The antimicrobial and bactericidal activity of secondary amine with 2-hydroxyethyl group

Abstract

The antimicrobial properties of substances have been studied in vitro by serial dilution in a liquid nutrient medium.2 Staphylococous aurous strain N=209 “P”, as the most stable species from the coccus group of bacteria, and Escherichia coli 0 III B:4-24, as the most stable species from enterobacteria, were used as indicator microorganisms. Test cultures by morphological, tinctorial, and cultural and biochemical properties are typical. Bacteria were cultured on MPA and MPB (pH =7.2-7.4). In the experiments, second generations of daily agar test cultures were used. The substances 2, 3 have activity in relation to the Staph aureus strain #209. The substance 2 surpasses the antimicrobial ethogenium (ethylene-1,2-bis/N-dimethylcarbodecoxymethylammonium dichloride) used in medical practice for anti-staphylococcal activity and can be used in the chemical and pharmaceutical industry to produce an anti-staphylococcal preparation.2 The studied compounds are not active against gram-negative microorganisms (Escherichia coli).