Nature Reviews Microbiology最新文献_第2页

Gut microorganisms in the middle of drug-drug interactions. 药物-药物相互作用中的肠道微生物。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-04-17 DOI: 10.1038/s41579-026-01308-9

Andrea Du Toit

引用次数: 0

Mpox emergence, epidemiology, biology, clinical features and control. m痘的出现、流行病学、生物学、临床特征和控制。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-04-08 DOI: 10.1038/s41579-026-01305-y

Dimie Ogoina,Jake Dunning,Inger Damon,Placide Mbala,Krutika Kuppalli

{"title":"Mpox emergence, epidemiology, biology, clinical features and control.","authors":"Dimie Ogoina,Jake Dunning,Inger Damon,Placide Mbala,Krutika Kuppalli","doi":"10.1038/s41579-026-01305-y","DOIUrl":"https://doi.org/10.1038/s41579-026-01305-y","url":null,"abstract":"Mpox, a zoonotic orthopoxvirus disease, has transitioned from a rare infection confined to African rainforests to a global public health threat. Originally identified in laboratory monkeys in 1958, the first human case was documented in 1970 in the Democratic Republic of Congo. Following the declaration of smallpox eradication in 1980 and the subsequent cessation of smallpox vaccination, mpox cases persisted at low levels before surging, ultimately leading to the declaration of two Public Health Emergencies of International Concern by the WHO in 2022 and 2024, and the Africa CDC declaration of mpox as a Public Health Emergency of Continental Security in August 2024. Monkeypox virus comprises two major clades: clade I (formerly the Central African clade) subdivided into Ia and emerging Ib variants, and clade II (formerly the West African clade) also subdivided into IIa and the globally circulating IIb subclade. Recent outbreaks demonstrate enhanced human-to-human transmission, particularly through sexual networks, challenging traditional epidemiological patterns. Clinical presentation varies by clade and transmission route, ranging from classical centrifugal rash with high lesion counts to localized anogenital lesions. This Review outlines the emergency, epidemiology, biology, transmission dynamics, risk factors, clinical characteristics, and prevention and control strategies of mpox, and identifies future priorities for addressing this ongoing global issue.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"43 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The aquatic plastisphere: ecology, pathogen dissemination and antimicrobial resistance. 水生塑料圈：生态学、病原体传播和抗菌素耐药性。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-04-02 DOI: 10.1038/s41579-026-01301-2

Michael J Ormsby,Richard S Quilliam

{"title":"The aquatic plastisphere: ecology, pathogen dissemination and antimicrobial resistance.","authors":"Michael J Ormsby,Richard S Quilliam","doi":"10.1038/s41579-026-01301-2","DOIUrl":"https://doi.org/10.1038/s41579-026-01301-2","url":null,"abstract":"The escalating volume of plastic debris in the aquatic environment has created a novel ecological niche for microorganisms. This habitat, known as the plastisphere, hosts ecologically diverse microbial communities, yet its degree of divergence in composition and function from natural substrates remains a key topic of debate. In this Review, we provide a comprehensive overview of the aquatic plastisphere, highlighting its community composition, assembly dynamics and key functional traits, such as degradation pathways and nutrient cycling. We explore how this novel environment acts as a critical hub for the persistence and dissemination of human pathogens and antimicrobial resistance. We discuss how dynamic environmental factors, together with complex inter-kingdom metabolic interactions, can reshape community composition, accelerate the evolution of resistant pathotypes and influence pathogen virulence. We conclude by emphasizing that climate-induced changes in temperature, ultraviolet light radiation, salinity and hydrodynamic patterns are likely to further influence the microbial composition and phenotypic expression of pathogens within the aquatic plastisphere. Finally, we underscore the need for a One Health approach to study the plastisphere and advocate moving the field from descriptive ecology towards a mechanistic, policy-relevant framework to address the growing public health threat amid accelerating plastic pollution and climate-driven shifts.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"18 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging microbial phylogeny for computational efficiency. 利用微生物系统发育提高计算效率。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-30 DOI: 10.1038/s41579-026-01303-0

Zachary Ardern

引用次数: 0

Candida albicans steals magnesium and Pseudomonas aeruginosa unleashes resistance 白色念珠菌窃取镁，铜绿假单胞菌释放耐药性。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-26 DOI: 10.1038/s41579-026-01304-z

Diana S. M. Ottoz

引用次数: 0

Microbial phosphorus cycling in terrestrial ecosystems 陆地生态系统中微生物磷循环

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-24 DOI: 10.1038/s41579-026-01296-w

Josep Peñuelas, Bangxiao Zheng, Akash Tariq, Jordi Sardans

引用次数: 0

A trapped polymerase hastens avian influenza virus evolution 捕获的聚合酶加速了禽流感病毒的进化。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-20 DOI: 10.1038/s41579-026-01302-1

Andrea Du Toit

引用次数: 0

Bacterial allies against food anaphylaxis 细菌同盟对抗食物过敏反应。

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-20 DOI: 10.1038/s41579-026-01300-3

Agustina Taglialegna

引用次数: 0

Human herpesvirus evasion of humoral immunity and implications for vaccine development. 人类疱疹病毒逃避体液免疫及其对疫苗开发的影响。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-13 DOI: 10.1038/s41579-026-01295-x

Claire E Otero,Matthew D Slein,Libby Mitchell,Adarsh Ramloul,Philipp Kolb,Margaret E Ackerman,Sallie R Permar

引用次数: 0

Impacts of climate extremes on plant pathogens, microbiomes and plant health. 极端气候对植物病原体、微生物群和植物健康的影响。

IF 88.1 1区生物学

Nature Reviews Microbiology Pub Date : 2026-03-11 DOI: 10.1038/s41579-026-01290-2

Chao Xiong,An-Hui Ge,Min Gao,Brajesh K Singh

{"title":"Impacts of climate extremes on plant pathogens, microbiomes and plant health.","authors":"Chao Xiong,An-Hui Ge,Min Gao,Brajesh K Singh","doi":"10.1038/s41579-026-01290-2","DOIUrl":"https://doi.org/10.1038/s41579-026-01290-2","url":null,"abstract":"Plant diseases pose a great risk to global food security, and recent research indicates that pathogen pressures on plant productivity will substantially increase under ongoing climate change (that is, increasing CO2 levels and global warming). However, our mechanistic and predictive knowledge of the impacts of climate extremes, such as heatwaves and prolonged droughts, and their interaction with other climatic factors, on plant pathogens, hosts and microbiomes, remains largely unknown. This is an important knowledge gap that limits our ability to develop effective strategies to mitigate the socioeconomic impacts of climate change-induced plant disease outbreaks. This Review examines the impacts of key climate extremes on soil-borne pathogens, plant microbiomes and host physiology that ultimately determine disease outcomes. We explore evidence that suggests that the responses of pathogen-host-microbiome interactions to climate extremes may differ in many ways from those to long-term climate change. Climate extremes may increase the virulence and distribution of many pathogens, suppress certain plant immune responses, and weaken the core functions of host microbiomes within the disease triangle, thereby facilitating disease outbreaks. We propose an integrated pathway for harnessing microbiomes to address the critical challenges posed by climate extremes. These insights offer new approaches to mitigate disease risks by harnessing microbiomes and metabolites under climate extremes, with the potential to support climate-resilient and sustainable agricultural and natural ecosystems.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"1 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0