Minerva dental and oral science最新文献

{"title":"Comparing polynomial regression and exponential growth model in predicting recession gain based on clinical gingival recession.","authors":"Pradeep Kumar Yadalam, Maria Maddalena Marrapodi, Vincenzo Ronsivalle, Rocco Franco, Patrizio Bollero, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.25.05045-4","DOIUrl":"10.23736/S2724-6329.25.05045-4","url":null,"abstract":"<p><strong>Background: </strong>Gingival recession (GR) is a common issue causing plaque accumulation, root caries, abrasion, cervical wear, and dentin hypersensitivity. Studies show a prevalence of thick and thin gingival biotypes, with no significant association between age, gender, or recession. This study aims to use polynomial regression and exponential growth models to predict recession gain based on clinical data. GR is a common issue causing plaque accumulation, root caries, abrasion, cervical wear, and dentin hypersensitivity. Studies show a prevalence of thick and thin gingival biotypes, with no significant association between age, gender, or recession. This study aims to use polynomial regression and exponential growth models to predict recession gain based on clinical data.</p><p><strong>Methods: </strong>The study analyzed recession coverage in upper and lower anterior teeth after connective tissue and free gingival grafting procedures from institute database. Data was preprocessed and analyzed using polynomial regression and exponential growth models. Polynomial regression allowed for nonlinear trends in recession gain, while exponential growth models provided insights into cumulative effects of specific factors on recession progression.</p><p><strong>Results: </strong>The polynomial of degree 3 with the lowest MSE of 0.0612 fit best. This shows that cubic polynomials better represent the \"Days\"-\"Gain Width\" relationship than linear or higher-degree polynomials. The exponential growth model fitted to \"Post Op\" data predicts an initial value of 0.7735 and a growth rate of 0.0101. This model proposes that \"Post Op\" measurements expand exponentially, with predicted parameters reflecting this growth.</p><p><strong>Conclusions: </strong>Based on clinical data, this study compares polynomial regression and exponential growth models for periodontal recession gain prediction. The findings emphasize the need of proper mathematical models to better understand periodontal diseases and guide dental care prevention and treatment.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"161-168"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health challenges among elite and paralympic athletes: a neglected burden.","authors":"Luca Fiorillo, Vincenzo Ronsivalle, Vini Mehta","doi":"10.23736/S2724-6329.25.05229-5","DOIUrl":"10.23736/S2724-6329.25.05229-5","url":null,"abstract":"","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"234-235"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing implant therapy success through comprehensive evaluation of implant biomechanics: a systematic review.","authors":"Luca Fiorillo, Cesare D'Amico, Matteo Peditto, Giacomo Oteri, Gabriele Cervino","doi":"10.23736/S2724-6329.25.04896-X","DOIUrl":"10.23736/S2724-6329.25.04896-X","url":null,"abstract":"<p><strong>Introduction: </strong>Dental implants are recognized as the optimal solution for replacing missing teeth due to their high success rates and broad applications. However, not all dental implant therapies yield successful outcomes, and failures can occur due to various biological and mechanical factors. This systematic review aims to evaluate primary studies focusing on the biomechanical properties of dental implants, to identify key factors that contribute to the success of implant therapy.</p><p><strong>Evidence acquisition: </strong>A comprehensive search was conducted across electronic databases, including MEDLINE (PubMed), EMBASE, Google Scholar, and CAB Abstracts. The search strategy incorporated six significant biomechanical properties, utilizing keywords and Boolean operators. The review encompassed human and animal studies, including observational studies, trials, and in vitro investigations. Out of 234 titles obtained from the online search, 59 studies were selected for full-text review following the abstract screening. Among these, nine full-text articles were selected for data extraction and analysis. All the included studies were conducted in vitro and therefore provide preclinical biomechanical evidence that may not directly translate to clinical outcomes. Among the in vitro studies, six assessed loss of preload, five assessed fatigue strength, four examined implant-abutment connection design, and one evaluated implant diameter.</p><p><strong>Evidence synthesis: </strong>Preload values decreased over time, with the most loss occurring within 10 seconds of tightening. The 8-degree internal conical implant demonstrated superior performance to the interior hex design. Studies also indicated a higher rate of complications (such as porcelain chipping and de-cementation) in cantilever groups. Biomechanical properties such as preload, torque, cantilever design, and implant abutment design significantly influence the success rates of dental implants.