Nature Reviews Microbiology最新文献

Measles is resurging in the Americas and the world is watching 麻疹正在美洲死灰复燃，全世界都在关注

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-30 DOI: 10.1038/s41579-025-01198-3

Amy K. Winter, Spencer J. Fox

引用次数: 0

Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility 铜绿假单胞菌：生态学、进化、发病机制和耐药性

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-29 DOI: 10.1038/s41579-025-01193-8

Morgana Letizia, Stephen P. Diggle, Marvin Whiteley

{"title":"Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility","authors":"Morgana Letizia, Stephen P. Diggle, Marvin Whiteley","doi":"10.1038/s41579-025-01193-8","DOIUrl":"https://doi.org/10.1038/s41579-025-01193-8","url":null,"abstract":"Pseudomonas aeruginosa has long served as a model organism in microbiology, particularly for studies on gene expression, quorum sensing, antibiotic resistance, virulence and biofilm formation. Its genetic tractability has advanced the understanding of complex regulatory networks and experimental evolution. The versatility of this bacterium stems from its genomic variability, metabolic flexibility and phenotypic diversity, enabling it to thrive in diverse environments, both as a harmless saprophyte and an opportunistic human pathogen. P. aeruginosa can cause acute and chronic human infections, particularly in patients with underlying immune deficiencies. Its intrinsic antibiotic tolerance and resistance, together with its ability to produce multiple virulence factors while rapidly adapting to infection conditions, pose a major clinical challenge. In this Review, we explore key features contributing to the ecological and pathogenic versatility of P. aeruginosa. We examine the molecular mechanisms and ecological and evolutionary implications of quorum sensing and biofilm formation. We explore the virulence strategies and in vivo fitness determinants, as well as the evolutionary dynamics and global epidemiology of P. aeruginosa, with a focus on antimicrobial resistance. Finally, we discuss emerging strategies to control P. aeruginosa infections and address outstanding questions in the field.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"17 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microorganisms thriving together as communities 微生物作为群落一起繁荣

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-29 DOI: 10.1038/s41579-025-01199-2

Eric Olo Ndela

引用次数: 0

Metagenomics distilled: new k-mer-based methods 宏基因组学：基于k-mer的新方法

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-23 DOI: 10.1038/s41579-025-01192-9

Timothy J. Rozday

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Microbial interactions and ecology in fermented food ecosystems 发酵食品生态系统中的微生物相互作用与生态学

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-23 DOI: 10.1038/s41579-025-01191-w

Jennifer M. Auchtung, Heather E. Hallen-Adams, Robert Hutkins

{"title":"Microbial interactions and ecology in fermented food ecosystems","authors":"Jennifer M. Auchtung, Heather E. Hallen-Adams, Robert Hutkins","doi":"10.1038/s41579-025-01191-w","DOIUrl":"https://doi.org/10.1038/s41579-025-01191-w","url":null,"abstract":"Fermented foods and beverages, produced by the intentional growth of microorganisms, have long been among the most widely consumed foods in the human diet. Whether microorganisms are added directly to food substrates, or the growth and activity of autochthonous microorganisms colonizing food substrates is encouraged by selective conditions, the production of organic acids, ethanol and other metabolic end products enhance the safety, shelf-life, sensory and functional properties of foods. Whereas some fermented foods may be produced by communities dominated by only a few taxa of limited phylogenetic diversity, others are produced through the concerted action of diverse microbial communities. In this Review, we describe the ecological interactions shaping microbial community structure and function across various categories of fermented foods by providing specific examples. We also describe how the manufacture, quality and sustainability of even traditional fermented foods can be improved by contemporary technologies. Finally, we briefly discuss current research on the ecological impact of microorganisms found in fermented food on the human gut.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"144 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inheriting traits 继承特征

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-23 DOI: 10.1038/s41579-025-01197-4

Andrea Du Toit

引用次数: 0

Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses 高致病性H5甲型禽流感病毒的进化、传播和影响

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-22 DOI: 10.1038/s41579-025-01189-4

Beatriz Bellido-Martín, Willemijn F. Rijnink, Matteo Iervolino, Thijs Kuiken, Mathilde Richard, Ron A. M. Fouchier

{"title":"Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses","authors":"Beatriz Bellido-Martín, Willemijn F. Rijnink, Matteo Iervolino, Thijs Kuiken, Mathilde Richard, Ron A. M. Fouchier","doi":"10.1038/s41579-025-01189-4","DOIUrl":"https://doi.org/10.1038/s41579-025-01189-4","url":null,"abstract":"Since their first detection in 1996, highly pathogenic avian influenza viruses with H5 haemagglutinin of the A/Goose/Guangdong/1/1996 (Gs/Gd) lineage have caused outbreaks in domestic and wild animals associated with mass morbidity and mortality, and economic losses as well as sporadic human infections. These viruses have spread to hosts across the European, Asian, African, and North and South American continents, and most recently Antarctica, representing a major threat to wildlife, domestic animals and humans. Owing to continuous circulation in poultry, Gs/Gd lineage viruses have diversified into numerous distinct genetic and antigenic (sub)clades, and genetic diversity has further increased by extensive reassortment with low pathogenic avian influenza viruses of wild birds. In this Review, we discuss the historical emergence of Gs/Gd lineage viruses and their evolution and geographical spread. An overview of the major determinants of host range and cross-species transmission is provided to summarize phenotypic changes that may signal increased zoonotic or pandemic risks. The recent unusual outbreaks in wild carnivorous mammals and dairy cows is discussed, as well as the changing risk to humans. Countermeasures and mitigation strategies are described from the One Health perspective for future (pre-)pandemic preparedness.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"1 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An engineered Vibrio to remediate ’em all 一种工程弧菌来修复它们

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-22 DOI: 10.1038/s41579-025-01196-5

Agustina Taglialegna

引用次数: 0

A gut fungus protects the liver 肠道真菌保护肝脏

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-21 DOI: 10.1038/s41579-025-01194-7

Andrea Du Toit

引用次数: 0

To end the HIV-1 pandemic, concerted research efforts must focus on sub-Saharan Africa 为了结束艾滋病毒-1大流行病，协调一致的研究努力必须集中在撒哈拉以南非洲

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-14 DOI: 10.1038/s41579-025-01188-5

Monray E. Williams, Jaclyn K. Mann, Thumbi Ndung’u, Marius B. Tincho, Marcel Tongo, Ntobeko A. B. Ntusi, Thulani P. Makhalanyane

引用次数: 0