting potent larvicidal activity. The active extract phase was further purified via silica gel column chromatography, followed by the identification of active components using gas chromatography-mass spectrometry (GC-MS). Additionally, the larvicidal activity of the identified components, as well as their inhibitory effects on acetylcholinesterase (AChE) and alkaline phosphatase (ALP), were evaluated. Results The Q1 fraction of the petroleum ether phase extract of Artemisia scoparia exhibited a 100% mortality rate against mosquito larvae at 100 ppm. GC-MS analysis results showed that capillene, methyl eugenol, capillin, and caryophyllene oxide are the most representative constituents. The following larvicidal activity results showed that caryophyllene oxide and methyl eugenol had potent larvicidal activity with 50% lethal concentration (LC 50 ) values of 67.6 ppm and 101.6 ppm, respectively. These two monomer compounds had potent inhibitory activity against ALP with inhibition rates of 47% and 37% respectively. Conclusion In this study, the Q1 fraction of A. scoparia PE extract demonstrated potent larvicidal activity against Aedes albopictus . Notably, methyl eugenol and caryophyllene oxide were found to exhibit significant larvicidal activity. Enzyme inhibition assays further revealed that these two compounds may induce larval mortality by inhibiting ALP activity. These findings suggest that A. scoparia extract, as well as its active constituents, holds promise as an effective larvicide for mosquito control.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Pharmacological Effects of Sanhuang Erxiang Powder in the Treatment of Ultraviolet-induced Skin Damage: Insights from Network Pharmacology and Experimental Validation","authors":"Qian Wang, Cairang Nima, Linli La, Guiqin Liu, Delong Duo, Junbo Zhu, Junjun Han, Xiangyang Li, Ning Qu","doi":"10.1177/1934578x251345699","DOIUrl":"https://doi.org/10.1177/1934578x251345699","url":null,"abstract":"Objectives: Prolonged and intense ultraviolet (UV) exposure can cause skin photoaging diseases. Therefore, there is a need for more natural and safe drugs to treat UV skin damage diseases. Methods: This study explored the mechanism of Sanhuang Erxiang Powder (SHEX) in the treatment of UV-induced skin through network pharmacology and verified the results by creating UV-induced injury models in BJ human fibroblasts and SD rats. Results: A total of 707 SHEX targets, 7244 UV damage targets, and 651 drug-disease targets were obtained by network pharmacology. The enrichment analysis suggested that SHEX may have a therapeutic role in UV damage through the MAPK signaling pathway. The in vitro model demonstrated that SHEX significantly increased BJ fibroblast viability as well as intracellular antioxidant enzyme levels. In vivo experiments showed that SHEX reduced the degree of skin damage in rats, increased the levels of antioxidant enzymes in skin tissues, and inhibited the release of p38 MAPK and MMP-1 in the MAPK signaling pathway. Conclusion: SHEX can be used to treat UV damage by a mechanism that may be related to antioxidant effects and the inhibition of p38 MAPK and MMP-1 release.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eriocalyxin B Inhibits Autophagy in Hepatocellular Carcinoma Cells via mTOR/ULK1 Signaling Pathway Inactivation","authors":"Mingxia Tong, Xiaojin Gao, Maowei Lian, Xiaocong Xiang, Xiaobing Gong","doi":"10.1177/1934578x251339276","DOIUrl":"https://doi.org/10.1177/1934578x251339276","url":null,"abstract":"Background Hepatocellular carcinoma (HCC) has become one of the most common malignancies worldwide. Eriocalyxin B (EriB) is a natural, ent-kaurane diterpenoid isolated from Isodon eriocalyx that has been reported to exhibit remarkable antitumor and immunoregulatory activities. Objectives The aim of this study is to explore the role of autophagy in EriB-induced cell death in HCC cell lines. Methods The Cell Counting Kit-8 (CCK-8) was used to assess the EriB effects on HCC cell proliferation. Flow cytometry and confocal microscopy were performed to detect cell apoptosis and autophagic flux. Western blot and immunohistochemistry analyses were used to evaluate the expressions of related proteins. The antitumor effects were observed in a xenograft tumor model of HCCLM3. Results EriB significantly suppresses HCC cell proliferation while concurrently inducing apoptosis. Mechanistically, EriB triggers dose-dependent accumulation of autophagy markers LC3B-II and p62, accompanied by increased autophagosome formation. Paradoxically, EriB impedes late-stage autophagy by reducing acidified autophagic vesicles (RFP + GFP−) and attenuating autophagic flux, suggesting blockade of autophagosome-lysosome fusion. This autophagy-inhibitory effect is mediated through suppression of the mTOR/ULK1 signaling axis. In vivo , EriB markedly inhibits HCC tumor growth. Notably, EriB overcomes sorafenib resistance by antagonizing therapy-induced protective autophagy. Combination therapy with sorafenib synergistically enhances anti-HCC efficacy, as evidenced by significantly reduced tumor burden and weight compared to monotherapy regimens. The chemosensitizing effect of EriB is attributed to its ability to inhibit mTOR/ULK1-driven autophagy, thereby disrupting cancer cell survival mechanisms. Conclusion EriB offers a novel therapeutic strategy for natural product-based combination targeted therapy, demonstrating promising potential to overcome sorafenib resistance in hepatocellular carcinoma HCC.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Ionic Liquid Microwave-Assisted Extraction Protocol of Lycopene from Tomato","authors":"Junkai Wu, Jianping Hu, Yingqian Jiang, Feiyan Zhang, Youxia Huang","doi":"10.1177/1934578x251330953","DOIUrl":"https://doi.org/10.1177/1934578x251330953","url":null,"abstract":"Objective To refine the lycopene extraction from tomato powder with ionic liquid-microwave assistance, seeking a more efficient and cost-effective process that optimizes resource usage, lowers extraction costs, and boosts the economic value of lycopene. Methods The study investigated the effects of various factors on the extraction yield of lycopene. The researchers screened ionic liquids and constructed a BP (Back Propagation) neural network model to optimize the experimental data. This model was further refined using a genetic algorithm-neural network approach to determine the optimal extraction process parameters. Results After conducting the optimization process and subsequent verification experiments, the study identified the optimal conditions for the ionic liquid-microwave-assisted extraction of lycopene from tomato powder. These conditions were found to be a microwave power of 800 w, an extraction time of 150 s, an ionic liquid concentration of 0.17 mol/L, and a liquid-to-material ratio of 15:1 (mL/g). Under these conditions, the lycopene content achieved was 0.177 mg/g, which corresponded to the highest extraction efficiency. Conclusions The study optimized lycopene extraction with ionic liquid-microwave assistance, improving efficiency, reducing waste, and lowering costs to enhance its economic value from tomatoes.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}