Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02551-9
Arunima Singh
{"title":"Molecular motion in situ","authors":"Arunima Singh","doi":"10.1038/s41592-024-02551-9","DOIUrl":"10.1038/s41592-024-02551-9","url":null,"abstract":"Algorithms help to capture macromolecular motion and structural heterogeneity in native cellular environments.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2229-2230"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02550-w
Lei Tang
{"title":"More dimensions of the 3D genome","authors":"Lei Tang","doi":"10.1038/s41592-024-02550-w","DOIUrl":"10.1038/s41592-024-02550-w","url":null,"abstract":"Advances aim to capture comprehensive, dynamic genome structures in living cells.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2229-2229"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02548-4
Nina Vogt
{"title":"Biomechanical modeling of whole bodies","authors":"Nina Vogt","doi":"10.1038/s41592-024-02548-4","DOIUrl":"10.1038/s41592-024-02548-4","url":null,"abstract":"Detailed biomechanical models of animal bodies can help to tackle questions about how the brain controls movement and bodily interactions with the environment.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2228-2228"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02539-5
Yuval Bussi, Leeat Keren
{"title":"Multiplexed image analysis: what have we achieved and where are we headed?","authors":"Yuval Bussi, Leeat Keren","doi":"10.1038/s41592-024-02539-5","DOIUrl":"10.1038/s41592-024-02539-5","url":null,"abstract":"Multiplexed tissue imaging has transformed tissue biology by revealing cellular diversity and interactions, but the analysis of its massive datasets remains a bottleneck. Here, we provide an overview of computational advancements, discuss current challenges and envision an AI-driven future in which integrated tools streamline analysis and visualization, unlocking the full potential of multiplexed imaging for breakthroughs in spatial biology.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2212-2215"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02545-7
Arunima Singh
{"title":"Understanding protein interaction dynamics","authors":"Arunima Singh","doi":"10.1038/s41592-024-02545-7","DOIUrl":"10.1038/s41592-024-02545-7","url":null,"abstract":"Experimental and computational studies are paving way for a deeper understanding of the dynamic nature of protein–protein interactions.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2226-2227"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02565-3
{"title":"Method of the Year 2024: spatial proteomics","authors":"","doi":"10.1038/s41592-024-02565-3","DOIUrl":"10.1038/s41592-024-02565-3","url":null,"abstract":"Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2195-2196"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41592-024-02565-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02536-8
Vivien Marx
{"title":"Atlases galore: where to next?","authors":"Vivien Marx","doi":"10.1038/s41592-024-02536-8","DOIUrl":"10.1038/s41592-024-02536-8","url":null,"abstract":"Hundreds of researchers collaborate on maps of the human body and the subcellular realm. As they scout out their next mapping expeditions, they take stock of atlas-making.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2203-2208"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02547-5
Lin Tang
{"title":"Mapping cell history and fates","authors":"Lin Tang","doi":"10.1038/s41592-024-02547-5","DOIUrl":"10.1038/s41592-024-02547-5","url":null,"abstract":"New experimental and computational methods illuminate the history of cell differentiation and its molecular underpinnings.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2227-2228"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature MethodsPub Date : 2024-12-06DOI: 10.1038/s41592-024-02542-w
Daniela F. Quail, Logan A. Walsh
{"title":"Revolutionizing cancer research with spatial proteomics and visual intelligence","authors":"Daniela F. Quail, Logan A. Walsh","doi":"10.1038/s41592-024-02542-w","DOIUrl":"10.1038/s41592-024-02542-w","url":null,"abstract":"Spatial proteomics has transformed cancer research by providing unparalleled insights into the microenvironmental landscape of tumors. Here we discuss how these technologies have significantly advanced our understanding of cell–cell interactions, tissue organization and spatially coordinated mechanisms underlying antitumor immune responses, and will pave the way for emerging breakthroughs in cancer research.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2216-2219"},"PeriodicalIF":36.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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