Urothelial Papilloma of Urethra: Mimickers

Abstract

Urethral neoplasms are relatively rare, considering the diversity of pathological diseases in the urethral region. From the perspective of a urologist or a pathologist, benign urethral lesions may mimic cancer. However, due to the rarity of urethral neoplasms, it can be challenging to finalise the definitive diagnosis. We presented the case of a 53-year-old gentleman, a chronic smoker with a history of painless haematuria for three weeks associated with incomplete voiding and urinary frequency. Cystoscopy revealed fluffy, polypoid tissues over the prostatic urethra. Clinically, urothelial carcinoma cannot be excluded. Interestingly, the histopathological assessment revealed a case of urothelial papilloma. An illustration of the diagnostic approach based on solitary polypoid lesions and papillary neoplasms from the urethra was elaborated. The salient features of each disease spectrum were also highlighted. A pathological approach in conjunction with clinical and radiological findings may help correctly recognise urethral pathology.