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Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis. 重离子辐照提高天眼中米卡芬津前体FR901379的产量及其机理分析。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-12-12 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2426484
Yongjuan Liu, Beibei Wang, Xiaoxi Zhang, Ping Men, Meng Gu, Yu Zhou, Wei Hu, Zhuanzi Wang, Min Wang, Xuenian Huang, Xuefeng Lu
{"title":"Improving the production of micafungin precursor FR901379 in <i>Coleophoma empetri</i> using heavy-ion irradiation and its mechanism analysis.","authors":"Yongjuan Liu, Beibei Wang, Xiaoxi Zhang, Ping Men, Meng Gu, Yu Zhou, Wei Hu, Zhuanzi Wang, Min Wang, Xuenian Huang, Xuefeng Lu","doi":"10.1080/21501203.2024.2426484","DOIUrl":"10.1080/21501203.2024.2426484","url":null,"abstract":"<p><p>Micafungin is a semisynthetic echinocandin antifungal agent derived from fungal natural product FR901379 produced by <i>Coleophoma empetri</i>, facing challenges in biomanufacturing due to poor chassis performance and unclear high-yield mechanisms. In this study, the mutagenic effects of heavy-ion beam and how fungi repaired damage show that compared to the wild-type strain, nonhomologous end-joining pathway deficient mutants were more sensitive to heavy ion radiation, resulting in higher lethality rates and more mutations from the same radiation dose. Moreover, mutants obtained through two rounds of heavy-ion irradiation mutagenesis produced 1.1 g/L of FR901379, representing a remarkable increase of 253.7%. Compared to the parent strain, the mutants displayed noticeable differences in morphology and fermentation status. Comparative genomic analysis revealed mutations in several genes critical for morphological differentiation, which may have enhanced the production of FR901379 in the excellent mutants. This study has implications for the application of heavy-ion irradiation to filamentous fungi breeding. Additionally, the mutants with high FR901379 titre not only improve the production efficiency of micafungin but also provide a better chassis and theoretical guidance for subsequent metabolic engineering.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"941-955"},"PeriodicalIF":4.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Species diversity, taxonomic classification and ecological habits of polypore fungi in China. 中国多孔真菌的物种多样性、分类和生态习性。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-26 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2384567
Tai-Min Xu, Dong-Mei Wu, Neng Gao, Shun Liu, Yi-Fei Sun, Bao-Kai Cui
{"title":"Species diversity, taxonomic classification and ecological habits of polypore fungi in China.","authors":"Tai-Min Xu, Dong-Mei Wu, Neng Gao, Shun Liu, Yi-Fei Sun, Bao-Kai Cui","doi":"10.1080/21501203.2024.2384567","DOIUrl":"10.1080/21501203.2024.2384567","url":null,"abstract":"<p><p>Polypore fungi are an important part of forest ecosystems. In the last decade, the taxonomic status and species number of polypore fungi have changed greatly, and many new taxa have been discovered. China is one of the countries with the most abundant and diverse polypore fungi in the world, and a total of 1,214 polypore fungal species were reported here. This study lists the polypore fungi with their diversity, taxonomic status, habitats, geographical distributions, and molecular data. All the polypore fungi in China belong to the phylum <i>Basidiomycota</i>, subphylum <i>Agaricomycotina</i>, and class <i>Agaricomycetes</i>, including 11 orders, 55 families, and 266 genera. The orders <i>Polyporales</i> and <i>Hymenochaetales</i> are dominant, and the families <i>Polyporaceae</i> and <i>Hymenochaetaceae</i> are dominant. The overall distribution trend of polypore fungi in China shows that more species are distributed in the south and fewer are distributed in the north. In addition, different nutritional modes of polypore fungi have different preferences for host species, with white-rot fungi preferring angiosperm trees and brown-rot fungi preferring gymnosperm trees.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"419-544"},"PeriodicalIF":4.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interference with sexual mating of Sporisorium scitamineum by verrucarin A isolated from Paramyrothecium sp. 副疣胞菌疣胞素A对甘蔗孢子菌有性交配的干扰。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-25 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2426480
