Mycology最新文献_第3页

Risk of candidiasis associated with interleukin-17 inhibitors: implications and management 白细胞介素-17抑制剂与念珠菌病相关的风险:影响和管理

2区生物学

Mycology Pub Date : 2023-10-20 DOI: 10.1080/21501203.2023.2265664

Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Wenjie Fang, Wenqiang Chang, Bin Yin, Ning-Jing Song, Zhongrong Liu, Dongxing Zhang, Fen Yao, Xun Wang, Qian Wang, Lin Cai, Bing Hou, Jiayue Wang, Chunyan Mao, Lingxi Liu, Yuebin Zeng

{"title":"Risk of candidiasis associated with interleukin-17 inhibitors: implications and management","authors":"Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Wenjie Fang, Wenqiang Chang, Bin Yin, Ning-Jing Song, Zhongrong Liu, Dongxing Zhang, Fen Yao, Xun Wang, Qian Wang, Lin Cai, Bing Hou, Jiayue Wang, Chunyan Mao, Lingxi Liu, Yuebin Zeng","doi":"10.1080/21501203.2023.2265664","DOIUrl":"https://doi.org/10.1080/21501203.2023.2265664","url":null,"abstract":"The application of interleukin-17 (IL-17) inhibitors, including secukinumab, ixekizumab, brodalumab, and bimekizumab, are associated with elevated risk of candidiasis. These medications interfere with the IL-17 pathway, which is essential for maintaining mucosal barriers and coordinating the immune response against Candida species. The observational data and clinical trials demonstrate the increased incidence of candidiasis in individuals treated with IL-17 inhibitors. Brodalumab and bimekizumab pose a greater risk than secukinumab in eliciting candidiasis, whereas the data regarding ixekizumab are equivocal. Higher doses and prolonged treatment duration of IL-17 inhibitors increase the risk of candidiasis by compromising the immune response against Candida species. Prior to prescribing IL-17 inhibitors, healthcare professionals should comprehensively evaluate patients’ medical histories and assess their risk factors. Patients should be educated on the signs and symptoms of candidiasis to facilitate early detection and intervention. Future research should focus on identifying the risk factors associated with candidiasis in patients receiving IL-17 inhibitors. Prospective studies and long-term surveillance are required to explore the impact of specific inhibitors on the incidence and severity of candidiasis and to evaluate the effectiveness of combination therapies, such as concurrent use of IL-17 inhibitors and prophylactic antifungal agents.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135570624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic properties of Inonotus obliquus (Chaga mushroom): a review 桦尺蠖(Inonotus obliquus)的治疗特性综述

2区生物学

Mycology Pub Date : 2023-10-20 DOI: 10.1080/21501203.2023.2260408

Phoebe Tee Yon Ern, Tang Yin Quan, Fung Shin Yee, Adeline Chia Yoke Yin

{"title":"Therapeutic properties of Inonotus obliquus (Chaga mushroom): a review","authors":"Phoebe Tee Yon Ern, Tang Yin Quan, Fung Shin Yee, Adeline Chia Yoke Yin","doi":"10.1080/21501203.2023.2260408","DOIUrl":"https://doi.org/10.1080/21501203.2023.2260408","url":null,"abstract":"Inonotus obliquus, also known as Chaga, is a medicinal mushroom that has been used for therapeutic purposes since the sixteenth century. Collections of folk medicine record the application of Chaga for the treatment of diseases such as gastrointestinal cancer, diabetes, bacterial infection, and liver diseases. Modern research provides scientific evidence of the therapeutic properties of I. obliquus extracts, including anti-inflammatory, antioxidant, anticancer, anti-diabetic, anti-obesity, hepatoprotective, renoprotective, anti-fatigue, antibacterial, and antiviral activities. Various bioactive compounds, including polysaccharides, triterpenoids, polyphenols, and lignin metabolites have been found to be responsible for the health-benefiting properties of I. obliquus. Furthermore, some studies have elucidated the underlying mechanisms of the mushroom’s medicinal effects, revealing the compounds’ interactions with enzymes or proteins of important pathways. Thus, this review aims to explore available information on the therapeutic potentials of Inonotus obliquus for the development of an effective naturally sourced treatment option.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histoplasmosis: an epidemiological and clinical update in China, review and a case report 组织胞浆菌病:中国流行病学和临床进展、综述和病例报告

