Mini-reviews in Organic Chemistry最新文献

{"title":"Recent Advances in Synthesis and Applications of Organic Ionic Salts-based Sensor Arrays","authors":"H. Chopra, Pawanpreet Kaur, A. Parmar","doi":"10.2174/1570193x20666230614141728","DOIUrl":"https://doi.org/10.2174/1570193x20666230614141728","url":null,"abstract":"\u0000\u0000Sensor arrays contain a group of sensors, improve observations with new dimensions, provide better estimations, and additional parameters in comparison to the individual selective sensor. The array-based sensing technique provides good performance to respond to various gaseous or liquid analytes. Room temperature ionic liquids (RTILs) (melting point <25oC) and Group of uniform materials based on organic salts (GUMBOS) (melting point =25-250oC) are organic ionic salts, composed of an oppositely charged pair of bulky organic cations and bulky organic/inorganic anion and shows interesting tunable physicochemical properties. In this review article, we will discuss the sensing performance of ILs- and GUMBOS-based sensor arrays. ILs-based sensor arrays have been used in electrochemical gas sensing, solvent discrimination, colorimetric gas sensing, sensing of organic compounds, optoelectronic sensing of vapors and solutions, and vapour sensing through IL/QCM systems. GUMBOS-based sensor arrays have been employed in vapour sensing through the GUMBOS/QCM method, detection, and discrimination of proteins.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45118308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives","authors":"Gopal L. Khatik, Ramesh Ambatwar, Vaibhav Gupta, Sumit Kumar","doi":"10.2174/1570193x20666230601093704","DOIUrl":"https://doi.org/10.2174/1570193x20666230601093704","url":null,"abstract":"\u0000\u0000In synthetic and medicinal chemistry, multi-component reactions (MCRs) are considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These reactions have been strategically used in drug discovery and development because of ease and economy.\u0000\u0000\u0000\u0000The current manuscript aims to highlight the importance of the Biginelli reaction in the synthesis of diverse dihydropyrimidinones with medicinal applications.\u0000\u0000\u0000\u0000We searched various keywords, including “multicomponent reaction”, “Biginelli reaction” and “dihydropyrimidinone” on “PubMed, PubChem, and google scholar” and collected the relevant articles for including the current work.\u0000\u0000\u0000\u0000Biginelli reaction involving ketoester, aldehyde, and urea is a high-yielding, atom-economical, environmentally benign reaction for developing a library of new dihydropyrimidinones to drive the process of drug discovery. Several developments were achieved with modifications of synthetic techniques, including C-H activation, coupling, cycloaddition, etc. Inclusively, these modifications give access to a wide range of dihydropyrimidinones.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48352239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-based ionic liquids and solid-loaded catalysts in fuel oil desulfurization: A review","authors":"Hang Xu, Anqi Niu, Qinlin Yuan, Fengmin Wu, Xuefeng Wei","doi":"10.2174/1570193x20666230601093152","DOIUrl":"https://doi.org/10.2174/1570193x20666230601093152","url":null,"abstract":"\u0000\u0000Metal-based ionic liquids (MILs) have the advantages of designability, efficiency, stability, and regenerative cycle and can efficiently convert thiophene and its derivatives, which are important for the production of \"ultra-low sulfur\" oils. This paper provides an overview of the research progress of MILs in the field of fuel desulfurization, focusing on the current status of MILs and solid-loaded MILs catalysts in extractive desulfurization, oxidative desulfurization, extraction-catalyzed oxidative desulfurization, and catalytic-adsorption desulfurization processes. For MILs, the anion and cation can be altered by design so as to impart specific functions. Loading is one of the effective ways to solidify MILs, and the combination of MILs with different carriers can not only reduce the usage while ensuring the catalytic activity but also improve the reusability of the catalyst. The combination of MILs with specially structured carriers also allows solution-free adsorption and removal of oxidation products. Compared with conventional MILs, polymetallic-based ionic liquids (PMILs) exhibit ultra-high catalytic activity and are one of the most promising materials available, but are still in their infancy in the field of fuel catalysis, and researchers are needed to enrich the gap in this field. Finally, some problems faced by various types of MILs are pointed out in order to design new functional MILs catalysts with better properties in the future and promote the further development of MILs in the field of fuel catalysis.