Ranying He, Haifei Xie, Jin Xie, Bin Wang, Zhigang Li, Xihui Liu, Wenxia Fang
{"title":"Interference with sexual mating of <i>Sporisorium scitamineum</i> by verrucarin A isolated from <i>Paramyrothecium</i> sp.","authors":"Ranying He, Haifei Xie, Jin Xie, Bin Wang, Zhigang Li, Xihui Liu, Wenxia Fang","doi":"10.1080/21501203.2024.2426480","DOIUrl":"10.1080/21501203.2024.2426480","url":null,"abstract":"<p><p>Sugarcane smut, caused by <i>Sporisorium scitamineum</i>, poses a significant global threat, leading to substantial economic losses. The pathogenic process involves haploid spores engaging in sexual mating to produce diploid mycelia, which then initiates the disease by penetrating sugarcane tissues. Targeting the mating process has thus emerged as the Achilles' heel in controlling sugarcane smut. In this study, we isolated a fungus designated as P-6 from a bryophyte, which impeded the mycelia formation of <i>S. scitamineum</i>. Phylogenetic and morphological analyses classified the strain P-6 within the genus <i>Paramyrothecum</i>. Through ethyl acetate extraction, subsequent separation, and nuclear magnetic resonance (NMR) analysis, we identified the active compound responsible for inhibiting the mating process as verrucarin A (Ver-A). Specifically, Ver-A inhibited the sexual mating of <i>S. scitamineum</i> by modulating the gene expression of loci <i>a</i> and <i>b</i>. Greenhouse pot experiments underscored the efficacy of strain P-6's fermentation products in reducing the incidence of sugarcane smut. These findings lay a robust groundwork for the development and application of P-6 as a novel biocontrol strain against sugarcane smut.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"929-940"},"PeriodicalIF":4.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phylogeny and species diversity of Armillaria in China based on morphological, mating test, and GCPSR criteria. 基于形态、交配试验和GCPSR标准的中国蜜环菌系统发育和物种多样性研究。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-13 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2404121
Guo-Fu Qin, Wen-Min Qin, Han-Chen Wang, Jun Zhao, Kari Korhonen, Jian Chen, Yu-Cheng Dai, Yuan Yuan
{"title":"Phylogeny and species diversity of <i>Armillaria</i> in China based on morphological, mating test, and GCPSR criteria.","authors":"Guo-Fu Qin, Wen-Min Qin, Han-Chen Wang, Jun Zhao, Kari Korhonen, Jian Chen, Yu-Cheng Dai, Yuan Yuan","doi":"10.1080/21501203.2024.2404121","DOIUrl":"10.1080/21501203.2024.2404121","url":null,"abstract":"<p><p>More than 600 Chinese specimens of <i>Armillaria</i> were identified by mating tests, Genealogical Concordance Phylogenetic Species Recognition (GCPSR), and comparison of morphological characteristics. Sixteen Chinese Biological Species (CBS) of <i>Armillaria</i> were identified by 30,340 mate pair combinations. Fifteen Chinese Phylogenetic Species (CPS) were recognised based on Independent Evolutionary Lineage (IEL) recognition and concatenated six-gene analysis (<i>actin</i>, <i>h3h</i>, <i>hisps</i>, LSU rDNA, <i>rpb</i>1, and <i>tef</i>1α). All the biological species and phylogenetic species were identical and possessed the same species boundary, except for CBS K (<i>A. mellea</i>) and CBS G (<i>A. mellea</i> ssp. <i>nipponica</i>) which were the same phylogenetic species. On the basis of CBS and CPS, eight new species of <i>Armillaria</i> in China were distinguished using macro and micro morphology, and they are described as <i>A. algida</i>, <i>A. amygdalispora</i>, <i>A. bruneocystidia</i>, <i>A. luteopileata</i>, <i>A. pungentisquamosa</i>, <i>A. sinensis</i>, <i>A. tibetica</i>, and <i>A. violacea</i>. This study indicates that the GCPSR approach provides the same resolution as mating tests in identification of <i>Armillaria</i> species.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"777-811"},"PeriodicalIF":4.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAP superfamily proteins (VdPRYs) manipulate plant immunity and contribute to the virulence of Verticillium dahliae. CAP超家族蛋白(VdPRYs)调控植物免疫并参与大丽花黄萎病的毒力。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-08 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2419882
