Asian Journal of Medicine and Biomedicine最新文献_第5页

Gorham-Stout Disease; A Differential Diagnostic Dilemma. 戈勒姆-斯托特病；鉴别诊断难题。

Asian Journal of Medicine and Biomedicine Pub Date : 2023-10-20 DOI: 10.37231/ajmb.2023.7.2.640

Thiban Sivapragasam, C. Nadarajan, Norosliza Mamat, Mariana Daud, M. Jais

引用次数: 0

Bone Tumour Sterilization Using Pasteurization for Autologous Bone Reconstruction 利用巴氏灭菌法为自体骨重建进行骨肿瘤灭菌

Asian Journal of Medicine and Biomedicine Pub Date : 2023-10-20 DOI: 10.37231/ajmb.2023.7.2.608

Nik Alyani Nik Abdul Adel

{"title":"Bone Tumour Sterilization Using Pasteurization for Autologous Bone Reconstruction","authors":"Nik Alyani Nik Abdul Adel","doi":"10.37231/ajmb.2023.7.2.608","DOIUrl":"https://doi.org/10.37231/ajmb.2023.7.2.608","url":null,"abstract":"Primary bone malignancies have incidence of 0.2% among all malignant tumours and 15% in all primary tumours. The commonest primary bone malignancy is osteosarcoma which the frequency had increased by 0.3% yearly over the last decade. Improvement in treatment of bone sarcoma by multidisplinary protocols involving diagnostic imaging, chemotherapy and surgical technique has improved the survival rate from 20% to 80%, hence paradigm of treatment shifted from amputation to limb preserving surgery. Bone reconstruction techniques varies from prosthetic replacement, allograft and bone autograft method. Bone autograft method needed sterilizing technique to devitalised tumour cells and pasteurization is a good option in maintaining its biomorphogenic properties when heated to 60°C -70°C for 30-40 minutes. This article will be discussing on histopathology findings, biomechanical outcome and clinical outcome of bone reconstruction using pasteurized autograft bone method. The advantages of pasteurization include less risk of disease transmission, no risk of allogenic immunogenicity, readily available, simple, less expensive and satisfactory bone remodelling. However, in certain cases it also shows deteriorating outcome in long term follow up due to issues with graft fracture, infection and resorption.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Aplastic Anaemia in a 14-year-old boy 一名 14 岁男孩的重型再生障碍性贫血

Asian Journal of Medicine and Biomedicine Pub Date : 2023-10-20 DOI: 10.37231/ajmb.2023.7.2.639

Sumaiyah Adzahar, Adibah Daud, Nurul Asyikin Nizam Akbar

引用次数: 0

Dosimetric Investigation of Interstitial Versus Combined Interstitial with Intracavitary High Dose Rate Brachytherapy for Cervical Cancer 宫颈癌间质治疗与腔内高剂量率近距离放射治疗相结合的剂量学研究

Asian Journal of Medicine and Biomedicine Pub Date : 2023-10-20 DOI: 10.37231/ajmb.2023.7.2.614

Reduan Abdullah, N. Zailani, A. Azahari, G. Appalanaido, M. Mohamad, M. Z. Abdul Aziz

{"title":"Dosimetric Investigation of Interstitial Versus Combined Interstitial with Intracavitary High Dose Rate Brachytherapy for Cervical Cancer","authors":"Reduan Abdullah, N. Zailani, A. Azahari, G. Appalanaido, M. Mohamad, M. Z. Abdul Aziz","doi":"10.37231/ajmb.2023.7.2.614","DOIUrl":"https://doi.org/10.37231/ajmb.2023.7.2.614","url":null,"abstract":"The purpose of the study was to evaluate clinical target (HR-CTV) coverage and OAR doses of ISBT and IS-ICBT brachytherapy techniques for cervix cancer. As this is a retrospective study, 11 patients treated from 2018 to 2022 were identified, ISBT (n=4) and IC-ISBT (n=7). Dose-volume histogram (DVH) from Oncentra Treatment Planning System and dosimetric parameters were analyzed and evaluated.The results showed the mean EQD2 of HR-CTV for both techniques were 89.1 ± 11.71 Gy while the mean EQD2 of D2cc for bladder, rectum and sigmoid were 88.9 ± 16.71 Gy, 81.2 ± 12.63 Gy, and 70.1 ± 15.95 Gy, respectively. For IC-ISBT technique, the mean EQD2 of HR-CTV was 91.5 ± 8.4 Gy which was slightly exceeds the dose constraints of 80 to 90 Gy based on ABS recommendation. HR-CTV volume that ranged from 34.93 - 168.33 cm3. The mean of CI was 0.90 and the mean of DHI for this technique was 0.36 ± 0.06. Meanwhile for ISBT technique, the mean HR-CTV volume range from 26.95 - 82.82 cm3. The mean EQD2 of HR-CTV was at 85.1 ± 16.75. The mean CI and DHI were at 0.85 ± 0.16 and 0.37 ± 0.1, respectively. As a conclusion, the mean EQD2 doses to the rectum (81.2 Gy) in both techniques slightly exceeded the limit from ABS recommendation. The mean DHI value was not quite significant different in both techniques. However, the IS-ICBT technique was more superior in conforming dose to HR-CTV based on higher CI value compared to ISBT alone.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Descriptive Analysis of Computed Tomography Urography (CTU) Cases in Patients With Hematuria in Comparison with Ultrasound Kub(US) And Cystoureteroscopy (CU) 血尿患者计算机断层尿路造影(CTU)与超声(US)、膀胱输尿管镜(CU)对比分析

