Pseudo aptamer expands aptamer’s applications

Because of broad range of applications and distinctive properties of aptamer, the global market size was valued at USD 723.6 million in 2016 and is projected to grow at the compound annual growth rate (CAGR) of 28.2%,1 and expected to reach $8.91 Billion by 2025, growing rapidly. Aptamers and the derivatives are also referred to as “synthetic antibodies” or “chemical antibodies”2‒5 that are able to bind with high affinity and specificity to almost all types of molecules as well as antigens, cells. Because of their unique properties, aptamers have a wide range of applications, particularly in biological and medical sciences, including diagnosis, therapies, forensics, and biodefense.6‒9 So far, hundreds of aptamer reagents have been developed for the applications,10 which are faster, cheaper, and less or without the predictable problems associated with the production of recombinant antibodies. This review summarizes the resent technologies of modified analogous of aptamer, so called pseudo aptamers in this script.