Nature Reviews Microbiology最新文献

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Sticky Candida auris 粘性耳念珠菌。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-13 DOI: 10.1038/s41579-023-00986-z
Andrea Du Toit
{"title":"Sticky Candida auris","authors":"Andrea Du Toit","doi":"10.1038/s41579-023-00986-z","DOIUrl":"10.1038/s41579-023-00986-z","url":null,"abstract":"This study reports the identification of the novel Candida auris-specific adhesin Scf1, which, together with the adhesin Iff4109, is a key mediator of surface association, infection and long-term colonization.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 12","pages":"770-770"},"PeriodicalIF":88.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Algal blooms in the ocean: hot spots for chemically mediated microbial interactions 海洋中的藻类水华:化学介导的微生物相互作用的热点。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-13 DOI: 10.1038/s41579-023-00975-2
Constanze Kuhlisch, Adva Shemi, Noa Barak-Gavish, Daniella Schatz, Assaf Vardi
{"title":"Algal blooms in the ocean: hot spots for chemically mediated microbial interactions","authors":"Constanze Kuhlisch, Adva Shemi, Noa Barak-Gavish, Daniella Schatz, Assaf Vardi","doi":"10.1038/s41579-023-00975-2","DOIUrl":"10.1038/s41579-023-00975-2","url":null,"abstract":"The cycling of major nutrients in the ocean is affected by large-scale phytoplankton blooms, which are hot spots of microbial life. Diverse microbial interactions regulate bloom dynamics. At the single-cell level, interactions between microorganisms are mediated by small molecules in the chemical crosstalk that determines the type of interaction, ranging from mutualism to pathogenicity. Algae interact with viruses, bacteria, parasites, grazers and other algae to modulate algal cell fate, and these interactions are dependent on the environmental context. Recent advances in mass spectrometry and single-cell technologies have led to the discovery of a growing number of infochemicals — metabolites that convey information — revealing the ability of algal cells to govern biotic interactions in the ocean. The diversity of infochemicals seems to account for the specificity in cellular response during microbial communication. Given the immense impact of algal blooms on biogeochemical cycles and climate regulation, a major challenge is to elucidate how microscale interactions control the fate of carbon and the recycling of major elements in the ocean. In this Review, we discuss microbial interactions and the role of infochemicals in algal blooms. We further explore factors that can impact microbial interactions and the available tools to decipher them in the natural environment. In this Review, Vardi and colleagues examine the different microbial interactions that modulate algal blooms in the ocean, discuss the role of microbial chemicals in mediating such interactions and explore the latest technological developments aimed at deepening our understanding of cellular communication in the ocean.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 3","pages":"138-154"},"PeriodicalIF":88.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial metabolism influences insulin resistance 细菌代谢影响胰岛素抵抗。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-12 DOI: 10.1038/s41579-023-00977-0
Ashley York
{"title":"Bacterial metabolism influences insulin resistance","authors":"Ashley York","doi":"10.1038/s41579-023-00977-0","DOIUrl":"10.1038/s41579-023-00977-0","url":null,"abstract":"A recent study found that carbohydrate metabolism by gut microbiota contributes to insulin resistance.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 11","pages":"703-703"},"PeriodicalIF":88.1,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapting to host life 适应主人的生活。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-12 DOI: 10.1038/s41579-023-00976-1
Ashley York
{"title":"Adapting to host life","authors":"Ashley York","doi":"10.1038/s41579-023-00976-1","DOIUrl":"10.1038/s41579-023-00976-1","url":null,"abstract":"This study found that the bacterial second messenger cyclic diguanylate (c-di-GMP) has a key role in establishing host–bacteria symbiosis.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 11","pages":"702-702"},"PeriodicalIF":88.1,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing AI-supported Research Highlights 介绍人工智能支持的研究亮点。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-12 DOI: 10.1038/s41579-023-00978-z
{"title":"Introducing AI-supported Research Highlights","authors":"","doi":"10.1038/s41579-023-00978-z","DOIUrl":"10.1038/s41579-023-00978-z","url":null,"abstract":"With the debut of our AI-supported Research Highlights, we combine advances in large language models with the trust and expertise of human editors.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 11","pages":"701-701"},"PeriodicalIF":88.1,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41579-023-00978-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Small RNAs and their mighty roles in plasmid replication 作者更正:小RNA及其在质粒复制中的强大作用。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-12 DOI: 10.1038/s41579-023-00983-2
Edmund Loh
{"title":"Author Correction: Small RNAs and their mighty roles in plasmid replication","authors":"Edmund Loh","doi":"10.1038/s41579-023-00983-2","DOIUrl":"10.1038/s41579-023-00983-2","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 12","pages":"833-833"},"PeriodicalIF":88.1,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41579-023-00983-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and functional diversity of type IV secretion systems IV型分泌系统的结构和功能多样性。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-09 DOI: 10.1038/s41579-023-00974-3
Tiago R. D. Costa, Jonasz B. Patkowski, Kévin Macé, Peter J. Christie, Gabriel Waksman