</p><p><strong>Conclusions: </strong>This review provides important parameters for successful implant therapy, albeit with certain limitations.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"169-181"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mesenchymal stem cells: biological characteristics and emerging therapeutic applications.","authors":"Andrea Ballini, Alfredo DE Rosa, Maria E Bizzoca, Lidia S Taccone, Eleonora Lo Muzio, Donato Antonacci, Armando Coppola, Mario Dioguardi, Stefania Cantore, Filiberto Mastrangelo","doi":"10.23736/S2724-6329.26.05286-1","DOIUrl":"10.23736/S2724-6329.26.05286-1","url":null,"abstract":"<p><p>Mesenchymal stem cells (MSCs) originating from the oral cavity constitute an accessible and minimally invasive reservoir of multipotent progenitors with broad relevance in regenerative medicine. Within this heterogeneous family, dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), periodontal ligament stem cells (PDLSCs), gingival MSCs (GMSCs), and stem cells from the apical papilla (SCAPs) have been extensively studied. These populations share key MSC characteristics: clonogenicity, self-renewal, multilineage differentiation, and a bioactive secretome, while displaying distinct biological signatures that influence their therapeutic applications. This review integrates findings from preclinical and early clinical studies focused on the molecular markers, functional attributes, and regenerative potential of oral MSCs. Attention was given to comparative analyses of their differentiation behaviors, immunomodulatory profiles, and interactions with biomaterials and molecular regulators. DPSCs and SHEDs demonstrate prominent neurogenic and osteogenic potential and release a secretome with neuroprotective and anti-apoptotic properties, supporting their use in disorders of the nervous system. DFSCs and PDLSCs possess strong osteogenic and cementogenic activity, combined with notable immunomodulation, making them suitable for periodontal and bone regeneration. GMSCs exhibit high proliferative efficiency, genomic stability, and robust anti-inflammatory actions, partly mediated by extracellular vesicles. SCAPs, residing in the apical papilla, maintain viability in inflamed environments and are pivotal in regenerative endodontics. Emerging evidence underscores the contribution of scaffolds and non-coding RNAs in enhancing the therapeutic performance of these cells across dento-alveolar, neuroregenerative, and immune-mediated conditions. A refined understanding of the distinctive properties and mechanisms of action of oral MSCs is essential for optimizing translational strategies and advancing toward standardized, predictable regenerative therapies in dentistry and related medical fields.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"223-233"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based assessment of temporomandibular disorders in complete denture versus partial denture users: a systematic review.","authors":"Jayant Prakash, Tushar Sinha, Hiroj Bagde, Nirupama Rajegowda, Sneha Bhat, Ashwini Dhopte, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.25.04903-4","DOIUrl":"10.23736/S2724-6329.25.04903-4","url":null,"abstract":"<p><strong>Introduction: </strong>Dental health and overall well-being are greatly impacted by temporomandibular disorders (TMDs), which encompass a spectrum of illnesses that impact the temporomandibular joint and its surrounding structures. The use of dental prostheses, including complete and partial dentures, is common among individuals with missing teeth. However, the association between denture types and the prevalence of TMD remains a subject of interest and concern in the field of oral health.</p><p><strong>Evidence acquisition: </strong>Relevant databases were comprehensively searched to identify eligible studies. The search strategy included terms related to Temporomandibular joint disorders and dentures. Studies reporting on the prevalence of TMD in denture wearers, categorized as complete or partial, were included. Quality assessment and data extraction were performed following established guidelines. Two reviewers independently screened articles, conducted data extraction and risk assessment. Meta-analysis was carried out using random-effects models, and subgroup analyses were conducted to explore potential sources of heterogeneity.</p><p><strong>Evidence syntesis: </strong>A total of three studies were included in the analysis. Two studies reported TMD to be prevalent in partial denture (PD) in higher proportions as compared to Complete Denture (CD) while another showed CD patients exhibiting greater TMD cases. The results remain inconclusive owing to the limited number of studies and evidence. The quality of the included studies ranged from moderate to low risk.</p><p><strong>Conclusions: </strong>The current evidence regarding the association between denture type and TMD is inconclusive and limited. The heterogeneity of study designs and the lack of standardized assessment tools for TMD diagnosis and denture classification contribute to the variability in findings. This information can help prosthodontists and other dental practitioners improve the general health and oral hygiene of their patients who wear dental prosthesis.