Mycology最新文献

New bioactive secondary metabolites from fungi: 2024. 真菌中新的生物活性次生代谢物；2024。

IF 4.4 2区生物学

Mycology Pub Date : 2025-07-11 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2526772

Meiyan Bao, Ying Shi, Xiaoyi Gong, Yutong Guo, Jing Wang, Xiaofei Chen, Ling Liu

引用次数: 0

Functional diversification of epidithiodiketopiperazine methylation and oxidation towards pathogenic fungi. 附硫碘二酮哌嗪甲基化和氧化对病原菌的功能多样化。

IF 4.4 2区生物学

Mycology Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2496190

Shengquan Zhang, Peng-Lin Wei, Yuanyuan Li, Zedong Ren, Jie Fan, Wen-Bing Yin

{"title":"Functional diversification of epidithiodiketopiperazine methylation and oxidation towards pathogenic fungi.","authors":"Shengquan Zhang, Peng-Lin Wei, Yuanyuan Li, Zedong Ren, Jie Fan, Wen-Bing Yin","doi":"10.1080/21501203.2025.2496190","DOIUrl":"10.1080/21501203.2025.2496190","url":null,"abstract":"The genus Trichoderma plays a vital role in agriculture by promoting plant growth, enhancing nutrient uptake, and protecting crops from pathogens through biocontrol mechanisms. This can be largely attributed to its production of diverse secondary metabolites (SMs), including epidithiodiketopiperazines (ETPs). Our previous study has reported the complex biosynthesis of α, β'-disulfide bridged ETPs, in which TdaH and TdaG are highly conserved in catalyzing C6'-O-methylation and C4, C5-epoxidation, respectively. Here we proved the functional diversification of ETP methylation and oxidation by TdaH and TdaG towards eleven pathogenic fungi, including Fusarium, Aspergillus, and Botrytis species. Elimination of C6'-O-methylation and C4, C5-epoxidation reduced the antagonistic effects of Trichoderma hypoxylon against various pathogenic fungi. However, each deletion mutant showed varying antagonistic effects against different pathogenic fungi. Our results highlight the importance of ETP structural diversity in T. hypoxylon's ecological adaptation and biocontrol potential, offering insights into developing enhanced antifungal agents against plant pathogens.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1418-1431"},"PeriodicalIF":4.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the mycobiota of Daqu at the species level using metabarcoding of full-length ITS sequences. 利用ITS全长序列元条形码在种水平上揭示大曲菌群。

IF 4.4 2区生物学

Mycology Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2460495

Da-Yong Han, Xue-Wei Wang, Jos Houbraken, Liang Song, Zhang Wen, Hai-Yan Zhu, Yu-Hua Wei, Lu-Jun Luo, Ju-Wei Wang, Shen-Xi Chen, Shang-Jie Yao, Zhen-Rong Liang, Meng-Meng Zhang, Chao-Jiu He, Feng-Yan Bai, Pei-Jie Han

{"title":"Unraveling the mycobiota of Daqu at the species level using metabarcoding of full-length ITS sequences.","authors":"Da-Yong Han, Xue-Wei Wang, Jos Houbraken, Liang Song, Zhang Wen, Hai-Yan Zhu, Yu-Hua Wei, Lu-Jun Luo, Ju-Wei Wang, Shen-Xi Chen, Shang-Jie Yao, Zhen-Rong Liang, Meng-Meng Zhang, Chao-Jiu He, Feng-Yan Bai, Pei-Jie Han","doi":"10.1080/21501203.2025.2460495","DOIUrl":"10.1080/21501203.2025.2460495","url":null,"abstract":"Daqu, the starter used in Baijiu making process, is produced by spontaneous solid-state fermentation and contains numerous microbes and enzymes, significantly influencing the yield and flavour profile of Baijiu. In this study, we employed a full-length ITS metabarcoding approach using the PacBio sequencing technology to investigate the fungal diversity in 296 samples of low- (LTD), medium- (MTD) and high-temperature Daqu (HTD) collected from 10 provinces in China. In total, we identified 86 species or species groups in the fungal communities of Daqu. The fungal communities of the three types of Daqu were significantly different and the differences were also associated with their geographical origins. Ascoideales (relative abundance 21.04%), Pichiales (15.38%), Mucorales (39.54%) and Eurotiales (19.96%) totally accounted for 95.92% of the fungal community of the Daqu samples. The former two were significantly enriched in the LTD samples and the latter two in the MTD and HTD samples, respectively. We also identified the distinct fungal species that showed differential enrichment within each Daqu type as well as among samples of the same type originating from different regions. These findings offer a deeper insight into the fungal communities associated with various Daqu types and their geographical origins at the species level.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1339-1356"},"PeriodicalIF":4.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatophytes adaptation to the human host exemplified by Microsporum canis. 皮肤真菌对人类宿主的适应，以犬小孢子菌为例。

IF 4.4 2区生物学

Mycology Pub Date : 2025-02-16 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2461720

Xin Zhou, Ricardo Belmonte, Chao Tang, Vania Aparecida Vicente, Sybren de Hoog, Peiying Feng

{"title":"Dermatophytes adaptation to the human host exemplified by Microsporum canis.","authors":"Xin Zhou, Ricardo Belmonte, Chao Tang, Vania Aparecida Vicente, Sybren de Hoog, Peiying Feng","doi":"10.1080/21501203.2025.2461720","DOIUrl":"10.1080/21501203.2025.2461720","url":null,"abstract":"Dermatophytes are a taxonomic group of keratinophilic fungi that engender cutaneous infections across human and animal populations. The zoophilic species Microsporum canis, which exhibits a widespread distribution, predominantly affects domesticated felines and canines and has recently been associated with an increased risk of human adaptation. This study conducted a comparative genome analysis, validating the adaptive expression of 12 relevant genes through neutrality tests and selection pressure analyses, with a particular focus on the evolutionary mechanisms underlying the transition from zoophilic to anthropophilic Microsporum. The results demonstrated a high degree of consistency in the nuclear and mitochondrial genomes among the three Microsporum species, while significant differences were observed in protein domains. Notably, the anthropophilic species M. audouinii and M. ferrugineum exhibited more gene duplication events and expansions in domains such as MFS and Zn2Cys6 transcription factors. Among the 138 identified genes, specific protease subfamilies (e.g. S08A, M77, S53) and CAZy subfamilies (e.g. GH18, AA1, AA3) showed strong ecological correlations with either zoophilic or anthropophilic lifestyles. The key functions of these genes from these subfamilies focus on modulating sporulation, endoproteases, lipolysis, pH regulatory adaptability, chitinase, and conidial pigment biosynthesis. Microenvironmental factors such as pH, lipid concentration, and osmolarity significantly influenced the expression of these key genes. Anthropophilic strains demonstrated higher tolerance to acidic pH and enhanced keratinase activity in lipid-rich environments, with M. ferrugineum exhibiting the strongest osmotic tolerance. These findings highlight the inherent evolutionary dynamics and adaptive mechanisms of dermatophytes, providing valuable insights into the pathogenicity of Microsporum.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1357-1372"},"PeriodicalIF":4.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 4.6 2区生物学

Mycology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2461914

引用次数: 0

Correction. 修正。

IF 4.6 2区生物学

Mycology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2461915

引用次数: 0

Correction. 修正。

IF 4.6 2区生物学

Mycology Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2461912

引用次数: 0

The genus Thaxterogaster (Cortinariaceae): phylogeny and species diversity in Western China. 标题中国西部山菖蒲属植物的系统发育与物种多样性。

IF 4.4 2区生物学

Mycology Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2441178

Zi-Rui Wang, Song-Yan Zhou, Fei-Fei Liu, Zhu L Yang

引用次数: 0

Phylogeny of Geoglossomycetes with species diversity in China. 标题中国地舌菌的系统发育与物种多样性。

IF 4.4 2区生物学

Mycology Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2436000

Hongli Su, Kevin D Hyde, Qing Cai, Wenyan Chen, Fatimah Al-Otibi, K W Thilini Chethana, Zhu L Yang, Qi Zhao

引用次数: 0

Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans. 去泛素酶Ubp5对新型隐球菌的肺免疫逃避和血液传播至关重要。

IF 4.4 2区生物学

Mycology Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2025.2453739

Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang

{"title":"Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans.","authors":"Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang","doi":"10.1080/21501203.2025.2453739","DOIUrl":"10.1080/21501203.2025.2453739","url":null,"abstract":"The dynamic interplay between pathogens and host immune system determines the outcome of fungal infections. This study investigates the role of Ubp5 in modulating host defenses during Cryptococcus neoformans H99 infections. Ubp5 deletion significantly reduces both pulmonary invasion and extrapulmonary dissemination, resulting in prolonged survival and decreased fungal burdens in mice. Attenuated virulence is closely associated with enhanced host immune responses, rather than diminished pathogen fitness alone. Histopathological and leukocyte analyses revealed a shift towards protective adaptive immune responses in ubp5Δ-infected lungs, characterized by lymphocyte-dominated inflammatory infiltration and an increased Th1/Th17 cytokine response. Under host-associated conditions, ubp5Δ mutants exhibited morphological changes, including distorted shapes and cell wall heterogeneity, alongside defects in key virulence factors such as the polysaccharide capsule and melanin. These changes likely promote exposure of immunostimulatory cell wall components, enhancing host immunity. Additionally, Ubp5 deletion resulted in a significant reduction in intracellular ribosomal particles in C. neoformans, which likely impairs protein synthesis, contributing to reduced growth and pathogenic fitness in vivo. These findings underscore the pivotal role of Ubp5 in maintaining cryptococcal virulence and suggest that targeting Ubp5 could enhance host immunity against cryptococcosis by promoting protective immune responses and limiting fungal dissemination.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1373-1385"},"PeriodicalIF":4.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0