Nature Plants最新文献_第3页

Post-genomic illumination of paclitaxel biosynthesis 紫杉醇生物合成的后基因组学启示

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-27 DOI: 10.1038/s41477-024-01869-8

Alisdair R. Fernie, Fang Liu, Youjun Zhang

{"title":"Post-genomic illumination of paclitaxel biosynthesis","authors":"Alisdair R. Fernie, Fang Liu, Youjun Zhang","doi":"10.1038/s41477-024-01869-8","DOIUrl":"10.1038/s41477-024-01869-8","url":null,"abstract":"Paclitaxel rapidly became one of the most effective anticancer drugs. However, the production of paclitaxel is hindered by substantial challenges, particularly considering the significant quantities of drug required and the inherently low concentration of paclitaxel and its intermediates in plants. Paclitaxel is currently produced in a so-called semi-synthesis in which baccatin III is extracted from Taxus species and chemically converted to paclitaxel. Despite the fact that many of the intermediates of paclitaxel biosynthesis are yet to be experimentally determined, a set of recent papers—facilitated by the sequencing and assembly of three Taxus genomes—has uncovered the minimal gene sets for both baccatin III and paclitaxel biosynthesis. Here we summarize the key milestones towards our understanding of paclitaxel biosynthesis and highlight recent advancements made possible by genome-level analysis of potential key genes involved. We argue that these studies will ultimately pave the way towards the elucidation of the entire paclitaxel biosynthetic pathway and facilitate the industrial production of paclitaxel via synthetic biology approaches. However, several major challenges lie ahead before we can fully tap into the amazing curative potential that taxanes provide. The production of the anticancer drug paclitaxel depends on the extraction of the intermediate baccatin III from Taxus species. This Review highlights recent progress in genome-level analysis of paclitaxel and baccatin III biosynthesis based on sequenced Taxus genomes to guide the future discovery of biosynthesis genes.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 12","pages":"1875-1885"},"PeriodicalIF":15.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZmICE1a regulates the defence–storage trade-off in maize endosperm ZmICE1a调节玉米胚乳中防御与储存的权衡

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-27 DOI: 10.1038/s41477-024-01845-2

Qun Wang, Fan Feng, Kechun Zhang, Yonghui He, Weiwei Qi, Zeyang Ma, Rentao Song

{"title":"ZmICE1a regulates the defence–storage trade-off in maize endosperm","authors":"Qun Wang, Fan Feng, Kechun Zhang, Yonghui He, Weiwei Qi, Zeyang Ma, Rentao Song","doi":"10.1038/s41477-024-01845-2","DOIUrl":"10.1038/s41477-024-01845-2","url":null,"abstract":"The endosperm of cereal grains feeds the entire world as a major food supply; however, little is known about its defence response during endosperm development. The Inducer of CBF Expression 1 (ICE1) is a well-known regulator of cold tolerance in plants. ICE1 has a monocot-specific homologue that is preferentially expressed in cereal endosperms but with an unclear regulatory function. Here we characterized the function of monocot-specific ZmICE1a, which is expressed in the entire endosperm, with a predominant expression in its peripheral regions, including the aleurone layer, subaleurone layer and basal endosperm transfer layer in maize (Zea mays). Loss of function of ZmICE1a reduced starch content and kernel weight. RNA sequencing and CUT&Tag-seq analyses revealed that ZmICE1a positively regulates genes in starch synthesis while negatively regulating genes in aleurone layer-specific defence and the synthesis of indole-3-acetic acid and jasmonic acid (JA). Exogenous indole-3-acetic acid and JA both induce the expression of numerous defence genes, which show distinct spatial-specific expression in the basal endosperm transfer layer and subaleurone layer, respectively. Moreover, we dissected a JA–ZmJAZ9–ZmICE1a–MPI signalling axis involved in JA-mediated defence regulation. Overall, our study revealed ZmICE1a as a key regulator of endosperm defence response and a coordinator of the defence–storage trade-off in endosperm development. A cereal-specific transcription factor, ZmICE1a, positively regulates storage in the central part of the endosperm while negatively regulating defence in its peripheral region, revealing the molecular mechanism underlying the antagonism between resistance and yield, which is crucial for cereal crop improvement.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 12","pages":"1999-2013"},"PeriodicalIF":15.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agile nutrient network evolution 灵活的营养网络演变

