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Research progress on activity and biosynthesis of diketopiperazines 二酮哌嗪类化合物的活性及生物合成研究进展
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-12 DOI: 10.2174/1570193x20666230512162559
Ning Chen, Bing-jing Liu, Ruiyang Lu, Hongliang Yuan, Jintong Zhao, Yuechen Zhao
{"title":"Research progress on activity and biosynthesis of diketopiperazines","authors":"Ning Chen, Bing-jing Liu, Ruiyang Lu, Hongliang Yuan, Jintong Zhao, Yuechen Zhao","doi":"10.2174/1570193x20666230512162559","DOIUrl":"https://doi.org/10.2174/1570193x20666230512162559","url":null,"abstract":"\u0000\u0000Diketopiperazines (DKPs) are mainly produced by microorganisms. In recent years, active natural products with DKPs structure have been isolated from marine bacteria, actinomycetes and fungi. The stable six-membered ring framework makes DKPs a vital pharmacophore in medicinal chemistry. Several recent studies have demonstrated that it has antibacterial, antifungal, antiviral, antitumor, immunosuppressive, neuroprotective, anti-malaria, anti-prion, and anti-hyperglycemia properties. Some DKPs are signaling molecules for intercellular communication, which can activate or inhibit bacterial Lux R-mediated quorum sensing. They are considered potential new anti-infective drugs that could control biofilm formation by interfering with information communication between microbes. DKPs possess excellent biological activities and have received extensive attention from medicinal chemistry workers. Bioactivity studies of DKPs have revealed that many highly active lead compounds exist in antibacterial, antitumor, and antiviral fields and in treating neurological disorders. This paper reviews the research progress of diketopiperazines in the past ten years.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49104973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Decennial Update on the Applications of Trifluroacetic acid 三氟乙酸应用十年新进展
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-11 DOI: 10.2174/1570193x20666230511121812
Dr. Ravi Varala, M. Alam, Vittal Seema
{"title":"A Decennial Update on the Applications of Trifluroacetic acid","authors":"Dr. Ravi Varala, M. Alam, Vittal Seema","doi":"10.2174/1570193x20666230511121812","DOIUrl":"https://doi.org/10.2174/1570193x20666230511121812","url":null,"abstract":"\u0000\u0000Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements, functional group deprotections, condensations, hydroarylations and trifluoroalkylations, among others. The decennial mini-review examines key TFA synthetic applications from the middle of 2013 to the present, providing the organic chemistry research community with an opportunity to delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low boiling point reagent.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43300475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in chemistry of 2-(Piperazin-1-YL) Quinoline (Part IV) 2-(哌嗪-1- yl)喹啉的化学研究进展(四)
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-09 DOI: 10.2174/1570193x20666230509142134
M. Gouda, G. G. El-Bana
{"title":"Advances in chemistry of 2-(Piperazin-1-YL) Quinoline (Part IV)","authors":"M. Gouda, G. G. El-Bana","doi":"10.2174/1570193x20666230509142134","DOIUrl":"https://doi.org/10.2174/1570193x20666230509142134","url":null,"abstract":"\u0000\u0000This review described the preparation of 2-(piperazin-1-yl) quinoline derivatives from 2-haloquinolines and anilides, which underwent alkylation, arylation, acylation, and reductive amination to form the 2-piprazinoquinolines. 2-(Piperazin-1-yl) quinoline used as building blocks for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44320315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ionic liquids as a Non-conventional Catalyst for the Synthesis of N-heterocycles 离子液体作为n-杂环合成的非常规催化剂
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-07 DOI: 10.2174/1570193x20666230507183754
Ambika, Pradeep Pratap Singh, Saraswati Kanodia
{"title":"Ionic liquids as a Non-conventional Catalyst for the Synthesis of N-heterocycles","authors":"Ambika, Pradeep Pratap Singh, Saraswati Kanodia","doi":"10.2174/1570193x20666230507183754","DOIUrl":"https://doi.org/10.2174/1570193x20666230507183754","url":null,"abstract":"\u0000\u0000Ionic liquids (ILs) have emerged as one of the potential alternates of organic solvents in chemistry. Nitrogen-containing heterocyclic compounds are the important structural motifs of some bioactive compounds. A variety of ILs such as first-generation, second-generation, and third-generation ILs have been used in the synthesis of various types of nitrogen-containing heterocyclic compounds, such as aziridine, indole, pyrrazole, imidazole, oxazole, thiazole, triazole, pyridine, pyrimidine, quinolones, benzodiazapiene and their derivatives. Due to their unique chemical and physical properties, ILs can act as both solvent and catalyst and have contributed towards high efficiency, improved yield, and recyclability, for the synthesis of heterocyclic skeleton. In this review, the application of ILs in the synthesis of different nitrogen-containing heterocyclic compounds has been discussed.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45149112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc Acetate in Organic Synthesis and Catalysis: A Review 醋酸锌的有机合成及其催化研究进展
