Mycology最新文献

{"title":"Fungal infections in diabetic foot and other dermatoses: new species and clinical outcomes.","authors":"Jing-Zu Sun, Qiu-Hong Yan, Shan Li, Lei Dong, Tao Wang, Hong-Wei Liu, Xiao-Ying Yuan","doi":"10.1080/21501203.2025.2594944","DOIUrl":"10.1080/21501203.2025.2594944","url":null,"abstract":"","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2594944"},"PeriodicalIF":4.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research advances and public health strategies in China on WHO priority fungal pathogens.","authors":"Yue Wang, Li Han, Jie Gong, Liu Liu, Beibei Miao, Jianping Xu","doi":"10.1080/21501203.2025.2561612","DOIUrl":"10.1080/21501203.2025.2561612","url":null,"abstract":"<p><p>Fungal pathogens pose significant and increasing threats to public health. Each year, over a billion people are infected by fungal pathogens, directly contributing to millions of deaths. To overcome the challenge of fungal threat, in 2022, World Health Organization (WHO) issued a Fungal Priority Pathogens List (FPPL) aimed at strengthening international response, promoting research, and enhancing policy intervention development. Over the past four decades, China has made tremendous progress in advancing our knowledge of fungal infections. Here, we review research trends and recent progress in China on fungal pathogens on the WHO FPPL, with an emphasis on four critical pathogens: <i>Cryptococcus neoformans</i>, <i>Candidozyma auris</i>, <i>Aspergillus fumigatus</i>, and <i>Candida albicans</i> since 2022. In addition, we describe national policies and strategic measures aimed at large-scale prevention and control of fungal infections. Our bibliometric analyses of articles published by Chinese researchers from 1983 to 2024 in the Web of Science Core Collection (WOSCC, English-language) and China National Knowledge Infrastructure (CNKI, Chinese-language) revealed increasing number of peer-reviewed publications on human fungal pathogens in both databases up to 2008 when the number in the CKNI database dropped and remained relatively flat since while that in the WOSCC database continued to increase, reflecting the strategic emphasis by Chinese institutions and funding agencies on achieving greater international visibility, academic impact, and integration within the global scientific community. In both databases, the four critical priority pathogens accounted for > 45% of the studies and the progresses made by Chinese researchers since 2022 on them are described here. A shared challenge for treating all fungal infections is the emergence and spread of antifungal resistance. We highlight antifungal resistance, tolerance, and persistence, and describe recent developments in antifungal drug pipelines, including those in China. Beyond scientific breakthroughs, China has been making coordinated prevention efforts and robust policy measures. However, significant challenges remain in understanding pathogen population dynamics and host-pathogen interactions; in developing and deploying rapid, sensitive, specific, and cost-effective diagnosis; in designing geographic region-specific and personalized prevention and treatments; and in alleviating the growing burden of antifungal resistance.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 4","pages":"1437-1477"},"PeriodicalIF":4.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upholding integrity and advancing innovation: development of scientific journals at the Institute of Microbiology, Chinese Academy of Sciences.","authors":"Qun Yan, Lei Cai, Wen Wu, Hongyu Chen, Wei Qian, George Fu Gao","doi":"10.1080/21501203.2025.2537486","DOIUrl":"10.1080/21501203.2025.2537486","url":null,"abstract":"","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 4","pages":"1433-1436"},"PeriodicalIF":4.