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Foodborne bacterial pathogens: genome-based approaches for enduring and emerging threats in a complex and changing world 食源性细菌病原体：基于基因组的方法，应对复杂多变世界中的持久威胁和新出现的威胁。
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-24 DOI: 10.1038/s41579-024-01051-z
Alison E. Mather, Matthew W. Gilmour, Stuart W. J. Reid, Nigel P. French
{"title":"Foodborne bacterial pathogens: genome-based approaches for enduring and emerging threats in a complex and changing world","authors":"Alison E. Mather, Matthew W. Gilmour, Stuart W. J. Reid, Nigel P. French","doi":"10.1038/s41579-024-01051-z","DOIUrl":"10.1038/s41579-024-01051-z","url":null,"abstract":"Foodborne illnesses pose a substantial health and economic burden, presenting challenges in prevention due to the diverse microbial hazards that can enter and spread within food systems. Various factors, including natural, political and commercial drivers, influence food production and distribution. The risks of foodborne illness will continue to evolve in step with these drivers and with changes to food systems. For example, climate impacts on water availability for agriculture, changes in food sustainability targets and evolving customer preferences can all have an impact on the ecology of foodborne pathogens and the agrifood niches that can carry microorganisms. Whole-genome and metagenome sequencing, combined with microbial surveillance schemes and insights from the food system, can provide authorities and businesses with transformative information to address risks and implement new food safety interventions across the food chain. In this Review, we describe how genome-based approaches have advanced our understanding of the evolution and spread of enduring bacterial foodborne hazards as well as their role in identifying emerging foodborne hazards. Furthermore, foodborne hazards exist in complex microbial communities across the entire food chain, and consideration of these co-existing organisms is essential to understanding the entire ecology supporting pathogen persistence and transmission in an evolving food system. In this Review, Mather et al. discuss the role of genome-based approaches in deepening our understanding of both enduring and emerging bacterial foodborne pathogens in the context of evolving global food systems and environmental changes.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 9","pages":"543-555"},"PeriodicalIF":69.2,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut–airway microbiome axis in health and respiratory diseases 健康和呼吸道疾病中的肠道-气道微生物群轴。
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-22 DOI: 10.1038/s41579-024-01048-8
Mustafa Özçam, Susan V. Lynch
{"title":"The gut–airway microbiome axis in health and respiratory diseases","authors":"Mustafa Özçam, Susan V. Lynch","doi":"10.1038/s41579-024-01048-8","DOIUrl":"10.1038/s41579-024-01048-8","url":null,"abstract":"Communication between the gut and remote organs, such as the brain or the cardiovascular system, has been well established and recent studies provide evidence for a potential bidirectional gut–airway axis. Observations from animal and human studies indicate that respiratory insults influence the activity of the gut microbiome and that microbial ligands and metabolic products generated by the gut microbiome shape respiratory immunity. Information exchange between these two large mucosal surface areas regulates microorganism–immune interactions, with significant implications for the clinical and treatment outcomes of a range of respiratory conditions, including asthma, chronic obstructive pulmonary disease and lung cancer. In this Review, we summarize the most recent data in this field, offering insights into mechanisms of gut–airway crosstalk across spatial and temporal gradients and their relevance for respiratory health. In this Review, Özçam and Lynch examine recent findings reporting the interaction between the gut and the airway microbiomes and explore the role of gut–airway crosstalk in human health and respiratory diseases.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 8","pages":"492-506"},"PeriodicalIF":69.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defending against plasmids 抵御质粒
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-21 DOI: 10.1038/s41579-024-01063-9
Andrea Du Toit
{"title":"Defending against plasmids","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01063-9","DOIUrl":"10.1038/s41579-024-01063-9","url":null,"abstract":"This study reports the mechanism of plasmid clearance by the DNA defence module DdmDE of the Vibrio cholerae seventh pandemic strain.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"387-387"},"PeriodicalIF":88.1,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovering molecular paradigms of microbial carcinogenesis 发现微生物致癌的分子范式
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-20 DOI: 10.1038/s41579-024-01060-y
Carrie L. Shaffer
{"title":"Discovering molecular paradigms of microbial carcinogenesis","authors":"Carrie L. Shaffer","doi":"10.1038/s41579-024-01060-y","DOIUrl":"10.1038/s41579-024-01060-y","url":null,"abstract":"In this Journal Club, Carrie Shaffer discusses a study revealing that infection with CagA-positive Helicobacter pylori strains is associated with an increased risk of developing stomach adenocarcinoma.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"389-389"},"PeriodicalIF":88.1,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking through the concept barrier to develop broad-spectrum antiviral counter-measures 突破概念障碍，开发广谱抗病毒措施
