Nature Reviews Microbiology最新文献

Bacterial cell envelope-targeting antibiotics. 细菌包膜靶向抗生素。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-13 DOI: 10.1038/s41579-025-01247-x

Charalampos Ntallis, Nathaniel I Martin, Andrew M Edwards, Markus Weingarth

{"title":"Bacterial cell envelope-targeting antibiotics.","authors":"Charalampos Ntallis, Nathaniel I Martin, Andrew M Edwards, Markus Weingarth","doi":"10.1038/s41579-025-01247-x","DOIUrl":"https://doi.org/10.1038/s41579-025-01247-x","url":null,"abstract":"The emergence of multidrug-resistant bacteria presents a critical threat to global health. These multidrug-resistant bacteria are often protected by complex cell envelopes that many antibiotics cannot penetrate, creating an important barrier to treatment. In response, targeting bacterial envelopes has long been recognized as an effective strategy, offering potential to bypass the challenges of drug entry and efflux resistance mechanisms. Moreover, many unique bacterial envelope sites remain clinically untapped, and new compounds directed at them have the potential to diversify the space of antimicrobial mechanisms, lowering the risk for cross-resistance. Compounds that target non-proteinaceous envelope components, such as lipopolysaccharide or prenylated peptidoglycan-precursors, are particularly attractive owing to their reduced susceptibility to antimicrobial resistance development. In this Review, we explore both recently discovered compounds and established envelope-targeting antibiotics, including compounds that target Gram-positive bacteria, more complex Gram-negative bacteria and mycobacterial pathogens, shedding light on this still clinically underexplored and vital therapeutic approach.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":103.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energizing antibiotic killing. 激活抗生素杀伤。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-08 DOI: 10.1038/s41579-025-01252-0

Andrea Du Toit

引用次数: 0

Viral emergence and pandemic preparedness in a One Health framework. “同一个健康”框架下的病毒出现和大流行防范。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-03 DOI: 10.1038/s41579-025-01243-1

Reina S Sikkema,Marion Koopmans

{"title":"Viral emergence and pandemic preparedness in a One Health framework.","authors":"Reina S Sikkema,Marion Koopmans","doi":"10.1038/s41579-025-01243-1","DOIUrl":"https://doi.org/10.1038/s41579-025-01243-1","url":null,"abstract":"The risk of viral pathogen transmission between humans and animals (spillover events) and subsequent spread has been increasing due to human impacts on the planet, which lead to changes in the interactions between humans, animals, ecosystems and their pathogens. Key factors (drivers) that increase the risk of disease emergence include climate change, urbanization, land-use changes and global travel, all of which can alter human-animal-environment interactions and increase the likelihood of zoonotic spillovers and vector-borne diseases. Incorporating data on these drivers (such as ecological shifts and patterns of animal movement) into disease surveillance systems can help identify hot spots for disease emergence, which could in theory enable earlier detection of outbreaks and, in turn, increase the effectiveness of intervention strategies. A One Health approach, emphasizing the interconnectedness of human, animal and environmental health, is advocated for addressing these complex challenges. Although conceptually clear and widely endorsed, implementation of One Health approaches towards primary prevention of spillovers is extremely challenging. Here, we summarize current knowledge on disease emergence and its drivers, and discuss how this knowledge could be used towards primary prevention and for the development of risk-targeted One Health early warning surveillance. We consider integrating innovative tools for diagnostics, surveillance and virus characterization, and propose an outlook towards more integrated prevention, early warning and control of emerging infections at the human-animal interface.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"38 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How tick-borne encephalitis virus gains entry. 蜱传脑炎病毒如何进入。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-02 DOI: 10.1038/s41579-025-01249-9

Andrea Du Toit

引用次数: 0

The human gut mycobiome in the context of primate evolution. 灵长类动物进化背景下的人类肠道菌群。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-02 DOI: 10.1038/s41579-025-01250-2