2区生物学

Mycology Pub Date : 2023-09-26 DOI: 10.1080/21501203.2023.2259934

Lihua Chen, Danyang Hu, Congming Zhang, Tianrui Wu, Xiangning Cheng, Ferry Hagen, Hui Zhu, Shuwen Deng

{"title":"Histoplasmosis: an epidemiological and clinical update in China, review and a case report","authors":"Lihua Chen, Danyang Hu, Congming Zhang, Tianrui Wu, Xiangning Cheng, Ferry Hagen, Hui Zhu, Shuwen Deng","doi":"10.1080/21501203.2023.2259934","DOIUrl":"https://doi.org/10.1080/21501203.2023.2259934","url":null,"abstract":"Histoplasmosis is a systemic mycosis caused by the dimorphic fungus in the genus Histoplasma. Histoplasmosis is overlooked in China. This study aims to provide an epidemiological and clinical update on histoplasmosis in China by literature review. We reviewed cases of histoplasmosis reported in recent 11 years and described a case of histoplasmosis-triggered hemophagocytic lymphohistiocytosis (HLH) in an immunocompetent patient. A total of 225 cases of histoplasmosis diagnosed in China between 2012 and 2022 were involved in this study, compared with 300 cases reviewed from 1990 to 2011, an increasing number of cases of histoplasmosis have been diagnosed in the last 11 years. The majority of cases of histoplasmosis were autochthonous cases, mainly from provinces Sichuan (56/225, 24.9%), Hunan (50/225, 22.2%), Guangdong (31/225, 13.8%), and Yunnan (24/225, 10.7%). Higher incidence (52.5%, 53/99) of histoplasmosis occurred in immunocompetent patients which is similar to those from the previous 21 years, and the prevalence of the disease did not vary highly over time. Of note, the number of histoplasmosis cases is increasing, and the geographic distribution is shifting southwards over time. Improved awareness is critically important for informing clinical practice in China.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135718772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The disulphide cleavage derivative (C42-4) of 11′-deoxyverticillin A (C42) fails to induce apoptosis and genomic instability in HeLa cells 11 ' -脱氧维拉西林A (C42)的二硫裂解衍生物(C42-4)不能诱导HeLa细胞凋亡和基因组不稳定

2区生物学

Mycology Pub Date : 2023-09-13 DOI: 10.1080/21501203.2023.2248168

Bolin Hou, Huaiyi Yang, Erwei Li, Xuejun Jiang

引用次数: 0

Advances in the production of fungi-derived lignocellulolytic enzymes using agricultural wastes 利用农业废弃物生产真菌来源的木质纤维素水解酶的研究进展

2区生物学

Mycology Pub Date : 2023-09-13 DOI: 10.1080/21501203.2023.2253827

Jiaqi Huang, Jianfei Wang, Shijie Liu

{"title":"Advances in the production of fungi-derived lignocellulolytic enzymes using agricultural wastes","authors":"Jiaqi Huang, Jianfei Wang, Shijie Liu","doi":"10.1080/21501203.2023.2253827","DOIUrl":"https://doi.org/10.1080/21501203.2023.2253827","url":null,"abstract":"Lignocellulolytic enzymes play an important role in various industrial applications as well as the sustainable valorisation of lignocellulosic materials. Enzyme production using lignocellulosic fungi has shown great advantages such as high enzyme diversity, high production efficiency, and the availability of solid waste as raw materials. Agricultural waste, an abundant and non-food competitive feedstock, can be used to produce fungal lignocellulolytic enzymes. Pretreatment helps break down the complex structure of the raw material, thereby significantly improving product yield but also requiring more energy consumption. Multiple fermentation technologies, including submerged fermentation, solid-state fermentation, and co-culture, can be used for producing lignocellulolytic enzymes. Process optimisation may promote the yield and productivity of such enzymes without additional investment. Genetic engineering is also useful for enhancing enzyme production to meet industrial requirements. This review summarises the research progress in the fungal production of lignocellulolytic enzymes from various agricultural wastes via advanced fermentation strategies. It aims to provide technical references for the scale-up production of fungal lignocellulolytic enzymes.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135783512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of fungi in the diagnosis of colorectal cancer. 真菌在大肠癌诊断中的作用

