Mycology最新文献_第8页

Characterization of a new strain of Metarhizium novozealandicum with potential to be developed as a biopesticide. 一株具有生物农药开发潜力的新绿僵菌的鉴定。

IF 4.2 2区生物学

Mycology Pub Date : 2021-06-18 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1935359

Laura F Villamizar, Gloria Barrera, Mark Hurst, Travis R Glare

{"title":"Characterization of a new strain of Metarhizium novozealandicum with potential to be developed as a biopesticide.","authors":"Laura F Villamizar, Gloria Barrera, Mark Hurst, Travis R Glare","doi":"10.1080/21501203.2021.1935359","DOIUrl":"https://doi.org/10.1080/21501203.2021.1935359","url":null,"abstract":"The fungal species Metarhizium novozealandicum, that occurs only in New Zealand and Australia has been poorly studied. In this work, a new strain of M. novozealandicum isolated from a larva of Wiseana sp. is described based on morphology, genomic multilocus (ITS, EF-1α and β-tubulin) phylogeny, growth in different culture media and insecticidal activity. The isolate AgR-F177 was clustered in the same clade with M. novozealandicum. AgR-F177 colonies developed faster on Sabouraud Dextrose Agar (SDA) than on Potato Dextrose Agar (PDA) when incubated at 25°C, with no growth observed at 30°C on either media. Conidia yield on an oat-based medium in semisolid fermentation was 7.41 x 108conidia/g of substrate and a higher yield of 1.68 x 109conidia/g of substrate was obtained using solid fermentation on cooked rice. AgR-F177 formed microsclerotia (MS) in liquid fermentation after 7 days reaching the maximum yield of 3.3 × 103 MS/mL after 10 days. AgR-F177 caused mortality in Wiseana copularis, Costelytra giveni and Plutella xylostella larvae with efficacies up to 100%, 69.2%, and 45.7%, respectively. The ease of production of AgR-F177 with different fermentation systems and its pathogenicity against different insect pests reveal its potential as a new biopesticide.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 4","pages":"261-278"},"PeriodicalIF":4.2,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2021.1935359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39720016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Fungal interactions induce changes in hyphal morphology and enzyme production. 真菌相互作用诱导菌丝形态和酶产生的变化。

IF 4.2 2区生物学

Mycology Pub Date : 2021-06-04 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1932627

Samim Dullah, Dibya Jyoti Hazarika, Assma Parveen, Merilin Kakoti, Tanushree Borgohain, Trishnamoni Gautom, Ashok Bhattacharyya, Madhumita Barooah, Robin Chandra Boro

{"title":"Fungal interactions induce changes in hyphal morphology and enzyme production.","authors":"Samim Dullah, Dibya Jyoti Hazarika, Assma Parveen, Merilin Kakoti, Tanushree Borgohain, Trishnamoni Gautom, Ashok Bhattacharyya, Madhumita Barooah, Robin Chandra Boro","doi":"10.1080/21501203.2021.1932627","DOIUrl":"https://doi.org/10.1080/21501203.2021.1932627","url":null,"abstract":"In nature, species interacts/competes with one other within their surrounding for food and space and the type of interactions are unique to each species. The interacting partners secrete different metabolites, which may have high importance in human welfare. Fungal-fungal interactions are complex mechanisms that need better understanding. Here, 14 fungal isolates were facilitated in 105 possible combinations to interact on potato dextrose agar. Morphologically, no changes were observed when the same fungal isolates were allowed to interact within them. However, 10 interactions between different fungal isolates showed mutual replacement with each fungus; capturing territory from the other. Contrastingly, 35 interactions resulted into complete replacement as one of the fungi was inhibited by rapid growth of the other fungus. In 46 interactions, formation of barrage was observed leading to deadlock type of interaction wherein both fungi have restricted growth. To study in details about the barrage formation, two fungal interactions were taken (i) T. coccinea vs. L. lactinea and (ii) T. coccinea vs. T. versicolor. Microscopic changes in the hyphal growth during interaction were observed. There was significant increase in the enzymatic activities including cellulase, xylanase and chitinase during in-vitro fungal-fungal interaction, suggesting the importance of such interactions for commercial enzyme production.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 4","pages":"279-295"},"PeriodicalIF":4.2,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2021.1932627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39720017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Fomitopsis meliae CFA 2, a novel brown rot for endoglucanase: emphasis towards enhanced endoglucanase production by statistical approach. meliae fitopsis CFA 2，一种新的内切葡聚糖酶褐腐病:强调用统计方法提高内切葡聚糖酶的产量。

IF 4.2 2区生物学

Mycology Pub Date : 2021-04-30 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1918277