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is <i>Fusarium</i> forma specialis?","authors":"Shiling Han, Peng Zhao, Mengmeng Wang, Xiaoyu Jiang, Fang Liu, Junen Huang, Lei Cai","doi":"10.1080/21501203.2025.2528352","DOIUrl":"10.1080/21501203.2025.2528352","url":null,"abstract":"<p><p>The forma specialis concept has been a cornerstone in <i>Fusarium</i> phytopathology for 85 years, classifying pathogens based on host specificity. However, its validity as a natural and practical framework has been increasingly questioned. In this study, we critically re-evaluate the forma specialis concept through an extensive survey of Fusarium wilt diseases across 37 crop hosts from 23 provinces of China. Through multi-locus phylogenetic analyses, morphological assessments, and pathogenicity tests on 659 strains isolated from 171 diseased samples, we identified 46 <i>Fusarium</i> species, including seven newly described taxa, and uncovered extensive cross-host pathogenicity, with up to 21 species associated with the same wilt disease. In addition, 57% of samples exhibited multiple species co-infections, revealing significant inconsistencies with the forma specialis framework. These findings challenge the long-standing paradigm of host specificity in <i>Fusarium</i> pathogens and advocate for a shift of perspective to a \"pathobiome\" framework, where disease dynamics are largely driven by community-level interactions rather than single-pathogen relationships. Applying these conceptual advances to Fusarium wilt research could fundamentally transform our comprehension of host-pathogen relationships and facilitate the development of more ecologically sustainable disease management approaches.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 4","pages":"1522-1557"},"PeriodicalIF":4.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of macrofungi in southeast Xizang, China 2.","authors":"Jin-Rong Lu, Lei Lei, Feng-Ming Yu, Xue-Tai Zhu, Jun-Feng Liang, Liu-Kun Jia, Li-Heng Mu, Jin-Ming Zhang, Geng-Shen Wang, Ying Zhang, Kevin D Hyde, Zhu-Liang Yang, Qi Zhao","doi":"10.1080/21501203.2025.2525864","DOIUrl":"10.1080/21501203.2025.2525864","url":null,"abstract":"<p><p>Southeast Xizang, situated in southwestern China, is a global biodiversity hotspot harbouring exceptionally rich fungal diversity. This study, part of the Second Qinghai-Xizang Plateau Scientific Expedition and Research Program, undertook a comprehensive survey of macrofungal diversity in the region from 2019 to 2024, resulting in the collection of over 1,600 specimens. As the second instalment in the series of \"<i>Diversity of macrofungi in southeast Xizang</i>\", this study identified and documented 480 macrofungal species through combined morphological and molecular evidence, and they are belonging to two phyla, seven classes, 17 orders, 67 families, and 158 genera. Species composition analyses revealed 15 dominant families (each containing ≥ 10 species): Russulaceae, Agaricaceae, Cortinariaceae, Boletaceae, Inocybaceae, Hymenogastraceae, Omphalotaceae, Entolomataceae, Amanitaceae, Strophariaceae, Hygrophoraceae, Mycenaceae, Psathyrellaceae, Hydnangiaceae, and Lycoperdaceae. At the genus-level, 23 dominant genera (each containing ≥ 5 species), including <i>Lactarius</i>, <i>Russula</i>, and <i>Cortinarius</i>, etc., accounted for 265 species (55.21% of the total diversity). Among the documented species, 115 are edible, 15 medicinal, and 53 poisonous. Notably, the study proposed eight new species, i.e. <i>Callistosporium motuoense</i>, <i>Chromosera chayuensis</i>, <i>Clavulinopsis motuoensis</i>, <i>Cudonia linzhiensis</i>, <i>Elaiopezia chayuensis</i>, <i>Sarcoleotia motuoensis</i>, <i>Trichoderma atrosphaericum</i>, and <i>Volvariella parvoalba</i>, with detailed descriptions and illustrations.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2525864"},"PeriodicalIF":4.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophytic fungi as a source of antimicrobial compounds against emerging methicillin-resistant <i>Staphylococcus aureus</i>.","authors":"Shefali Bansal, Mahavir Joshi, Prachi Mahajan, Smile Sharma, Sukhminderjit Kaur, Babita Thakur, Prabhjot Singh Jassal, Ranjan Singh, Manikant Tripathi","doi":"10.1080/21501203.2025.2531886","DOIUrl":"10.1080/21501203.2025.2531886","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) represents a critical global health threat, significantly impacting treatment outcomes, increasing mortality, and imposing economic burdens. It also hinders progress towards Sustainable Development Goal (SDG) 3: Good Health and