Nature Reviews Microbiology最新文献

Streptococcus pneumoniae epidemiology, pathogenesis and control 肺炎链球菌的流行病学、发病机制和控制

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-11-06 DOI: 10.1038/s41579-024-01116-z

Ana Rita Narciso, Rebecca Dookie, Priyanka Nannapaneni, Staffan Normark, Birgitta Henriques-Normark

{"title":"Streptococcus pneumoniae epidemiology, pathogenesis and control","authors":"Ana Rita Narciso, Rebecca Dookie, Priyanka Nannapaneni, Staffan Normark, Birgitta Henriques-Normark","doi":"10.1038/s41579-024-01116-z","DOIUrl":"https://doi.org/10.1038/s41579-024-01116-z","url":null,"abstract":"Infections caused by Streptococcus pneumoniae (also known as pneumococci) pose a threat to human health. Pneumococcal infections are the most common cause of milder respiratory tract infections, such as otitis and sinusitis, and of more severe diseases, including pneumonia (with or without septicaemia) and meningitis. The introduction of pneumococcal conjugate vaccines in the childhood vaccination programme in many countries has led to a notable decrease of severe invasive pneumococcal disease in vaccinated children. However, infections caused by non-vaccine types have concurrently increased, causing invasive pneumococcal disease in unvaccinated populations (such as older adults), which has hampered the effect of these vaccines. Moreover, emerging antibiotic resistance is threatening effective therapy. Thus, new approaches are needed for the treatment and prevention of pneumococcal infections, and recent advances in the field may pave the way for new strategies. Recently, several important findings have been gained regarding pneumococcal epidemiology, genomics and the effect of the introduction of pneumococcal conjugate vaccines and of the COVID-19 pandemic. Moreover, elucidative pathogenesis studies have shown that the interactions between pneumococcal virulence factors and host receptors may be exploited for new therapies, and new vaccine candidates have been suggested. In this Review, we summarize some recent findings from clinical disease to basic pathogenesis studies that may be of importance for future control strategies.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":88.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome-colonizing RNAs 微生物定殖 RNA

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-30 DOI: 10.1038/s41579-024-01122-1

Andrea Du Toit

引用次数: 0

Anti-defence islands in plasmids 质粒中的抗防御岛

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-23 DOI: 10.1038/s41579-024-01120-3

Andrea Du Toit

引用次数: 0

Examining the healthy human microbiome concept 研究健康人体微生物组概念

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-23 DOI: 10.1038/s41579-024-01107-0

Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen Raes, Jacques Ravel, Anne Salonen, Pauline D. Scanlan, Andrey Shkoporov, Catherine Stanton, Ines Thiele, Igor Tolstoy, Jens Walter, Bo Yang, Natalia Yutin, Alexandra Zhernakova, Hub Zwart, Joël Doré, R. Paul Ross

{"title":"Examining the healthy human microbiome concept","authors":"Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen Raes, Jacques Ravel, Anne Salonen, Pauline D. Scanlan, Andrey Shkoporov, Catherine Stanton, Ines Thiele, Igor Tolstoy, Jens Walter, Bo Yang, Natalia Yutin, Alexandra Zhernakova, Hub Zwart, Joël Doré, R. Paul Ross","doi":"10.1038/s41579-024-01107-0","DOIUrl":"https://doi.org/10.1038/s41579-024-01107-0","url":null,"abstract":"Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a ‘healthy’ human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome–health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":88.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing symbiotic bacteria for disease control 利用共生细菌控制疾病

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-21 DOI: 10.1038/s41579-024-01115-0

Abraham Morales-Cruz, Leo A. Baumgart

引用次数: 0

Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention 血流感染：发病机制和干预机会

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-17 DOI: 10.1038/s41579-024-01105-2

Caitlyn L. Holmes, Owen R. Albin, Harry L. T. Mobley, Michael A. Bachman

{"title":"Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention","authors":"Caitlyn L. Holmes, Owen R. Albin, Harry L. T. Mobley, Michael A. Bachman","doi":"10.1038/s41579-024-01105-2","DOIUrl":"https://doi.org/10.1038/s41579-024-01105-2","url":null,"abstract":"Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune system and filtering organs but, in some cases, they can cause an acute infection and trigger sepsis, a systemic response to infection that leads to circulatory collapse, multiorgan dysfunction and death. Most BSIs are caused by bacteria, although fungi also contribute to a substantial portion of cases. Escherichia coli, Staphylococcus aureus, coagulase-negative Staphylococcus, Klebsiella pneumoniae and Candida albicans are leading causes of BSIs, although their prevalence depends on patient demographics and geographical region. Each species is equipped with unique factors that aid in the colonization of initial sites and dissemination and survival in the blood, and these factors represent potential opportunities for interventions. As many pathogens become increasingly resistant to antimicrobials, new approaches to diagnose and treat BSIs at all stages of infection are urgently needed. In this Review, we explore the prevalence of major BSI pathogens, prominent mechanisms of BSI pathogenesis, opportunities for prevention and diagnosis, and treatment options.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":88.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity and ecology of microbial sulfur metabolism 微生物硫代谢的多样性和生态学