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"182-190"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graph attention network-based prediction of oral multi-drug resistance efflux protein sequence.","authors":"Pradeep K Yadalam, Swarnambiga Ayyachamy, Vincenzo Ronsivalle, Maria M Marrapodi, Marco Cicciù, Giuseppe Minervini","doi":"10.23736/S2724-6329.25.04946-0","DOIUrl":"https://doi.org/10.23736/S2724-6329.25.04946-0","url":null,"abstract":"<p><strong>Background: </strong>Prediction of the oral resistome protein sequence is crucial to have multi-drug efflux pumps for both drug discovery and resistance management. Sophisticated machine learning and deep learning techniques called graph attention networks (GATs) and hyperattention processes are used to predict protein sequences and their interactions in molecular biology. Our goal is to forecast the oral multi-drug resistance efflux protein sequence's graph attention network.</p><p><strong>Methods: </strong>The FASTA sequences (UniProt ids: P0ACR9, P0ACH5, P60752, P0AE82, P0A7V8, P24177, P76399) were retrieved from MprA, MarA, CpxA, and MdtC. These sequences were located and their quality assessed. The Deepbio program was used to analyze hyperattention and graph attention networks using FASTA sequences.</p><p><strong>Results: </strong>Sensitivity = TP / (TP + FN) = 0.51 represents the percentage of positive cases identified by hyper attention and graph attention network, while the percentage of negative cases the model properly recognizes is 0.83 TNR. also known as particularity. Technique for computation: Hyper attention and the graph attention network have specificities of TN / (TN + FP) = 0.83 and 0.91, respectively.</p><p><strong>Conclusions: </strong>Oral multi-drug resistome sequences can be predicted using the GAT model, which can also be applied to future resistant sequences.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser treatment for venous malformations in the upper airway region: a systematic review.","authors":"Niccolò G Armogida, Parisa Soltani, Gianrico Spagnuolo, Francesco Riccitiello, Sandro Rengo, Michele Simeone","doi":"10.23736/S2724-6329.25.04911-3","DOIUrl":"10.23736/S2724-6329.25.04911-3","url":null,"abstract":"<p><strong>Introduction: </strong>Laser treatment of venous malformations (VMs), frequently observed in the upper airway, has been recently proposed. The aim of this systematic review was to analyze the effectiveness of the laser in treating oropharyngeal VMs.</p><p><strong>Evidence acquisition: </strong>Five electronic databases were searched: National Library of Medicine (MEDLINE-PubMed), Scopus, Embase, Cochrane Library and Web of Science. OpenGrey was also searched to retrieve relevant grey literature. The analysis considered all the articles published from 1900 to 20/02/2023 excluding those still in the publication phase. Reference lists of included studies were manually searched for identification of other potential papers. Data on clinical characteristics of VMs, type and protocols of laser treatments, achieved outcomes and complications were collected and a qualitative analysis was performed.</p><p><strong>Evidence synthesis: </strong>Nine studies were selected for data extraction. Nd:YAG laser was used in seven studies and diode laser in two studies. Almost all treated lesions had volume reduction >75%. No major complications had been reported.</p><p><strong>Conclusions: </strong>Although some clinical factors were not reported in most of the studies, the results showed that the LT could be an effective and minimally invasive therapeutic option in the treatment of VMs. Further clinical controlled trials can shed more light on the role of laser in the treatment of VMs.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"127-138"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of platelet-rich fibrin in immediate dental implant placement: a systematic literature review.","authors":"Ieva Pliatkute, Vykintas Pliavga, Aine Jakonyte, Gintaras Juodzbalys","doi":"10.23736/S2724-6329.25.05171-X","DOIUrl":"10.23736/S2724-6329.25.05171-X","url":null,"abstract":"<p><strong>Introduction: </strong>During immediate dental implant placement, regenerative materials are often used to fill the peri-implant space following tooth extraction and implant insertion. One such material gaining popularity in contemporary dentistry is platelet-rich fibrin (PRF). This study aims to examine existing scientific literature to determine if PRF effectively promotes the filling of the peri-implant gap and regeneration of soft tissue in single-unit immediate dental implant placement compared to alternative materials.</p><p><strong>Evidence acquisition: </strong>The systematic literature review was performed according to PRISMA guidelines. Databases searched included PubMed, Cochrane Library, ScienceDirect, Google Scholar, Scopus, and ResearchGate, up to November 19, 2024. Selection criteria included studies on humans, written in English, and using PRF for the management of the peri-implant gap in immediate implantation.