Well-being. Among the most concerning resistant pathogens is Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), a multidrug-resistant bacterium whose genetic adaptability and rapid evolution have rendered many conventional antibiotics ineffective. The clinical and agricultural use and misuse of antimicrobial agents is hastening the development of resistant strains, and there is an urgent need for new therapeutics to address this issue. Endophytic fungi live asymptomatically within plant tissues and have great potential as a largely unexplored source of structurally diverse secondary metabolites that can exhibit potent antibacterial properties. This review aims to highlight the classes of fungal metabolites that are active against MRSA, including alkaloids, polyketides, terpenoids, peptides, flavonoids, and quinones, while describing their mechanisms of action, which include inhibition of cell wall biosynthesis, disruption of biofilm production, and inhibition of nucleic acid or protein synthesis. The review will also highlight the ecological relevance of endophytes and structure-activity relationships (SAR) as they relate to drug development. By aligning with aspects of the \"One Health\" prescription for integrating the health of humans, animals, and the environment, the present review highlights the viability of endophytic fungi as compelling players in the global response to AMR-and brings the potential of the use of natural products in a more sustainable manner to promote and develop more antimicrobial strategies in all sectors.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2531886"},"PeriodicalIF":4.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between <i>Shiraia</i> and its fruiting body-associated <i>Rhodococcus</i> sp. No. 3 via hypocrellin A and carotenoid biosynthesis.","authors":"Li Ping Zheng, Qun Yan Huang, Xin Ping Li, Jian Qin Zhou, Jian Wen Wang","doi":"10.1080/21501203.2025.2531888","DOIUrl":"10.1080/21501203.2025.2531888","url":null,"abstract":"<p><p>Hypocrellin A (HA), a bioactive perylenequinone from <i>Shiraia</i> fruiting bodies, serves as an efficient photodynamic therapy photosensitiser. While these fruiting bodies harbour diverse bacteria, host-microbe functional interactions remain poorly characterised. This study elucidates a metabolite-mediated interplay between <i>Shiraia</i> sp. S9 and its fruiting body-associated bacterium <i>Rhodococcus</i> sp. No. 3. As non-contact co-cultivation significantly enhanced fungal HA production, bacterial volatile organic compounds (VOCs) such as dimethyl disulphide and 4-aminoacetophenone were identified for the elicitation. Bacterial VOCs increased fungal membrane permeability, induced reactive oxygen species (ROS) generation, and up-regulated HA biosynthetic gene expressions. Conversely, photoactivated HA induced cellular damage and growth inhibition on <i>Rhodococcus</i> sp. No. 3 via light-dependent ROS accumulation. Bacterial counteradaptation occurred through HA-induced carotenoid biosynthesis. This work provides the first evidence of a defense-driven feedback loop between <i>Shiraia</i> and its bacterial symbiont, revealing how VOCs act as biochemical elicitors while the photosensitiser HA shapes bacterial antioxidant responses. These insights advance our understanding of cross-kingdom interactions in fungal fruiting bodies and offer novel strategies for secondary metabolite enhancement.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2531888"},"PeriodicalIF":4.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungus <i>Aspergillus flavus</i>.","authors":"Guoqi Li, Elisabeth Tumukunde, Yuanyuan Chen, Yao Zhang, Yunlu Kuang, John Adejor, Meifang Wen, Shihua Wang","doi":"10.1080/21501203.2025.2522081","DOIUrl":"10.1080/21501203.2025.2522081","url":null,"abstract":"<p><p>This study evaluates the effects of pyruvate decarboxylase and its lysine succinylation (Ksucc) on the development of <i>Aspergillus flavus</i> and the production of secondary metabolites. Mutant strains, including the knockout (∆<i>pdc1</i>), <i>pdc1</i> point mutants (K258R and K258E) and complementary (∆<i>pdc1.com</i>) were constructed. The results showed that both Δ<i>pdc1</i> and