Nature Reviews Microbiology最新文献_第9页

The pathobiology of human fungal infections 人类真菌感染的病理生物学

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-25 DOI: 10.1038/s41579-024-01062-w

Gordon D. Brown, Elizabeth R. Ballou, Steven Bates, Elaine M. Bignell, Andrew M. Borman, Alexandra C. Brand, Alistair J. P. Brown, Carolina Coelho, Peter C. Cook, Rhys A. Farrer, Nelesh P. Govender, Neil A. R. Gow, William Hope, J. Claire Hoving, Rachael Dangarembizi, Thomas S. Harrison, Elizabeth M. Johnson, Liliane Mukaremera, Mark Ramsdale, Christopher R. Thornton, Jane Usher, Adilia Warris, Duncan Wilson

{"title":"The pathobiology of human fungal infections","authors":"Gordon D. Brown, Elizabeth R. Ballou, Steven Bates, Elaine M. Bignell, Andrew M. Borman, Alexandra C. Brand, Alistair J. P. Brown, Carolina Coelho, Peter C. Cook, Rhys A. Farrer, Nelesh P. Govender, Neil A. R. Gow, William Hope, J. Claire Hoving, Rachael Dangarembizi, Thomas S. Harrison, Elizabeth M. Johnson, Liliane Mukaremera, Mark Ramsdale, Christopher R. Thornton, Jane Usher, Adilia Warris, Duncan Wilson","doi":"10.1038/s41579-024-01062-w","DOIUrl":"10.1038/s41579-024-01062-w","url":null,"abstract":"Human fungal infections are a historically neglected area of disease research, yet they cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of these infections has increased considerably over the past decade, through major insights into both the host and pathogen factors that contribute to the phenotype and severity of these diseases. Recent studies are revealing multiple mechanisms by which fungi modify and manipulate the host, escape immune surveillance and generate complex comorbidities. Although the emergence of fungal strains that are less susceptible to antifungal drugs or that rapidly evolve drug resistance is posing new threats, greater understanding of immune mechanisms and host susceptibility factors is beginning to offer novel immunotherapeutic options for the future. In this Review, we provide a broad and comprehensive overview of the pathobiology of human fungal infections, focusing specifically on pathogens that can cause invasive life-threatening infections, highlighting recent discoveries from the pathogen, host and clinical perspectives. We conclude by discussing key future challenges including antifungal drug resistance, the emergence of new pathogens and new developments in modern medicine that are promoting susceptibility to infection. In this Review, Brown et al. provide an overview of fungal pathobiology from the pathogen, host and clinical perspectives, focusing specifically on pathogens that can cause invasive life-threatening infections.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"687-704"},"PeriodicalIF":69.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pertussis vaccines, epidemiology and evolution 百日咳疫苗、流行病学和演变

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-21 DOI: 10.1038/s41579-024-01064-8

Matthieu Domenech de Cellès, Pejman Rohani

{"title":"Pertussis vaccines, epidemiology and evolution","authors":"Matthieu Domenech de Cellès, Pejman Rohani","doi":"10.1038/s41579-024-01064-8","DOIUrl":"10.1038/s41579-024-01064-8","url":null,"abstract":"Pertussis, which is caused by Bordetella pertussis, has plagued humans for at least 800 years, is highly infectious and can be fatal in the unvaccinated, especially very young infants. Although the rollout of whole-cell pertussis (wP) vaccines in the 1940s and 1950s was associated with a drastic drop in incidence, concerns regarding the reactogenicity of wP vaccines led to the development of a new generation of safer, acellular (aP) vaccines that have been adopted mainly in high-income countries. Over the past 20 years, some countries that boast high aP coverage have experienced a resurgence in pertussis, which has led to substantial debate over the basic immunology, epidemiology and evolutionary biology of the bacterium. Controversy surrounds the duration of natural immunity and vaccine-derived immunity, the ability of vaccines to prevent transmission and severe disease, and the impact of evolution on evading vaccine immunity. Resolving these issues is made challenging by incomplete detection of pertussis cases, the absence of a serological marker of immunity, modest sequencing of the bacterial genome and heterogeneity in diagnostic methods of surveillance. In this Review, we lay out the complexities of contemporary pertussis and, where possible, propose a parsimonious explanation for apparently incongruous observations. In this Review, Domenech de Cellès and Rohani explore the contemporary epidemiology of pertussis and discuss the controversies surrounding the mechanisms responsible for the re-emergence of pertussis, including the effectiveness and duration of natural immunity and vaccine-derived immunity, the ability of vaccines to prevent transmission and severe disease, and the impact of evolution on evading vaccine immunity.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"722-735"},"PeriodicalIF":69.2,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141435850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteria curb emissions in farmland 细菌抑制农田中的废气排放

