Minerva dental and oral science最新文献

{"title":"Mitochondrial DNA content as a biomarker for oral carcinogenesis: correlation with clinicopathologic parameters.","authors":"Reema Raina,&nbsp;Devi C Shetty,&nbsp;Nighat Nasreen,&nbsp;Shukla DAS,&nbsp;Aashka Sethi,&nbsp;Atul Chikara,&nbsp;Gargi Rai,&nbsp;Anshuman Kumar,&nbsp;Sonam Tulsyan,&nbsp;Sandeep Sisodiya,&nbsp;Showket Hussain","doi":"10.23736/S2724-6329.23.04756-3","DOIUrl":"10.23736/S2724-6329.23.04756-3","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial genome (mtDNA) exhibits greater vulnerability to mutations and/or copy number variations than nuclear counterpart (nDNA) in both normal and cancer cells due to oxidative stress generated by inflammation, viral infections, physical, mechanical, and chemical load. The study was designed to evaluate the mtDNA content in oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC). Various parameters were analyzed including its variation with human papillomavirus (HPV) during oral carcinogenesis.</p><p><strong>Methods: </strong>The present cross-sectional study comprised of two hundred patients (100 OPMDs and 100 OSCCs) and 100 healthy controls. PCR amplifications were done for mtDNA content and HPV in OPMDs and OSCC using real-time and conventional PCR respectively.</p><p><strong>Results: </strong>The relative mtDNA content was assessed quantitatively and it was observed that mtDNA was greater in OSCC (7.60±0.94) followed by OPMDs (5.93±0.92) and controls (5.37±0.95). It showed a positive linear correlation with habits and increasing histopathological grades. Total HPV-positive study groups showed higher mtDNA content (7.06±1.64) than HPV-negative counterparts (6.21±1.29).</p><p><strong>Conclusions: </strong>An elevated mutant mtDNA may be attributed to increased free radicals and selective cell clonal proliferation in test groups. Moreover, sustained HPV infection enhances tumorigenesis through mitochondria mediated apoptosis. Since, mtDNA content is directly linked to oxidative DNA damage, these quantifications might serve as a surrogate measure for invasiveness in dysplastic lesions and typify their malignant potential.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"211-220"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9303414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary microRNAs as innovative biomarkers for early diagnosis of oral diseases: a comparison of conventional cigarette smokers and tobacco heating system 2.2 users.","authors":"Giuseppe Minervini,&nbsp;Aida Meto,&nbsp;Luca Fiorillo,&nbsp;Rocco Franco,&nbsp;Fabrizio di Francesco,&nbsp;Marco Cicciù,&nbsp;Gabriele Cervino","doi":"10.23736/S2724-6329.23.04790-3","DOIUrl":"10.23736/S2724-6329.23.04790-3","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNAs) are considered valid prognostic and diagnostic biomarkers. The different miRNA expression profiles in cancer cells compared to normal cells make them potential biomarkers used for the early diagnosis of oral diseases. Following exposure to cigarette smoking, miRNA altered profile expression is associated with resistance mechanisms against anticancer therapies. Cellular models showed a reduced human gingival epithelium alteration after exposure to THS2.2 and a lower pathogenicity than 3R4F CS. The aim of the study was to compare the expression of saliva miRNA profile of THS2.2 and 3R4F CS users compared to patients not exposed to the risk factor and to identify and study the modulation of miRNAs associated with the development of oral diseases. In particular, we will focus on the analysis of a group of miRNAs know to be involved in the development of smoking-related diseases.</p><p><strong>Methods: </strong>The study will be performed in 18 months and dentists and biochemists will be involved in the different phases. To perform the study, healthy volunteers, including smokers of THS2.2 or 3R4F CS, will be enrolled.</p><p><strong>Results: </strong>The samples will be collected from 3 experimental groups, each consisting of 30 subjects: group 1 (no smoking subjects), group 2 (subjects exposed to THS2.2), group 3 (subjects exposed to 3R4F CS). The collection of the saliva sample will be conducted in a standardized way. Following the collection, saliva will be processed.</p><p><strong>Conclusions: </strong>Previous studies have suggested that miRNAs are prognostic biomarkers for various smoking-related diseases. Based on the post-transcriptional regulation of some mRNAs connected to different oral pathologies, we expect a specific miRNA-mRNA interaction, which could be a starting point for the development of new possible diagnostic, therapeutic and prognostic approaches.