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Decoding pathogen evolution to curb antimicrobial resistance 破解病原体进化以抑制抗菌素耐药性
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-03-17 DOI: 10.1038/s41579-025-01168-9
Vignesh Shetty, Ankur Mutreja
{"title":"Decoding pathogen evolution to curb antimicrobial resistance","authors":"Vignesh Shetty, Ankur Mutreja","doi":"10.1038/s41579-025-01168-9","DOIUrl":"https://doi.org/10.1038/s41579-025-01168-9","url":null,"abstract":"This Genome Watch highlights how genomic lineage resolution is revolutionizing precision diagnostics by providing insights into pathogen evolution, transmission dynamics and the emergence of antimicrobial resistance.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tricking plants into starvation 诱使植物陷入饥饿
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-03-12 DOI: 10.1038/s41579-025-01170-1
Andrea Du Toit
{"title":"Tricking plants into starvation","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01170-1","DOIUrl":"https://doi.org/10.1038/s41579-025-01170-1","url":null,"abstract":"This study shows that fungal plant pathogens use hydrolase effectors to induce phosphate starvation signalling in host plants and suppress immune responses to promote disease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"32 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions and evolutionary relationships among bacterial mobile genetic elements 细菌移动遗传元素之间的相互作用和进化关系
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-03-11 DOI: 10.1038/s41579-025-01157-y
Andrew S. Lang, Alison Buchan, Vincent Burrus
{"title":"Interactions and evolutionary relationships among bacterial mobile genetic elements","authors":"Andrew S. Lang, Alison Buchan, Vincent Burrus","doi":"10.1038/s41579-025-01157-y","DOIUrl":"https://doi.org/10.1038/s41579-025-01157-y","url":null,"abstract":"<p>Mobile genetic elements (MGEs) have profound influence on the ecology and evolution of organisms, including bacteria. During the past two decades, a great number of new types of MGEs have been discovered that now seem to be prevalent in diverse bacterial lineages. With the rapid discovery of new categories of MGEs comes an array of new acronyms that present a challenge to grasp. Moreover, it is now clear that there are complex evolutionary connections and molecular interactions among MGEs, and that these entities are not discrete, independent genetic elements acting in isolation. Different types of MGEs share and exchange genes, and coresident MGEs interact with each other within cells, in both cooperative and antagonistic ways. This all greatly affects the end results that are felt by the host organism. In this Review, we strive to clarify emerging bacterial MGE terms and elements while also presenting a comprehensive overview of the current knowledge landscape regarding MGEs in bacteria, their evolutionary relationships and interactions with their host and with one another.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"2 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities 炎症性肠病中的微生物群：疾病机制和治疗机会
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-03-10 DOI: 10.1038/s41579-025-01163-0
Iliyan D. Iliev, Ashwin N. Ananthakrishnan, Chun-Jun Guo
{"title":"Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities","authors":"Iliyan D. Iliev, Ashwin N. Ananthakrishnan, Chun-Jun Guo","doi":"10.1038/s41579-025-01163-0","DOIUrl":"https://doi.org/10.1038/s41579-025-01163-0","url":null,"abstract":"<p>Perturbations in the intestinal microbiome are strongly linked to the pathogenesis of inflammatory bowel disease (IBD). Bacteria, fungi and viruses all make up part of a complex multi-kingdom community colonizing the gastrointestinal tract, often referred to as the gut microbiome. They can exert various effects on the host that can contribute to an inflammatory state. Advances in screening, multiomics and experimental approaches have revealed insights into host–microbiota interactions in IBD and have identified numerous mechanisms through which the microbiota and its metabolites can exert a major influence on the gastrointestinal tract. Looking into the future, the microbiome and microbiota-associated processes will be likely to provide unparalleled opportunities for novel diagnostic, therapeutic and diet-inspired solutions for the management of IBD through harnessing rationally designed microbial communities, powerful bacterial and fungal metabolites, individually or in combination, to foster intestinal health. In this Review, we examine the current understanding of the cross-kingdom gut microbiome in IBD, focusing on bacterial and fungal components and metabolites. We examine therapeutic and diagnostic opportunities, the microbial metabolism, immunity, neuroimmunology and microbiome-inspired interventions to link mechanisms of disease and identify novel research and therapeutic opportunities for IBD.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"132 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of bacterial metabolism in antimicrobial resistance 细菌代谢在抗菌素耐药性中的作用
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-20 DOI: 10.1038/s41579-025-01155-0
