异氰酸二氯磷酯:其衍生物的合成、化学反应和生物活性

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2023-05-26 DOI:10.2174/1570193x20666230526104159

Nejib Ben Hussein Mekni, F. Medini, L. Aroua

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引用次数: 0

摘要

异氰酸二氯磷酯(DCPI)是最基本、最容易引入有机基团的磷酸异氰酸酯底物。自1954年合成以来，DCPI通过在异氰酸酯基团的碳原子上的亲核加成反应，对伯烷基和仲烷基、醇类、酚类、硫醇类和胺类具有很高的反应活性。除了它们的合成外，所得到的产物还经历氯原子的亲核取代。它们与亲核试剂和双亲核试剂反应，分别生成无环和p杂环化合物。所得化合物具有不同的潜在抗菌、抗真菌和抗肿瘤活性。

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Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its derivatives

Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo nucleophilic substitutions of the chlorine atoms. Their reactions with nucleophilic and bi-nucleophile reagents yield acyclic and P-heterocyclic compounds, respectively. The resulting compounds have different potential antibacterial, antifungal, and antitumor activities.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry