Nature Reviews Microbiology最新文献_第7页

To end the HIV-1 pandemic, concerted research efforts must focus on sub-Saharan Africa 为了结束艾滋病毒-1大流行病，协调一致的研究努力必须集中在撒哈拉以南非洲

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-14 DOI: 10.1038/s41579-025-01188-5

Monray E. Williams, Jaclyn K. Mann, Thumbi Ndung’u, Marius B. Tincho, Marcel Tongo, Ntobeko A. B. Ntusi, Thulani P. Makhalanyane

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Gut microbiota-derived short-chain fatty acids and their role in human health and disease 肠道菌群衍生的短链脂肪酸及其在人类健康和疾病中的作用

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-13 DOI: 10.1038/s41579-025-01183-w

Indrani Mukhopadhya, Petra Louis

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Promoting early-life vaccine responses with bifidobacteria 促进双歧杆菌的早期生命疫苗反应

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-07 DOI: 10.1038/s41579-025-01190-x

Alakananda Karthick

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Chikungunya virus and other emerging arthritogenic alphaviruses 基孔肯雅病毒和其他新出现的致关节炎的甲病毒

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-07 DOI: 10.1038/s41579-025-01177-8

William M. de Souza, Marc Lecuit, Scott C. Weaver

{"title":"Chikungunya virus and other emerging arthritogenic alphaviruses","authors":"William M. de Souza, Marc Lecuit, Scott C. Weaver","doi":"10.1038/s41579-025-01177-8","DOIUrl":"10.1038/s41579-025-01177-8","url":null,"abstract":"Arthritogenic alphaviruses are arboviruses (arthropod-borne viruses) that are genetically and serologically related positive-strand RNA viruses and cause epidemics on a global scale. They are transmitted by mosquitoes and cause diseases in humans that are mainly characterized by fever and often debilitating, sometimes chronic polyarthralgia. At present, approved treatments or vaccines are not available for most arthritogenic alphaviruses, and recently licensed vaccines against chikungunya virus are awaiting implementation in endemic areas. Most arthritogenic alphaviruses are currently limited to specific geographic areas due to vector distributions and availability of amplifying hosts, but they pose a substantial risk of emergence in other regions. The exception is chikungunya virus, which has emerged repeatedly from Africa, established sustained and efficient transmission in urban areas (including in temperate climates) and has caused major epidemics across the world. In this Review, we highlight recent advances in our understanding of the transmission cycles of arthritogenic alphaviruses, their vectors, epidemiology, transmission dynamics, evolution, pathophysiology and immune responses. We also outline strategies and countermeasures to anticipate and mitigate the impact of arthritogenic alphaviruses on human health. In this Review, Weaver and colleagues discuss the transmission cycles of arthritogenic alphaviruses, their vectors, epidemiology, transmission dynamics, evolution, pathophysiology and immune responses. They also outline strategies and countermeasures to anticipate and mitigate the impact of arthritogenic alphaviruses on human health.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 9","pages":"585-601"},"PeriodicalIF":103.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 spike protein: structure, viral entry and variants SARS-CoV-2刺突蛋白：结构、病毒侵入和变异

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-06 DOI: 10.1038/s41579-025-01185-8

Bing Chen, Michael Farzan, Hyeryun Choe

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Aspergillus fumigatus biology, immunopathogenicity and drug resistance 烟曲霉生物学、免疫致病性和耐药性

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-05-02 DOI: 10.1038/s41579-025-01180-z

Frank L. van de Veerdonk, Agostinho Carvalho, Joost Wauters, George Chamilos, Paul E. Verweij

{"title":"Aspergillus fumigatus biology, immunopathogenicity and drug resistance","authors":"Frank L. van de Veerdonk, Agostinho Carvalho, Joost Wauters, George Chamilos, Paul E. Verweij","doi":"10.1038/s41579-025-01180-z","DOIUrl":"10.1038/s41579-025-01180-z","url":null,"abstract":"Aspergillus fumigatus is a saprophytic fungus prevalent in the environment and capable of causing severe invasive infection in humans. This organism can use strategies such as molecule masking, immune response manipulation and gene expression alteration to evade host defences. Understanding these mechanisms is essential for developing effective diagnostics and therapies to improve patient outcomes in Aspergillus-related diseases. In this Review, we explore the biology and pathogenesis of A. fumigatus in the context of host biology and disease, highlighting virus-associated pulmonary aspergillosis, a newly identified condition that arises in patients with severe pulmonary viral infections. In the post-pandemic landscape, in which immunotherapy is gaining attention for managing severe infections, we examine the host immune responses that are critical for controlling invasive aspergillosis and how A. fumigatus circumvents these defences. Additionally, we address the emerging issue of azole resistance in A. fumigatus, emphasizing the urgent need for greater understanding in an era marked by increasing antimicrobial resistance. This Review provides timely insights necessary for developing new immunotherapeutic strategies against invasive aspergillosis. In this Review, van de Veerdonk and colleagues explore Aspergillus fumigatus biology, the host immune responses and the fungal mechanisms of immune evasion, as well as emerging challenges such as virus-associated pulmonary aspergillosis and azole resistance, and reflect on future directions for therapeutics and patient care improvement.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 10","pages":"652-666"},"PeriodicalIF":103.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of artificial intelligence in microbial sciences to support climate resilience 人工智能在微生物科学中支持气候适应能力的作用

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-04-25 DOI: 10.1038/s41579-025-01178-7

Jack A. Gilbert, Karsten Zengler

引用次数: 0

Epstein–Barr virus pathogenesis and emerging control strategies 爱泼斯坦-巴尔病毒的发病机制和新的控制策略

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-04-25 DOI: 10.1038/s41579-025-01181-y

Christian Münz

{"title":"Epstein–Barr virus pathogenesis and emerging control strategies","authors":"Christian Münz","doi":"10.1038/s41579-025-01181-y","DOIUrl":"10.1038/s41579-025-01181-y","url":null,"abstract":"Sixty years after its discovery as the first human tumour virus, Epstein–Barr virus (EBV)-specific therapies and vaccines have entered clinical trials. These might not only be applicable for EBV-associated malignancies, where the virus was originally discovered, but also to immunopathologies, including the autoimmune disease multiple sclerosis, which might be triggered in susceptible individuals by primary EBV infection. This Review discusses the surprisingly large spectrum of diseases that EBV seems to cause, as well as which of these might be treated by the therapeutic approaches that are currently being developed or are already clinically applied. New pharmacological inhibitors, antibody therapies, adoptive T cell therapies and active vaccinations are beginning to offer possibilities to target the various EBV infection programmes that are associated with different diseases. These novel developments might allow us to specifically target EBV rather than its host cells in virus-associated pathologies. Sixty years after the discovery of the Epstein–Barr virus (EBV), Münz discusses new developments in the immunobiology of the first discovered human tumour virus, including vaccines and the role of EBV in the initiation of autoimmune diseases, especially multiple sclerosis.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"23 10","pages":"667-679"},"PeriodicalIF":103.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E. faecium gains an edge from bacteriocin 大肠杆菌从细菌素中获得优势

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-04-24 DOI: 10.1038/s41579-025-01187-6

Alakananda Karthick

引用次数: 0

Scavenging a pyrimidine to thrive 清除一种嘧啶来茁壮成长

IF 103.3 1区生物学

Nature Reviews Microbiology Pub Date : 2025-04-24 DOI: 10.1038/s41579-025-01186-7

Agustina Taglialegna

引用次数: 0