Nature Reviews Microbiology最新文献

Antimicrobial peptides: structure, functions and translational applications 抗菌肽：结构、功能和翻译应用

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-07-11 DOI: 10.1038/s41579-025-01200-y

Nelson G. Oliveira Júnior, Camila M. Souza, Danieli F. Buccini, Marlon H. Cardoso, Octávio L. Franco

引用次数: 0

A molecular decoy for phage defence 噬菌体防御的分子诱饵

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-07-08 DOI: 10.1038/s41579-025-01212-8

Shimona Starling

引用次数: 0

Coordinated action by individuals orchestrates infection through the division of labour 个人的协调行动通过分工协调感染

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-07-07 DOI: 10.1038/s41579-025-01210-w

Ka-Wai Ma

引用次数: 0

Building climate-resilient agriculture through science and local action 通过科学和地方行动建设适应气候变化的农业

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-07-01 DOI: 10.1038/s41579-025-01207-5

Dilfuza Egamberdieva

引用次数: 0

Mycobacterium tuberculosis biology, pathogenicity and interaction with the host 结核分枝杆菌的生物学、致病性及与宿主的相互作用

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-06-30 DOI: 10.1038/s41579-025-01201-x

Digby F. Warner, Amy K. Barczak, Maximiliano G. Gutierrez, Valerie Mizrahi

{"title":"Mycobacterium tuberculosis biology, pathogenicity and interaction with the host","authors":"Digby F. Warner, Amy K. Barczak, Maximiliano G. Gutierrez, Valerie Mizrahi","doi":"10.1038/s41579-025-01201-x","DOIUrl":"https://doi.org/10.1038/s41579-025-01201-x","url":null,"abstract":"Since the release of the first Mycobacterium tuberculosis genome in 1998, major advances have been made in understanding the biology of this pathogen, the leading infectious cause of death in modern human history. In this Review, we outline the physiological and metabolic features thought to underpin the survival, evasion and subversion strategies employed by M. tuberculosis as it drives a cycle of transmission, infection and disease in its obligate human host. We also consider adaptations to key host innate immune effectors, including the roles of granulocytes, phagosomal damage and repair, autophagy and cell death in determining host–mycobacterium outcomes. Given the increasing awareness of the importance of asymptomatic M. tuberculosis infection and transmission, we advocate for the need to ensure greater intersection between laboratory and clinical research, taking into account the environmental context in which natural infection and disease occur. We identify knowledge gaps in the field and reflect on the opportunities and challenges for integrating host, bacterium and environment into future investigations to inform intervention strategies to control tuberculosis disease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"46 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenetics and molecular evolution to understand and curb the HIV pandemic 了解和遏制艾滋病毒流行的系统发育和分子进化

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-06-30 DOI: 10.1038/s41579-025-01202-w

Huldrych F. Günthard, Katharina Kusejko, Roger D. Kouyos

{"title":"Phylogenetics and molecular evolution to understand and curb the HIV pandemic","authors":"Huldrych F. Günthard, Katharina Kusejko, Roger D. Kouyos","doi":"10.1038/s41579-025-01202-w","DOIUrl":"https://doi.org/10.1038/s41579-025-01202-w","url":null,"abstract":"Despite decades of research and medical advances, the HIV-1 pandemic still presents major public health challenges, with most countries failing to meet the defined targets for HIV elimination. HIV-1 is the first chronic viral disease for which extensive virus sequence data became available through genotypic resistance testing. Phylogenetic methods have been instrumental in answering pathogenesis-related questions, such as ongoing viral replication on antiretroviral therapy and the role of the viral genome in pathogenesis and immunity. Molecular data have also largely enabled the development and application of phylogenetic and molecular epidemiology approaches to large populations, providing unique insights. These insights include the origin and timing of the HIV-1 pandemic, its global spread, transmission dynamics within and between subpopulations, and quantifying the impact of public health interventions on ongoing transmission. Such knowledge is essential for improving our understanding of key epidemic dynamics at both the micro and macro levels, as well as of the underlying biological mechanisms. In the future, these insights could be provided in real time to guide and optimize prevention measures. Molecular public health approaches should be expanded, particularly in low-income and middle-income countries where most of the pandemic’s burden persists.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"18 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A genomic perspective on fungal diversity and evolution 真菌多样性和进化的基因组视角

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-06-30 DOI: 10.1038/s41579-025-01195-6

Stephen J. Mondo, Igor V. Grigoriev

{"title":"A genomic perspective on fungal diversity and evolution","authors":"Stephen J. Mondo, Igor V. Grigoriev","doi":"10.1038/s41579-025-01195-6","DOIUrl":"https://doi.org/10.1038/s41579-025-01195-6","url":null,"abstract":"Originating from aquatic unicellular ancestors, over the course of ~1 billion years, the fungi have evolved to occupy nearly all aerobic environments on the planet, diversified into millions of different ‘species’ and have developed complex multicellular structures. Their relatively small, simple genomes have facilitated massive-scale sequencing and allowed us to explore genome evolution across an ancient eukaryotic kingdom. With thousands of genomes from diverse lineages now available, this Review will discuss insights into fungal biology and evolution gleaned with genomics and other multi-omics approaches. Using published genomes available through GenBank and the Joint Genome Institute’s MycoCosm platform, we generated kingdom-wide phylogenies and used them to highlight how fungal genomes have changed over time. With this phylogeny as a guide, we also discuss major evolutionary transitions that occurred across the fungal kingdom. Although progress has been made, these efforts are hampered by biases in genome representation and limited characterization of gene functions. Here, we discuss these challenges and possible future directions to address them, including initiatives to characterize conserved genes of unknown function and scale up sequencing towards 10,000 annotated fungal genomes.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"27 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A misplaced microbiome 错位的微生物群

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-06-26 DOI: 10.1038/s41579-025-01208-4

Andrea Du Toit

引用次数: 0

A long-lost species 一个消失已久的物种

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-06-25 DOI: 10.1038/s41579-025-01209-3

Andrea Du Toit

引用次数: 0

Persistence over virulence in Yersinia pestis 鼠疫耶尔森菌毒力的持久性