{"title":"Self-sacrificing cell death to thwart phage infection","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01162-1","DOIUrl":"https://doi.org/10.1038/s41579-025-01162-1","url":null,"abstract":"This study describes the bacterial type IV Thoeris defence system, which contains both a Toll/interleukin-1 receptor (TIR) domain protein and a caspase-like protease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"30 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The intruders that stole the master key","authors":"Miguel F. Romero","doi":"10.1038/s41579-025-01158-x","DOIUrl":"https://doi.org/10.1038/s41579-025-01158-x","url":null,"abstract":"This Genome Watch article highlights how genomics and different experimental approaches reveal how intracellular bacteria control key processes of their hosts.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"5 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A gut microbiome-restoring diet","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01161-2","DOIUrl":"https://doi.org/10.1038/s41579-025-01161-2","url":null,"abstract":"In this study, Li et al. perform a randomized controlled feeding trial to test the effects of a microbiome restoration strategy on gut microbiome features, host physiology and health.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"50 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RNA evolution shapes SARS-CoV-2 success","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01160-3","DOIUrl":"https://doi.org/10.1038/s41579-025-01160-3","url":null,"abstract":"In this study, Mears et al. show that SARS-CoV-2 can evolve not only through protein changes but also through functional RNA adaptations to increase fitness and immune evasion.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"16 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gordon Ramage, Ryan Kean, Riina Rautemaa-Richardson, Craig Williams, Jose L. Lopez-Ribot
{"title":"Fungal biofilms in human health and disease","authors":"Gordon Ramage, Ryan Kean, Riina Rautemaa-Richardson, Craig Williams, Jose L. Lopez-Ribot","doi":"10.1038/s41579-025-01147-0","DOIUrl":"https://doi.org/10.1038/s41579-025-01147-0","url":null,"abstract":"<p>Increased use of implanted medical devices, use of immunosuppressants and an ageing population have driven the rising frequency of fungal biofilm-related diseases. Fungi are now recognized by the World Health Organization (WHO) as an emergent threat to human health, with most medically important species defined as critical or high-priority organisms capable of forming biofilms. Although we strive for a better understanding of diagnostic and therapeutic approaches to detect and treat these fungal diseases more generally, the issue of hard-to-treat biofilms is an ever-increasing problem. These are communities of interspersed cells that are attached to one another on a surface, such as a catheter, or trapped into a cavity such as a paranasal sinus. Biofilms are difficult to detect, difficult to remove and intrinsically tolerant to most antifungal agents. These factors can lead to devastating consequences for the patient, including unnecessary morbidity and mortality, need for reoperations and prolonged hospital stay. This Review describes the breadth and growing impact fungal biofilms have on patient management and explains the mechanisms promoting biofilm formation, focusing on how targeting these can improve therapeutic options.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"39 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mining microbiomes for microproteins","authors":"B. Anne Neville, Trevor D. Lawley","doi":"10.1038/s41579-025-01154-1","DOIUrl":"10.1038/s41579-025-01154-1","url":null,"abstract":"This Genome Watch discusses strategies to detect small open reading frames and study microproteins encoded in microbiomes to understand their diversity and functions across microorganisms.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"146-146"},"PeriodicalIF":69.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Overcoming research challenges in resource-limited settings: perspectives from Thailand","authors":"Claire Chewapreecha, Thongchai Chewprecha","doi":"10.1038/s41579-025-01148-z","DOIUrl":"10.1038/s41579-025-01148-z","url":null,"abstract":"This Comment highlights the challenges and rewards of researchers working in resource-limited settings, specifically Thailand, and provides potential solutions to help Thai researchers overcome these difficulties.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"141-142"},"PeriodicalIF":69.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bacterial contact killing","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01151-4","DOIUrl":"10.1038/s41579-025-01151-4","url":null,"abstract":"This study reports that bacteria protect plants against filamentous fungal infections via intercellular contacts between the bacterial cells and the conidia of the fungi.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"143-143"},"PeriodicalIF":69.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A kill switch for tuberculosis","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01152-3","DOIUrl":"10.1038/s41579-025-01152-3","url":null,"abstract":"In two recent studies, Smith, Su, Wallach et al. engineered a safer version of Bacille Calmette–Guerin with strong protection against Mycobacterium tuberculosis, while Wang, Su, Wallach, Wagner et al. developed an engineered M. tuberculosis strain as a candidate for human challenge studies.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"144-144"},"PeriodicalIF":69.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stopping Marburg virus in its tracks","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01153-2","DOIUrl":"10.1038/s41579-025-01153-2","url":null,"abstract":"In this study, Cross, Woolsey, Prasad et al. report obeldesivir as a promising post-exposure prophylaxis for filoviruses.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"144-144"},"PeriodicalIF":69.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}