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"247-254"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9551935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate loading full-arch rehabilitation using transmucosal tissue-level implants with different variables associated: a one-year observational study.","authors":"Francesco Pera,&nbsp;Paolo Pesce,&nbsp;Maria Menini,&nbsp;Francesco Fanelli,&nbsp;Byung-Chan Kim,&nbsp;Khrystyna Zhurakivska,&nbsp;Yaniv Mayer,&nbsp;Gaetano Isola,&nbsp;Giulia Cianciotta,&nbsp;Armando Crupi,&nbsp;Giulia Ambrogio,&nbsp;Nicola Scotti,&nbsp;Massimo Carossa","doi":"10.23736/S2724-6329.23.04782-4","DOIUrl":"10.23736/S2724-6329.23.04782-4","url":null,"abstract":"<p><strong>Background: </strong>The aim of the present observational study was to investigate the application of transmucosal tissue-level implants in immediate loading full-arch rehabilitation with different variables associated.</p><p><strong>Methods: </strong>Patients needing a full-arch implant rehabilitation were recruited and rehabilitated with four transmucosal tissue level implants. Data related to implants' diameters and lengths, jaw distributions, and presence of angulated abutments were collected. The following outcomes were evaluated: survival rate, marginal bone loss (MBL), Plaque Index (PI), bleeding on probing (BoP), probing depth (PD). Descriptive statistical analysis was reported and univariate linear regression models were built to assess a significant correlation between MBL and the different implant related factors.</p><p><strong>Results: </strong>Twenty patients were rehabilitated for a total implant number of 80; 11 rehabilitations were performed on the maxilla, while 9 were performed on the mandible; 48 implants presented a 3.8 mm diameter and 32 implants presented a 4.25 mm diameter. Implants length varied between 10 to 15 mm; 40 tilted implants were connected to angulated abutment, while 40 straight implants were connected directly to the prostheses (no abutments). At the one year follow-up visit no implants failed resulting in an implant survival rate of 100%. The overall MBL was 1.19±0.30 mm. No statistically significant difference (P>0.05) was highlighted among any of the subgroups analyzed.</p><p><strong>Conclusions: </strong>Despite different variables associated, tissue level implants seem to represent a valid option when applied in immediate loading full-arch rehabilitation. Further research and longer observational periods are encouraged to confirm the result.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"230-238"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of salivary MicroRNA-6734, microRNA-3123 and microRNA-4483 expression in smoker and nonsmoker patients: a case control study.","authors":"Parya Atapour,&nbsp;Abbas Farmany,&nbsp;Hamidreza Abdolsamadi,&nbsp;Ehsan Hashemi,&nbsp;Mina Jazaeri","doi":"10.23736/S2724-6329.23.04787-3","DOIUrl":"10.23736/S2724-6329.23.04787-3","url":null,"abstract":"<p><strong>Background: </strong>Tobacco is a major risk factor in oral diseases. Considering the important role of expression miRNA molecules in different diseases, the present study aimed to compare the expression of salivary miRNA-6734, miRNA-3123 and miRNA-4483 in smoker and non-smoker peoples.</p><p><strong>Methods: </strong>In this case-control study, salivary samples were obtained from 30 smoker's patients and 27 healthy nonsmokers and matched in term of age and sex. RNA was extracted in salivary samples and gene expression was evaluated in all samples. Statistical analysis of data was performed using T and chi-square tests by SPSS (Ver. 16) software at a significant level of less than 0.05.</p><p><strong>Results: </strong>The results of this study showed that the expression level of miRNA-3123 and miRNA-4483 in smokers group was 2.8 and 3.2, respectively, which was increased compared to non-smokers with expression level of 1 (P<0.01). There was a significant decrease in the expression rate of miRNA-6734 in smokers (0.6%) compared to non-smokers (P<0.05).</p><p><strong>Conclusions: </strong>Based on the results of this study, considering the increasing miRNA-4483 and miRNA-3123 level, as well as the reducing miRNA-6734 level in smokers compared to non-smokers, it seems that evaluation of these two miRNAs as indicator for diagnosis and determination of prognosis of oral diseases associated with smoking can be used.