Yan He, Jun Wang, Junjiao Li, Xiayu Wang, Xingyong Yang, Jieyin Chen, Dandan Zhang
{"title":"CAP superfamily proteins (VdPRYs) manipulate plant immunity and contribute to the virulence of <i>Verticillium dahliae</i>.","authors":"Yan He, Jun Wang, Junjiao Li, Xiayu Wang, Xingyong Yang, Jieyin Chen, Dandan Zhang","doi":"10.1080/21501203.2024.2419882","DOIUrl":"10.1080/21501203.2024.2419882","url":null,"abstract":"<p><p>CAP (cysteine-rich secretory proteins, antigen5, pathogenesis-related proteins) superfamily proteins are widely distributed, can be subdivided into 11 subfamilies, and form a unique branch in fungi, named PRY proteins. <i>Verticillium dahliae</i> is a soil-borne fungal pathogen of vascular plants that causes plant Verticillium wilt. However, the roles of CAP superfamily proteins in this fungus is unclear. Here, four CAP superfamily members with a conserved domain were identified in <i>V. dahliae</i>: VdPRY1, VdPRY2, VdPRY3, and VdPRY4. VdPRY1 and VdPRY3 were found to be key in suppressing plant immune responses. Moreover, these four members are highly expressed during early infection of cotton by <i>V. dahliae</i>. Deleting <i>VdPRY1</i>, <i>VdPRY2</i>, or <i>VdPRY3</i> reduced the fungus's ability to cause disease, but <i>VdPRY4</i> deletion did not affect virulence. Deletion of any of four members did not impact fungal growth or carbon source use. Yeast two-hybrid experiments suggest that these proteins may function through interactions with each other. This investigation has, for the initial time, elucidated the pivotal roles of <i>V. dahliae</i> CAP superfamily proteins in inhibiting plant immunity and exerting virulence during interaction with the host plant.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"876-890"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalogue of fungi in China 4: Didymiaceae and Physaraceae (Myxomycetes). 中国真菌目录4:粘菌科和粘菌科。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-07 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2410508
Xuefei Li, Jiajun Hu, Yonglan Tuo, You Li, Dan Dai, Frederick Leo Sossah, Minghao Liu, Jiajia Wang, Jiage Song, Bo Zhang, Xiao Li, Yu Li
{"title":"Catalogue of fungi in China 4: Didymiaceae and Physaraceae (Myxomycetes).","authors":"Xuefei Li, Jiajun Hu, Yonglan Tuo, You Li, Dan Dai, Frederick Leo Sossah, Minghao Liu, Jiajia Wang, Jiage Song, Bo Zhang, Xiao Li, Yu Li","doi":"10.1080/21501203.2024.2410508","DOIUrl":"10.1080/21501203.2024.2410508","url":null,"abstract":"<p><p>Myxomycetes play crucial ecological roles, yet their species diversity, distribution, and taxonomic relationships remain poorly understood. In this study, we examined 104 specimens from 19 provinces in China. Through morphological analysis, we identified a group of species with reduced lime formation, a feature typically associated with the Physaraceae, but with key morphological similarities to the <i>Diderma</i>. A comprehensive phylogenetic analysis was conducted using three genes (nSSU, <i>EF-1α</i>, and <i>COI</i>), resulting in a dataset of 452 sequences from 116 species. Notably, we identified a distinct clade within Didymiaceae containing species with fewer lime knots, a trait traditionally linked to Physaraceae. This clade, designated as the new genus <i>Neodiderma</i>, was phylogenetically positioned as a sister group to <i>Diderma</i>, potentially representing a transitional group between Didymiaceae and Physaraceae, supported by both morphological and molecular evidence. Eleven new species - <i>N. macrosporum</i>, <i>N. pseudobisporum</i>, <i>N. verrucocapillitium</i>, <i>N. rigidocapillitium</i>, <i>N. rufum</i>, <i>Physarum guangxiense</i>, <i>P. subviride</i>, <i>P. nigritum</i>, <i>P. biyangense</i>, <i>P. neoovoideum</i>, and <i>P. jilinense</i> - were identified from China, and their phylogenetic positions were analysed. Additionally, <i>N. spumarioides</i> (formerly <i>Diderma spumarioides</i>) was recombined. The new and recombined species were formally described and illustrated, and a key to the sections and species of <i>Neodiderma</i> and <i>Physarum</i> was provided.