Shimona Starling

引用次数: 0

Clostridioides difficile pathogenesis and control. 艰难梭菌发病机理及防治。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-02 DOI: 10.1038/s41579-025-01242-2

Caroline H Chilton, Virginie Viprey, Charmaine Normington, Ines B Moura, Anthony M Buckley, Jane Freeman, Kerrie Davies, Mark H Wilcox

{"title":"Clostridioides difficile pathogenesis and control.","authors":"Caroline H Chilton, Virginie Viprey, Charmaine Normington, Ines B Moura, Anthony M Buckley, Jane Freeman, Kerrie Davies, Mark H Wilcox","doi":"10.1038/s41579-025-01242-2","DOIUrl":"https://doi.org/10.1038/s41579-025-01242-2","url":null,"abstract":"Clostridioides difficile infection (CDI) continues to be a notable burden worldwide, both in terms of patient mortality and morbidity, and the economic costs associated with treatment, diagnosis and management. The epidemiology of C. difficile has changed markedly over the decades, with high CDI rates driven by clinical pressures exacerbated by the severe acute respiratory syndrome coronavirus 2 pandemic, antibiotic resistance and selective pressures caused by antimicrobial use. C. difficile is challenging to diagnose and treat as it forms spores and can persist asymptomatically within the gut. Some strains express multiple virulence factors, including adhesins and toxins. The gut microbiota is crucially important in CDI, as a healthy microbiota is resistant to colonization with C. difficile. Dysbiosis, often caused by antimicrobial exposure, enables C. difficile spores to germinate and produce toxin, causing symptoms that can range from mild diarrhoea to fulminant colitis and death. This Review describes changes in epidemiology and effects on diagnosis, discusses recent breakthroughs in the understanding of pathogenesis and antibiotic resistance and explores the role of microbiota dysbiosis in CDI and novel microbiota therapies in CDI treatment.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":103.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making waves: how biofilms find their rhythm. 掀起波澜：生物膜如何找到自己的节奏。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-10-01 DOI: 10.1038/s41579-025-01245-z

Liam Mark Rooney

引用次数: 0

Prophage against phage 噬菌体对抗噬菌体。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-09-24 DOI: 10.1038/s41579-025-01246-y

Andrea Du Toit

引用次数: 0

Zoonotic threats hidden in wildlife. 隐藏在野生动物中的人畜共患病威胁。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-09-22 DOI: 10.1038/s41579-025-01239-x

Alannah C King, Kate C Mellor

引用次数: 0

Fusobacterium nucleatum: ecology, pathogenesis and clinical implications. 核梭杆菌：生态学、发病机制和临床意义。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-09-22 DOI: 10.1038/s41579-025-01237-z

Shan-Shan Jiang,Ying-Xuan Chen,Jing-Yuan Fang

{"title":"Fusobacterium nucleatum: ecology, pathogenesis and clinical implications.","authors":"Shan-Shan Jiang,Ying-Xuan Chen,Jing-Yuan Fang","doi":"10.1038/s41579-025-01237-z","DOIUrl":"https://doi.org/10.1038/s41579-025-01237-z","url":null,"abstract":"Fusobacterium nucleatum, a commensal microorganism and opportunistic pathogen (a pathobiont), has emerged as a key player in both local and systemic diseases. In humans, F. nucleatum is found in the oral microbiota, but under certain conditions, it can spread to other ecological niches within the body, such as the gut microbiota. Importantly, F. nucleatum has a pathogenic role in periodontal disease, inflammatory bowel disease and various cancers, particularly colorectal cancer. F. nucleatum can promote oncogenesis via several mechanisms, including virulence factors, chronic inflammation, immune evasion and direct interactions with tumour cells. The strong link between this pathobiont microorganism and cancer has led to the emergence of several potential diagnostic strategies and possible therapeutic interventions. Given its increasing association with cancer progression and poor clinical outcomes, understanding the role of F. nucleatum in disease treatment offers critical insights for future research and clinical applications. This Review underscores the importance of F. nucleatum in microbiology, oncology and translational medicine.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"223 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0