{"title":"Structural and functional diversity of type IV secretion systems","authors":"Tiago R. D. Costa, Jonasz B. Patkowski, Kévin Macé, Peter J. Christie, Gabriel Waksman","doi":"10.1038/s41579-023-00974-3","DOIUrl":"10.1038/s41579-023-00974-3","url":null,"abstract":"Considerable progress has been made in recent years in the structural and molecular biology of type IV secretion systems in Gram-negative bacteria. The latest advances have substantially improved our understanding of the mechanisms underlying the recruitment and delivery of DNA and protein substrates to the extracellular environment or target cells. In this Review, we aim to summarize these exciting structural and molecular biology findings and to discuss their functional implications for substrate recognition, recruitment and translocation, as well as the biogenesis of extracellular pili. We also describe adaptations necessary for deploying a breadth of processes, such as bacterial survival, host–pathogen interactions and biotic and abiotic adhesion. We highlight the functional and structural diversity that allows this extremely versatile secretion superfamily to function under different environmental conditions and in different bacterial species. Additionally, we emphasize the importance of further understanding the mechanism of type IV secretion, which will support us in combating antimicrobial resistance and treating type IV secretion system-related infections. In this Review, Costa and colleagues summarize the current knowledge of type IV secretion system functioning in Gram-negative bacteria, with a focus on their architectures and adaptations for specialized functions. They also explore the biogenesis pathways and spatial localization of type IV secretion systems.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 3","pages":"170-185"},"PeriodicalIF":88.1,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The HIV epidemic 40 years on 艾滋病流行40年了。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-09 DOI: 10.1038/s41579-023-00979-y
Linda-Gail Bekker
{"title":"The HIV epidemic 40 years on","authors":"Linda-Gail Bekker","doi":"10.1038/s41579-023-00979-y","DOIUrl":"10.1038/s41579-023-00979-y","url":null,"abstract":"In 1981, acquired immunodeficiency syndrome (AIDS) was first recognized and, by 1983, the aetiological agent, human immunodeficiency virus (HIV), had been identified. The development and roll out of antiretroviral therapy has led to a reversal of the devastating mortality. Despite substantial progress, the epidemic is far from over and renewed global commitment is urgently needed to ensure the goal of epidemic control by 2030 is met. This Comment article highlights the progress that has been made over the past 40 years since the discovery of HIV, and discusses the commitment needed to end the HIV/AIDS epidemic and the ongoing challenges.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 12","pages":"767-768"},"PeriodicalIF":88.1,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibre-deprived Akkermansia worsens food allergy 缺乏纤维的阿克曼病会加重食物过敏。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-06 DOI: 10.1038/s41579-023-00982-3
Agustina Taglialegna
{"title":"Fibre-deprived Akkermansia worsens food allergy","authors":"Agustina Taglialegna","doi":"10.1038/s41579-023-00982-3","DOIUrl":"10.1038/s41579-023-00982-3","url":null,"abstract":"This study shows how the bacterium Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 12","pages":"769-769"},"PeriodicalIF":88.1,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burkholderia pseudomallei and melioidosis 假槌伯克霍尔德菌和类鼻疽。
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2023-10-04 DOI: 10.1038/s41579-023-00972-5
Ella M. Meumann, Direk Limmathurotsakul, Susanna J. Dunachie, Willem J. Wiersinga, Bart J. Currie
{"title":"Burkholderia pseudomallei and melioidosis","authors":"Ella M. Meumann, Direk Limmathurotsakul, Susanna J. Dunachie, Willem J. Wiersinga, Bart J. Currie","doi":"10.1038/s41579-023-00972-5","DOIUrl":"10.1038/s41579-023-00972-5","url":null,"abstract":"Burkholderia pseudomallei, the causative agent of melioidosis, is found in soil and water of tropical and subtropical regions globally. Modelled estimates of the global burden predict that melioidosis remains vastly under-reported, and a call has been made for it to be recognized as a neglected tropical disease by the World Health Organization. Severe weather events and environmental disturbance are associated with increased case numbers, and it is anticipated that, in some regions, cases will increase in association with climate change. Genomic epidemiological investigations have confirmed B. pseudomallei endemicity in newly recognized regions, including the southern United States. Melioidosis follows environmental exposure to B. pseudomallei and is associated with comorbidities that affect the immune response, such as diabetes, and with socioeconomic disadvantage. Several vaccine candidates are ready for phase I clinical trials. In this Review, we explore the global burden, epidemiology and pathophysiology of B. pseudomallei as well as current diagnostics, treatment recommendations and preventive measures, highlighting research needs and priorities. In this Review, Meumann et al. discuss current knowledge on Burkholderia pseudomallei virulence and interaction with the host, and examine the epidemiology of melioidosis, offering insights into diagnosis, treatment and prevention strategies for this disease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 3","pages":"155-169"},"PeriodicalIF":88.1,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41134095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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