IF 4.2 2区生物学

Mycology Pub Date : 2023-09-03 eCollection Date: 2024-01-01 DOI: 10.1080/21501203.2023.2249492

Xu-Huan Li, Ming-Ming Luo, Zu-Xiu Wang, Qi Wang, Bin Xu

引用次数: 0

Heteroverticillium phytelephatis gen. et sp. nov. intercepted from nuts of Phytelephas macrocarpa, with an updated phylogenetic assessment of Nectriaceae. 从 Phytelephas macrocarpa 坚果中截获的 Heteroverticillium phytelephatis gen.

IF 4.6 2区生物学

Mycology Pub Date : 2023-06-11 eCollection Date: 2023-01-01 DOI: 10.1080/21501203.2023.2210603

Xin Li, Shi-Ling Han, Yin-Yin Zhang, Lei Cai, Peng Zhao

{"title":"Heteroverticillium phytelephatis gen. et sp. nov. intercepted from nuts of Phytelephas macrocarpa, with an updated phylogenetic assessment of Nectriaceae.","authors":"Xin Li, Shi-Ling Han, Yin-Yin Zhang, Lei Cai, Peng Zhao","doi":"10.1080/21501203.2023.2210603","DOIUrl":"10.1080/21501203.2023.2210603","url":null,"abstract":"An entry postal parcel with mature nuts of Phytelephas macrocarpa from Togo was inspected at Dalian Customs (China) in December 2021, and four strains were isolated from symptomatic tissues of the nuts. Based on morphological observations and molecular phylogenetic analyses, above strains were identified as a new species which is mainly characterised by the verticillately branching conidiophores. Based on multi-locus phylogenetic analyses, this new species forms a monophyletic clade closely related to Corallomycetella, Paracremonium and Xenoacremonium but could not be accommodated in any known genera of Nectriaceae. Thus, a new genus Heteroverticillium is established to accommodate this new species (H. phytelephatis). To our knowledge, this is the first time that Chinese customs have intercepted a new fungal genus. In addition, we provided an updated backbone tree for the generic relationships in Nectriaceae, which may largely assist future identification of nectriaceous fungi to genus level in quarantine inspections. Based on our analysis, Varicosporellopsis is likely a late synonym of Paracremonium.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"14 3","pages":"155-174"},"PeriodicalIF":4.6,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/14/TMYC_14_2210603.PMC10424595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of fungal infections in Kenya. 肯尼亚真菌感染的负担。

IF 4.6 2区生物学

Mycology Pub Date : 2023-04-27 eCollection Date: 2023-01-01 DOI: 10.1080/21501203.2023.2204112

Stanley N Ratemo, David W Denning

{"title":"Burden of fungal infections in Kenya.","authors":"Stanley N Ratemo, David W Denning","doi":"10.1080/21501203.2023.2204112","DOIUrl":"10.1080/21501203.2023.2204112","url":null,"abstract":"The burden of fungal infections has been on the rise globally and remains a significant public health concern in Kenya. We estimated the incidence and prevalence of fungal infections using all mycology publications in Kenya up to January 2023, and from neighbouring countries where data lacked. We used deterministic modelling using populations at risk to calculate the disease burden. The total burden of serious fungal infections is estimated to affect 6,328,294 persons which translates to 11.57% of the Kenyan population. Those suffering from chronic infections such as chronic pulmonary aspergillosis are estimated to be 100,570 people (0.2% of the population) and probably nearly 200,000 with fungal asthma, all treatable with oral antifungal therapy. Serious acute fungal infections secondary to HIV (cryptococcal meningitis, disseminated histoplasmosis, pneumocystis pneumonia, and mucosal candidiasis) affect 196,543 adults and children (0.4% of the total population), while cancer-related invasive fungal infection cases probably exceed 2,299 and those in intensive care about 1,230 incident cases, including Candida auris bloodstream infection. The burden of fungal infections in Kenya is high; however, limited diagnostic test availability, low clinician awareness and inadequate laboratory capacity constrain the country's health system in responding to the syndemic of fungal disease in Kenya.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"14 2","pages":"142-154"},"PeriodicalIF":4.6,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/53/TMYC_14_2204112.PMC10161943.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors and mortality of the newly emerging Candida auris in a university hospital in Saudi Arabia. 沙特阿拉伯一所大学医院新发耳念珠菌的危险因素和死亡率