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 1","pages":"124-157"},"PeriodicalIF":4.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The P-type calcium pump Spf1 regulates immune response by maintenance of the endoplasmic reticulum-plasma membrane contacts during Candida albicans systemic infection. 在白色念珠菌全身性感染期间,p型钙泵Spf1通过维持内质网-质膜接触来调节免疫反应。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-07 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2409299
Yuchao Ji, Dou Chen, Menglin Shao, Zhuo Liu, Mingchun Li, Qilin Yu
{"title":"The P-type calcium pump Spf1 regulates immune response by maintenance of the endoplasmic reticulum-plasma membrane contacts during <i>Candida albicans</i> systemic infection.","authors":"Yuchao Ji, Dou Chen, Menglin Shao, Zhuo Liu, Mingchun Li, Qilin Yu","doi":"10.1080/21501203.2024.2409299","DOIUrl":"10.1080/21501203.2024.2409299","url":null,"abstract":"<p><p>Spf1 is an important P-type ATPase in <i>Candida albicans</i>, which functions as an endoplasmic reticulum calcium pump to maintain calcium homoeostasis. The deficiency of Spf1 attenuates the virulence of <i>C. albicans</i>. However, its impact on immune response remains to be investigated. This study discovered that deletion of <i>SPF1</i> resulted in a reduction of endoplasmic reticulum-plasma membrane contacts, an important structure mediating material and information exchange. This effect was attributed to the reduced plasma membrane localisation of the crucial endoplasmic reticulum-plasma membrane tethering proteins Ist2 and Tcb1/3. The reduction of the contacts led to a decrease in secretion of the virulence factors phospholipase, secreted aspartyl protease (SAP), candidalysin, and the cell wall-anchored protein Hwp1 during infection. Immunofluorescence staining and quantitative PCR assays further showed that the <i>SPF1</i> deletion led to a remarkable decrease in the levels of pro-inflammatory cytokines, suggesting the alleviation of the fungus-induced inflammatory response. Ultimately, the regulatory role of Spf1 in immune response significantly weakened the infectivity of <i>C. albicans</i>, and increased the survival rate of the hosts. This finding elucidated the role of fungal calcium pump-governed endoplasmic reticulum-plasma membrane contacts in regulation of immune response. It also makes it possible to regulate the host's immune response via control of <i>SPF1</i> expression and functions, providing a theoretical basis for treating fungal infections.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"856-875"},"PeriodicalIF":4.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marine-derived fungi from the genus Aspergillus (Ascomycota) and their anticancer properties. 海洋来源的曲霉属真菌及其抗癌特性。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-11-04 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2402309
Jessica Mélanie Wong Chin, Rajesh Jeewon, Abdulwahed Fahad Alrefaei, Daneshwar Puchooa, Theeshan Bahorun, Vidushi S Neergheen
