Nature Reviews Microbiology最新文献_第3页

Prioritizing soil microbiome management and microbial restoration in low-income settings. 优先考虑低收入环境下的土壤微生物组管理和微生物恢复。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-09-08 DOI: 10.1038/s41579-026-01363-2

Olubukola Oluranti Babalola, Okainemen Godfrey Oribhabor

引用次数: 0

Separating microbial signal from noise. 从噪声中分离微生物信号。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-09-07 DOI: 10.1038/s41579-026-01365-0

Soyeon Kim, Kelvin Sibuta, Yan Shao

引用次数: 0

Colibactin defends honeybees 大肠杆菌素保护蜜蜂。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-09-07 DOI: 10.1038/s41579-026-01366-z

Andrea Du Toit

引用次数: 0

Fungal Starship transposons for interspecies gene transfer 用于种间基因转移的真菌星舰转座子。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-09-01 DOI: 10.1038/s41579-026-01361-4

Ping-Hung Hsieh, Nam Ngoc Pham

引用次数: 0

The gut microbiota in malnutrition. 营养不良的肠道菌群。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-27 DOI: 10.1038/s41579-026-01359-y

Paula T Littlejohn, Ravi Holani, Bruce A Vallance, B Brett Finlay

{"title":"The gut microbiota in malnutrition.","authors":"Paula T Littlejohn, Ravi Holani, Bruce A Vallance, B Brett Finlay","doi":"10.1038/s41579-026-01359-y","DOIUrl":"https://doi.org/10.1038/s41579-026-01359-y","url":null,"abstract":"Malnutrition poses a substantial global health burden with long-lasting physical, social and economic effects. Now recognized as an spectrum of interrelated conditions, malnutrition manifests differently based on an individual's geography, health-care access and lifestyle. There is growing evidence that malnutrition is also driven by defects in the composition and function of the gut microbiota, a metabolically active 'virtual organ' known to play a central role in intestinal barrier function, energy harvest, immune regulation and metabolic signalling. Across the malnutrition spectrum, perturbed microbial composition and function have been consistently observed in both children and adults. This 'malnourished microbiota' is associated with impaired nutrient utilization, chronic inflammation and altered energy balance and is known to persist despite nutritional interventions. This Review synthesizes evidence from human cohorts and animal models showing that the gut microbiota functions as a central player in malnutrition. We discuss implications for diagnostic and therapeutic strategies, arguing that microbiome restoration could provide a partial solution for malnutrition. This reframing is particularly relevant given current challenges such as armed conflict, climate change and declining international support, all of which are associated with an increased global burden of malnutrition. Thus, integrating microbiota-based strategies could protect vulnerable populations and accelerate progress towards overcoming malnutrition.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":104.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage therapy: from basic biology to clinical application. 噬菌体治疗：从基础生物学到临床应用。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-27 DOI: 10.1038/s41579-026-01352-5

Holly A Sinclair, Ruby C Y Lin, Nouri L Ben Zakour, Paul L Bollyky, Jonathan R Iredell

{"title":"Phage therapy: from basic biology to clinical application.","authors":"Holly A Sinclair, Ruby C Y Lin, Nouri L Ben Zakour, Paul L Bollyky, Jonathan R Iredell","doi":"10.1038/s41579-026-01352-5","DOIUrl":"10.1038/s41579-026-01352-5","url":null,"abstract":"Bacteriophages have been applied therapeutically for more than a century for the management of bacterial infections in humans. Although their potential as a safe alternative or adjunct to antibiotics is well established, clinical success is difficult to predict from in vitro testing. There is currently no consensus on the optimal way to use them, nor are there any simple extrapolations from the use paradigms of conventional antibiotics. A rational approach to phage therapy requires informed phage selection and a comprehensive understanding of bacterial-phage-human host relationships and the management of bacterial and phage adaptations that occur in vivo. Phages may be used in ways that antibiotics are not and are a powerful approach for addressing the problem of antimicrobial resistance, not least because their optimal use requires a more thoughtful approach. In this Review, we explore key aspects of phage biology that underpin the effective use of phages for therapy. We outline clinical strategies for applying phages against a range of infections, highlighting their advantages and limitations. We then address challenges in production, scalability and regulation of phage preparations, identifying areas requiring further development. Finally, we discuss interactions between phages and the human immune system, and their importance for therapeutic success.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":104.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic strategies of Enterobacteriaceae gut colonization. 肠杆菌科肠道定植的代谢策略。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-21 DOI: 10.1038/s41579-026-01354-3

