Nature Reviews Microbiology最新文献_第6页

Fermented food microbiome: influence on oral and gut microbiota, and human health 发酵食品微生物群：对口腔和肠道微生物群及人体健康的影响。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-23 DOI: 10.1038/s41579-026-01333-8

Dongyeop Kim, Hae-In Joe, Jin-Woo Bae, Gary D. Wu, Charlene W. Compher, Hyun Koo

{"title":"Fermented food microbiome: influence on oral and gut microbiota, and human health","authors":"Dongyeop Kim, Hae-In Joe, Jin-Woo Bae, Gary D. Wu, Charlene W. Compher, Hyun Koo","doi":"10.1038/s41579-026-01333-8","DOIUrl":"10.1038/s41579-026-01333-8","url":null,"abstract":"The fermented food microbiome comprises live microorganisms, their genetic elements and their metabolites, and represents an established dietary approach for modulating host–microbiome interactions through the consumption of fermented foods. Fermentation enhances food preservation and nutrient bioavailability, and supplies the host with probiotics, prebiotic substrates and postbiotic metabolites. These bioactive compounds can influence the oral and gut microbiota, modulate immune function and support metabolic resilience. Fibre-rich, plant-based fermented foods retain such components within structured matrices that enhance microbial viability and mucosal interactions more consistently than do fermented dairy foods. This Review explores how the fermented food microbiome affects the oral–gut axis via both transient microbial exposure and metabolite-mediated signalling. Drawing on clinical and preclinical evidence, we examine how fermented food intake alters resident microbiota and host physiology throughout the digestive tract. Despite growing evidence, the mechanisms through which fermented food might promote health remain insufficiently defined in humans owing to strain variability, inconsistency in microbial composition across fermented foods, heterogeneous clinical outcomes and regulatory ambiguity. Taking into account these limitations, we propose a roadmap to integrate the fermented food microbiome into precision nutrition as a feasible, personalized, diet-based strategy to promote health and prevent disease. The bioactive compounds and microbial consortia contained in plant-based fermented foods support oral and gut microbiota, host immune function and metabolic resilience. This Review describes the impact of the fermented food microbiome on the oral–gut axis and identifies a strategic roadmap to integrate this edible microbiome into precision nutrition practices to promote health.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 11","pages":"771-789"},"PeriodicalIF":104.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Klebsiella genus as driver of human disease: from infections to non-communicable disorders 克雷伯氏菌属作为人类疾病的驱动因素：从感染到非传染性疾病。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-22 DOI: 10.1038/s41579-026-01331-w

Serena Porcari, Margherita Ferrari, Anna Melekhova, Andrea Severino, William Fusco, Aurora Sveva Carlà, Flavio De Maio, Herbert Tilg, Antonio Gasbarrini, Eran Elinav, Gianluca Ianiro

{"title":"Klebsiella genus as driver of human disease: from infections to non-communicable disorders","authors":"Serena Porcari, Margherita Ferrari, Anna Melekhova, Andrea Severino, William Fusco, Aurora Sveva Carlà, Flavio De Maio, Herbert Tilg, Antonio Gasbarrini, Eran Elinav, Gianluca Ianiro","doi":"10.1038/s41579-026-01331-w","DOIUrl":"10.1038/s41579-026-01331-w","url":null,"abstract":"Klebsiella spp. are pathobionts associated with acute infections, including pneumonia and infections in the urinary tract and bloodstream, often acquired in health-care settings. They represent a global threat owing to the prevalence of multidrug-resistant strains. Moreover, Klebsiella spp., similarly to other members of the human gut microbiota, can contribute to the pathogenesis of non-communicable disorders. In this Review, we describe the taxonomical and molecular characteristics of the Klebsiella genus, as well as its epidemiology and impact as an infectious agent. We also review current evidence that associates Klebsiella spp. with different non-communicable disorders, including chronic inflammatory and metabolic disorders and cancer. We discuss different approaches to target Klebsiella spp., including tailored antibiotics, faecal microbiota transplantation, live biotherapeutic products and bacteriophages. Finally, we discuss the importance of preventative measures, such as epidemiological surveillance, infection control practices and lifestyle interventions, to reduce the spread of Klebsiella spp. in health-care settings and the broader community. Klebsiella spp. are mainly known as harmful, potentially drug-resistant, infectious agents, but they can also contribute to non-infectious diseases. In this Review, Porcari and colleagues discuss the pathogenic contribution of Klebsiella spp. to non-communicable disorders and the therapeutic strategies to treat and control the spread of these pathogens.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 10","pages":"732-748"},"PeriodicalIF":104.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148299194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupling experiments and macroecological models to resolve multi-stressor effects in vector–pathogen systems 耦合实验和宏观生态模型解决媒介-病原体系统中的多重应激因子效应。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-22 DOI: 10.1038/s41579-026-01330-x