Mehrose Ahmad, Sai Varun Aduru, Robert P. Smith, Zirui Zhao, Allison J. Lopatkin
{"title":"The role of bacterial metabolism in antimicrobial resistance","authors":"Mehrose Ahmad, Sai Varun Aduru, Robert P. Smith, Zirui Zhao, Allison J. Lopatkin","doi":"10.1038/s41579-025-01155-0","DOIUrl":"https://doi.org/10.1038/s41579-025-01155-0","url":null,"abstract":"<p>The relationship between bacterial metabolism and antibiotic treatment is complex. On the one hand, antibiotics leverage cell metabolism to function. On the other hand, increasing research has highlighted that the metabolic state of the cell also impacts all aspects of antibiotic biology, from drug efficacy to the evolution of antimicrobial resistance (AMR). Given that AMR is a growing threat to the current global antibiotic arsenal and ability to treat infectious diseases, understanding these relationships is key to improving both public and human health. However, quantifying the contribution of metabolism to antibiotic activity and subsequent bacterial evolution has often proven challenging. In this Review, we discuss the complex and often bidirectional relationships between metabolism and the various facets of antibiotic treatment and response. We first summarize how antibiotics leverage metabolism for their function. We then focus on the converse of this relationship by specifically delineating the unique contribution of metabolism to three distinct but related arms of antibiotic biology: antibiotic efficacy, AMR evolution and AMR mechanisms. Finally, we note the relevance of metabolism in clinical contexts and explore the future of metabolic-based strategies for personalized antimicrobial therapies. A deeper understanding of these connections is crucial for the broader scientific community to address the growing crisis of AMR and develop future effective therapeutics.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"25 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Settling with the motion 与动议和解
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-17 DOI: 10.1038/s41579-025-01165-y
Andrea Du Toit
{"title":"Settling with the motion","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01165-y","DOIUrl":"10.1038/s41579-025-01165-y","url":null,"abstract":"This study reports two different mechanisms that enable bacterial surface colonization under high flow conditions.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"208-208"},"PeriodicalIF":69.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-sacrificing cell death to thwart phage infection 牺牲细胞死亡来阻止噬菌体感染
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-13 DOI: 10.1038/s41579-025-01162-1
Andrea Du Toit
{"title":"Self-sacrificing cell death to thwart phage infection","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01162-1","DOIUrl":"10.1038/s41579-025-01162-1","url":null,"abstract":"This study describes the bacterial type IV Thoeris defence system, which contains both a Toll/interleukin-1 receptor (TIR) domain protein and a caspase-like protease.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"207-207"},"PeriodicalIF":69.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intruders that stole the master key 偷了主钥匙的入侵者
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-11 DOI: 10.1038/s41579-025-01158-x
Miguel F. Romero
{"title":"The intruders that stole the master key","authors":"Miguel F. Romero","doi":"10.1038/s41579-025-01158-x","DOIUrl":"10.1038/s41579-025-01158-x","url":null,"abstract":"This Genome Watch article highlights how genomics and different experimental approaches reveal how intracellular bacteria control key processes of their hosts.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"209-209"},"PeriodicalIF":69.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A gut microbiome-restoring diet 恢复肠道微生物群的饮食
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-10 DOI: 10.1038/s41579-025-01161-2
Agustina Taglialegna
{"title":"A gut microbiome-restoring diet","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01161-2","DOIUrl":"10.1038/s41579-025-01161-2","url":null,"abstract":"In this study, Li et al. perform a randomized controlled feeding trial to test the effects of a microbiome restoration strategy on gut microbiome features, host physiology and health.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"208-208"},"PeriodicalIF":69.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA evolution shapes SARS-CoV-2 success RNA进化影响SARS-CoV-2的成功
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2025-02-10 DOI: 10.1038/s41579-025-01160-3
Agustina Taglialegna
{"title":"RNA evolution shapes SARS-CoV-2 success","authors":"Agustina Taglialegna","doi":"10.1038/s41579-025-01160-3","DOIUrl":"10.1038/s41579-025-01160-3","url":null,"abstract":"In this study, Mears et al. show that SARS-CoV-2 can evolve not only through protein changes but also through functional RNA adaptations to increase fitness and immune evasion.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 4","pages":"207-207"},"PeriodicalIF":69.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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