Christopher Schubert, Wolf-Dietrich Hardt

{"title":"Metabolic strategies of Enterobacteriaceae gut colonization.","authors":"Christopher Schubert, Wolf-Dietrich Hardt","doi":"10.1038/s41579-026-01354-3","DOIUrl":"https://doi.org/10.1038/s41579-026-01354-3","url":null,"abstract":"Enterobacteriaceae are facultative anaerobic bacteria that commonly colonize the gut and include both commensals and diverse pathogens. They can flexibly adapt their metabolic strategy to grow in the intestinal environment. As Enterobacteriaceae blooms are linked to enteric disease and the dissemination of antibiotic resistance, a deeper understanding of the factors that drive their expansion is needed. In the healthy intestine, Enterobacteriaceae subsist on low concentrations of diet-derived and mucus-derived monosaccharides that feed glycolysis and mixed-acid fermentation. Inflammation reshapes this niche as immune-derived oxidants generate new terminal electron acceptors, such as nitrate or tetrathionate, and facilitate oxygen diffusion into the gut lumen, thereby expanding facultative anaerobes and broadening the range of usable substrates. In this Review, we discuss recent evidence across Escherichia coli, Citrobacter rodentium, Klebsiella spp. and Salmonella Typhimurium to define a conserved, monosaccharide-fuelled programme for colonization and its inflammatory remodelling. Competition with commensal bacteria for these nutrients underpins colonization resistance, and genetic differences can determine competitive fitness. Metabolism lies at the core of these ecological dynamics, and recognizing its central role will help guide the design of future therapies.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":104.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitin drives Candida auris skin persistence 几丁质驱动耳念珠菌皮肤持久性。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-19 DOI: 10.1038/s41579-026-01360-5

Andrea Du Toit

引用次数: 0

Bacterial small regulatory RNAs. 细菌小调控rna。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-19 DOI: 10.1038/s41579-026-01353-4

Kai Papenfort

引用次数: 0

Bacterial lipid structural diversity mediates commensalism and pathogenesis 细菌脂质结构多样性介导共栖和发病机制。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-08-19 DOI: 10.1038/s41579-026-01351-6

Stacey L. Heaver, Ruth E. Ley

{"title":"Bacterial lipid structural diversity mediates commensalism and pathogenesis","authors":"Stacey L. Heaver, Ruth E. Ley","doi":"10.1038/s41579-026-01351-6","DOIUrl":"10.1038/s41579-026-01351-6","url":null,"abstract":"The human immune system must continuously distinguish between pathogenic bacteria and the numerous symbiotic bacteria that live in and on our bodies. In part, this distinction is driven by host sensing of specific lipid structures that comprise the bacterial membrane. Bacterial lipids from commensal and pathogenic bacteria alike are sensed via lipid recognition receptors, initiating downstream responses in the innate and adaptive immune systems. However, structural variations in the lipids from commensal bacteria tend to enable overall less stimulatory or more immunomodulatory outcomes following host recognition. This contributes to homeostatic immunity in their hosts, supporting normal immune development, proper immune responses and functional gut physiology. Conversely, in some pathogens, similar lipid modifications enable evasion or modulation of the immune system. Here, we review how the detection of pathogenic and commensal lipids via Toll-like receptor 2, Toll-like receptor 4 and CD1 lipid antigen presentation is mediated by bacterial lipid structure, with subsequent outcomes on host physiology. In this Review, Heaver and Ley overview the different lipid structures present in commensal and pathogenic bacteria and their recognition by Toll-like receptor 2, Toll-like receptor 4 and CD1 molecules, highlighting the different effects on host immune responses.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 11","pages":"754-770"},"PeriodicalIF":104.6,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0