Mycology最新文献

{"title":"Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol.","authors":"Guohua Yin, Geromy G Moore, Joan Wennstrom Bennett","doi":"10.1080/21501203.2025.2453717","DOIUrl":"10.1080/21501203.2025.2453717","url":null,"abstract":"<p><p>Different species of fungi usually share many common pathways but they also have some unique metabolic pathways (e.g. those for specialised metabolites). It is not clear how gene expression patterns significantly contribute to the creation of diverse volatile compounds. Based on the research of most VOCs, the functions of different fungal volatile compounds are mainly as follows: inhibitory or synergistic effects on other microorganisms, promoting growth in plants or inducing a defensive response in crops, and participating in the material cycle or affecting the interactions between organisms in the ecosystem. Approximately three hundred VOCs have been identified from fungi. According to their chemical properties, the major categories of fungal VOCs are terpenoids, aromatic compounds, alcohols, alkanes, esters, aldehydes, ketones, and heterocyclic compounds. The eight-carbon alcohol (1-octen-3-ol) is one of the most characteristic fungal VOC. This abundantly produced VOC results from the breakdown of linoleic acid and causes a distinctive mushroom-like odour. Consequently, its presence has been utilised as a signal of fungal growth. It is also produced by certain plants and functions as a semiochemical for numerous arthropods. The use of <i>Drosophila melanogaster</i> (fruit flies) as a model for testing the toxicity of fungal VOCs showed that some VOCs delayed metamorphosis and/or caused fly death at certain concentrations. When <i>Drosophila</i> was cultivated in an atmosphere shared with VOC mixtures released from growing cultures of several medically important fungi, including <i>Aspergillus fumigatus</i>, toxicity was observed. Additionally, we propose that components of the genetic immune system of <i>D. melanogaster</i> are engaged in the toxicity of fungal VOCs mainly via the elicitation of the Toll pathway. The presence of 1-octen-3-ol, for example, was associated with higher levels of toxicity in the fruit fly bioassay. In this review, we summarise (1) the diversity and functions of different fungal VOCs, (2) the biosynthesis and bioactive characteristics of 1-octen-3-ol, and (3) the use of <i>D. melanogaster</i> as a genetic model to assess the health impacts of fungal VOCs.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1011-1022"},"PeriodicalIF":4.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global diversity and phylogeny of Incrustoporiaceae (Polyporales, Basidiomycota) with an emphasis on <i>Skeletocutis</i>.","authors":"Zhan-Bo Liu, Hong-Gao Liu, Josef Vlasák, Genevieve M Gates, Zhen-Hao Li, Yu-Cheng Dai, Yuan Yuan","doi":"10.1080/21501203.2024.2448145","DOIUrl":"10.1080/21501203.2024.2448145","url":null,"abstract":"<p><p>This study presents the taxonomy and phylogeny of the family Incrustoporiaceae, based on comprehensive phylogenetic analyses utilising multi-gene data, including the internal transcribed spacer regions (ITS) and the large subunit of the nuclear ribosomal RNA gene (nLSU), for the accepted genera within Incrustoporiaceae. Additionally, a separate phylogenetic analysis focusing on the <i>Skeletocutis nivea</i> complex was performed using ITS sequences. A total of 20 new species within the genus <i>Skeletocutis</i> are described, namely <i>Skeletocutis crystallina</i>, <i>S. cunninghamiae</i>, <i>S. cylindrica</i>, <i>S. ellipsoidea</i>, <i>S. flavipora</i>, <i>S. latemarginata</i>, <i>S. liangdongii</i>, <i>S. monocotyledona</i>, <i>S. montanus</i>, <i>S. neoalbomarginata</i>, <i>S. oceanica</i>, <i>S. ochraceocarpa</i>, <i>S. quercicola</i>, <i>S. sinica</i>, <i>S. sinoalbomarginata</i>, <i>S. sinochrysella</i>, <i>S. subamorpha</i>, <i>S. subdiluta</i>, <i>S. subkrawtzewii</i>, and <i>S. sublilacina</i>. Detailed illustrated descriptions, voucher specimens, hosts, distribution, diagnoses, and remarks are provided for these 20 new species. Additionally, two new