{"title":"2-羟基乙基季铵盐的杀菌活性","authors":"Torosyan Gh, Hovhannisyan Nr","doi":"10.15406/MOJBOC.2018.02.00077","DOIUrl":null,"url":null,"abstract":"The chemical and spatial structure of a substance determines its bioactivity. During is designing the drug the chemists are tried to take into account, introducing the appropriate chemical groupings into the potential drug substance. The presence of alkyl chains, their elongation increases the lipophilicity of drug substances (solubility in fatty tissues that can serve as a drug depot) and facilitates their passage through bio-membranes. The branched alkyl substituents and the presence of halogen atoms make it difficult to metabolize (in particular biooxidation) drugs. The use of drugs with bioactive alcohol group changes the polarity of the drug molecule, improves the manifestation of pharmacological activity.","PeriodicalId":18674,"journal":{"name":"MOJ Bioorganic & Organic Chemistry","volume":"36 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The bactericidal activity of quaternary ammonium salts with 2-hydroxyethyl group\",\"authors\":\"Torosyan Gh, Hovhannisyan Nr\",\"doi\":\"10.15406/MOJBOC.2018.02.00077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The chemical and spatial structure of a substance determines its bioactivity. During is designing the drug the chemists are tried to take into account, introducing the appropriate chemical groupings into the potential drug substance. The presence of alkyl chains, their elongation increases the lipophilicity of drug substances (solubility in fatty tissues that can serve as a drug depot) and facilitates their passage through bio-membranes. The branched alkyl substituents and the presence of halogen atoms make it difficult to metabolize (in particular biooxidation) drugs. The use of drugs with bioactive alcohol group changes the polarity of the drug molecule, improves the manifestation of pharmacological activity.\",\"PeriodicalId\":18674,\"journal\":{\"name\":\"MOJ Bioorganic & Organic Chemistry\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MOJ Bioorganic & Organic Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/MOJBOC.2018.02.00077\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MOJ Bioorganic & Organic Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/MOJBOC.2018.02.00077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The bactericidal activity of quaternary ammonium salts with 2-hydroxyethyl group
The chemical and spatial structure of a substance determines its bioactivity. During is designing the drug the chemists are tried to take into account, introducing the appropriate chemical groupings into the potential drug substance. The presence of alkyl chains, their elongation increases the lipophilicity of drug substances (solubility in fatty tissues that can serve as a drug depot) and facilitates their passage through bio-membranes. The branched alkyl substituents and the presence of halogen atoms make it difficult to metabolize (in particular biooxidation) drugs. The use of drugs with bioactive alcohol group changes the polarity of the drug molecule, improves the manifestation of pharmacological activity.
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