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-26 DOI: 10.1038/s41477-024-01852-3

Jaccoline M. S. Zegers, Jan de Vries

引用次数: 0

Co-option of plant gene regulatory network in nutrient responses during terrestrialization 陆地化过程中植物基因调控网络在养分反应中的协同选择

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-26 DOI: 10.1038/s41477-024-01851-4

Yating Dong, Shalini Krishnamoorthi, Grace Zi Hao Tan, Zheng Yong Poh, Daisuke Urano

{"title":"Co-option of plant gene regulatory network in nutrient responses during terrestrialization","authors":"Yating Dong, Shalini Krishnamoorthi, Grace Zi Hao Tan, Zheng Yong Poh, Daisuke Urano","doi":"10.1038/s41477-024-01851-4","DOIUrl":"10.1038/s41477-024-01851-4","url":null,"abstract":"Plant responses to nitrate, phosphate and sucrose form a complex molecular network crucial for terrestrial adaptation. However, the origins, functional diversity and evolvability of this network during plant terrestrialization remain scarcely understood. Here we compare the transcriptomic response to these nutrients in the bryophyte Marchantia polymorpha and the streptophyte alga Klebsormidium nitens. We show that the largely species-specific nutrient response pattern is driven by gene regulatory network (GRN) alterations. Intriguingly, while pathways governing the GRNs exhibit modest conservation, M. polymorpha GRNs exhibit more regulatory connections through the redeployment of ancient transcription factor CSD. In M. polymorpha, functional analyses reveal the involvement of pre-existing cytokinin machineries in downstream targets, orchestrating plastic morpho-physiological responses to nutrient status. Our findings implicate the genetic co-option events facilitating successful land plant establishment. The first land plant faced environmental challenges during terrestrial colonization. This study shows how the co-option of gene regulatory networks contributes to nutrient responses, facilitating the terrestrial adaptation of ancestral land plants.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 12","pages":"1955-1968"},"PeriodicalIF":15.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Amborella’s ZW sex chromosome system 揭开安布雷拉 ZW 性染色体系统的神秘面纱

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-25 DOI: 10.1038/s41477-024-01830-9

Susanne S. Renner

引用次数: 0

ZW sex chromosome structure in Amborella trichopoda 伏牛花的 ZW 性染色体结构

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-25 DOI: 10.1038/s41477-024-01858-x

Sarah B. Carey, Laramie Aközbek, John T. Lovell, Jerry Jenkins, Adam L. Healey, Shengqiang Shu, Paul Grabowski, Alan Yocca, Ada Stewart, Teresa Jones, Kerrie Barry, Shanmugam Rajasekar, Jayson Talag, Charlie Scutt, Porter P. Lowry II, Jérôme Munzinger, Eric B. Knox, Douglas E. Soltis, Pamela S. Soltis, Jane Grimwood, Jeremy Schmutz, James Leebens-Mack, Alex Harkess