combinations are proposed: <i>S. minutula</i> and <i>Tyromyces subodorus</i>. Notably, our discoveries of <i>S. oceanica</i> and <i>S. subdiluta</i> in Australia underscore the significance of expanding research on <i>Skeletocutis</i> diversity in the Southern Hemisphere, where reports are scarce. Phylogenetic analyses also clarified the taxonomic positions of <i>Skeletocutis</i> and <i>Tyromyces</i> within the Incrustoporiaceae family, showing that <i>Tyromyces</i> is nested within the polyphyletic <i>Skeletocutis</i> clade. The morphological distinctions between <i>Skeletocutis</i> and <i>Tyromyces</i>, as well as between <i>Skeletocutis</i> and <i>Sidera</i>, are also discussed.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1083-1140"},"PeriodicalIF":4.4,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morpho-phylogenetic evidence reveals novel hyphomycetous fungi on medicinal plants in Southwestern China.","authors":"Hong-Zhi Du, Ning-Guo Liu, Na Wu, Ratchadawan Cheewangkoon, Jian-Kui Liu","doi":"10.1080/21501203.2024.2444436","DOIUrl":"10.1080/21501203.2024.2444436","url":null,"abstract":"<p><p>During a survey of saprobic fungi on medicinal plants in Southwestern China, thirty-nine hyphomycetous collections belonging to Dictyosporiaceae, Melanommataceae, and Stachybotryaceae were identified, representing nineteen distinct species. These taxa were characterised and identified based on morphological and culture characteristics, coupled with phylogenetic analyses of combined sequences of calmodulin (<i>cmdA</i>), the internal transcribed spacer region of ribosomal DNA (ITS), nuclear large subunit ribosomal DNA (LSU), RNA polymerase second-largest subunit (<i>rpb2</i>), the translation elongation factor 1-alpha (<i>tef1-α</i>), and β-tubulin (<i>tub2</i>). Twelve novel species are described, including <i>Camposporium alangii</i>, <i>C. polygoni</i>, <i>Dendryphiella verrucosispora</i>, <i>Jalapriya cheirospora</i>, <i>Memnoniella cnidiicola</i>, <i>M. guttulatispora</i>, <i>M. reniformis</i>, <i>M. reynoutriae</i>, <i>M. verrucosispora</i>, <i>Sirastachys aspidistrae</i>, <i>Sir. ellipsoidispora</i>, and <i>Striatibotrys biguttulatispora</i>. Additionally, three new host records, <i>M. alishanensis</i>, <i>Sir. castanedae</i>, and <i>Stachybotrys chartarum</i>, and four new hosts and geographical records of <i>M. ellipsoidea</i>, <i>M. pseudonilagirica</i>, <i>Str. rhabdospora</i>, and <i>Virgatospora echinofibrosa</i> are reported. <i>Memnoniella nilagirica</i> is revised and synonymised under <i>M. pseudonilagirica</i>. Key morphological characteristics, hosts specificity, and distributional data of <i>Memnoniella</i>, <i>Sirastachys</i>, and <i>Striatibotrys</i> were summarised. This study provides comprehensive illustrations, descriptions, and notes for each new taxon and record, marking the first report of these species from medicinal plants.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1023-1082"},"PeriodicalIF":4.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Hypoxylon luteogranulatum</i> (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits.","authors":"Sarunyou Wongkanoun, Esteban Charria-Girón, Marjorie Cedeño-Sanchez, Boonchuai Chainuwong, Sayanh Somrithipol, Eric Kuhnert, Prasert Srikitikulchai, Natapol Pornputtapong, Frank Surup, Jennifer Luangsa-Ard, Marc Stadler","doi":"10.1080/21501203.2024.2435979","DOIUrl":"10.1080/21501203.2024.2435979","url":null,"abstract":"<p><p>During the course of our ongoing study of the diversity of Thai fungi and their secondary metabolites, numerous specimens within the Hypoxylaceae have been characterised by traditional morphology, chemotaxonomy using ultra-high-performance liquid chromatography coupled to diode array detection and ion mobility tandem mass spectrometry (UHPLC-DAD-IM-MS/MS), and molecular phylogenetic analyses. MS/MS-based analysis of the major stromatal metabolites of a newly identified taxon, <i>Hypoxylon luteogranulatum</i>, indicated the production of distinct compounds compared to the azaphilone and binaphthalene pigments commonly found in the Hypoxylaceae, aside