IF 4.2 2区生物学

Mycology Pub Date : 2023-01-01 DOI: 10.1080/21501203.2023.2227218

Reham Kaki

{"title":"Risk factors and mortality of the newly emerging Candida auris in a university hospital in Saudi Arabia.","authors":"Reham Kaki","doi":"10.1080/21501203.2023.2227218","DOIUrl":"https://doi.org/10.1080/21501203.2023.2227218","url":null,"abstract":"Candida auris presents a global health threat. We investigated risk factors and mortality of Candida auris infections in a retrospective study in Saudi Arabia. We included 27 patients ≥14 with invasive Candida auris from 2015-2022, with median age 58, and 66.7% males. All patients had indwelling devices. The most common infection sources were central line-associated bloodstream infection in 17 (63.0%), and urinary tract infections in four (12%). Fever and shock were observed in nine patients (33.3%) each, and 22 (81%) were admitted to the intensive care unit. Common comorbidities were diabetes and heart disease in 13 (48.1%) patients each. The median hospital stay was 78 days, and the median Charlson index was 4. The C. auris cultures were 100% susceptible to voriconazole, caspofungin, and amphotericin, while three were fully susceptible to fluconazole (11.1%). Despite treatment, 18 (66.7%) patients died. In conclusion, invasive C. auris infection had varied presentations. All patients had indwelling devices, and many had lengthy hospital stays. All isolates were susceptible to amphotericin and echinocandins, while few were fully susceptible to fluconazole.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"14 3","pages":"256-263"},"PeriodicalIF":4.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/41/TMYC_14_2227218.PMC10424598.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Xenasmatellales ord. nov. and Xenasmatellaceae fam. nov. for Xenasmatella (Agaricomycetes, Basidiomycota). 香茅属和香茅科。11 .为Xenasmatella(木耳菌，担子菌)。

IF 4.2 2区生物学

Mycology Pub Date : 2023-01-01 DOI: 10.1080/21501203.2023.2216213

Shi-Liang Liu, Hao-Wen Wei, Li-Wei Zhou

{"title":"Xenasmatellales ord. nov. and Xenasmatellaceae fam. nov. for Xenasmatella (Agaricomycetes, Basidiomycota).","authors":"Shi-Liang Liu, Hao-Wen Wei, Li-Wei Zhou","doi":"10.1080/21501203.2023.2216213","DOIUrl":"https://doi.org/10.1080/21501203.2023.2216213","url":null,"abstract":"In the era of molecular phylogeny as dominant evidence in fungal taxonomy, the taxonomic framework of fungi adopted from morphological characteristics has been largely updated. Compared with other fungal groups, macrofungi underwent fewer updates at the order and higher level. In this study, the taxonomic placement of a poorly known macro-basidiomycetous genus Xenasmatella is studied. Phylogenetic and molecular clock analyses inferred from a seven-locus dataset support that the genus represents an order rank lineage. Accordingly, a monotypic order Xenasmatellales and a monotypic family Xenasmatellaceae are newly introduced for Xenasmatella within Agaricomycetes. The species diversity and relationships of Xenasmatella are further clarified with the aid of the phylogenetic analysis inferred from a four-locus dataset. In association with morphological characteristics, a new species Xenasmatella hjortstamii is described. Moreover, the distribution of Xenasmatella ailaoshanensis, X. gossypina, and X. wuliangshanensis previously known only from type localities in Yunnan Province, China are expanded. In addition, two unnamed single-specimen lineages of Xenasmatella from Victoria State, Australia and Sichuan, China are revealed, likely representing two potential new species of this genus. In summary, the current study updates the taxonomic framework of Agaricomycetes and provides a crucial supplement for comprehensively understanding the evolutionary history of this fungal class.","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"14 3","pages":"175-189"},"PeriodicalIF":4.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/1d/TMYC_14_2216213.PMC10424627.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10547144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0