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.477

Normazida Jusoh, Nur Latifah Mohd Zainudin, Auji Diyana Mohd Amin, Nurul Aifa Zahari, Fadhilah Mohamad, Ummu Habibah Sulaiman, Wan Arfah Nadiah Wan Abdul Jamil, W. R. Wan Taib, Elinah Ali, Mohd Nazri Mohd Nasir, Wan Zulkafli Wan Ibrahim

{"title":"A Descriptive Analysis of Computed Tomography Urography (CTU) Cases in Patients With Hematuria in Comparison with Ultrasound Kub(US) And Cystoureteroscopy (CU)","authors":"Normazida Jusoh, Nur Latifah Mohd Zainudin, Auji Diyana Mohd Amin, Nurul Aifa Zahari, Fadhilah Mohamad, Ummu Habibah Sulaiman, Wan Arfah Nadiah Wan Abdul Jamil, W. R. Wan Taib, Elinah Ali, Mohd Nazri Mohd Nasir, Wan Zulkafli Wan Ibrahim","doi":"10.37231/ajmb.2022.6.2.477","DOIUrl":"https://doi.org/10.37231/ajmb.2022.6.2.477","url":null,"abstract":"The aim of our study was to correlate and evaluate the accuracy of Computed Tomography Urography (CTU) results with other imaging modalities in patients who presented with haematuria in 2020. Retrospectively comparison of CTU findings with ultrasound KUB(US) and cytoureteroscopy (CU) also have been made. This is a retrospective study in which all CTU cases in a total of 186 patients with hematuria in 2020 were included in this study. The data was retrieved from the PACS system at Department of Radiology in Hospital Sultanah Nur Zahirah Kuala Terengganu. Frequency of the clinical manifestation were calculated among the patients and compared between US, CU and CTU findings. A total of 186 patients with hematuria involved in this study. Demographic data on clinical information have exhibited microscopic hematuria, calculi, hydronephrosis and renal calculi yielded higher percentage with 81.7%, 82.8%, 72.0% and 63.4%, respectively. The correlation between hematuria and US together with CTU findings was not significant with p value of 0.259. The data also revealed 133 patients (71.5%) had similar US and CTU findings. Meanwhile, 76.0% patients who underwent CU also yielded consistent findings with CTU. This study demonstrated no significant correlation between CTU - US findings in the detection of causes of hematuria. However, there was a good correlation of US and CU with CTU in a detection causes of hematuria with almost equal accuracy and sensitivity.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124980886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus Colitis in COVID-19 Patient: a Case Report COVID-19巨细胞病毒性结肠炎1例

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.499

Nurul Aimi Abdul Rahman, R. Ibrahim, S. Masri, N. Mohd Taib

引用次数: 0

Development and Validation of a New Knowledge, Attitude, and Practice Questionnaire on COVID-19 Pandemic Control and Prevention in Malaysia 马来西亚COVID-19大流行防控新知识、态度和实践问卷的制定和验证

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.497

Safiya Amaran, Husbani Mohd Amin Rebuan, A. Abdul Aziz, N. Yaacob, Suhaily Mohd Hairon

{"title":"Development and Validation of a New Knowledge, Attitude, and Practice Questionnaire on COVID-19 Pandemic Control and Prevention in Malaysia","authors":"Safiya Amaran, Husbani Mohd Amin Rebuan, A. Abdul Aziz, N. Yaacob, Suhaily Mohd Hairon","doi":"10.37231/ajmb.2022.6.2.497","DOIUrl":"https://doi.org/10.37231/ajmb.2022.6.2.497","url":null,"abstract":"The acceptance of COVID-19 control and preventive measures by the Malaysian public is crucial as Malaysia moves toward a safer endemic phase. Our study aimed to develop and validate a new tool to measure the knowledge, attitude, and practice of COVID-19 control and preventive measures among adults in Terengganu, Malaysia. A questionnaire was developed through theoretical research and expert consultations. A cross-sectional study was conducted among 670 staff and students of Universiti Sultan Zainal Abidin, Terengganu recruited by convenient sampling. Validity and reliability were analysed. The validity of the knowledge domain was determined through Item Response Theory (IRT) analysis which revealed 26 items derived from six categories: etiology, symptoms, mode of transmission, risk factor for infection, and high-risk group. The construct validity of the attitude domain was determined through Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) revealed 34 items that lead to seven factors: fear, responsibility, movement restriction, information, quarantine, screening, medium for information. Construct validity of the practice domain revealed 16 items that loaded to three factors: hand washing, movement restriction and mask-wearing. Among the key findings of this study was high level of knowledge of respondents regarding specific situations and activities and respondents agreed that the most effective way to receive information was via television casting. The questionnaire was shown to have satisfying psychometric properties and can be used as a tool in future research in public knowledge, attitude and practice to control and prevent COVID-19.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117075656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrative Bioinformatics Meta-Analysis of Microarray Data For Identifying Hub Genes As Biomarkers Of Autism Spectrum Disorder (ASD) 识别中心基因作为自闭症谱系障碍(ASD)生物标志物的微阵列数据整合生物信息学meta分析

