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Publisher Correction: Unveiling plasmid diversity in nature 出版商更正：揭示自然界质粒的多样性。
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-19 DOI: 10.1038/s41579-024-01112-3
Antonio Pedro Camargo
{"title":"Publisher Correction: Unveiling plasmid diversity in nature","authors":"Antonio Pedro Camargo","doi":"10.1038/s41579-024-01112-3","DOIUrl":"10.1038/s41579-024-01112-3","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"736-736"},"PeriodicalIF":69.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41579-024-01112-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and strategies for addressing antibacterial drug resistance in LMICs 应对低收入和中等收入国家抗菌药物耐药性的挑战和战略
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-13 DOI: 10.1038/s41579-024-01080-8
Ursula Theuretzbacher
{"title":"Challenges and strategies for addressing antibacterial drug resistance in LMICs","authors":"Ursula Theuretzbacher","doi":"10.1038/s41579-024-01080-8","DOIUrl":"10.1038/s41579-024-01080-8","url":null,"abstract":"Antibacterial drug resistance is a critical global health issue that affects countries across all economic levels, though it disproportionately affects populations in low- and middle-income countries. Infection and resistance rates vary considerably, necessitating tailored interventions to meet the specific demands of each area. This underscores the need for global solidarity and national accountability in effectively addressing antibacterial drug resistance.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"591-592"},"PeriodicalIF":69.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stronger commitment and faster action against antimicrobial resistance 做出更坚定的承诺，采取更迅速的行动，消除抗生素耐药性
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-13 DOI: 10.1038/s41579-024-01089-z
{"title":"Stronger commitment and faster action against antimicrobial resistance","authors":"","doi":"10.1038/s41579-024-01089-z","DOIUrl":"10.1038/s41579-024-01089-z","url":null,"abstract":"As the United Nations convenes its second High-Level Meeting on antimicrobial resistance, urgent global action is needed. This Focus issue draws attention to pressing challenges of bacterial antimicrobial resistance and underscores the need for fast and coordinated international efforts.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"589-590"},"PeriodicalIF":69.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41579-024-01089-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achieving sustainable access to antibiotics is more than just a last mile challenge 实现抗生素的可持续获取不仅仅是最后一英里的挑战
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-13 DOI: 10.1038/s41579-024-01083-5
Manica Balasegaram, Viviana Muñoz Tellez
{"title":"Achieving sustainable access to antibiotics is more than just a last mile challenge","authors":"Manica Balasegaram, Viviana Muñoz Tellez","doi":"10.1038/s41579-024-01083-5","DOIUrl":"10.1038/s41579-024-01083-5","url":null,"abstract":"Improving access to antibiotics will save lives and reduce the rise and spread of drug-resistant infections. Instead of traditional ‘last mile’ global health solutions, global leaders need to support efforts to develop suitable antibiotics and their rational use, ensuring that countries have the capacity to make them available.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"593-594"},"PeriodicalIF":69.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No viral rebound 无病毒反弹
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-10 DOI: 10.1038/s41579-024-01109-y
Andrea Du Toit
{"title":"No viral rebound","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01109-y","DOIUrl":"10.1038/s41579-024-01109-y","url":null,"abstract":"A new study reports sustained HIV remission in an individual who underwent allogeneic haematopoietic stem cell transplantation with cells from a donor with wild-type CCR5.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"667-667"},"PeriodicalIF":69.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rediscovering plasmid-dependent phages 重新发现依赖质粒的噬菌体
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-09 DOI: 10.1038/s41579-024-01102-5
Daniel Cazares, Wendy Figueroa, Adrian Cazares
{"title":"Rediscovering plasmid-dependent phages","authors":"Daniel Cazares, Wendy Figueroa, Adrian Cazares","doi":"10.1038/s41579-024-01102-5","DOIUrl":"10.1038/s41579-024-01102-5","url":null,"abstract":"This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"670-670"},"PeriodicalIF":69.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics 尿路感染：发病机制、宿主易感性和新兴疗法
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-09 DOI: 10.1038/s41579-024-01092-4