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"239-246"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9548544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of oral mucositis: a systematic review.","authors":"Joey Danwiek,&nbsp;Rahmi Amtha,&nbsp;Indrayadi Gunardi","doi":"10.23736/S2724-6329.23.04695-8","DOIUrl":"10.23736/S2724-6329.23.04695-8","url":null,"abstract":"<p><strong>Introduction: </strong>Oral mucositis is one of the most common complications following chemotherapy and/or head and neck radiotherapy. Various treatments for oral mucositis have been proposed. However, there has still been no review of the most frequent and most effective type of therapy to treat oral mucositis. This systematic review aims to determine the most frequent and effective types of therapy to treat and reduce the severity of oral mucositis.</p><p><strong>Evidence acquisition: </strong>The literature search was carried out using PRISMA guidelines. Publications included from 2010 to June 2021 with a clinical trial, prospective, and retrospective observational research design. The following databases were used: PubMed, Cochrane Library, and Wiley Online Library. The search was for limited articles published in English, which were screened and analyzed by three authors. The risk of bias of each study was also assessed by three authors simultaneously, using different types of instruments depending on its study design.</p><p><strong>Evidence synthesis: </strong>Forty-seven of 1274 journals were included. From 3577 subjects, oral mucositis was more common in males than females (2.12: 1), with a mean age of 56.39 (18-90 years). The most commonly used types of therapy are low-level laser therapy (396 subjects) and lysozyme-based compounds (314 subjects). Meanwhile, the most effective type of therapy is low-level laser therapy.</p><p><strong>Conclusions: </strong>Low-level laser therapy is the most commonly used oral mucositis therapy and is also the most effective in reducing the degree of oral mucositis and associated pain.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"255-270"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9309955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary interleukin-1β as a biomarker to differentiate between periodontal health, gingivitis, and periodontitis.","authors":"Marwa A Abdullameer,&nbsp;Ali A Abdulkareem","doi":"10.23736/S2724-6329.23.04778-2","DOIUrl":"10.23736/S2724-6329.23.04778-2","url":null,"abstract":"<p><strong>Background: </strong>Periodontal diagnosis is based on recording clinical parameters including bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL). These techniques may be prone to errors due to different factors. Available biomarkers in the oral biofluid such as interleukin (IL)-1β could provide solutions for these issues. The study aimed to determine the potential of salivary IL-1β to differentiate periodontal health from disease and between gingivitis and periodontitis.</p><p><strong>Methods: </strong>Patients with gingivitis (N.=25), periodontitis (N.=50), and healthy periodontium (N.=25) were recruited for this study. For each patient, whole unstimulated saliva was collected followed by recording periodontal parameters namely; Plaque Index (PI), BOP, PPD, CAL. Level of salivary IL-1β was assayed by using enzyme-linked immunosorbent assays. Sensitivity and specificity of IL-1β, to differentiate any given condition, was determined by Receiver operating characteristic curve and area under the curve (AUC).</p><p><strong>Results: </strong>Both BOP and PI were significantly higher in association with gingivitis and periodontitis groups as compared to controls. Concentration of salivary IL-1β in periodontal health was significantly lower than gingivitis and periodontitis groups. The biochemical analyses showed that salivary IL-1β differentiated periodontal health from gingivitis (AUC 0.949) and periodontitis (AUC 0.852) but could not discriminate gingivitis from periodontitis (AUC 0.532). The proposed cut-off points to differentiate periodontal health from gingivitis was 103.8 pg/mL, while the value of the biomarker to differentiate periodontal health from periodontitis was 102.0 pg/mL.</p><p><strong>Conclusions: </strong>Salivary IL-1β could be a reliable biomarker with a good level of accuracy to differentiate periodontal health from disease but not to discriminate gingivitis from periodontitis.