Amisha Patel, Jyoti Divecha, Amita Shah

{"title":"Fomitopsis meliae CFA 2, a novel brown rot for endoglucanase: emphasis towards enhanced endoglucanase production by statistical approach.","authors":"Amisha Patel, Jyoti Divecha, Amita Shah","doi":"10.1080/21501203.2021.1918277","DOIUrl":"https://doi.org/10.1080/21501203.2021.1918277","url":null,"abstract":"Brown rot basidiomycetes are a principal group of wood-decaying fungi which degrade wood cellulose and hemicellulose by the combination of carbohydrate active enzymes and non-enzymatic oxidation reactions. Very scant information is available on carbohydrate active enzymes of brown rot fungi. In this context, present study focused on the production of cellulolytic-hemicellulolytic enzymes from newly isolated brown rot Fomitopsis meliae CFA 2. Under solid-state fermentation using wheat bran as the substrate Fomitopsis meliae CFA 2 was able to produce a maximum of 1391.12 ± 21.13 U/g of endoglucanase along with other cellulolytic and hemicellulolytic enzymes. Various fermentation parameters were optimised for enhanced production of endoglucanase by employing Plackett-Burman design followed by Box-Behnken design. A well-fitted regression equation with R2 value of 98.91% was attained for endoglucanase. The yield of endoglucanase was enhanced by 1.83-fold after executing statistical optimisation of various fermentative parameters. The newly isolated Fomitopsis meliae CFA 2 was found to be a potential producer of endoglucanase. Enzymatic saccharification of alkali-treated wheat straw and rice straw resulted in release of 190.8 and 318.8 mg/g of reducing sugars, respectively.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 4","pages":"325-340"},"PeriodicalIF":4.2,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2021.1918277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39721004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Antimicrobial properties of marine fungi from sponges and brown algae of Mauritius. 毛里求斯海绵和褐藻中海洋真菌的抗菌特性。

IF 4.2 2区生物学

Mycology Pub Date : 2021-04-22 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1895347

Jessica Mélanie Wong Chin, Daneshwar Puchooa, Theeshan Bahorun, Rajesh Jeewon

{"title":"Antimicrobial properties of marine fungi from sponges and brown algae of Mauritius.","authors":"Jessica Mélanie Wong Chin, Daneshwar Puchooa, Theeshan Bahorun, Rajesh Jeewon","doi":"10.1080/21501203.2021.1895347","DOIUrl":"10.1080/21501203.2021.1895347","url":null,"abstract":"Purpose of the study: Marine fungi of Mauritius have been poorly studied. There are numerous reports on the bioactive secondary metabolites that are produced by fungi around the world. Yet, research on the molecular characterisation and the pharmaceutical potential of marine fungi in Mauritius is rather scanty. Method: The samples, which consisted of three sponges Haliclona sp., Iotrochota sp. and Biemna sp. and two brown algae Turbinaria conoides and Sargassum portierianum, were collected in the North of Mauritius during winter. No sporulating structures were observed from the fungal cultures making morphological analysis impossible. The molecular characterisation of the selected isolates was carried out by the amplification of the ITS regions and phylogenetic analysis. The antimicrobial properties were then determined using the disc diffusion and the minimum inhibitory concentration (MIC) assay. Results: Genus level identification was made from molecular data and for some isolates, species-level identification was even possible. Twelve fungi that showed the best antimicrobial properties were identified as Peniophora sp., Aspergillus cristatus, Acremonium sp., Cordyceps memorabilis, Aspergillus ochraceus, Biscogniauxia sp., Aspergillus keratitidis, Exserohilum rostratum, Chromocleista sp., Nigrospora oryzae, Aspergillus flavipes and Mycosphaerella. The lowest MIC result of 0.0098 mg/mL was obtained with Chromocleista sp. mycelium extract against Staphylococcus aureus. The MIC of the mycelium extracts was lower than the broth extracts for most isolates indicating that the antimicrobial compounds are not secreted. Conclusion: Marine fungi from the Mauritian waters have immense potential in the search for natural products against antibiotic-resistant bacteria.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 4","pages":"231-244"},"PeriodicalIF":4.2,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39720014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro interactions between the ectomycorrhizal Pisolithus tinctorius and the saprotroph Hypholoma fasciculare fungi: morphological aspects and volatile production. 外生菌根Pisolithus tinctorius与腐坏菌束状菌丝的体外相互作用:形态方面和挥发性产物。

IF 4.2 2区生物学

Mycology Pub Date : 2021-02-27 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1876778

Paula Baptista, Paula Guedes de Pinho, Nathalie Moreira, Ricardo Malheiro, Francisca Reis, Jorge Padrão, Rui Tavares, Teresa Lino-Neto