Morgan R. Timm, Seongmi K. Russell, Scott J. Hultgren
{"title":"Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics","authors":"Morgan R. Timm, Seongmi K. Russell, Scott J. Hultgren","doi":"10.1038/s41579-024-01092-4","DOIUrl":"https://doi.org/10.1038/s41579-024-01092-4","url":null,"abstract":"<p>Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys, account for an estimated 400 million infections and billions of dollars in health-care spending per year. The most common bacterium implicated in UTI is uropathogenic <i>Escherichia coli</i>, but diverse pathogens including <i>Klebsiella</i>, <i>Enterococcus</i>, <i>Pseudomonas</i>, <i>Staphylococcus</i> and even yeast such as <i>Candida</i> species can also cause UTIs. UTIs occur in both women and men and in both healthy and immunocompromised patients. However, certain patient factors predispose to disease: for example, female sex, history of prior UTI, or the presence of a urinary catheter or other urinary tract abnormality. The current clinical paradigm for the treatment of UTIs involves the use of antibiotics. Unfortunately, the efficacy of this approach is dwindling as the prevalence of antimicrobial resistance rises among UTI isolates, and the immense quantity of antibiotics prescribed annually for these infections contributes to the emergence of resistant pathogens. Therefore, there is an urgent need for new antibiotics and non-antibiotic treatment and prevention strategies. In this Review, we discuss how recent studies of bacterial pathogenesis, recurrence, persistence, host–pathogen interactions and host susceptibility factors have elucidated new and promising targets for the treatment and prevention of UTIs.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial siderophores: diversity, uptake pathways and applications 细菌嗜苷酸盐：多样性、吸收途径和应用
IF 88.1 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-05 DOI: 10.1038/s41579-024-01090-6
Isabelle J. Schalk
{"title":"Bacterial siderophores: diversity, uptake pathways and applications","authors":"Isabelle J. Schalk","doi":"10.1038/s41579-024-01090-6","DOIUrl":"https://doi.org/10.1038/s41579-024-01090-6","url":null,"abstract":"<p>Iron is an essential nutrient for the growth, survival and virulence of almost all bacteria. To access iron, many bacteria produce siderophores, molecules with a high affinity for iron. Research has highlighted substantial diversity in the chemical structure of siderophores produced by bacteria, as well as remarkable variety in the molecular mechanisms involved in strategies for acquiring iron through these molecules. The metal-chelating properties of siderophores, characterized by their high affinity for iron and ability to chelate numerous other metals (albeit with lower affinity compared with iron), have also generated interest in diverse fields. Siderophores find applications in the environment, such as in bioremediation and agriculture, in which emerging and innovative strategies are being developed to address pollution and enhance nutrient availability for plants. Moreover, in medicine, siderophores could be used as a tool for novel antimicrobial therapies and medical imaging, as well as in haemochromatosis, thalassemia or cancer treatments. This Review offers insights into the diversity of siderophores, highlighting their potential applications in environmental and medical contexts.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Things go sour in C. rodentium infection 啮齿动物感染的恶化
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-09-02 DOI: 10.1038/s41579-024-01100-7
Andrea Du Toit
{"title":"Things go sour in C. rodentium infection","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01100-7","DOIUrl":"10.1038/s41579-024-01100-7","url":null,"abstract":"This study shows that Citrobacter rodentium alters its growth and virulence in response to varying intestinal pH, and, in turn, the host actively induces stomach acidification.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 11","pages":"667-667"},"PeriodicalIF":69.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling plasmid diversity in nature 揭开自然界质粒多样性的面纱
IF 69.2 1区 生物学
Nature Reviews Microbiology Pub Date : 2024-08-28 DOI: 10.1038/s41579-024-01093-3
Antonio Pedro Camargo
{"title":"Unveiling plasmid diversity in nature","authors":"Antonio Pedro Camargo","doi":"10.1038/s41579-024-01093-3","DOIUrl":"10.1038/s41579-024-01093-3","url":null,"abstract":"This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 10","pages":"597-597"},"PeriodicalIF":69.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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