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-20 DOI: 10.1038/s41579-024-01059-5
Yi Shi
{"title":"Breaking through the concept barrier to develop broad-spectrum antiviral counter-measures","authors":"Yi Shi","doi":"10.1038/s41579-024-01059-5","DOIUrl":"10.1038/s41579-024-01059-5","url":null,"abstract":"In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 8","pages":"457-457"},"PeriodicalIF":69.2,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fat, Desulfovibrio and cancer 脂肪、脱硫弧菌和癌症
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-20 DOI: 10.1038/s41579-024-01061-x
Agustina Taglialegna
{"title":"Fat, Desulfovibrio and cancer","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01061-x","DOIUrl":"10.1038/s41579-024-01061-x","url":null,"abstract":"This study by Chen et al. reveals that a high-fat diet leads to a predominance of Desulfovibrio species in the gut, correlating with a poor prognosis of breast cancer.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"388-388"},"PeriodicalIF":88.1,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141069482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracking pathogen evolution through climate change 通过气候变化追踪病原体的演变
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-16 DOI: 10.1038/s41579-024-01057-7
Lia Bote, Mailis Maes
{"title":"Tracking pathogen evolution through climate change","authors":"Lia Bote, Mailis Maes","doi":"10.1038/s41579-024-01057-7","DOIUrl":"10.1038/s41579-024-01057-7","url":null,"abstract":"This Genome Watch article discusses the application of sequencing methods for monitoring the rise of infectious diseases associated with climate change.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"390-390"},"PeriodicalIF":88.1,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viruses on the move 移动中的病毒
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-15 DOI: 10.1038/s41579-024-01056-8
Andrea Du Toit
{"title":"Viruses on the move","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01056-8","DOIUrl":"10.1038/s41579-024-01056-8","url":null,"abstract":"This study shows how two umbravirus-like viruses induce systemic infection in the plant host in the absence of virus-encoded movement proteins.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"388-388"},"PeriodicalIF":88.1,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriocin diversity, function, discovery and application as antimicrobials 细菌素的多样性、功能、发现以及作为抗菌剂的应用
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-10 DOI: 10.1038/s41579-024-01045-x
Ivan Sugrue, R. Paul Ross, Colin Hill
{"title":"Bacteriocin diversity, function, discovery and application as antimicrobials","authors":"Ivan Sugrue, R. Paul Ross, Colin Hill","doi":"10.1038/s41579-024-01045-x","DOIUrl":"10.1038/s41579-024-01045-x","url":null,"abstract":"Bacteriocins are potent antimicrobial peptides that are produced by bacteria. Since their discovery almost a century ago, diverse peptides have been discovered and described, and some are currently used as commercial food preservatives. Many bacteriocins exhibit extensively post-translationally modified structures encoded on complex gene clusters, whereas others have simple linear structures. The molecular structures, mechanisms of action and resistance have been determined for a number of bacteriocins, but most remain incompletely characterized. These gene-encoded peptides are amenable to bioengineering strategies and heterologous expression, enabling metagenomic mining and modification of novel antimicrobials. The ongoing global antimicrobial resistance crisis demands that novel therapeutics be developed to combat infectious pathogens. New compounds that are target-specific and compatible with the resident microbiota would be valuable alternatives to current antimicrobials. As bacteriocins can be broad or narrow spectrum in nature, they are promising tools for this purpose. However, few bacteriocins have gone beyond preclinical trials and none is currently used therapeutically in humans. In this Review, we explore the broad diversity in bacteriocin structure and function, describe identification and optimization methods and discuss the reasons behind the lack of translation beyond the laboratory of these potentially valuable antimicrobials. In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved activity, and discuss their application in microbiome modulation and clinical potential.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 9","pages":"556-571"},"PeriodicalIF":69.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mosquito symbiont controls flaviviruses 一种蚊子共生体控制黄病毒
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-05-10 DOI: 10.1038/s41579-024-01055-9
Agustina Taglialegna
{"title":"A mosquito symbiont controls flaviviruses","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01055-9","DOIUrl":"10.1038/s41579-024-01055-9","url":null,"abstract":"In this study, Zhang et al. report that a bacterial symbiont residing in the gut of Aedes albopictus mosquitoes protects them from flavivirus infection.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 7","pages":"387-387"},"PeriodicalIF":88.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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