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":" ","pages":"221-229"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the accuracy between full-arch digital scans and scannable impression materials: an in vitro study.","authors":"Francesco Grande,&nbsp;Giordano Celeghin,&nbsp;Federica Gallinaro,&nbsp;Nicola Mobilio,&nbsp;Santo Catapano","doi":"10.23736/S2724-6329.23.04766-6","DOIUrl":"https://doi.org/10.23736/S2724-6329.23.04766-6","url":null,"abstract":"<p><strong>Background: </strong>In some clinical cases, full-arch impression could be difficult to take correctly with the digital way. Patients with high flow salivary rate or with difficulties in mouth opening can still benefit from a conventional impression with elastomer materials that can be directly or indirectly digitized. The aim of this study was to compare the accuracy and precision of two different intraoral scanners (IOSs) and an impression material with scannable properties, by means of three-dimensional analysis of a complete dental arch.</p><p><strong>Methods: </strong>An anatomical model of complete upper arch, modified with a Scan body placed in the retroincisive area, was used. It was firstly scanned by a desktop scanner to create a digital reference model. Then, 3 groups were created, each constituted by 5 samples. In the first group, 5 impressions were taken from the same master model with the scannable PVS material (Hydrorise Implant), 5 scans were taken using Trios4 (3Shape) and other 5 scans with iTero Element 5D (iTero). STL files obtained from IOSs, and scanned impressions were three-dimensionally superimposed on the STL file of the reference model using the Scan body geometry.</p><p><strong>Results: </strong>The ANOVA Test (P<0.005) did not show any statistically significant difference between the accuracy and precision values of the groups. Each group shows clinically acceptable deviations from the reference model.</p><p><strong>Conclusions: </strong>Scannable polyvinylsiloxane impression materials are equally accurate and precise as the two IOSs tested in full-arch dentate impressions.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":"72 4","pages":"168-175"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10149092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and microbiological comparison of knotless/barbed and silk sutures for impacted third-molar surgery.","authors":"Ahmet E Uysal,&nbsp;Metin Sencimen,&nbsp;Aydin Ozkan,&nbsp;Tugrul Hosbul,&nbsp;Sara Samur Erguven,&nbsp;Furkan Parlak","doi":"10.23736/S2724-6329.23.04764-2","DOIUrl":"https://doi.org/10.23736/S2724-6329.23.04764-2","url":null,"abstract":"<p><strong>Background: </strong>Several types of suture materials are available for oral surgery. However, the most used non-resorbable suture in oral surgery is 3/0 silk. The aim of the present study was to compare the effectiveness of knotless/barbed sutures with silk sutures during the postoperative period after the third molar surgery in terms of clinical and microbiological parameters.</p><p><strong>Methods: </strong>The study comprised 38 patients who underwent surgical extraction of a mandibular impacted third molar. The patients were divided into two groups. The mucoperiosteal flap was closed using 3/0 knotless/barbed sutures for the test group and 3/0 silk sutures for the control group. The duration of suturing was recorded during surgery. Pain level, postoperative edema, and trismus were measured at 3 and 7 days after surgery. The status of plaque formation on the sutures was scored using the Plaque Index at 3 and 7 days after the surgery. At 7 days, the suture materials were removed and submitted to the laboratory for microbiological analysis. The level of pain during suture removal was also recorded by a Visual Analog Scale.</p><p><strong>Results: </strong>The duration of suturing in the barbed sutures group was found significantly lower than in silk sutures (P<0.05). There was no significant difference between the suture types in terms of trismus and edema at 3 and 7 days after surgery (P>0.05). On the third day after surgery and during suture, removal pain scores were statistically significantly lower in the barbed suture group than in the silk suture group (P<0.05). The Plaque Index values of the barbed sutures were statistically significantly lower than that of the silk sutures at 3 and 7 days after surgery (P<0.05). Aerobic, anaerobic, and aerobic/anaerobic mean colony forming units (CFUs) were statistically significantly lower in the barbed suture group than in the silk suture group (P<0.05).