核梭杆菌:生态学、发病机制和临床意义。

IF 103.3 1区 生物学 Q1 MICROBIOLOGY
Shan-Shan Jiang,Ying-Xuan Chen,Jing-Yuan Fang
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引用次数: 0

摘要

核梭杆菌是一种共生微生物和条件致病菌(一种病原体),在局部和全身性疾病中都起着关键作用。在人类中,具核梭菌存在于口腔微生物群中,但在某些条件下,它可以传播到体内的其他生态位,如肠道微生物群。重要的是,核仁梭菌在牙周病、炎症性肠病和各种癌症,特别是结直肠癌中具有致病作用。核仁梭菌可通过多种机制促进肿瘤发生,包括毒力因子、慢性炎症、免疫逃避和与肿瘤细胞的直接相互作用。这种致病微生物与癌症之间的紧密联系导致了几种潜在诊断策略和可能的治疗干预措施的出现。鉴于其与癌症进展和不良临床结果的关联越来越大,了解核梭菌在疾病治疗中的作用为未来的研究和临床应用提供了关键的见解。本文综述了核梭菌在微生物学、肿瘤学和转化医学中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fusobacterium nucleatum: ecology, pathogenesis and clinical implications.
Fusobacterium nucleatum, a commensal microorganism and opportunistic pathogen (a pathobiont), has emerged as a key player in both local and systemic diseases. In humans, F. nucleatum is found in the oral microbiota, but under certain conditions, it can spread to other ecological niches within the body, such as the gut microbiota. Importantly, F. nucleatum has a pathogenic role in periodontal disease, inflammatory bowel disease and various cancers, particularly colorectal cancer. F. nucleatum can promote oncogenesis via several mechanisms, including virulence factors, chronic inflammation, immune evasion and direct interactions with tumour cells. The strong link between this pathobiont microorganism and cancer has led to the emergence of several potential diagnostic strategies and possible therapeutic interventions. Given its increasing association with cancer progression and poor clinical outcomes, understanding the role of F. nucleatum in disease treatment offers critical insights for future research and clinical applications. This Review underscores the importance of F. nucleatum in microbiology, oncology and translational medicine.
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来源期刊
Nature Reviews Microbiology
Nature Reviews Microbiology 生物-微生物学
CiteScore
74.00
自引率
0.50%
发文量
149
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Microbiology, our goal is to become the leading source of reviews and commentaries for the scientific community we cater to. We are dedicated to publishing articles that are not only authoritative but also easily accessible, supplementing them with clear and concise figures, tables, and other visual aids. Our objective is to offer an unparalleled service to authors, referees, and readers, and we continuously strive to maximize the usefulness and impact of each article we publish. With a focus on Reviews, Perspectives, and Comments spanning the entire field of microbiology, our wide scope ensures that the work we feature reaches the widest possible audience.
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