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-07 DOI: 10.2174/1570193x20666230507213511
Dr. Ravi Varala, M. Alam, Vittal Seema
{"title":"Zinc Acetate in Organic Synthesis and Catalysis: A Review","authors":"Dr. Ravi Varala, M. Alam, Vittal Seema","doi":"10.2174/1570193x20666230507213511","DOIUrl":"https://doi.org/10.2174/1570193x20666230507213511","url":null,"abstract":"\u0000\u0000Among the many zinc salts that can be found, zinc acetate is one of the readily available, affordable, low-hazardous Lewis acids. It can be referred to as a multifunctional catalyst due to its unique physical and chemical properties, which show that they are effective in enabling a variety of synthetic transformations in both organic synthesis and catalysis. This review included noteworthy innovations that have been created during the past two and half decades using zinc acetate as a catalyst or reagent.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47739363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quinoline and Analogs: Insight into the synthesis, biological activity, structure-activity relationship, and interaction with targets 喹啉和类似物:深入了解合成、生物活性、构效关系以及与靶标的相互作用
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-05 DOI: 10.2174/1570193x20666230505152611
Rajnish Kumar, Upendra Kumar, Dr. Avijit Mazumder, Salahuddin, Himanshu Singh, R. Yadav, Greesh Kumar
{"title":"Quinoline and Analogs: Insight into the synthesis, biological activity, structure-activity relationship, and interaction with targets","authors":"Rajnish Kumar, Upendra Kumar, Dr. Avijit Mazumder, Salahuddin, Himanshu Singh, R. Yadav, Greesh Kumar","doi":"10.2174/1570193x20666230505152611","DOIUrl":"https://doi.org/10.2174/1570193x20666230505152611","url":null,"abstract":"\u0000\u0000Quinoline and its derivatives have been utilized and marketed as antibacterial, antimalarial, anticancer, hypertension, asthma (COPD), etc. The diverse pharmacological properties of quinolone are related to its chemical structure. Nowadays, it is common practice to combine at least two pharmacophores to create a single molecule with powerful pharmacological effects. This helps to synergize pharmacological qualities, enables interaction with several targets, or lessens the negative effects related to them. Various synthetic approaches which have been used in recent times for the synthesis of quinoline and its derivatives are listed in the manuscript with their merits and demerit. The structure-activity relationship relating various pharmacological actions with molecular structure and interaction with several targets has also been highlighted to provide a good comprehension to the researchers for future studies on quinoline.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44744146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mini Review on Practical Synthesis of Muscimol and its Fluorinated Analogues 麝香草酚及其含氟类似物的实用合成综述
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-05-03 DOI: 10.2174/1570193x20666230503105616
Mohd Abdul Fatah Abdul manan
{"title":"A Mini Review on Practical Synthesis of Muscimol and its Fluorinated Analogues","authors":"Mohd Abdul Fatah Abdul manan","doi":"10.2174/1570193x20666230503105616","DOIUrl":"https://doi.org/10.2174/1570193x20666230503105616","url":null,"abstract":"\u0000\u0000Since the isolation and structural determination of muscimol, diverse chemical synthetic methods have been developed for the synthesis of the compound and its fluorinated derivatives such as fluoromuscimol and trifluoromethylmuscimol. These classes of compounds have been extensively employed as important building blocks in the design of drugs and pharmaceutical compounds with a broad spectrum of biological activities. However, when compared to other organohalogenic compounds, there are relatively limited methods for forming carbon-fluorine bonds in organic chemistry. Furthermore, there are very few naturally occurring organofluorine molecules exist, indicating that fluorination agents are scarce in nature. Despite the potential usage of fluorinated 5-membered heteroaromatic compounds and their functionalization in the life science industries, studies pertaining to the synthesis of substances containing such structural units are rare and challenging. This review discussed the progress made in the synthesis of natural product, muscimol and its fluoro and trifluoromethyl analogues. In addition to that, the mechanisms for the formation of isoxazole and fluoroisoxazole motifs were also discussed. This information provides important synthetic strategies for researchers in constructing such privileged structures.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49353463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developments in Synthesis Strategies of Spiro-Barbiturate compounds: A Classified Study 螺-巴比妥类化合物合成策略的分类研究进展
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-04-28 DOI: 10.2174/1570193x20666230428112212