</p><p><strong>Conclusions: </strong>Barbed sutures increase the ease of operation and patient comfort with less postoperative pain than silk sutures. Additionally, less plaque accumulation and lower bacterial colonization were found on the barbed/knotless sutures than on the silk sutures.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":"72 4","pages":"161-167"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9779906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing the spread of COVID-19 within the dental practice: the era of single use.","authors":"Saverio Ceraulo,&nbsp;Dorina Lauritano,&nbsp;Gianluigi Caccianiga,&nbsp;Marco Baldoni","doi":"10.23736/S2724-6329.20.04436-2","DOIUrl":"https://doi.org/10.23736/S2724-6329.20.04436-2","url":null,"abstract":"<p><p>The year 2020 will be remembered around the world for the Coronavirus pandemic. The better-known Coronavirus disease (COVID-19) is transmitted between individuals through the droplets produced by infected people and is an infectious disease caused by a type of Coronavirus when they exhale, cough or sneeze, or touch a contaminated surface and then touch their eyes, nose or mouth. The pandemic has activated all those measures that provide for a state of emergency with consequent remodeling of health facilities in cases of urgency that cannot be deferred. In this work, a path within a public or private medical facility was highlighted, using individual protective devices for the patient, establishing behaviors that can reduce the spread of the virus. The COVID-19 path has allowed the health personnel and the staff of the study to be able to work in peace as there is the perception of the total containment of the spread of the virus. Coronavirus disease (COVID-19) is an infectious disease caused by a Coronavirus type transmitted through droplets produced by infected people when they cough, sneeze or exhale. Our proposal in dictating the sequence and types of protective devices to be worn by patients minimizes the contagion between patients in a professional healthcare office and is applicable for any type of infectious emergency.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":"72 4","pages":"206-209"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9838277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable cranial parameters to evaluate the occlusal plane orientation in the frontal plane: a systematic review.","authors":"Raul E Frugone-Zambra,&nbsp;Oscar Silva-Fontana,&nbsp;Alessandro Bianchi,&nbsp;Antonio Jimenez-Silva,&nbsp;Sergio Bortolini","doi":"10.23736/S2724-6329.22.04659-9","DOIUrl":"https://doi.org/10.23736/S2724-6329.22.04659-9","url":null,"abstract":"<p><strong>Introduction: </strong>A systematic review of the literature available up to October 2020 has been conducted to determine which cranial plane could represent a stable and reliable parameter to evaluate the orientation of the occlusal plane in a frontal view.</p><p><strong>Evidence acquisition: </strong>An electronic research was performed across the following electronic databases: PUBMED, EBSCO, SCOPUS, WoS, COCHRANE LIBRARY, SciELO, EMBASE and GOOGLE SCHOLAR. Observational studies based on imaging and anthropometry were identified, and all languages have been included. The articles were selected and analyzed by three authors independently. PICO format was adopted to analyze the studies and AXIS guidelines were used to assess the quality of evidence.</p><p><strong>Evidence synthesis: </strong>We found eleven articles eligible for full-text analysis. All studies included only young subjects and analyzed the occlusal plane in relation to the frontal plane traced between the right and left tragus (Camper's and Frankfurt planes), to the interpupillary plane, and to other soft and hard tissues references. The outcomes of selected studies were various, with a low quality of evidence, and they did not allow to infer a stable cranial relation between the occlusal plane and other bone structures.</p><p><strong>Conclusions: </strong>The evidence does not support that the interpupillary plane represent a reliable parameter to evaluate the occlusal plane orientation in a frontal view; instead, the Frankfurt plane could be a much more stable reference parameter, from a morphological perspective. It is necessary to perform an observational study upon craniums to define which are the most stable cranial reference planes to determine the orientation of the occlusal plane in dentate subjects.</p>","PeriodicalId":18709,"journal":{"name":"Minerva dental and oral science","volume":"72 4","pages":"185-194"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}