细菌包膜靶向抗生素。

IF 103.3 1区 生物学 Q1 MICROBIOLOGY
Charalampos Ntallis, Nathaniel I Martin, Andrew M Edwards, Markus Weingarth
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引用次数: 0

摘要

耐多药细菌的出现对全球健康构成严重威胁。这些多重耐药细菌通常受到复杂的细胞包膜的保护,许多抗生素无法穿透,这对治疗造成了重要的障碍。因此,靶向细菌包膜长期以来被认为是一种有效的策略,提供了绕过药物进入和外排耐药机制挑战的潜力。此外,许多独特的细菌包膜位点仍未被临床开发,针对它们的新化合物有可能使抗菌机制的空间多样化,降低交叉耐药的风险。针对非蛋白包膜成分的化合物,如脂多糖或戊基化肽聚糖前体,由于其对抗菌素耐药性的敏感性降低而特别有吸引力。在这篇综述中,我们探讨了最近发现的化合物和已建立的包膜靶向抗生素,包括针对革兰氏阳性菌,更复杂的革兰氏阴性菌和分枝杆菌病原体的化合物,揭示了这一临床尚未充分探索的重要治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacterial cell envelope-targeting antibiotics.

The emergence of multidrug-resistant bacteria presents a critical threat to global health. These multidrug-resistant bacteria are often protected by complex cell envelopes that many antibiotics cannot penetrate, creating an important barrier to treatment. In response, targeting bacterial envelopes has long been recognized as an effective strategy, offering potential to bypass the challenges of drug entry and efflux resistance mechanisms. Moreover, many unique bacterial envelope sites remain clinically untapped, and new compounds directed at them have the potential to diversify the space of antimicrobial mechanisms, lowering the risk for cross-resistance. Compounds that target non-proteinaceous envelope components, such as lipopolysaccharide or prenylated peptidoglycan-precursors, are particularly attractive owing to their reduced susceptibility to antimicrobial resistance development. In this Review, we explore both recently discovered compounds and established envelope-targeting antibiotics, including compounds that target Gram-positive bacteria, more complex Gram-negative bacteria and mycobacterial pathogens, shedding light on this still clinically underexplored and vital therapeutic approach.

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来源期刊
Nature Reviews Microbiology
Nature Reviews Microbiology 生物-微生物学
CiteScore
74.00
自引率
0.50%
发文量
149
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Microbiology, our goal is to become the leading source of reviews and commentaries for the scientific community we cater to. We are dedicated to publishing articles that are not only authoritative but also easily accessible, supplementing them with clear and concise figures, tables, and other visual aids. Our objective is to offer an unparalleled service to authors, referees, and readers, and we continuously strive to maximize the usefulness and impact of each article we publish. With a focus on Reviews, Perspectives, and Comments spanning the entire field of microbiology, our wide scope ensures that the work we feature reaches the widest possible audience.
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