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48880573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Roman Dembinski","doi":"10.2174/1570193x2004230222122810","DOIUrl":"https://doi.org/10.2174/1570193x2004230222122810","url":null,"abstract":"","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135325034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemistry and Biological Activity of Thieno[3,4-b] quinoline, Thieno[3,4-c] quinolone, Thieno[3,2-g] quinoline and Thieno[2,3-g] quinoline Derivatives: A Review (Part IX)","authors":"A. Abu‐Hashem, Ahmed A. M. Abdelgawad, M. Gouda","doi":"10.2174/1570193x20666230601151439","DOIUrl":"https://doi.org/10.2174/1570193x20666230601151439","url":null,"abstract":"\u0000\u0000Over the previous decades, thieno-quinoline derivatives have acquired great interest due to their synthetic and biological applications. These reports have been disclosed on Thienoquinoline synthesis such as thieno[3,4-b]quinoline; thieno[3,4-c]quinolone; thieno [3,2-g]quinoline; thieno[2,3-g] quinoline; spiro-thieno[2,3-g]quinoline; benzo[b]thiophen-iso- quinoline derivatives, and therefore in the existent review, we provided an inclusive update on the synthesis of thienoquinolines. Characterization of the preparation methods and reactivity is categorized based on their types of reactions as addition, alkylation, chlorination, acylation, oxidation, reduction, cyclization and cyclo-condensation. Hence, this study will help the researchers to obtain knowledge from the last literature research to conquer their resolve problems in designing new compounds and processes.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41712689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress for the Synthesis of Pyrrole Derivatives – An Update","authors":"Ashish D. Patel, D. Patel, Drashti Shah, Krishi Patel, Ayush Patel, Tushar Bambharoliya, Anjali Mahavar","doi":"10.2174/1570193x20666230530161009","DOIUrl":"https://doi.org/10.2174/1570193x20666230530161009","url":null,"abstract":"\u0000\u0000Pyrrole is a versatile heterocyclic moiety exhibiting a wide range of pharmacological actions with high therapeutic value. The importance of pyrrole in the pharmaceutical field lies in its versatility, selectivity, and biocompatibility, and these properties make it a valuable tool for drug design and development. The pyrrole moiety is a fundamental building block for many biologically active molecules and has gathered significant attention in the fields of medicinal and organic chemistry; hence, its synthesis has been a crucial area for research. There are various conventional as well as modern approaches to acquiring a series of pyrrole scaffolds, with a wide range of attractive features and drawbacks pertaining to each approach. An extensive amount of literature must be studied to compare the best synthetic routes. This article highlights the applications of pyrrole derivatives in various fields, such as drug discovery, material science, and catalysis, and provides an overview of modern synthetic pathways that include metals, nanomaterials, and complex heterogeneous catalysed methods for pyrrole derivatives. Special emphasis is given to the use of green chemistry principles like green solvent-based methods, microwave-aided methods, and solvent-free methods in the synthesis of pyrroles, with the recent developments and prospects in the synthetic and organic chemistry fields. Overall, this review article provides a comprehensive overview of the synthesis of pyrroles and complies with all the possible developments in the synthetic routes for pyrroles within 2015–2022. Among all, the reactions catalysed by proline, copper oxides, and oxones have been shown to be the most effective synthetic route for pyrrole derivatives at mild reaction conditions and with excellent yields. This information will be helpful for researchers interested in the development of new pyrrole-based compounds. The categorization in this review provides an easy means for the reader to rationally select the best possible synthetic method for pyrrole derivatives.