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AI’s computing gap: academics lack access to powerful chips needed for research 人工智能的计算差距：学术界无法获得研究所需的强大芯片
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03792-6
{"title":"AI’s computing gap: academics lack access to powerful chips needed for research","authors":"","doi":"10.1038/d41586-024-03792-6","DOIUrl":"https://doi.org/10.1038/d41586-024-03792-6","url":null,"abstract":"Survey highlights disparity between academic and industry scientists’ access to computing power needed to train machine-learning models.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"36 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How ‘Made in China 2025’ helped supercharge scientific development in China’s cities 中国制造 2025》如何助力中国城市的科学发展
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03522-y
{"title":"How ‘Made in China 2025’ helped supercharge scientific development in China’s cities","authors":"","doi":"10.1038/d41586-024-03522-y","DOIUrl":"https://doi.org/10.1038/d41586-024-03522-y","url":null,"abstract":"The policy has boosted tech transfer and economic growth in some regions, but challenges remain around innovation in key technologies.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leading Nature Index science cities in health sciences: US institutions power country’s growth 自然指数科学城在健康科学领域处于领先地位：美国机构推动国家发展
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03528-6
{"title":"Leading Nature Index science cities in health sciences: US institutions power country’s growth","authors":"","doi":"10.1038/d41586-024-03528-6","DOIUrl":"https://doi.org/10.1038/d41586-024-03528-6","url":null,"abstract":"European cities make their mark while the United States extends its lead.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"128 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A guide to the Nature Index 自然指数指南
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03530-y
{"title":"A guide to the Nature Index","authors":"","doi":"10.1038/d41586-024-03530-y","DOIUrl":"https://doi.org/10.1038/d41586-024-03530-y","url":null,"abstract":"A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"231 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How being multilingual both helps and hinders me and my science 掌握多种语言对我和我的科学既有帮助又有阻碍
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03533-9
{"title":"How being multilingual both helps and hinders me and my science","authors":"","doi":"10.1038/d41586-024-03533-9","DOIUrl":"https://doi.org/10.1038/d41586-024-03533-9","url":null,"abstract":"Although I find new ways to express myself as a student abroad, sometimes it can be isolating to avoid my mother tongue, writes Rahul Roy.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"178 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma Gliocidin 是一种针对胶质母细胞瘤的烟酰胺模拟原药
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/s41586-024-08224-z
Yu-Jung Chen, Swathi V. Iyer, David Chun-Cheng Hsieh, Buren Li, Harold K. Elias, Tao Wang, Jing Li, Mungunsarnai Ganbold, Michelle C. Lien, Yu-Chun Peng, Xuanhua P. Xie, Chenura D. Jayewickreme, Marcel R. M. van den Brink, Sean F. Brady, S. Kyun Lim, Luis F. Parada
{"title":"Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma","authors":"Yu-Jung Chen, Swathi V. Iyer, David Chun-Cheng Hsieh, Buren Li, Harold K. Elias, Tao Wang, Jing Li, Mungunsarnai Ganbold, Michelle C. Lien, Yu-Chun Peng, Xuanhua P. Xie, Chenura D. Jayewickreme, Marcel R. M. van den Brink, Sean F. Brady, S. Kyun Lim, Luis F. Parada","doi":"10.1038/s41586-024-08224-z","DOIUrl":"https://doi.org/10.1038/s41586-024-08224-z","url":null,"abstract":"<p>Glioblastoma is incurable and in urgent need of improved therapeutics<sup>1</sup>. Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death<sup>2</sup>. Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD), by the enzyme nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) of the NAD<sup>+</sup> salvage pathway. The cryo-electron microscopy structure of GAD together with IMPDH2 demonstrates its entry, deformation and blockade of the NAD<sup>+</sup> pocket<sup>3</sup>. In vivo, gliocidin penetrates the blood–brain barrier and extends the survival of mice with orthotopic glioblastoma. The DNA alkylating agent temozolomide induces <i>Nmnat1</i> expression, causing synergistic tumour cell killing and additional survival benefit in orthotopic patient-derived xenograft models. This study brings gliocidin to light as a prodrug with the potential to improve the survival of patients with glioblastoma.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common genetic variants contribute more to rare diseases than previously thought 常见基因变异对罕见病的影响比以前想象的要大
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03554-4
Gerome Breen
{"title":"Common genetic variants contribute more to rare diseases than previously thought","authors":"Gerome Breen","doi":"10.1038/d41586-024-03554-4","DOIUrl":"https://doi.org/10.1038/d41586-024-03554-4","url":null,"abstract":"Assessing the influence of common mutations on rare disease risk.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum computing: physics–AI collaboration quashes quantum errors 量子计算：物理学与人工智能合作消除量子错误
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03557-1
Nadia Haider
{"title":"Quantum computing: physics–AI collaboration quashes quantum errors","authors":"Nadia Haider","doi":"10.1038/d41586-024-03557-1","DOIUrl":"https://doi.org/10.1038/d41586-024-03557-1","url":null,"abstract":"Machine-learning strategy for quantum error correction.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"41 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Squid-inspired jet devices deliver drugs without a need for needles 受乌贼启发的喷射装置无需针头即可输送药物
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/d41586-024-03767-7
{"title":"Squid-inspired jet devices deliver drugs without a need for needles","authors":"","doi":"10.1038/d41586-024-03767-7","DOIUrl":"https://doi.org/10.1038/d41586-024-03767-7","url":null,"abstract":"Systems that mimic cephalopods can jet drugs into the gastrointestinal tract.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"25 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-molecule states link transcription factor binding to gene expression 单分子状态将转录因子结合与基因表达联系起来
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-20 DOI: 10.1038/s41586-024-08219-w
Benjamin R. Doughty, Michaela M. Hinks, Julia M. Schaepe, Georgi K. Marinov, Abby R. Thurm, Carolina Rios-Martinez, Benjamin E. Parks, Yingxuan Tan, Emil Marklund, Danilo Dubocanin, Lacramioara Bintu, William J. Greenleaf
{"title":"Single-molecule states link transcription factor binding to gene expression","authors":"Benjamin R. Doughty, Michaela M. Hinks, Julia M. Schaepe, Georgi K. Marinov, Abby R. Thurm, Carolina Rios-Martinez, Benjamin E. Parks, Yingxuan Tan, Emil Marklund, Danilo Dubocanin, Lacramioara Bintu, William J. Greenleaf","doi":"10.1038/s41586-024-08219-w","DOIUrl":"https://doi.org/10.1038/s41586-024-08219-w","url":null,"abstract":"<p>The binding of multiple transcription factors (TFs) to genomic enhancers drives gene expression in mammalian cells<sup>1</sup>. However, the molecular details that link enhancer sequence to TF binding, promoter state and transcription levels remain unclear. Here we applied single-molecule footprinting<sup>2,3</sup> to measure the simultaneous occupancy of TFs, nucleosomes and other regulatory proteins on engineered enhancer–promoter constructs with variable numbers of TF binding sites for both a synthetic TF and an endogenous TF involved in the type I interferon response. Although TF binding events on nucleosome-free DNA are independent, activation domains recruit cofactors that destabilize nucleosomes, driving observed TF binding cooperativity. Average TF occupancy linearly determines promoter activity, and we decompose TF strength into separable binding and activation terms. Finally, we develop thermodynamic and kinetic models that quantitatively predict both the enhancer binding microstates and gene expression dynamics. This work provides a template for the quantitative dissection of distinct contributors to gene expression, including TF activation domains, concentration, binding affinity, binding site configuration and recruitment of chromatin regulators.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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