Nature Reviews Microbiology最新文献_第10页

The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer 肠道微生物组和膳食纤维：对肥胖、心脏代谢疾病和癌症的影响

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-10 DOI: 10.1038/s41579-024-01108-z

Nathalie M. Delzenne, Laure B. Bindels, Audrey M. Neyrinck, Jens Walter

{"title":"The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer","authors":"Nathalie M. Delzenne, Laure B. Bindels, Audrey M. Neyrinck, Jens Walter","doi":"10.1038/s41579-024-01108-z","DOIUrl":"10.1038/s41579-024-01108-z","url":null,"abstract":"Dietary fibres constitute a heterogeneous class of nutrients that are key in the prevention of various chronic diseases. Most dietary fibres are fermented by the gut microbiome and may, thereby, modulate the gut microbial ecology and metabolism, impacting human health. Dietary fibres may influence the occurrence of specific bacterial taxa, with this effect varying between individuals. The effect of dietary fibres on microbial diversity is a matter of debate. Most intervention studies with dietary fibres in the context of obesity and related metabolic disorders reveal the need for an accurate assessment of the microbiome to better understand the variable response to dietary fibres. Epidemiological studies confirm that a high dietary fibre intake is strongly associated with a reduced occurrence of many types of cancer. However, there is a need to determine the impact of intervention with specific dietary fibres on cancer risk, therapy efficacy and toxicity, as well as in cancer cachexia. In this Review, we summarize the mechanisms by which the gut microbiome can mediate the physiological benefits of dietary fibres in the contexts of obesity, cardiometabolic diseases and cancer, their incidence being clearly linked to low dietary fibre intake. In this Review, Delzenne et al. explore how dietary fibres interact with and modulate the gut microbiota, and discuss their effects on human physiology, particularly in the context of obesity, cardiometabolic diseases and cancer.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"225-238"},"PeriodicalIF":69.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142397749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial small molecule metabolites implicated in gastrointestinal cancer development 与胃肠道癌症发展有关的细菌小分子代谢物

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-07 DOI: 10.1038/s41579-024-01103-4

Tayah Turocy, Jason M. Crawford

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Towards next-generation treatment options to combat Plasmodium falciparum malaria 开发抗击恶性疟原虫疟疾的新一代治疗方案

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-10-04 DOI: 10.1038/s41579-024-01099-x

John Okombo, David A. Fidock

{"title":"Towards next-generation treatment options to combat Plasmodium falciparum malaria","authors":"John Okombo, David A. Fidock","doi":"10.1038/s41579-024-01099-x","DOIUrl":"10.1038/s41579-024-01099-x","url":null,"abstract":"Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic vaccines RTS, S/AS01 and R21/Matrix-M has ushered in hope of substantial reductions in mortality rates, especially when combined with other existing interventions. However, the efficacy of these vaccines is partial, and chemotherapy remains central to malaria treatment and control. For many antimalarial drugs, clinical efficacy has been compromised by the emergence of drug-resistant Plasmodium falciparum strains. Therefore, there is an urgent need for new antimalarial medicines to complement the existing first-line artemisinin-based combination therapies. In this Review, we discuss various opportunities to expand the present malaria treatment space, appraise the current antimalarial drug development pipeline and highlight examples of promising targets. We also discuss other approaches to circumvent antimalarial resistance and how potency against drug-resistant parasites could be retained. In this Review, Okombo and Fidock discuss the current antimalarial drug development pipeline and highlight examples of new, promising targets. They also explore different approaches to circumvent antimalarial resistance and how potency against drug-resistant parasites could be retained.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 3","pages":"178-191"},"PeriodicalIF":69.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial extracellular polymeric substances in the environment, technology and medicine 环境、技术和医学中的微生物胞外聚合物物质

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-27 DOI: 10.1038/s41579-024-01098-y

Hans-Curt Flemming, Eric D. van Hullebusch, Brenda J. Little, Thomas R. Neu, Per H. Nielsen, Thomas Seviour, Paul Stoodley, Jost Wingender, Stefan Wuertz

{"title":"Microbial extracellular polymeric substances in the environment, technology and medicine","authors":"Hans-Curt Flemming, Eric D. van Hullebusch, Brenda J. Little, Thomas R. Neu, Per H. Nielsen, Thomas Seviour, Paul Stoodley, Jost Wingender, Stefan Wuertz","doi":"10.1038/s41579-024-01098-y","DOIUrl":"10.1038/s41579-024-01098-y","url":null,"abstract":"Microbial biofilms exhibit a self-produced matrix of extracellular polymeric substances (EPS), including polysaccharides, proteins, extracellular DNA and lipids. EPS promote interactions of the biofilm with other cells and sorption of organics, metals and chemical pollutants, and they facilitate cell adhesion at interfaces and ensure matrix cohesion. EPS have roles in various natural environments, such as soils, sediments and marine habitats. In addition, EPS are relevant in technical environments, such as wastewater and drinking water treatment facilities, and water distribution systems, and they contribute to biofouling and microbially influenced corrosion. In medicine, EPS protect pathogens within the biofilm against the host immune system and antimicrobials, and emerging evidence suggests that EPS can represent potential virulence factors. By contrast, EPS yield a wide range of valuable products that include their role in self-repairing concrete. In this Review, we aim to explore EPS as a functional unit of biofilms in the environment, in technology and in medicine. In this Review, Flemming and colleagues aim to explore the roles of microbial extracellular polymeric substances in the environment, in technology and in medicine.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 2","pages":"87-105"},"PeriodicalIF":69.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The rising mpox crisis 不断上升的麻疹危机

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-20 DOI: 10.1038/s41579-024-01114-1

Agustina Taglialegna

引用次数: 0

Publisher Correction: Microorganisms, climate change, and the Sustainable Development Goals: progress and challenges 出版商更正：微生物、气候变化和可持续发展目标：进展与挑战。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-20 DOI: 10.1038/s41579-024-01111-4

Janet K. Jansson

引用次数: 0

ISME19 ISME19

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-20 DOI: 10.1038/s41579-024-01113-2

Agustina Taglialegna

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Publisher Correction: Unveiling plasmid diversity in nature 出版商更正：揭示自然界质粒的多样性。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-19 DOI: 10.1038/s41579-024-01112-3

Antonio Pedro Camargo

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Challenges and strategies for addressing antibacterial drug resistance in LMICs 应对低收入和中等收入国家抗菌药物耐药性的挑战和战略

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-13 DOI: 10.1038/s41579-024-01080-8

Ursula Theuretzbacher

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Stronger commitment and faster action against antimicrobial resistance 做出更坚定的承诺，采取更迅速的行动，消除抗生素耐药性

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-09-13 DOI: 10.1038/s41579-024-01089-z

引用次数: 0