K258R strains exhibited decreased conidiophore and conidia production and failed to generate sclerotia. The production of aflatoxin B1 (AFB1) was significantly increased in the Δ<i>pdc1</i> and K258R strains, while it decreased in the K258E strain. The results also indicate that <i>pdc1</i> and its Ksucc are involved in the stress response and pathogenicity of <i>A. flavus</i>. Through GC-MS analysis, Δ<i>pdc1</i> was found to produce several significantly decreased compounds, including n-hexadecanoic acid, 2-bromotetradecane, and palmitic acid, among others. Additionally, different volatile metabolites, such as 1-iodo-decane, <i>n</i>, <i>n</i>-dimethyloctanamide and <i>n</i>, <i>n</i>-dimethyl-7-octynamide, were not detected in the Δ<i>pdc1</i> strain compared to WT and Δ<i>pdc1.com</i>. HPLC results showed that the production of pyruvic acid, malic acid and succinic acid increased in both the Δ<i>pdc1</i> and K258R strains when compared to WT and Δ<i>pdc1.com</i> strains. Comparative RNA-seq analysis revealed a total of 3,817 differentially expressed genes (DEGs) including 1,913 up-regulated and 1,904 down-regulated genes in Δ<i>pdc1 vs</i>. WT. These results suggest that PDC1 and K258 play a crucial role in the biosynthesis of secondary metabolites, development and stress responses of <i>A. flavus</i>.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2522081"},"PeriodicalIF":4.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New bioactive secondary metabolites from fungi: 2024.","authors":"Meiyan Bao, Ying Shi, Xiaoyi Gong, Yutong Guo, Jing Wang, Xiaofei Chen, Ling Liu","doi":"10.1080/21501203.2025.2526772","DOIUrl":"10.1080/21501203.2025.2526772","url":null,"abstract":"<p><p>Fungi have been recognised as a prolific source of structurally unique secondary metabolites with promising pharmacological properties. This review comprehensively summarises the chemical architectures, bioactivities, and research strategies for new fungal-derived natural products, focusing on representative studies published in 2024. A total of 907 novel fungal-derived compounds are systematically cataloged (isomers are also contained in the total count), including 284 polyketides, 362 terpenoids, 28 steroids, 108 alkaloids, 75 peptides, and 50 glycosides, while highlighting cutting-edge methodologies such as metabolomics-guided discovery platforms and biosynthetic pathway engineering. By establishing connections between chemical novelty and therapeutic value, this review not only provides strategic guidance for fungal chemical diversity exploration but also illuminates their transformative potential in overcoming drug discovery bottlenecks.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"961-987"},"PeriodicalIF":4.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of new bianthrones and chlorinated bianthrones with cytotoxic activity against cancer cells from <i>Penicillium hispanicum</i> guided by HSQC-based DeepSAT.","authors":"Ruiyun Huo, Minhui Ji, Gaoran Liu, Ling Liu","doi":"10.1080/21501203.2025.2526766","DOIUrl":"10.1080/21501203.2025.2526766","url":null,"abstract":"<p><p>Three new racemic bianthrones, including two pairs of (±)-penithrones A (<b>1</b>) and B (<b>2</b>), and a chlorinated derivative (±)-penithrone C (<b>3</b>), along with their biogenetic precursors (<b>4</b>-<b>6</b>) were discovered from the culture extract of the mangrove-derived fungus <i>Penicillium hispanicum</i> LA032 using HSQC-based DeepSAT. The structural elucidation of these new compounds was achieved through comprehensive integration of NMR spectroscopy, high-resolution mass spectrometry (HRESIMS), and NMR calculations with CP3 analysis. Compounds <b>1</b> and <b>2</b> exhibited significant cytotoxic activity against HeLa, HCT116, and MCF-7 cancer cell lines, with IC₅₀ values ranging from 5.09 ± 0.65 to 9.47 ± 0.22 μmol/L. In addition, network pharmacology analysis and molecular docking studies revealed Mitogen-Activated Protein Kinase 10 (MAPK10) as a potential target of <b>1</b> for its anticancer effect.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"17 1","pages":"2526766"},"PeriodicalIF":4.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}