{"title":"Achieving sustainable access to antibiotics is more than just a last mile challenge","authors":"Manica Balasegaram, Viviana Muñoz Tellez","doi":"10.1038/s41579-024-01083-5","DOIUrl":"10.1038/s41579-024-01083-5","url":null,"abstract":"Improving access to antibiotics will save lives and reduce the rise and spread of drug-resistant infections. Instead of traditional ‘last mile’ global health solutions, global leaders need to support efforts to develop suitable antibiotics and their rational use, ensuring that countries have the capacity to make them available.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"593-594"},"PeriodicalIF":69.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"No viral rebound","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01109-y","DOIUrl":"10.1038/s41579-024-01109-y","url":null,"abstract":"A new study reports sustained HIV remission in an individual who underwent allogeneic haematopoietic stem cell transplantation with cells from a donor with wild-type CCR5.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"667-667"},"PeriodicalIF":69.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rediscovering plasmid-dependent phages","authors":"Daniel Cazares, Wendy Figueroa, Adrian Cazares","doi":"10.1038/s41579-024-01102-5","DOIUrl":"10.1038/s41579-024-01102-5","url":null,"abstract":"This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"670-670"},"PeriodicalIF":69.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Things go sour in C. rodentium infection","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01100-7","DOIUrl":"10.1038/s41579-024-01100-7","url":null,"abstract":"This study shows that Citrobacter rodentium alters its growth and virulence in response to varying intestinal pH, and, in turn, the host actively induces stomach acidification.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"667-667"},"PeriodicalIF":69.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling plasmid diversity in nature","authors":"Antonio Pedro Camargo","doi":"10.1038/s41579-024-01093-3","DOIUrl":"10.1038/s41579-024-01093-3","url":null,"abstract":"This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"597-597"},"PeriodicalIF":69.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From soil to battling antimicrobial resistance","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01096-0","DOIUrl":"10.1038/s41579-024-01096-0","url":null,"abstract":"In this study, Li, Feng et al. identify an antimicrobial compound produced by plant root-associated Pseudomonas fluorescens with potent activity against drug-resistant, Gram-positive bacteria.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"596-596"},"PeriodicalIF":69.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Testing fast with uRAST","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01097-z","DOIUrl":"10.1038/s41579-024-01097-z","url":null,"abstract":"In this study, Kim, Kang, Jang et al. report a phenotype-based, ultra-rapid and blood culture-free antimicrobial susceptibility testing approach.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"596-596"},"PeriodicalIF":69.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tagging for degradation — bacteria do it too","authors":"Francesca Ester Morreale","doi":"10.1038/s41579-024-01094-2","DOIUrl":"10.1038/s41579-024-01094-2","url":null,"abstract":"In this Journal Club, Francesca Ester Morreale revisits a paper reporting that arginine phosphorylation marks proteins for degradation in bacteria.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"669-669"},"PeriodicalIF":69.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting the spread of antimicrobial resistance plasmids","authors":"Ashley York","doi":"10.1038/s41579-024-01095-1","DOIUrl":"10.1038/s41579-024-01095-1","url":null,"abstract":"A recent study demonstrates targeting plasmid-encoded bacterial proteins containing immunoglobulin-like domains to prevent the conjugation and spread of antimicrobial resistance plasmids.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"595-595"},"PeriodicalIF":69.2,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141973776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Designer antibiotics","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01091-5","DOIUrl":"10.1038/s41579-024-01091-5","url":null,"abstract":"This study used structure-based drug design and modular synthesis to identify small molecules with antimicrobial activity.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"595-595"},"PeriodicalIF":69.2,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}