D. Magoo, Anju Srivastava, Shruti Gupta, Reena Jain, Soma Mondal Ghorai, Yashna Dawer, Sumedha Sengupta, Soni Rani
{"title":"Developments in Synthesis Strategies of Spiro-Barbiturate compounds: A Classified Study","authors":"D. Magoo, Anju Srivastava, Shruti Gupta, Reena Jain, Soma Mondal Ghorai, Yashna Dawer, Sumedha Sengupta, Soni Rani","doi":"10.2174/1570193x20666230428112212","DOIUrl":"https://doi.org/10.2174/1570193x20666230428112212","url":null,"abstract":"\u0000\u0000Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three\u0000dimensionalities, and prominently hold a position of interest in the fields of synthetic and medicinal\u0000chemistry, pharmacology, material sciences and physics. Spirobarbiturate compounds which incorporate barbituric ring derivatives into spirocyclic structures have emerged as attractive synthetic targets\u0000for drug discovery as they are known to exhibit far-ranging pharmacological applications. In this review, we aim to bring to light the extensive, contemporary research applied to the synthesis of different spirobarbiturates having varied ring sizes (3, 5, 6 and 7 membered) in a classified manner. It presents the reported methods of synthesis along with their mechanistic pathways as well as the pharmacological activities of some of these synthesized biologically significant motifs.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47795685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occurrence, Isolation, Pharmacological Potential, Metabolism, and Toxicity of Myristicin: A Naturally Occurring Alkoxy-Substituted Allylbenzene 天然存在的烷氧基取代烯丙基苯肉豆蔻素的产生、分离、药理潜力、代谢和毒性
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-03-14 DOI: 10.2174/1570193x20666230314105024
S. Kaushal, Vishaldeep Kaur, Heena, D. Utreja
{"title":"Occurrence, Isolation, Pharmacological Potential, Metabolism, and Toxicity of Myristicin: A Naturally Occurring Alkoxy-Substituted Allylbenzene","authors":"S. Kaushal, Vishaldeep Kaur, Heena, D. Utreja","doi":"10.2174/1570193x20666230314105024","DOIUrl":"https://doi.org/10.2174/1570193x20666230314105024","url":null,"abstract":"\u0000\u0000Natural products are secondary metabolites obtained from plants, animals, and microorganisms with diverse chemical structures resulting in diverse biological functions and drug-like properties.\u0000\u0000\u0000\u0000This review article summarizes in detail the occurrence, detection, isolation, various pharmacological properties, metabolism, and toxicity of a natural compound i.e., 5-Allyl-1-methoxy-2,3-methylenedioxybenzene commonly known as Myristicin.\u0000\u0000\u0000\u0000A relevant literature search was made using the keywords essential oil, mace, myristicin, nutmeg, and pharmacological activities from different databases such as Pub Med, Sci finder, Science Direct, and Google Scholar. The literature search results presented articles from 1963 to 2022. Thereafter, the articles were carefully screened and selected for review.\u0000\u0000\u0000\u0000Myristicin, an alkoxy-substituted allylbenzene is present in major to minor amounts in the essential oils obtained from different plant parts and exhibits various pharmacological properties such as antimicrobial, antioxidant, antiproliferative, anti-inflammatory, insecticidal, and hepatoprotective. It forms 10 metabolites by reduction, demethylation, hydroxylation, ring formation, ring-opening, and conjugate formation. In the liver, myristicin has been metabolized by Cytochrome P450 complex enzymes to generate active metabolite (1ˈ hyroxymyristicin) responsible for cytotoxic, genotoxic and apoptotic effects (150 µM). But, myristicin at 600 µM does not produce enough 1ʼ-hydroxymyristicin to give the final toxicant.\u0000\u0000\u0000\u0000Myristicin poses no major risk to human health through the consumption of herbs and spices due to its presence in low amounts. It has great potential to be used in the traditional system of medicine. We hope that this review will provide complete knowledge about myristicin on a single platform.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Catalytic Conversion of Aldehydes to Nitriles 醛类直接催化转化为腈类
IF 2.3 4区 化学
Mini-reviews in Organic Chemistry Pub Date : 2023-03-10 DOI: 10.2174/1570193x20666230310092812
N. G. Khaligh, Fathiy Mutalabisin, M. Johan
{"title":"Direct Catalytic Conversion of Aldehydes to Nitriles","authors":"N. G. Khaligh, Fathiy Mutalabisin, M. Johan","doi":"10.2174/1570193x20666230310092812","DOIUrl":"https://doi.org/10.2174/1570193x20666230310092812","url":null,"abstract":"\u0000\u0000Nitriles are employed in many academic and industrial fields, especially organic synthesis. They are crucial precursors to synthesize aldehydes, amines, amides, carboxylic acids, and tetrazoles. There are many routes to synthesize nitriles from various species such as aldehydes, alcohols and amines. This review summarized the recently developed direct conversion of aldehydes to nitriles, focusing on the simple and efficient reaction.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42766827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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