from the presence of the chemotaxonomic marker binaphthalene tetrol (BNT). Further analysis suggested that one of the major metabolites had the molecular formula C₁₃H₁₃NO₃, identical to hypoxyvermelhotin A, a yellow pigment so far exclusively found in <i>Hypoxylon lechatii</i>. Its identity was confirmed after purification by preparative high-performance liquid chromatography with nuclear magnetic resonance (NMR) data, and genome analysis of <i>H. lechatii</i> revealed the presence of different hybrid polyketide synthases-non-ribosomal peptide synthetases (PKS-NRPS) hybrid clusters. Despite chemotaxonomic similarities with <i>H. lechatii</i>, we propose a new species, which is morphologically distinct from <i>H. lechatii</i>. Our molecular phylogenetic study provides substantial evidence distinguishing <i>H. luteogranulatum</i> clearly from <i>H. lechatii</i> and allied members within the Hypoxylaceae. Additionally, future studies are needed to better understand the ecological behaviour of <i>H. luteogranulatum</i> and identify the ecological role of the vermelhotin-like molecules within this putative interaction.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1296-1314"},"PeriodicalIF":4.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species diversity, taxonomy, multi-gene phylogeny, and divergence times of Meruliaceae (Polyporales, Basidiomycota).","authors":"Yue Li, Yi-Feng Cao, Karen K Nakasone, Shi-Liang Liu, Man-Rong Huang, Shuang-Hui He","doi":"10.1080/21501203.2024.2443216","DOIUrl":"10.1080/21501203.2024.2443216","url":null,"abstract":"<p><p>Meruliaceae is one of the three major families of the phlebioid clade in the Polyporales that consists primarily of wood-decaying species. We undertook an in-depth survey on species diversity, generic delimitations, phylogeny, and divergence times within the Meruliaceae with an emphasis on specimens from East Asia. In total, 26 genera including two new genera, <i>Meruliella</i> and <i>Porophlebia</i>, are recognised; ten new species, viz. <i>Crustodontia vietnamensis</i>, <i>Luteochaete odontoidea</i>, <i>Meruliella hainanensis</i>, <i>Merulius pinicola</i>, <i>Mycoacia beijingensis</i>, <i>Phlebiporia crystallifera</i>, <i>P. odontoidea</i>, <i>Pseudophlebia vesiculosa</i>, <i>Scopuloides ellipsoidea</i>, and <i>S. grandinioides</i> are introduced; eleven new combinations, viz. <i>Allophlebia formosana</i>, <i>Aurantiopileus albidus</i>, <i>A</i>. <i>semisupina</i>, <i>Meruliella lindtneri</i>, <i>Merulius croceum</i>, <i>M. leptospermi</i>, <i>M. serialis</i>, <i>Phlebicolorata austroasiana</i>, <i>Phlebiodontia caspica</i>, <i>P. fissurata</i> and <i>Porophlebia fimbriata</i>, and one new name, <i>Mycoacia neotuberculata</i>, are proposed. <i>Noblesia</i> is placed as a synonymy of <i>Merulius</i>, whereas <i>Ceriporiopsis</i> and <i>Lilaceophlebia</i> are accepted as synonyms of <i>Mycoacia</i>. Descriptions and illustrations are provided for the new genera and species, and discussions are provided for all 26 genera and new taxa. The molecular clock analysis results show that the Meruliaceae emerged with a mean stem age of 186.71 Mya of the early Jurassic, and the genera diverged with a mean stem age between 44.29 to 169.46 Mya.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1180-1221"},"PeriodicalIF":4.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in <i>Candida albicans</i>.","authors":"Yulin Qin, Quanzhen Lv, Hongtao Xu, Yongbing Cao, Bing Han","doi":"10.1080/21501203.2024.2432424","DOIUrl":"10.1080/21501203.2024.2432424","url":null,"abstract":"<p><p>Acquired resistance in <i>Candida albicans</i> brings about a serious challenge to the clinical application of azoles, so it is urgent to elucidate the mechanisms of azole resistance to improve the therapeutic efficiency. In the aim of searching for the potential targets mediating fluconazole resistance, we screened a mutant library of 48 transcription factor deletion <i>Candida albicans</i> strains. The screening results showed that <i>hap2Δ/Δ</i> mutants were significantly more susceptible to azoles, especially to miconazole (MCZ). Under MCZ treatment, the intracellular reactive oxygen species (ROS) were significantly higher in <i>hap2Δ/Δ</i> mutants compared to the control strain SN250. The addition of antioxidants reversed the MCZ-sensitive phenotype caused by the deletion of <i>HAP2</i>. Consistently, the expression of antioxidases responsible for scavenging ROS was shown to decrease in <i>hap2Δ/Δ</i> mutants, suggesting that the transcription factor Hap2p is involved in the regulation of oxidative stress responses in <i>C. albicans</i>. In addition, <i>HAP2</i> deficiency also resulted in impaired mitochondrial function and affected cellular energy supply, which may be related to the iron deficiency regulated by HAP complex. <i>HAP2</i> disruption also decreased efflux-mediated resistance of <i>C. albicans</i>, as demonstrated by a significant decrease in Cdr1p expression and a slight decrease in Mdr1p expression in <i>hap2Δ/Δ</i> strains under the action of MCZ. The above results indicate that the transcription factor Hap2p was required for the resistance of <i>C. albicans</i> to azoles, which could provide a new strategy to solve the clinical azoles resistance.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1386-1399"},"PeriodicalIF":4.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and functional characterisation and regulatory mechanisms of SWI/SNF and RSC chromatin remodelling complexes in fungi.","authors":"Lirong Zhu, Qianqian Liu, Chao Zhao, Meichen Zhu, Xuewei Yang, Jinkui Yang","doi":"10.1080/21501203.2024.2425170","DOIUrl":"10.1080/21501203.2024.2425170","url":null,"abstract":"<p><p>Chromatin remodellers utilise energy generated from ATP hydrolysis to remodel nucleosomes and modulate histones, which are crucial for eukaryotic gene expression and chromatin architecture. The SWI/SNF (switching defective/sucrose non-fermenting) class of ATP-dependent chromatin modifiers in eukaryotes includes two complexes, SWI/SNF and RSC (remodeling the structure of chromatin). In the past 10 years, SWI/SNF and RSC chromatin remodellers have been a focus of research in various organisms, including animals, plants and fungi. In fungi, these two complexes have multiple functions, including roles in regulating hyphal differentiation, sporulation, stress responses, and pathogenicity. In addition to describing conserved structural properties and mechanisms of action, we highlight evidence for sequence and functional divergence in fungal evolution. This review provides a basis for further comparative analyses of the roles and regulatory mechanisms of the SWI/SNF and RSC complexes in taxonomically diverse fungi, laying a good foundation for potential applications in controlling pathogenic fungi.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"988-1010"},"PeriodicalIF":4.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into <i>Cortinarius</i>: Novel taxa from subtropical China.","authors":"Meng-Le Xie, Yong Yu, Pan Long, Zuo-Hong Chen, Zi-Rui Wang, Hai-Xia Ma, Tie-Zheng Wei, Jin-Peng Liao, Chang-Tian Li, Zhen-Quan Yang, Yi Li","doi":"10.1080/21501203.2024.2434584","DOIUrl":"10.1080/21501203.2024.2434584","url":null,"abstract":"<p><p><i>Cortinarius</i> species are widely distributed in the world and constitute a diverse group of ectomycorrhizal fungi that are associated with a broad range of plant hosts. The species diversity of this genus has been investigated in China, but it remains poorly understood, especially in the subtropical region. In this study, one new section, six novel species, one new combination, one new name, and one new record of <i>Cortinarius</i> are reported from subtropical China based on the morphological and molecular evidences. <i>Cortinarius lilacinicarpus</i>, <i>C. sinocalaisopus</i>, <i>C. sinosalor</i>, <i>C. vividus</i> spp. nov., <i>C. orientisalor</i> nom. nov., and <i>C. illibatus</i> are typical species of the section <i>Delibuti</i>. <i>Cortinarius macroflavicapus</i> sp. nov. belongs to <i>Macroflavicapi</i> sect. nov., a new section in the subgenus <i>Dermocybe</i>. <i>Cortinarius tianbaoyanensis</i> sp. nov. and <i>C. dryadicola</i> comb. nov. belong to the section <i>Spilomei</i>. Detailed descriptions, basidiocarps, and microscopic photographs are provided for these species. In addition, <i>C. leptospermorum</i> comb. nov. in the section <i>Pauperae</i> and subgenus <i>Dermocybe</i> is proposed.