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How to create psychedelics’ benefits without the ‘trip’ 如何创造迷幻药的益处而不产生 "眩晕"？
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-22 DOI: 10.1038/d41586-024-03800-9
{"title":"How to create psychedelics’ benefits without the ‘trip’","authors":"","doi":"10.1038/d41586-024-03800-9","DOIUrl":"https://doi.org/10.1038/d41586-024-03800-9","url":null,"abstract":"Stimulating certain brain cells in mice seems to ease anxiety without causing hallucination-like effects.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"58 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA need not apply: Books in brief DNA 无需申请：书籍简介
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-22 DOI: 10.1038/d41586-024-03863-8
{"title":"DNA need not apply: Books in brief","authors":"","doi":"10.1038/d41586-024-03863-8","DOIUrl":"https://doi.org/10.1038/d41586-024-03863-8","url":null,"abstract":"Andrew Robinson reviews five of the best science picks.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notching up a win: fresh tools for activating Notch 取得胜利：激活 Notch 的新工具
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03822-3
{"title":"Notching up a win: fresh tools for activating Notch","authors":"","doi":"10.1038/d41586-024-03822-3","DOIUrl":"https://doi.org/10.1038/d41586-024-03822-3","url":null,"abstract":"Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"13 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Daily briefing: Why the man behind a ‘mouse utopia’ disappeared from the scientific literature 每日简报：老鼠乌托邦 "的幕后推手为何从科学文献中消失？
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03861-w
{"title":"Daily briefing: Why the man behind a ‘mouse utopia’ disappeared from the scientific literature","authors":"","doi":"10.1038/d41586-024-03861-w","DOIUrl":"https://doi.org/10.1038/d41586-024-03861-w","url":null,"abstract":"We learn that our friends, and our friends’ friends, have an influence on our gut microbiome and revisit the work of a once-influential behavioural researcher.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"71 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘A place of joy’: why scientists are joining the rush to Bluesky 欢乐之地"：科学家为何纷纷加入蓝天计划
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03784-6
{"title":"‘A place of joy’: why scientists are joining the rush to Bluesky","authors":"","doi":"10.1038/d41586-024-03784-6","DOIUrl":"https://doi.org/10.1038/d41586-024-03784-6","url":null,"abstract":"Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"19 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chimps tickle and wrestle in play to pave the way for teamwork 黑猩猩在游戏中搔痒和摔跤，为团队合作铺平道路
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03802-7
{"title":"Chimps tickle and wrestle in play to pave the way for teamwork","authors":"","doi":"10.1038/d41586-024-03802-7","DOIUrl":"https://doi.org/10.1038/d41586-024-03802-7","url":null,"abstract":"Six years of observations show that play encourages group efforts and eases tension between adult chimpanzees.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"55 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteria found on a space rock turn out to be Earth-grown 太空岩石上发现的细菌原来是在地球上生长的
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03806-3
{"title":"Bacteria found on a space rock turn out to be Earth-grown","authors":"","doi":"10.1038/d41586-024-03806-3","DOIUrl":"https://doi.org/10.1038/d41586-024-03806-3","url":null,"abstract":"Microorganisms on a sample of asteroid are clearly terrestrial — despite strict protocols to avoid contamination.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"60 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic photobiocatalysis for enantioselective triple radical sorting 用于对映选择性三自由基分选的协同光生物催化作用
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/s41586-024-08399-5
Zhongqiu Xing, Fulu Liu, Jianqiang Feng, Lu Yu, Zhouping Wu, Beibei Zhao, Bin Chen, Heng Ping, Yuanyuan Xu, Aokun Liu, Yue Zhao, Chuanyong Wang, Binju Wang, Xiaoqiang Huang
{"title":"Synergistic photobiocatalysis for enantioselective triple radical sorting","authors":"Zhongqiu Xing, Fulu Liu, Jianqiang Feng, Lu Yu, Zhouping Wu, Beibei Zhao, Bin Chen, Heng Ping, Yuanyuan Xu, Aokun Liu, Yue Zhao, Chuanyong Wang, Binju Wang, Xiaoqiang Huang","doi":"10.1038/s41586-024-08399-5","DOIUrl":"https://doi.org/10.1038/s41586-024-08399-5","url":null,"abstract":"<p>Multicomponent reactions – those where three or more substrates combine into a product – have been highly useful in rapidly building chemical building blocks of increased complexity<sup>4</sup>, but achieving this enzymatically has remained rare.<sup>5</sup> This limitation primarily arises because an enzyme’s active site is not typically set up to address multiple substrates, especially in cases involving multiple radical intermediates<sup>6</sup>. Recently, chemical catalytic radical sorting has emerged as an enabling strategy for a variety of useful reactions<sup>7,8</sup>. However, making such processes enantioselective is highly challenging due to the inherent difficulty in the stereochemical control of radicals<sup>9</sup>. Here, we repurpose a thiamine-dependent enzyme<sup>1</sup><sup>0,11</sup> through directed evolution, combine it with photoredox catalysis, to achieve a photobiocatalytic enantioselective three-component radical cross-coupling. This approach combines three readily available starting materials — aldehydes, α-bromo-carbonyls and alkenes — to give access to enantioenriched ketone products. Mechanistic investigations provide insights into how this dual photo-/enzyme system precisely directs the three distinct radicals involved in the transformation, unlocking new enzyme reactivity. Our approach has achieved exceptional stereoselectivity, with 25 out of 33 examples achieving ≥97% enantiomeric excess.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"4 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI could pose pandemic-scale biosecurity risks. Here’s how to make it safer 人工智能可能带来大规模的生物安全风险。如何让它更安全
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03815-2
Jaspreet Pannu, Sarah Gebauer, Greg McKelvey Jr, Anita Cicero, Tom Inglesby
{"title":"AI could pose pandemic-scale biosecurity risks. Here’s how to make it safer","authors":"Jaspreet Pannu, Sarah Gebauer, Greg McKelvey Jr, Anita Cicero, Tom Inglesby","doi":"10.1038/d41586-024-03815-2","DOIUrl":"https://doi.org/10.1038/d41586-024-03815-2","url":null,"abstract":"AI-enabled research might cause immense harm if it is used to design pathogens with worrying new properties. To prevent this, we need better collaboration between governments, AI developers and experts in biosafety and biosecurity.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-generation snakebite therapies could reduce death toll 新一代蛇咬伤疗法可减少死亡人数
IF 64.8 1区 综合性期刊
Nature Pub Date : 2024-11-21 DOI: 10.1038/d41586-024-03818-z
{"title":"Next-generation snakebite therapies could reduce death toll","authors":"","doi":"10.1038/d41586-024-03818-z","DOIUrl":"https://doi.org/10.1038/d41586-024-03818-z","url":null,"abstract":"Venomous snakes kill tens of thousands of people each year. Treatments that are simpler to administer and more effective than conventional antivenom could curb this number.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"4 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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