{"title":"ZW sex chromosome structure in Amborella trichopoda","authors":"Sarah B. Carey, Laramie Aközbek, John T. Lovell, Jerry Jenkins, Adam L. Healey, Shengqiang Shu, Paul Grabowski, Alan Yocca, Ada Stewart, Teresa Jones, Kerrie Barry, Shanmugam Rajasekar, Jayson Talag, Charlie Scutt, Porter P. Lowry II, Jérôme Munzinger, Eric B. Knox, Douglas E. Soltis, Pamela S. Soltis, Jane Grimwood, Jeremy Schmutz, James Leebens-Mack, Alex Harkess","doi":"10.1038/s41477-024-01858-x","DOIUrl":"10.1038/s41477-024-01858-x","url":null,"abstract":"Sex chromosomes have evolved hundreds of times across the flowering plant tree of life; their recent origins in some members of this clade can shed light on the early consequences of suppressed recombination, a crucial step in sex chromosome evolution. Amborella trichopoda, the sole species of a lineage that is sister to all other extant flowering plants, is dioecious with a young ZW sex determination system. Here we present a haplotype-resolved genome assembly, including highly contiguous assemblies of the Z and W chromosomes. We identify a ~3-megabase sex-determination region (SDR) captured in two strata that includes a ~300-kilobase inversion that is enriched with repetitive sequences and contains a homologue of the Arabidopsis METHYLTHIOADENOSINE NUCLEOSIDASE (MTN1-2) genes, which are known to be involved in fertility. However, the remainder of the SDR does not show patterns typically found in non-recombining SDRs, such as repeat accumulation and gene loss. These findings are consistent with the hypothesis that dioecy is derived in Amborella and the sex chromosome pair has not significantly degenerated. The haplotype-resolved genome in Amborella trichopoda addresses outstanding questions on the structure and gene content of the recently evolved ZW sex chromosomes.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 12","pages":"1944-1954"},"PeriodicalIF":15.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41477-024-01858-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ABA-activated low-nanomolar Ca2+–CPK signalling controls root cap cycle plasticity and stress adaptation ABA激活的低纳摩尔Ca2+-CPK信号控制根帽周期可塑性和胁迫适应性

IF 18 1区生物学

Nature Plants Pub Date : 2024-11-22 DOI: 10.1038/s41477-024-01865-y

Ziwei Lin, Ying Guo, Ruiyuan Zhang, Yiming Li, Yue Wu, Jen Sheen, Kun-hsiang Liu

{"title":"ABA-activated low-nanomolar Ca2+–CPK signalling controls root cap cycle plasticity and stress adaptation","authors":"Ziwei Lin, Ying Guo, Ruiyuan Zhang, Yiming Li, Yue Wu, Jen Sheen, Kun-hsiang Liu","doi":"10.1038/s41477-024-01865-y","DOIUrl":"https://doi.org/10.1038/s41477-024-01865-y","url":null,"abstract":"Abscisic acid (ABA) regulates plant stress adaptation, growth and reproduction. Despite extensive ABA–Ca2+ signalling links, imaging ABA-induced increases in Ca2+ concentration has been challenging, except in guard cells. Here we visualize ABA-triggered [Ca2+] dynamics in diverse organs and cell types of Arabidopsis thaliana using a genetically encoded Ca2+ ratiometric sensor with a low-nanomolar Ca2+-binding affinity and a large dynamic range. The subcellular-targeted Ca2+ ratiometric sensor reveals time-resolved and unique spatiotemporal Ca2+ signatures from the initial plasma-membrane nanodomain, to cytosol, to nuclear oscillation. Via receptors and sucrose-non-fermenting1-related protein kinases (SnRK2.2/2.3/2.6), ABA activates low-nanomolar Ca2+ transient and Ca2+-sensor protein kinase (CPK10/30/32) signalling in the root cap cycle from stem cells to cell detachment. Surprisingly, unlike the prevailing NaCl-stimulated micromolar Ca2+ spike, salt stress induces a low-nanomolar Ca2+ transient through ABA signalling, repressing key transcription factors that dictate cell fate and enzymes that are crucial to root cap maturation and slough. Our findings uncover ABA–Ca2+–CPK signalling that modulates root cap cycle plasticity in adaptation to adverse environments.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"42 1","pages":""},"PeriodicalIF":18.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the centromere landscape and evolution in the model plant Nicotiana benthamiana 揭示模式植物烟草的中心粒景观与进化

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-22 DOI: 10.1038/s41477-024-01872-z

引用次数: 0

Climate warming speeds up species succession in Himalayan treelines 气候变暖加速喜马拉雅山脉树系的物种演替

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-21 DOI: 10.1038/s41477-024-01860-3

引用次数: 0

Alternate routes to gene functions 基因功能的替代途径

IF 15.8 1区生物学

Nature Plants Pub Date : 2024-11-18 DOI: 10.1038/s41477-024-01870-1

引用次数: 0