{"title":"Marine-derived fungi from the genus <i>Aspergillus</i> (Ascomycota) and their anticancer properties.","authors":"Jessica Mélanie Wong Chin, Rajesh Jeewon, Abdulwahed Fahad Alrefaei, Daneshwar Puchooa, Theeshan Bahorun, Vidushi S Neergheen","doi":"10.1080/21501203.2024.2402309","DOIUrl":"10.1080/21501203.2024.2402309","url":null,"abstract":"<p><p>Marine fungi are promising sources of bioactive natural products. The harsh marine conditions favour the production of natural products with unique structures and functions. The different classes of bioactive metabolites produced by these marine fungi can exhibit cytotoxic, apoptotic, anti-proliferative, antiangiogenic, and autophagy inducing effects on a plethora of cancer cell lines. This review, based on research articles that have been published from 2002 to 2023, provides a concise overview of the anticancer properties of metabolites from marine <i>Aspergillus</i> fungal species. A total of 204 papers are reviewed and 208 most active cytotoxic molecules are reported from <i>Aspergillus</i>. The source as well as the growth medium utilised for the production of cytotoxic metabolites are listed. The mechanism of action of some compounds, which could be used as potential drugs, is also reported. These fungi, under optimal growth conditions, have immense potential as anticancer agents, produce novel metabolites with specific structures that can kill a panel of human cancer cells. However, there is a dire need for more clinical trials and understanding of the mechanisms of action of pharmacologically active constituent. Research should also target how to improve culture methods and perform clinical research on human subjects with more scientific reproducibility.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"545-592"},"PeriodicalIF":4.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome analysis of Ochratoxin a (OTA) producing Aspergillus westerdijkiae fc-1 under varying osmotic pressure. 不同渗透压下产生赭曲霉毒素a (OTA)的西部曲霉fc-1的转录组分析。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-10-29 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2408259
Yanling Ma, Muyuan Zhuang, Tanvir Ahmad, Mingxuan Li, Guangyou Tan, Yingyao Deng, Yang Liu
{"title":"Transcriptome analysis of Ochratoxin a (OTA) producing <i>Aspergillus westerdijkiae</i> fc-1 under varying osmotic pressure.","authors":"Yanling Ma, Muyuan Zhuang, Tanvir Ahmad, Mingxuan Li, Guangyou Tan, Yingyao Deng, Yang Liu","doi":"10.1080/21501203.2024.2408259","DOIUrl":"10.1080/21501203.2024.2408259","url":null,"abstract":"<p><p>Ochratoxin A (OTA) is a toxic secondary metabolite produced by the <i>Aspergillus</i> species which can contaminate various food products. This study analysed the transcriptome of the <i>Aspergillus westerdijkiae</i> fc-1 strain under NaCl concentrations of 0, 20, and 100 g/L using RNA-Seq technology to examine gene transcriptional changes linked to osmotic stress and OTA production. Significant changes were observed in metabolic-pathways associated with carbohydrates, cellular communication, and hydrolase activity under 20 g/L NaCl. The <i>HOG1</i> gene, associated with osmotic pressure regulation was down-regulated by 78.06%. In contrast, OTA biosynthesis genes <i>otaA</i>, <i>otaB</i>, and <i>otaC</i> were up-regulated by 3.26 fold, 1.99 fold, and 2.06 fold, respectively. Conversely, the <i>otaD</i> gene was down-regulated by 43.50%. At 100 g/L NaCl, pathways related to ion transport, peptide metabolism, ribosomal function, and transmembrane transporter protein activities were significantly up-regulated. The <i>HOG1</i> gene was up-regulated by 28.32% and OTA biosynthesis genes <i>otaA</i>, <i>otaB</i>, <i>otaC</i>, and <i>otaD</i> showed up-regulation of 27.06%, 36.80%, 19.59%, and 5.72 fold, respectively. The study highlights the role of metabolic pathways in osmotic stress regulation and the correlations between <i>HOG1</i> expression and OTA biosynthesis genes, providing insights for developing strategies to prevent OTA contamination in food.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"903-917"},"PeriodicalIF":4.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First case of fungemia caused by a rare and pan-echinocandin resistant yeast Sporopachydermia lactativora in China. 中国首例由一种罕见的泛棘白菌素耐药酵母菌引起的真菌病。
IF 4.6 2区 生物学
Mycology Pub Date : 2024-10-28 eCollection Date: 2025-01-01 DOI: 10.1080/21501203.2024.2418111
Qiushi Zheng, Shuzhen Xiao, Lingyu Ji, Jian Bing, Bing Li, Lizhong Han, Haiqing Chu, Guanghua Huang
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