{"title":"Campylobacter spreads colorectal cancer","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01139-6","DOIUrl":"10.1038/s41579-024-01139-6","url":null,"abstract":"This study shows that the Campylobacter jejuni-derived genotoxin named cytolethal distending toxin promotes colorectal cancer metastasis.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 2","pages":"68-68"},"PeriodicalIF":69.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metagenomics for drug discovery","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01138-7","DOIUrl":"10.1038/s41579-024-01138-7","url":null,"abstract":"In this study, Padhi et al. demonstrate the potential of metagenomics-based approaches for the discovery of natural products from complex ecosystems.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 2","pages":"67-67"},"PeriodicalIF":69.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy A. Scott, Kate S. Baker, Caroline Trotter, Claire Jenkins, Serge Mostowy, Jane Hawkey, Hayden Schmidt, Kathryn E. Holt, Nicholas R. Thomson, Stephen Baker
{"title":"Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions","authors":"Timothy A. Scott, Kate S. Baker, Caroline Trotter, Claire Jenkins, Serge Mostowy, Jane Hawkey, Hayden Schmidt, Kathryn E. Holt, Nicholas R. Thomson, Stephen Baker","doi":"10.1038/s41579-024-01126-x","DOIUrl":"https://doi.org/10.1038/s41579-024-01126-x","url":null,"abstract":"<p><i>Shigella sonnei</i> is a major cause of diarrhoea globally and is increasing in prevalence relative to other <i>Shigella</i> because of multiple demographic and environmental influences. This single-serotype species has traditionally received less attention in comparison to <i>Shigella flexneri</i> and <i>Shigella dysenteriae</i>, which were more common in low-income countries and more tractable in the laboratory. In recent years, we have learned that <i>Shigella</i> are highly complex and highly susceptible to environmental change, as exemplified by epidemiological trends and increasing relevance of <i>S</i>. <i>sonnei</i>. Ultimately, methods, tools and data generated from decades of detailed research into <i>S</i>. <i>flexneri</i> have been used to gain new insights into the epidemiology, microbiology and pathogenesis of <i>S</i>. <i>sonnei</i>. In parallel, widespread adoption of genomic surveillance has yielded insights into antimicrobial resistance, evolution and organism transmission. In this Review, we provide an overview of current knowledge of <i>S</i>. <i>sonnei</i>, highlighting recent insights into this globally disseminated antimicrobial-resistant pathogen and assessing how novel data may impact future vaccine development and implementation.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"25 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methanogens implicated by DNA evidence","authors":"Matthew Kellom","doi":"10.1038/s41579-024-01135-w","DOIUrl":"10.1038/s41579-024-01135-w","url":null,"abstract":"This Genome Watch article highlights recent findings that expand the known diversity of methanogenic archaea and the metagenomic evidence that led to their identification and cultivation.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 2","pages":"71-71"},"PeriodicalIF":69.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The consequences of SARS-CoV-2 within-host persistence","authors":"Alex Sigal, Richard A. Neher, Richard J. Lessells","doi":"10.1038/s41579-024-01125-y","DOIUrl":"https://doi.org/10.1038/s41579-024-01125-y","url":null,"abstract":"<p>SARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less than a month. Yet some people with severely weakened immune systems fail to clear the virus, leading to persistent infections with high viral titres in the respiratory tract. In a subset of cases, persistent SARS-CoV-2 replication results in an accelerated accumulation of adaptive mutations that confer escape from neutralizing antibodies and enhance cellular infection. This may lead to the evolution of extensively mutated SARS-CoV-2 variants and introduce an element of chance into the timing of variant evolution, as variant formation may depend on evolution in a single person. Whether long COVID is also caused by persistence of replicating SARS-CoV-2 is controversial. One line of evidence is detection of SARS-CoV-2 RNA and proteins in different body compartments long after SARS-CoV-2 infection has cleared from the upper respiratory tract. However, thus far, no replication competent virus has been cultured from individuals with long COVID who are immunocompetent. In this Review, we consider mechanisms of viral persistence, intra-host evolution in persistent infections, the connection of persistent infections with SARS-CoV-2 variants and the possible role of SARS-CoV-2 persistence in long COVID. Understanding persistent infections may therefore resolve much of what is still unclear in COVID-19 pathophysiology, with possible implications for other emerging viruses.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"2 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatitis B and D virus entry","authors":"Koichi Watashi, Kaho Shionoya, Chisa Kobayashi, Takeshi Morita","doi":"10.1038/s41579-024-01121-2","DOIUrl":"https://doi.org/10.1038/s41579-024-01121-2","url":null,"abstract":"<p>Hepatitis B virus (HBV) entry is the initial step of viral infection, leading to the formation of covalently closed circular DNA, which is a molecular reservoir of viral persistence and a key obstacle for HBV cure. The restricted entry of HBV into specific cell types determines the nature of HBV, which has a narrow host range in tissues and species. Hepatitis D virus (HDV) shares viral surface antigens with HBV and thus follows a similar entry mechanism at its early stages. In late 2012, sodium taurocholate cotransporting polypeptide was discovered as an HBV and HDV entry receptor. Since then, the mechanisms of HBV and HDV entry have been extensively analysed. These analyses have expanded our understanding of HBV and HDV host tropism and have provided new strategies for the development of antiviral agents. Notably, the structures of sodium taurocholate cotransporting polypeptide and its interaction with the 2–48 amino acid region of viral preS1 have been recently solved. These findings will stimulate further entry studies. In this Review, we summarize current understanding of HBV and HDV entry and future perspectives.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"3 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting phage–host specificity","authors":"Ashley York","doi":"10.1038/s41579-024-01132-z","DOIUrl":"10.1038/s41579-024-01132-z","url":null,"abstract":"In a recent study, Gaborieau, Vaysset, Tesson et al. developed a method to predict phage–host specificity using genomic data.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 1","pages":"5-5"},"PeriodicalIF":69.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Designer viral receptors","authors":"Ashley York","doi":"10.1038/s41579-024-01133-y","DOIUrl":"10.1038/s41579-024-01133-y","url":null,"abstract":"In a recent study, Liu, Huang, Guo, McCallum et al. present a method to create functional, customized coronavirus receptors, which could facilitate the development of infection models that do not rely on native receptors.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 1","pages":"6-6"},"PeriodicalIF":69.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Iron gatekeeper in malaria","authors":"Ashley York","doi":"10.1038/s41579-024-01134-x","DOIUrl":"10.1038/s41579-024-01134-x","url":null,"abstract":"Loveridge and Sigala uncover a divalent metal transporter that is required for cellular iron metabolism in Plasmodium falciparum parasites.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 1","pages":"7-7"},"PeriodicalIF":69.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Waning resistance","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01131-0","DOIUrl":"10.1038/s41579-024-01131-0","url":null,"abstract":"This study provides insights into how adaptive changes in evolved microbial communities can affect pathogen invasion.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 1","pages":"7-7"},"PeriodicalIF":69.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