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.262

Nor Azian Abdul Murad

{"title":"An Integrative Bioinformatics Meta-Analysis of Microarray Data For Identifying Hub Genes As Biomarkers Of Autism Spectrum Disorder (ASD)","authors":"Nor Azian Abdul Murad","doi":"10.37231/ajmb.2022.6.2.262","DOIUrl":"https://doi.org/10.37231/ajmb.2022.6.2.262","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder primarily affecting young children. ASD is a complex disease involving genetic and environmental factors. Environmental risk factors identified include gestational exposure to pollution, pesticides, maternal infections, and inflammation. Genetic mutations account for about 10 – 20% of ASD cases. Based on the Centre for Disease Control (CDC) in the United States, 1 in 68 children are affected with ASD. Recent advancements in genetic technologies have enabled the detection of biomarkers for the early detection of diseases and risk identification. Aim: This meta-analysis aims to determine the gene signatures involved in ASD. We conducted a meta-analysis to identify the differentially expressed genes (DEGs) in ASD microarray datasets comprising 122 ASD and 89 control peripheral blood mononuclear cell (PBMC) and whole blood samples from two microarray studies. We performed gene ontology, pathway enrichment, and protein-protein interaction (PPI) network analysis to identify associations between autism and altered gene expression levels. At a false discovery rate (FDR) < 0.05, we identified 1862 DEGs; 1056 genes were upregulated, and 806 genes were downregulated. DEGs revealed that dysregulated genes were significantly enriched in the “Primary immunodeficiency pathway”, “Influenzae A”, “Epstein-Barr virus infection pathway”, and other signalling pathways from the analyses using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Subsequently, protein-protein interactions (PPI) analysis identified SUMO1, SP1, EGR1, EP300, and VHL as hub genes to be the potential biomarkers for ASD. In total, eighteen differentially expressed hub genes could potentially be used as potential biomarkers for the diagnosis of ASD.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124768161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urothelial Papilloma of Urethra: Mimickers 尿道上皮乳头状瘤:拟态者

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.485

N. Zawawi, Izyan Rifhana Muhamad

引用次数: 0

Knowledge, Attitude, Practice and Perceived Barriers on Palliative Care Pain Management among the Healthcare Providers: A Single Centre Study 知识，态度，实践和感知障碍在姑息治疗疼痛管理中的医疗服务提供者:一个单一的中心研究

Asian Journal of Medicine and Biomedicine Pub Date : 2022-11-30 DOI: 10.37231/ajmb.2022.6.2.487

Nurul Aifaa Mohd Azmi, Laila Abdul Mukmin, Fahisham Taib, Afiq Izzuddin Abdul Rahim, Saedah Ali

{"title":"Knowledge, Attitude, Practice and Perceived Barriers on Palliative Care Pain Management among the Healthcare Providers: A Single Centre Study","authors":"Nurul Aifaa Mohd Azmi, Laila Abdul Mukmin, Fahisham Taib, Afiq Izzuddin Abdul Rahim, Saedah Ali","doi":"10.37231/ajmb.2022.6.2.487","DOIUrl":"https://doi.org/10.37231/ajmb.2022.6.2.487","url":null,"abstract":"Healthcare providers’ knowledge and attitude on cancer pain control remain a debatable topic. The study aims to determine the knowledge, attitude, practice and perceived barriers among the healthcare providers in delivering effective analgesic in palliative care. A cross-sectional study was conducted among the specialists and post-graduate students from the medical and surgical programme using the convenience sampling method. A set of questionnaires related to the pain management in palliative patients was distributed. The questionnaire covered demographic characteristics, knowledge, attitudes, practice, and perceived barrier regarding cancer pain management. A total of 300 questionnaires were analysed with 75% response rate. About two-third (66.3%) of the respondents have knowledge deficit to prescribe opioids in pain management of palliative care patients. The medical specialty and lacking pain management training were significant factors associated with knowledge deficit. About half (48.3%) of the respondents thought that cancer pain therapy could be satisfactorily achieved as an outcome and 58.7% respondents admitting to practice daily pain assessment in patients with cancer. The main perceived barriers in managing pain for palliative patients were inadequate pain assessment (71.2%) and inadequate staff knowledge (53.6%). The knowledge differences among the different medical specialties and lack of pain management training have significantly impacted the pain management in palliative patients. A targeted educational strategy for pain management in palliative care patients is needed to improve physicians’ knowledge and clinical practice.","PeriodicalId":189900,"journal":{"name":"Asian Journal of Medicine and Biomedicine","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132911542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0