</p><p><strong>Evidence synthesis: </strong>Seven publications were reviewed: 2 studies compared PRF with blood clots, 2 with collagen and bone substitute, and 3 with bone substitute alone. Implant stability quotient results in slightly favoured PRF over blood clot and collagen with bone substitute, although results were inferior to bone substitutes alone. One study noted significant crestal bone improvement with PRF versus collagen and deproteinized bovine bone (DBB). One study reported higher resorption in the PRF group compared to DBB and beta-tricalcium phosphate at the buccal site. Control groups generally exhibited lower peri-implant pocket depths, though no significant differences were observed between groups across studies and follow-up.</p><p><strong>Conclusions: </strong>PRF effectively promotes regeneration of the peri-implant hard and of soft tissue in single-unit immediate dental implant placement compared to control groups, although no significant differences were observed between alternative materials across studies and follow-up.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"110-126"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric and radioisotopic analysis of an adult mandibular bone fragment found together with anatomical forceps and two scalpel blades.","authors":"Antonio Della Valle, Eleonora Lo Muzio, Caterina Lovece, Lorenzo Lo Muzio, Maria E Bizzoca","doi":"10.23736/S2724-6329.25.05269-6","DOIUrl":"10.23736/S2724-6329.25.05269-6","url":null,"abstract":"<p><strong>Background: </strong>During excavation works for high-speed railway infrastructure in central Italy, at a depth of 430 cm in clayey-gravelly soil, a mandibular bone fragment was discovered together with metal artefacts. The find emerged in the context of geotechnical stabilization works aimed at ensuring ground support for the railway line.</p><p><strong>Methods: </strong>The mandibular fragment, preserved with erupted teeth, was cleaned and analyzed by radiological tomography using software for morphometric and densitometric evaluation. A subsample was examined at a Nuclear Physics Centre for radioisotopic dating and to assess the individual's physical and nutritional status at the time of death. Comparative archaeological analyses were performed to identify the nature and chronology of the associated metal artefacts.</p><p><strong>Results: </strong>Morphometric assessment confirmed the remains belonged to an adult primate of the Order Eutheria, with traits consistent with a human specimen. Radiological and isotopic studies yielded data on bone density, preservation, and temporal context. The artefacts displayed distinct morphological features attributable to manufactured tools. Archaeological comparison indicated they were most likely the tips of surgical instruments, dating to the Roman period (first century AD).</p><p><strong>Conclusions: </strong>This multidisciplinary investigation demonstrates the value of combining morphometric, radiological, radioisotopic, and archaeological analyses in reconstructing the biological and cultural significance of osteological finds. The evidence suggests the mandibular fragment belonged to an adult individual, and the associated artefacts can be interpreted as surgical instruments from the Roman era, providing rare insights into ancient medical practices.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"78-97"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral superior labial artery embolization for arteriovenous malformation.","authors":"Carlo Fornaseri, Ylenia Gugliotta, Alberto Balderi, Giovanni Gerbino, Marco Bernardi","doi":"10.23736/S2724-6329.25.05169-1","DOIUrl":"10.23736/S2724-6329.25.05169-1","url":null,"abstract":"<p><p>Lip arteriovenous malformations (AVMs) are typically present at birth and can lead to progressive tissue destruction and functional and cosmetic issues. Their management is challenging due to the lack of standardized protocols and may involve both surgical and non-surgical approaches. The authors present a case of upper lip AVM with feeders bilaterally from both facial arteries and their superior labial branch arteries. Bilateral Gelfoam embolization of the labial arteries followed by surgical resection was performed. The upper lip was reconstructed using a bilateral advancement flap. The patient's intraoperative and postoperative courses were uneventful, and no recurrence was recorded. The functional and aesthetic results were good and satisfying for the patient at the 1-year follow-up. Upper lip AVMs can be managed through a combination of presurgical embolization and complete surgical resection. The use of a rapidly absorbable embolic material does not compromise the surgical resection procedure and reduces the risk of complications such as necrosis of the upper lip, especially in cases where it is necessary to embolize both upper labial arteries.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"152-159"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}