{"title":"In vitro interactions between the ectomycorrhizal Pisolithus tinctorius and the saprotroph Hypholoma fasciculare fungi: morphological aspects and volatile production.","authors":"Paula Baptista, Paula Guedes de Pinho, Nathalie Moreira, Ricardo Malheiro, Francisca Reis, Jorge Padrão, Rui Tavares, Teresa Lino-Neto","doi":"10.1080/21501203.2021.1876778","DOIUrl":"https://doi.org/10.1080/21501203.2021.1876778","url":null,"abstract":"Ectomycorrhizal fungi are crucial for forests sustainability. For Castanea sativa, ectomycorrhizal fungus Pisolithus tinctorius is an important mutualist partner. Saprotrophic fungi Hypholoma fasciculare, although used for biocontrol of Armillaria root disease, it negatively affected the interaction between the P. tinctorius and plant host roots, by compromise the formation of P. tinctorius-C. sativa mycorrhizae. In this work, fungal morphology during inhibition of H. fasciculare against P. tinctorius was elucidated. P. tinctorius growth was strongly affected by H. fasciculare, which was significantly reduced after six days of co-culture and become even more significant through time. During this period, P. tinctorius developed vesicles and calcium oxalate crystals, which were described as mechanisms to stress adaption by fungi. H. fasciculare produced different volatile organic compounds in co-cultures over time and differ between single or in dual-species. H. fasciculare highly produced sesquiterpenes (namely, α-muurolene) and nitrogen-containing compounds, which are recognised as having antimicrobial activity.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 3","pages":"216-229"},"PeriodicalIF":4.2,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2021.1876778","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39440185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Plant associated fungal endophytes as a source of natural bioactive compounds. 植物相关真菌内生菌作为天然生物活性化合物的来源。

IF 4.2 2区生物学

Mycology Pub Date : 2021-01-27 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2020.1870579

Nilesh Rai, Priyanka Kumari Keshri, Ashish Verma, Swapnil C Kamble, Pradeep Mishra, Suvakanta Barik, Santosh Kumar Singh, Vibhav Gautam

{"title":"Plant associated fungal endophytes as a source of natural bioactive compounds.","authors":"Nilesh Rai, Priyanka Kumari Keshri, Ashish Verma, Swapnil C Kamble, Pradeep Mishra, Suvakanta Barik, Santosh Kumar Singh, Vibhav Gautam","doi":"10.1080/21501203.2020.1870579","DOIUrl":"https://doi.org/10.1080/21501203.2020.1870579","url":null,"abstract":"Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plant-associated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 3","pages":"139-159"},"PeriodicalIF":4.2,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2020.1870579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Fungal communities in bat guano, speleothem surfaces, and cavern water in Madai cave, Northern Borneo (Malaysia). 北婆罗洲(马来西亚)Madai洞穴蝙蝠鸟粪、洞穴表面和洞穴水中的真菌群落。

IF 4.2 2区生物学

Mycology Pub Date : 2021-01-25 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2021.1877204

Ibrahem G Wasti, Faisal Ali Anwarali Khan, Henry Bernard, Noor Haliza Hassan, Tom Fayle, Jaya Seelan Sathiya Seelan

{"title":"Fungal communities in bat guano, speleothem surfaces, and cavern water in Madai cave, Northern Borneo (Malaysia).","authors":"Ibrahem G Wasti, Faisal Ali Anwarali Khan, Henry Bernard, Noor Haliza Hassan, Tom Fayle, Jaya Seelan Sathiya Seelan","doi":"10.1080/21501203.2021.1877204","DOIUrl":"https://doi.org/10.1080/21501203.2021.1877204","url":null,"abstract":"The island of Borneo is a global biodiversity hotspot. However, its limestone caves are one of its least-studied ecosystems. We report for the first time the fungal species richness, diversity and abundance from Madai cave, situated in north-eastern Borneo. Environmental samples from inside the cave environment were collected (guano, speleothem, and cavern water) via opportunistic sampling. The dilution method was performed for isolation of fungi. Morphological characterisation and molecular analysis of the ITS region were utilised for the identification of isolates. Fifty-five pure cultures of fungi were attained, comprising 32 species from 15 genera, eight orders, and two divisions, Ascomycota and Basidiomycota. Ascomycetes dominated the fungal composition, accounting for 53 (96%) out of 55 total isolates. Penicillium spp. accounted for more than 47.1% of fungal abundance in all sample types. However, Aspergillus spp. had the highest occurrence rate, being isolated from all environmental samples except one. Purpureocillium lilacinum was isolated most frequently, appearing in five separate samples across all three substrates. Annulohypoxylon nitens, Ganoderma australe, Pyrrhoderma noxium, and Xylaria feejeensis were discovered and reported for the first time from the cave environment. This study provides additional data for further research on the mycoflora of Sabah's various ecosystems, especially limestone caves.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 3","pages":"188-202"},"PeriodicalIF":4.2,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2021.1877204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39440183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Molecular virulence determinants of Magnaporthe oryzae: disease pathogenesis and recent interventions for disease management in rice plant. 水稻大孔霉的分子毒力决定因素:疾病发病机制和水稻病害管理的最新干预措施。