Marina Treskova, Joacim Rocklöv

引用次数: 0

It takes three to modulate colitis 调节结肠炎需要三次。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-19 DOI: 10.1038/s41579-026-01335-6

Agustina Taglialegna

引用次数: 0

A new antibiotic scaffold hits a new target 一个新的抗生素支架击中了一个新的目标。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-19 DOI: 10.1038/s41579-026-01336-5

Andrea Du Toit

引用次数: 0

Bundibugyo virus outbreak: when a concerning pathogen meets a humanitarian emergency 本迪布焦病毒爆发：当有关病原体遇到人道主义紧急情况时。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-19 DOI: 10.1038/s41579-026-01332-9

Nahid Bhadelia

引用次数: 0

Antimicrobial stewardship in LMICs: from paper promises to purpose-driven people 中低收入国家的抗微生物药物管理：从纸上承诺到目标驱动的人。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-17 DOI: 10.1038/s41579-026-01328-5

Debra A. Goff, Adrian J. Brink

引用次数: 0

Impacts of climate change on dengue 气候变化对登革热的影响。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-12 DOI: 10.1038/s41579-026-01329-4

Erin Mordecai

引用次数: 0

A phage puts a new spin on bacterial flagella 噬菌体在细菌鞭毛上进行新的旋转。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-12 DOI: 10.1038/s41579-026-01334-7

Andrea Du Toit

引用次数: 0

Mechanisms of HIV-1 assembly, release and maturation HIV-1的组装、释放和成熟机制。

IF 104.6 1区生物学

Nature Reviews Microbiology Pub Date : 2026-06-11 DOI: 10.1038/s41579-026-01327-6

Alex B. Kleinpeter, Eric O. Freed

{"title":"Mechanisms of HIV-1 assembly, release and maturation","authors":"Alex B. Kleinpeter, Eric O. Freed","doi":"10.1038/s41579-026-01327-6","DOIUrl":"10.1038/s41579-026-01327-6","url":null,"abstract":"Over the past decade, major advances in structural biology and in vitro and cell-based technologies have enhanced our understanding of HIV-1 assembly, release and maturation. The cryo-electron microscopy revolution, alongside developments in single-molecule approaches and live-cell imaging techniques, have enabled researchers to visualize biological complexes at remarkably high resolution, reconstitute biochemical processes under physiologically relevant conditions and directly observe these processes in cells and virions. Effective integration of these methods with both classical and novel molecular virology approaches has yielded a wealth of basic knowledge that has driven the development of potent inhibitors targeting virus maturation and highlighted mechanisms by which events that take place late in the virus replication cycle prime newly formed virus particles for infection of a new host cell. This Review outlines the recent progress in elucidating the molecular underpinnings of the late stages of the HIV-1 replication cycle and highlights the interplay between virology, host cell biology and the development of antiretroviral compounds with therapeutic potential. In this Review, Kleinpeter and Freed explore recent insights into HIV-1 assembly, release and maturation, showing how late-stage replication events prime infectivity. They also highlight progress in inhibitors targeting late-stage events and the therapeutic promise for people with HIV.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 10","pages":"685-701"},"PeriodicalIF":104.6,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0