发布求助
文献互助 智能选刊 最新文献

MOJ Bioorganic & Organic Chemistry最新文献

筛选
英文 中文
The bactericidal activity of quaternary ammonium salts with 2-hydroxyethyl group 2-羟基乙基季铵盐的杀菌活性
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-07-12 DOI: 10.15406/MOJBOC.2018.02.00077
Torosyan Gh, Hovhannisyan Nr
{"title":"The bactericidal activity of quaternary ammonium salts with 2-hydroxyethyl group","authors":"Torosyan Gh, Hovhannisyan Nr","doi":"10.15406/MOJBOC.2018.02.00077","DOIUrl":"https://doi.org/10.15406/MOJBOC.2018.02.00077","url":null,"abstract":"The chemical and spatial structure of a substance determines its bioactivity. During is designing the drug the chemists are tried to take into account, introducing the appropriate chemical groupings into the potential drug substance. The presence of alkyl chains, their elongation increases the lipophilicity of drug substances (solubility in fatty tissues that can serve as a drug depot) and facilitates their passage through bio-membranes. The branched alkyl substituents and the presence of halogen atoms make it difficult to metabolize (in particular biooxidation) drugs. The use of drugs with bioactive alcohol group changes the polarity of the drug molecule, improves the manifestation of pharmacological activity.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73933028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Edema reducing potentials of some emerging Schiff’s bases of murrayanine 一些新出现的鼠尾草碱的消肿电位
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-07-11 DOI: 10.15406/MOJBOC.2018.02.00076
D. Mahapatra, K. Dadure, Ruchi Shivhare
{"title":"Edema reducing potentials of some emerging Schiff’s bases of murrayanine","authors":"D. Mahapatra, K. Dadure, Ruchi Shivhare","doi":"10.15406/MOJBOC.2018.02.00076","DOIUrl":"https://doi.org/10.15406/MOJBOC.2018.02.00076","url":null,"abstract":"Murrayanine is the most active and popular phytoconstituent present in the Indian curry plant, also known as Murraya koenigii L. (family: Rutaceae).1 Till date, the ethnopharmacological importance of the root, stem bark, and leaves are known successfully such as purgative, anthelminthic, febrifuge, carminative, astringent, and stomachic.2 In our previous research done so far, benzothiazepine,3 oxadiazole,4 3,4-methylenedioxy,5 thiazole,6 benzoxazepine,7 thiadiazole,8 isoxazole,9 hydantoin,10 phthalimide,11 pyrimidine,12 benzodiazepine,13 pyrazole,14 chalcone,15 and methylsulfone16 derivatives of murryanine have been rationally synthesized as hybrids in our laboratory, characterized comprehensively, and biologically screened in various animal models to explore their pharmacological potentials such as anti-convulsant, anti-inflammatory, anti-anxiety, anti-diabetic, anti-oxidant, anti-fungal, and anti-bacterial.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78585449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Development of alum from kaolin deposit using response surface methodology 用响应面法研究高岭土中明矾
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-22 DOI: 10.15406/MOJBOC.2018.02.00075
J. Adeoye, J. Omoleye, M. Ojewumi
{"title":"Development of alum from kaolin deposit using response surface methodology","authors":"J. Adeoye, J. Omoleye, M. Ojewumi","doi":"10.15406/MOJBOC.2018.02.00075","DOIUrl":"https://doi.org/10.15406/MOJBOC.2018.02.00075","url":null,"abstract":"A novel approach of for the formation of Hydrated Sodium Aluminium Sulpahte (Alum) from metakaolin was employed in this study. This process was used to form alum from metakaolin. It majorly involves captivating the self generated energy as a result of acid solvating in metakaolin-water solution to supply the mixing and activation energies requirement of the process without external heat source. The study gives a regression equation for the formation of Alum at a given volume of acid per gram metakaolin, temperature of reaction and desired conversion level.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73000327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Influence of acoustic vibrations on the kinetics of liquid-phase chemical reactions involving associates 声波振动对液相化学反应动力学的影响
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-18 DOI: 10.15406/MOJBOC.2018.02.00074
T. P. Kulagina, L. Smirnov, Andrianova Zs
{"title":"Influence of acoustic vibrations on the kinetics of liquid-phase chemical reactions involving associates","authors":"T. P. Kulagina, L. Smirnov, Andrianova Zs","doi":"10.15406/MOJBOC.2018.02.00074","DOIUrl":"https://doi.org/10.15406/MOJBOC.2018.02.00074","url":null,"abstract":"Where γ is some structure-sensitive coefficient and σ changes as σ=Р0sin(2πvt). At the initial stage, the formation of dimmers is governed by the value of k(v)–i. It is almost convenient to create in a reaction system the density fluctuation, uniform in space, at the expense of external periodic force, influencing system an acoustic wave. At the action of a acoustic wave with a frequency v the stretching σ and compression created in system lead to change of kinetic constants k(v)-and destruction of associates. This constant has view:","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"03 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86401459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Metal ligand complexes of alpha nitroso beta naphthol 亚硝基萘酚的金属配体配合物
