Nature Reviews Microbiology最新文献_第8页

Malaria vaccines: a new era of prevention and control 疟疾疫苗：预防和控制的新时代。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-18 DOI: 10.1038/s41579-024-01065-7

Patrick E. Duffy, J. Patrick Gorres, Sara A. Healy, Michal Fried

{"title":"Malaria vaccines: a new era of prevention and control","authors":"Patrick E. Duffy, J. Patrick Gorres, Sara A. Healy, Michal Fried","doi":"10.1038/s41579-024-01065-7","DOIUrl":"10.1038/s41579-024-01065-7","url":null,"abstract":"Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015. Additionally, parasites and mosquitoes resistant to existing interventions are spreading across Africa and other regions. Vaccines offer hope to reduce the mortality burden: the first licensed malaria vaccines, RTS,S and R21, will be widely deployed in 2024 and should substantially reduce childhood deaths. In this Review, we provide an overview of the malaria problem and the Plasmodium parasite, then describe the RTS,S and R21 vaccines (the first vaccines for any human parasitic disease), summarizing their benefits and limitations. We explore next-generation vaccines designed using new knowledge of malaria pathogenesis and protective immunity, which incorporate antigens and platforms to elicit effective immune responses against different parasite stages in human or mosquito hosts. We describe a decision-making process that prioritizes malaria vaccine candidates for development in a resource-constrained environment. Future vaccines might improve upon the protective efficacy of RTS,S or R21 for children, or address the wider malaria scourge by preventing pregnancy malaria, reducing the burden of Plasmodium vivax or accelerating malaria elimination. In this Review, Duffy et al. examine the malaria vaccine landscape, showcasing both achievements and setbacks over the past decades. They discuss approaches and assays for different parasite stages, summarize recent advancements, propose a decision-making process for the field and identify future priorities to address unmet needs.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 12","pages":"756-772"},"PeriodicalIF":69.2,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tearing CRISPR apart 拆解 CRISPR

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-17 DOI: 10.1038/s41579-024-01084-4

Andrea Du Toit

引用次数: 0

Cross-kingdom nutrient exchange in the plant–arbuscular mycorrhizal fungus–bacterium continuum 植物-丛枝菌根真菌-细菌连续体中的跨领域养分交换

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-16 DOI: 10.1038/s41579-024-01073-7

Shilong Duan, Gu Feng, Erik Limpens, Paola Bonfante, Xianan Xie, Lin Zhang

{"title":"Cross-kingdom nutrient exchange in the plant–arbuscular mycorrhizal fungus–bacterium continuum","authors":"Shilong Duan, Gu Feng, Erik Limpens, Paola Bonfante, Xianan Xie, Lin Zhang","doi":"10.1038/s41579-024-01073-7","DOIUrl":"10.1038/s41579-024-01073-7","url":null,"abstract":"The association between plants and arbuscular mycorrhizal fungi (AMF) affects plant performance and ecosystem functioning. Recent studies have identified AMF-associated bacteria as cooperative partners that participate in AMF–plant symbiosis: specific endobacteria live inside AMF, and hyphospheric bacteria colonize the soil that surrounds the extraradical hyphae. In this Review, we describe the concept of a plant–AMF–bacterium continuum, summarize current advances and provide perspectives on soil microbiology. First, we review the top-down carbon flow and the bottom-up mineral flow (especially phosphorus and nitrogen) in this continuum, as well as how AMF–bacteria interactions influence the biogeochemical cycling of nutrients (for example, carbon, phosphorus and nitrogen). Second, we discuss how AMF interact with hyphospheric bacteria or endobacteria to regulate nutrient exchange between plants and AMF, and the possible molecular mechanisms that underpin this continuum. Finally, we explore future prospects for studies on the hyphosphere to facilitate the utilization of AMF and hyphospheric bacteria in sustainable agriculture. Most plants form symbioses with arbuscular mycorrhizal fungi, which themselves harbour endobacteria and hyphospheric bacteria. In this Review, Duan et al. explore how nutrients are transferred between the partners in this plant–fungus–bacterium continuum.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 12","pages":"773-790"},"PeriodicalIF":69.2,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indirect intervention 间接干预

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-16 DOI: 10.1038/s41579-024-01085-3

Andrea Du Toit

引用次数: 0

The interplay between diet and the gut microbiome: implications for health and disease 饮食与肠道微生物组之间的相互作用：对健康和疾病的影响。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-15 DOI: 10.1038/s41579-024-01068-4

Fiona C. Ross, Dhrati Patangia, Ghjuvan Grimaud, Aonghus Lavelle, Eugene M. Dempsey, R. Paul Ross, Catherine Stanton

{"title":"The interplay between diet and the gut microbiome: implications for health and disease","authors":"Fiona C. Ross, Dhrati Patangia, Ghjuvan Grimaud, Aonghus Lavelle, Eugene M. Dempsey, R. Paul Ross, Catherine Stanton","doi":"10.1038/s41579-024-01068-4","DOIUrl":"10.1038/s41579-024-01068-4","url":null,"abstract":"Diet has a pivotal role in shaping the composition, function and diversity of the gut microbiome, with various diets having a profound impact on the stability, functionality and diversity of the microbial community within our gut. Understanding the profound impact of varied diets on the microbiome is crucial, as it will enable us not only to make well-informed dietary decisions for better metabolic and intestinal health, but also to prevent and slow the onset of specific diet-related diseases that stem from suboptimal diets. In this Review, we explore how geographical location affects the gut microbiome and how different diets shape its composition and function. We examine the mechanisms by which whole dietary regimes, such as the Mediterranean diet, high-fibre diet, plant-based diet, high-protein diet, ketogenic diet and Western diet, influence the gut microbiome. Furthermore, we underscore the need for exhaustive studies to better understand the causal relationship between diet, host and microorganisms for the development of precision nutrition and microbiome-based therapies. In this Review, Stanton and colleagues examine the effect of different whole diets on the composition and function of the gut microbiome and explore how the diet–microbiome relationship influences human health and the progression of different chronic diseases.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"671-686"},"PeriodicalIF":69.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting wound closure with Alcaligenes 用阿尔卡莱纳菌封闭伤口

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-08 DOI: 10.1038/s41579-024-01082-6

Agustina Taglialegna

引用次数: 0

Busting Cryptococcus with brilacidin 用青蒿素消灭隐球菌

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-08 DOI: 10.1038/s41579-024-01081-7

Agustina Taglialegna

引用次数: 0

New WHO proposed terminology for respiratory pathogen transmission 世界卫生组织提出的呼吸道病原体传播新术语。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-03 DOI: 10.1038/s41579-024-01067-5

Nancy H. L. Leung, Donald K. Milton

引用次数: 0

Author Correction: Respiratory syncytial virus infection and novel interventions 作者更正：呼吸道合胞病毒感染与新型干预措施。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-07-02 DOI: 10.1038/s41579-024-01078-2

Annefleur C. Langedijk, Louis J. Bont

引用次数: 0

Bacterial barcoding facilitates plant microbiome studies 细菌条形码有助于植物微生物组研究。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-26 DOI: 10.1038/s41579-024-01069-3

Hualan Liu

引用次数: 0