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-20 DOI: 10.1038/s41579-024-01071-9

Agustina Taglialegna

引用次数: 0

Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics 粪肠球菌：进化、适应、致病机理和新兴疗法。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-18 DOI: 10.1038/s41579-024-01058-6

Yahan Wei, Dennise Palacios Araya, Kelli L. Palmer

{"title":"Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics","authors":"Yahan Wei, Dennise Palacios Araya, Kelli L. Palmer","doi":"10.1038/s41579-024-01058-6","DOIUrl":"10.1038/s41579-024-01058-6","url":null,"abstract":"The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emergence of vancomycin-resistant E. faecium, which causes many hospital-acquired infections. In this Review, we explore recent discoveries about the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of E. faecium and vancomycin-resistant E. faecium. These studies provide critical insights necessary for developing novel preventive and therapeutic approaches against vancomycin-resistant E. faecium and also reveal the intricate interrelationships between the environment, the microorganism and the host, providing knowledge that is broadly relevant to how antibiotic-resistant pathogens emerge and endure. This Review explores recent insights into the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of Enterococcus faecium, and highlight potential novel preventative and therapeutic approaches to its infections.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"705-721"},"PeriodicalIF":69.2,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gassy archaea 气态古菌

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-18 DOI: 10.1038/s41579-024-01072-8

Andrea Du Toit

引用次数: 0

A virus hastens ageing in flies 一种病毒加速了苍蝇的衰老

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-14 DOI: 10.1038/s41579-024-01070-w

Agustina Taglialegna

引用次数: 0

Supra-structures to target lipid II 针对脂质 II 的超结构。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-11 DOI: 10.1038/s41579-024-01066-6

Andrea Du Toit

引用次数: 0

ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics ESKAPE 病原体：抗菌药耐药性、流行病学、临床影响和疗法

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-03 DOI: 10.1038/s41579-024-01054-w

William R. Miller, Cesar A. Arias

{"title":"ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics","authors":"William R. Miller, Cesar A. Arias","doi":"10.1038/s41579-024-01054-w","DOIUrl":"10.1038/s41579-024-01054-w","url":null,"abstract":"The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been recognized as emerging threats to public health. The ESKAPE pathogens — Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. — were initially identified as critical multidrug-resistant bacteria for which effective therapies were rapidly needed. Now, entering the third decade of the twenty-first century, and despite the introduction of several new antibiotics and antibiotic adjuvants, such as novel β-lactamase inhibitors, these organisms continue to represent major therapeutic challenges. These bacteria share several key biological features, including adaptations for survival in the modern health-care setting, diverse methods for acquiring resistance determinants and the dissemination of successful high-risk clones around the world. With the advent of next-generation sequencing, novel tools to track and combat the spread of these organisms have rapidly evolved, as well as renewed interest in non-traditional antibiotic approaches. In this Review, we explore the current epidemiology and clinical impact of this important group of bacterial pathogens and discuss relevant mechanisms of resistance to recently introduced antibiotics that affect their use in clinical settings. Furthermore, we discuss emerging therapeutic strategies needed for effective patient care in the era of widespread antimicrobial resistance. In this Review, Miller and Arias summarize recent advances in understanding ESKAPE pathogens, focusing on their molecular epidemiology, clinical impact, emerging mechanisms of resistance and novel therapeutic approaches.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"598-616"},"PeriodicalIF":69.2,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A spatially constrained independent component analysis jointly informed by structural and functional network connectivity. 由结构和功能网络连通性共同提供信息的空间约束独立成分分析。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-06-01 DOI: 10.1101/2023.08.13.553101