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-14 DOI: 10.15406/mojboc.2018.02.00073
J. Ramkumar, S. ramouleeswaran
{"title":"Metal ligand complexes of alpha nitroso beta naphthol","authors":"J. Ramkumar, S. ramouleeswaran","doi":"10.15406/mojboc.2018.02.00073","DOIUrl":"https://doi.org/10.15406/mojboc.2018.02.00073","url":null,"abstract":"Alpha nitroso beta naphthol is a well known gravimetric reagent and can also be used for extractive spectrophotometric determination of metal ions.1 The foremost advantages of the method are its high sensitivity and reproducibility but it suffers from sensitivity towards ammonia concentration and the low solubility of cobaltnitrosonaphtholate. Modification of the gravimetry methodology was carried out by Chatterjee et al.,2 wherein precipitation was carried out in acidic solution with a reagent prepared by heating alpha-nitrosobeta-naphthol in a mixture of glacial acetic acid, hydrogen peroxide and syrupy phosphoric acid. The complex of cobalt was ignited and weighed. There was no interferences from ions like iron(III), copper, chromium(III), vanadium(V), tungsten(VI), aluminium, molybdenum, nickel, titanium, zirconium, uranium(VI) and cerium.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84295440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Conversion of 2,3,8,9-dibenzo-4,7-Dimethyl-5,6-dihydro-1,10 phenanthroline to Dibenzo[b,j][1,10]phenanthrolines 2,3,8,9-二苯并-4,7-二甲基-5,6-二氢-1,10菲罗啉转化为二苯并[b,j][1,10]菲罗啉
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-11 DOI: 10.15406/mojboc.2018.02.0072
H. Ji, N. Johnson
{"title":"Conversion of 2,3,8,9-dibenzo-4,7-Dimethyl-5,6-dihydro-1,10 phenanthroline to Dibenzo[b,j][1,10]phenanthrolines","authors":"H. Ji, N. Johnson","doi":"10.15406/mojboc.2018.02.0072","DOIUrl":"https://doi.org/10.15406/mojboc.2018.02.0072","url":null,"abstract":"","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88957335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudo aptamer expands aptamer’s applications 伪适体扩展了适体的应用
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-07 DOI: 10.15406/MOJBOC.2018.02.00071
Hengguang Li, Grace M Chavis
{"title":"Pseudo aptamer expands aptamer’s applications","authors":"Hengguang Li, Grace M Chavis","doi":"10.15406/MOJBOC.2018.02.00071","DOIUrl":"https://doi.org/10.15406/MOJBOC.2018.02.00071","url":null,"abstract":"Because of broad range of applications and distinctive properties of aptamer, the global market size was valued at USD 723.6 million in 2016 and is projected to grow at the compound annual growth rate (CAGR) of 28.2%,1 and expected to reach $8.91 Billion by 2025, growing rapidly. Aptamers and the derivatives are also referred to as “synthetic antibodies” or “chemical antibodies”2‒5 that are able to bind with high affinity and specificity to almost all types of molecules as well as antigens, cells. Because of their unique properties, aptamers have a wide range of applications, particularly in biological and medical sciences, including diagnosis, therapies, forensics, and biodefense.6‒9 So far, hundreds of aptamer reagents have been developed for the applications,10 which are faster, cheaper, and less or without the predictable problems associated with the production of recombinant antibodies. This review summarizes the resent technologies of modified analogous of aptamer, so called pseudo aptamers in this script.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"47 Suppl 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77584498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The antimicrobial and bactericidal activity of secondary amine with 2-hydroxyethyl group 含2-羟基乙基仲胺的抑菌活性
MOJ Bioorganic & Organic Chemistry Pub Date : 2018-06-07 DOI: 10.15406/mojboc.2018.02.00070
Torosyan Gh, Hovhannisyan Nr
{"title":"The antimicrobial and bactericidal activity of secondary amine with 2-hydroxyethyl group","authors":"Torosyan Gh, Hovhannisyan Nr","doi":"10.15406/mojboc.2018.02.00070","DOIUrl":"https://doi.org/10.15406/mojboc.2018.02.00070","url":null,"abstract":"The antimicrobial properties of substances have been studied in vitro by serial dilution in a liquid nutrient medium.2 Staphylococous aurous strain N=209 “P”, as the most stable species from the coccus group of bacteria, and Escherichia coli 0 III B:4-24, as the most stable species from enterobacteria, were used as indicator microorganisms. Test cultures by morphological, tinctorial, and cultural and biochemical properties are typical. Bacteria were cultured on MPA and MPB (pH =7.2-7.4). In the experiments, second generations of daily agar test cultures were used. The substances 2, 3 have activity in relation to the Staph aureus strain #209. The substance 2 surpasses the antimicrobial ethogenium (ethylene-1,2-bis/N-dimethylcarbodecoxymethylammonium dichloride) used in medical practice for anti-staphylococcal activity and can be used in the chemical and pharmaceutical industry to produce an anti-staphylococcal preparation.2 The studied compounds are not active against gram-negative microorganisms (Escherichia coli).","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79154841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信