IF 4.2 2区生物学

Mycology Pub Date : 2021-01-15 eCollection Date: 2021-01-01 DOI: 10.1080/21501203.2020.1868594

Lovely Gupta, Maansi Vermani, Simran Kaur Ahluwalia, Pooja Vijayaraghavan

引用次数: 9

Dual identities for various alcohols in two different yeasts. 两种不同酵母中不同醇的双重特性。

IF 4.2 2区生物学

Mycology Pub Date : 2020-12-07 DOI: 10.1080/21501203.2020.1837976

Nitin Mahendra Chauhan, S Mohan Karuppayil

{"title":"Dual identities for various alcohols in two different yeasts.","authors":"Nitin Mahendra Chauhan, S Mohan Karuppayil","doi":"10.1080/21501203.2020.1837976","DOIUrl":"https://doi.org/10.1080/21501203.2020.1837976","url":null,"abstract":"Most of the yeast bypasses the developmental stage from simple unicellular yeast to elongated structure like hyphae. Regulation of this transition is governed by various quorum sensing and signalling molecules produced under different conditions of growth, that differ significantly, both physiologically and chemically. The evidence of fungal quorum sensing was uncovered ten years ago after the discovery of farnesol as first eukaryotic quorum sensing molecules in Candida albicans. In addition to farnesol, tyrosol was identified as second quorum sensing molecules in C. albicans controlling physiological activities. After the discovery of farnesol and tyrosol, regulation of morphogenesis through the production of chemical signalling molecules such as isoamyl alcohol, 2-phenylethyl alcohol, 1-dodecanol, E-nerolidol, etc. is reported in C. albicans. Some of the evidence suggests that the budding yeast Saccharomyces cerevisiae exhibits this type of regulation and the signals are regulated by aromatic alcohols which are the end product of amino acid metabolism. The effects of these molecules on morphogenesis are not similar in both yeasts, making comparisons hard. It is hypothesized that these signals works in microorganisms to derive a competitive advantage. Here, we present an example for utilization of competitive strategy by C. albicans and S. cerevisiae over other microorganisms.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 1","pages":"25-38"},"PeriodicalIF":4.2,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2020.1837976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25401487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro. 星形屋脊的体外抗氧化、抗菌和神经保护作用。

IF 4.2 2区生物学

Mycology Pub Date : 2020-12-02 DOI: 10.1080/21501203.2020.1816584

Mustafa Sevindik, Hasan Akgul, Zeliha Selamoglu, Nady Braidy

{"title":"Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro.","authors":"Mustafa Sevindik, Hasan Akgul, Zeliha Selamoglu, Nady Braidy","doi":"10.1080/21501203.2020.1816584","DOIUrl":"https://doi.org/10.1080/21501203.2020.1816584","url":null,"abstract":"Octaviania asterosperma (hypogeous Basidiomycota) We investigated the phenolic composition, and antioxidant, antimicrobial and antigenotoxic effects of methanol extracts of fruiting bodies from Octaviania asterosperma. The total phenolic content (ppm) of O. asterosperma was found to be catechin (54.73 ± 4.68), epicatechin (123.90 ± 8.52), caffeic acid (4.23 ± 0.97), p-hydroxybenzoic acid (37.72 ± 3.84), cinnamic acid (58.07 ± 5.40), gallic acid (56.64 ± 6.39), clorogenic acid (80.76 ± 4.92) and coumaric acid (2.45 ± 0.15). The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were 3.410 ± 0.099 mmol/L, 7.548 ± 0.147 μmol/L and 0.221 ± 0.005 respectively. O. asterosperma showed some promising antimicrobial activity. The extract showed no genotoxic potential and attenuated hydrogen peroxide (H2O2)-induced oxidative DNA damage in neurons. Pre-treatment with O. asterosperma maintained mitochondrial function, reduced expression levels of cleaved-caspase-3 and apoptosis-inducing factor (AIF) when HT22 cells were exposed to pathophysiological concentrations of GLU (25 mM) and modulated protein kinase B (Akt), the mammalian target of rapamycin (mTOR), and the phosphotase and tensin homolog on chromosome ten (PTEN). O. asterosperma is an important food for the treatment or management of neurodegenerative disorders due to its phenolic content and potent antioxidant and anti-excitotoxic effects.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"12 2","pages":"128-138"},"PeriodicalIF":4.2,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21501203.2020.1816584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39019210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10