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68075187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-Cyanoacetylthiosemicarbazides: Recent Advances In Their Synthesis, Reactivity In Heterocyclization, And Bio Applications","authors":"S. Bondock, Nada Alabbad, Aisha Hossana, M. Abdou","doi":"10.2174/1570193x20666230529155754","DOIUrl":"https://doi.org/10.2174/1570193x20666230529155754","url":null,"abstract":"\u0000\u0000The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic precursors and their derivatives. The present survey aims to summarize an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical transformation. A particular focus is given to their metal complexes and bio applications\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46846699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its derivatives","authors":"Nejib Ben Hussein Mekni, F. Medini, L. Aroua","doi":"10.2174/1570193x20666230526104159","DOIUrl":"https://doi.org/10.2174/1570193x20666230526104159","url":null,"abstract":"\u0000\u0000Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo nucleophilic substitutions of the chlorine atoms. Their reactions with nucleophilic and bi-nucleophile reagents yield acyclic and P-heterocyclic compounds, respectively. The resulting compounds have different potential antibacterial, antifungal, and antitumor activities.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43525622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemistry of Thieno [2,3-h]-/[3,2-h] quinoline and Thieno [2,3-f]-/[3,2-f] quinoline derivatives part (x), Reactivities, and Biological Activities","authors":"M. Gouda, Nahlah A. Al-Hadhrami, A. Abu‐Hashem, Ahmed A. M. Abdelgawad, M. A. Salem","doi":"10.2174/1570193x20666230525120540","DOIUrl":"https://doi.org/10.2174/1570193x20666230525120540","url":null,"abstract":"\u0000\u0000Several thieno [2,3-h] /[3,2-h] quinolines and thieno [2,3-f] /[3,2-f] quinolines (TQs) are discussed in this review from a few perspectives, including various preparation and processing methods employing cutting-edge machinery. The preparation of (TQs), from 4-(5)aminobenzothiophene, 2(3)chloromethylthiophene, 2(3)thienylboric acid, and other chemical reagents is illustrated via a number of chemical procedures in this review. The formation of (TQs) was clarified using the Michael addition, Photocyclization, Skraup reaction, Ullmann-Fetvadjian process, Suzuki-Miyaura and Sonogashira reaction, aza-Diels-Alder reaction, and Friedel-Crafts reaction.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44296586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Strategies in the Chemical Control of Fusarium Oxysporum using Synthetic Bioisosteres of Secondary Metabolites: A Review of the Synthetic Methods for Novel Compounds with Potential Antifungal Activity","authors":"Diego Quiroga, Paola Borrego-Muñoz, E. Coy-Barrera","doi":"10.2174/1570193x20666230516144539","DOIUrl":"https://doi.org/10.2174/1570193x20666230516144539","url":null,"abstract":"\u0000\u0000One of the main problems affecting the world is food scarcity which is occasioned by different causes, including difficult climatic conditions, economic and technical limitations, infrastructure and transportation, food safety and insecurity, and diseases caused by microorganisms (phytopathogens) such as Fusarium oxysporum whose damage triggers a series of irreversible effects on several crops, causing economic losses worldwide. Given the complexity that the chemical control of phytopathogens represents, various investigations have been refocused on exploring new biomimetic actions that lead to synthesizing new compounds with potential antifungal activity. In addition, computational chemistry and chemoinformatics tools (molecular docking and molecular dynamics) make it possible to understand and often predict these compounds' mechanisms of action, thereby formulating Quantitative Structure-Activity Relationship (QSAR) models. These strategies have established an important advance in designing new molecules capable of inhibiting pathogens from a rational development of antifungal compounds. This article reviewed the novel synthetic bioisosteres of secondary metabolites biologically active against Fusarium oxysporum, their synthetic protocols, and the strategies implemented for its control. The most innovative examples of this class of active organic compounds are presented, such as N,S-dialkyl dithiocarbamates, Schiff bases, N-alkyl substituted amides, and several heterocyclic systems with potential antifungal activity. Likewise, the use of computational tools is discussed, showing how these results can conduce to the design of new antifungal agents.\u0000","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41463731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}