Antimicrobial peptides: structure, functions and translational applications

IF 69.2 1区 生物学 Q1 MICROBIOLOGY
Nelson G. Oliveira Júnior, Camila M. Souza, Danieli F. Buccini, Marlon H. Cardoso, Octávio L. Franco
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引用次数: 0

Abstract

Novel solutions to combat the rapid evolution of antimicrobial resistance in human and animal pathogens are urgently required. Antimicrobial peptides (AMPs) represent promising therapeutic molecules, as they exhibit structural nuances and distinct molecular targets against pathogenic microorganisms. In this Review, we explore the multifaceted structural nature of AMPs and advanced structural conformations, discuss the distinct mechanisms of action and explore novel targets. Additionally, we discuss resistance mechanisms, cross-resistance and innovative strategies for AMP design and optimization. We argue that gaining insight into novel AMP structural arrangements, targets and design optimization is crucial for the development of innovative therapies that can be translated into clinical as well as broader applications.

Abstract Image

抗菌肽:结构、功能和翻译应用
迫切需要新的解决方案来对抗人类和动物病原体中抗菌素耐药性的快速演变。抗菌肽(AMPs)是一种很有前景的治疗分子,因为它们具有结构上的细微差别和针对病原微生物的独特分子靶点。在这篇综述中,我们探讨了amp的多面结构性质和先进的结构构象,讨论了不同的作用机制和探索新的靶点。此外,我们还讨论了电阻机制、交叉电阻以及AMP设计和优化的创新策略。我们认为,深入了解新的AMP结构安排、靶点和设计优化对于开发创新疗法至关重要,这些疗法可以转化为临床和更广泛的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Reviews Microbiology
Nature Reviews Microbiology 生物-微生物学
CiteScore
74.00
自引率
0.50%
发文量
149
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Microbiology, our goal is to become the leading source of reviews and commentaries for the scientific community we cater to. We are dedicated to publishing articles that are not only authoritative but also easily accessible, supplementing them with clear and concise figures, tables, and other visual aids. Our objective is to offer an unparalleled service to authors, referees, and readers, and we continuously strive to maximize the usefulness and impact of each article we publish. With a focus on Reviews, Perspectives, and Comments spanning the entire field of microbiology, our wide scope ensures that the work we feature reaches the widest possible audience.
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