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1277-1295"},"PeriodicalIF":4.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Penicillium psychrofluorescens</i> sp. nov., a naturally autofluorescent Antarctic fungus.","authors":"Alinta Furnell, Nicole Benaud, Xabier Vázquez-Campos, Edward C Y Liew, Allison Mertin, Jordan A Vink, Kate Montgomery, Marc R Wilkins, Brett A Summerell, Belinda C Ferrari","doi":"10.1080/21501203.2024.2421319","DOIUrl":"10.1080/21501203.2024.2421319","url":null,"abstract":"<p><p>A new fungal species, <i>Penicillium psychrofluorescens</i> sp. nov. is described as a member of section <i>Torulomyces</i>. The new species is sister to <i>P. catalonicum</i>, and was isolated from soil collected from Robinson Ridge, East Antarctica, following enrichment cultivation under oligotrophic conditions supplemented with excess hydrogen gas. <i>Penicillium psychrofluorescens</i> is named for its intense autofluorescence derived from a combination of compounds that may include NADPH, porphyrins, and secondary metabolites, such as polyketides. Comparative genomics with both Antarctic and mesophilic <i>Penicillium</i> spp. shows that <i>Penicillium psychrofluorescens</i> has a wide repertoire of glycoside hydrolases, but almost no polysaccharide lyases, has comparably large effector proteins, lacks the machinery to use nitrate as an N-source, but has the genes for the assimilation of phosphorus from phosphonates via oxidative pathway. The strain was found to have 30 biosynthetic gene clusters (BGCs), the majority of which were unrelated to known compound BGCs. Given the remarkable diversity of natural products already characterised from <i>Penicillium</i> spp. and the presence of >30 BGCs with low similarity to known genes, there is biotechnological potential within this novel species that is yet to be explored.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 3","pages":"1315-1338"},"PeriodicalIF":4.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures.","authors":"Xin Ping Li, Wen Hao Shen, Jian Wen Wang, Li Ping Zheng","doi":"10.1080/21501203.2024.2430726","DOIUrl":"10.1080/21501203.2024.2430726","url":null,"abstract":"<p><p>Hypocrellins, a group of naturally occurring perylenequinone pigments produced by <i>Shiraia bambusicola</i>, are notable for their potential use in photodynamic therapy (PDT) for treating cancers and viruses. Traditionally, hypocrellins have been extracted from the fruiting bodies of <i>S. bambusicola</i>, a parasitic fungus on bamboo. However, the yield from wild <i>Shiraia</i> fruiting bodies is often insufficient, prompting a shift towards seeking other fungi with higher yields of hypocrellins as alternative sources. This review comprehensively examines the current research on the isolation, identification, and bioactivity of fungal perylenequinones from <i>Shiraia</i> isolates from ascostromata or fruiting bodies, <i>Shiraia</i>-like endophytes, and other endophytes from bamboos. Additionally, the review discusses the culture methods and conditions for solid-state and submerged fermentation of hypocrellin-producing fungi, including medium components, culture conditions, and optimisation of fermentation factors, as mycelium cultures have emerged as a promising alternative for the production of hypocrellins. Furthermore, novel elicitation strategies are presented to address the bottleneck of lower production of hypocrellins in mycelium cultures, focusing on the preparation, characterisation, and application of biotic and abiotic elicitors. This review aims to facilitate further exploration and utilisation of fungal resources and elicitation strategies for enhanced production of hypocrellins in mycelium cultures.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"593-616"},"PeriodicalIF":4.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}