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-17 DOI: 10.1038/s41579-024-01104-3

Zhichao Zhou, Patricia Q. Tran, Elise S. Cowley, Elizabeth Trembath-Reichert, Karthik Anantharaman

{"title":"Diversity and ecology of microbial sulfur metabolism","authors":"Zhichao Zhou, Patricia Q. Tran, Elise S. Cowley, Elizabeth Trembath-Reichert, Karthik Anantharaman","doi":"10.1038/s41579-024-01104-3","DOIUrl":"https://doi.org/10.1038/s41579-024-01104-3","url":null,"abstract":"Sulfur plays a pivotal role in interactions within the atmosphere, lithosphere, pedosphere, hydrosphere and biosphere, and the functioning of living organisms. In the Earth’s crust, mantle, and atmosphere, sulfur undergoes geochemical transformations due to natural and anthropogenic factors. In the biosphere, sulfur participates in the formation of amino acids, proteins, coenzymes and vitamins. Microorganisms in the biosphere are crucial for cycling sulfur compounds through oxidation, reduction and disproportionation reactions, facilitating their bioassimilation and energy generation. Microbial sulfur metabolism is abundant in both aerobic and anaerobic environments and is interconnected with biogeochemical cycles of important elements such as carbon, nitrogen and iron. Through metabolism, competition or cooperation, microorganisms metabolizing sulfur can drive the consumption of organic carbon, loss of fixed nitrogen and production of climate-active gases. Given the increasing significance of sulfur metabolism in environmental alteration and the intricate involvement of microorganisms in sulfur dynamics, a timely re-evaluation of the sulfur cycle is imperative. This Review explores our understanding of microbial sulfur metabolism, primarily focusing on the transformations of inorganic sulfur. We comprehensively overview the sulfur cycle in the face of rapidly changing ecosystems on Earth, highlighting the importance of microbially-mediated sulfur transformation reactions across different environments, ecosystems and microbiomes.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":88.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A gut bacterium trims mucosal immunity 一种肠道细菌能增强黏膜免疫力

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-15 DOI: 10.1038/s41579-024-01117-y

Agustina Taglialegna

引用次数: 0

Re-emergence of Oropouche virus 奥罗普切病毒再次出现

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-15 DOI: 10.1038/s41579-024-01118-x

Agustina Taglialegna

引用次数: 0

Anthropogenic impacts on the terrestrial subsurface biosphere 人类活动对陆地地下生物圈的影响

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-15 DOI: 10.1038/s41579-024-01110-5

Kaela K. Amundson, Mikayla A. Borton, Michael J. Wilkins

{"title":"Anthropogenic impacts on the terrestrial subsurface biosphere","authors":"Kaela K. Amundson, Mikayla A. Borton, Michael J. Wilkins","doi":"10.1038/s41579-024-01110-5","DOIUrl":"https://doi.org/10.1038/s41579-024-01110-5","url":null,"abstract":"The terrestrial subsurface is estimated to be the largest reservoir of microbial life on Earth. However, the subsurface also harbours economic, industrial and environmental resources, on which humans heavily rely, including diverse energy sources and formations for the storage of industrial waste and carbon dioxide for climate change mitigation. As a result of this anthropogenic activity, the subsurface landscape is transformed, including the subsurface biosphere. Through the creation of new environments and the introduction of substrates that fuel microbial life, the structure and function of subsurface microbiomes shift markedly. These microbial changes often have unintended effects on overall ecosystem function and are frequently challenging to manage from the surface of the Earth. In this Review, we highlight emerging research that investigates the impacts of anthropogenic activity on the terrestrial subsurface biosphere. We explore how humans alter the constraints on microbial life in the subsurface through drilling, mining, contamination and resource extraction, along with the resulting impacts of microorganisms on resource recovery and subsurface infrastructure.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":null,"pages":null},"PeriodicalIF":88.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0