Mahshid Fouladivanda, Armin Iraji, Lei Wu, Theodorus G M van Erp, Aysenil Belger, Faris Hawamdeh, Godfrey D Pearlson, Vince D Calhoun

{"title":"A spatially constrained independent component analysis jointly informed by structural and functional network connectivity.","authors":"Mahshid Fouladivanda, Armin Iraji, Lei Wu, Theodorus G M van Erp, Aysenil Belger, Faris Hawamdeh, Godfrey D Pearlson, Vince D Calhoun","doi":"10.1101/2023.08.13.553101","DOIUrl":"10.1101/2023.08.13.553101","url":null,"abstract":"<p><p>There are a growing number of neuroimaging studies motivating joint structural and functional brain connectivity. Brain connectivity of different modalities provides insight into brain functional organization by leveraging complementary information, especially for brain disorders such as schizophrenia. In this paper, we propose a multi-modal independent component analysis (ICA) model that utilizes information from both structural and functional brain connectivity guided by spatial maps to estimate intrinsic connectivity networks (ICNs). Structural connectivity is estimated through whole-brain tractography on diffusion-weighted MRI (dMRI), while functional connectivity is derived from resting-state functional MRI (rs-fMRI). The proposed structural-functional connectivity and spatially constrained ICA (sfCICA) model estimates ICNs at the subject level using a multi-objective optimization framework. We evaluated our model using synthetic and real datasets (including dMRI and rs-fMRI from 149 schizophrenia patients and 162 controls). Multi-modal ICNs revealed enhanced functional coupling between ICNs with higher structural connectivity, improved modularity, and network distinction, particularly in schizophrenia. Statistical analysis of group differences showed more significant differences in the proposed model compared to the unimodal model. In summary, the sfCICA model showed benefits from being jointly informed by structural and functional connectivity. These findings suggest advantages in simultaneously learning effectively and enhancing connectivity estimates using structural connectivity.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"10 1","pages":""},"PeriodicalIF":69.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79617989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co‐evolution of early Earth environments and microbial life 早期地球环境与微生物生命的共同进化。

IF 69.2 1区生物学

Nature Reviews Microbiology Pub Date : 2024-05-29 DOI: 10.1038/s41579-024-01044-y

Timothy W. Lyons, Christopher J. Tino, Gregory P. Fournier, Rika E. Anderson, William D. Leavitt, Kurt O. Konhauser, Eva E. Stüeken

{"title":"Co‐evolution of early Earth environments and microbial life","authors":"Timothy W. Lyons, Christopher J. Tino, Gregory P. Fournier, Rika E. Anderson, William D. Leavitt, Kurt O. Konhauser, Eva E. Stüeken","doi":"10.1038/s41579-024-01044-y","DOIUrl":"10.1038/s41579-024-01044-y","url":null,"abstract":"Two records of Earth history capture the evolution of life and its co-evolving ecosystems with interpretable fidelity: the geobiological and geochemical traces preserved in rocks and the evolutionary histories captured within genomes. The earliest vestiges of life are recognized mostly in isotopic fingerprints of specific microbial metabolisms, whereas fossils and organic biomarkers become important later. Molecular biology provides lineages that can be overlayed on geologic and geochemical records of evolving life. All these data lie within a framework of biospheric evolution that is primarily characterized by the transition from an oxygen-poor to an oxygen-rich world. In this Review, we explore the history of microbial life on Earth and the degree to which it shaped, and was shaped by, fundamental transitions in the chemical properties of the oceans, continents and atmosphere. We examine the diversity and evolution of early metabolic processes, their couplings with biogeochemical cycles and their links to the oxygenation of the early biosphere. We discuss the distinction between the beginnings of metabolisms and their subsequent proliferation and their capacity to shape surface environments on a planetary scale. The evolution of microbial life and its ecological impacts directly mirror the Earth’s chemical and physical evolution through cause-and-effect relationships. In this Review, Lyons, Tino and colleagues explore the evolution of microbial life on Earth and examine the diversity of early microbial metabolic pathways, their associations with biogeochemical cycles and how they shaped and responded to changing surface environments over billions of years.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 9","pages":"572-586"},"PeriodicalIF":69.2,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0