Medicina Clinica最新文献

{"title":"Síndrome de Eagle como causa infrecuente de disfagia en el adulto mayor","authors":"Yanira Aranda Rubio , Natalia Loren Lázaro , María Asenjo Cambra","doi":"10.1016/j.medcli.2025.107171","DOIUrl":"10.1016/j.medcli.2025.107171","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 5","pages":"Article 107171"},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ictus múltiples como presentación de neurosífilis en un paciente con infección por el VIH","authors":"Vanesa Garrigasait Vilaseca , Mª del Mar Gutierrez Macia , Sara Castells Buchle","doi":"10.1016/j.medcli.2025.107177","DOIUrl":"10.1016/j.medcli.2025.107177","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 5","pages":"Article 107177"},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of systemic mastocytosis in appendectomy","authors":"Juan Manuel Molina López, Evelyn Beatriz Troncoso Hernández, Artemio Payá Romá","doi":"10.1016/j.medcli.2025.107173","DOIUrl":"10.1016/j.medcli.2025.107173","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 5","pages":"Article 107173"},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelo y criterios de acreditación de Web Médica Acreditada: consolidación de 25 años de trayectoria","authors":"Gustavo Tolchinsky Wisen , Albert Casasa , Mercedes Martinez Pérez , Jaume Padrós i Selma","doi":"10.1016/j.medcli.2025.107141","DOIUrl":"10.1016/j.medcli.2025.107141","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 6","pages":"Article 107141"},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencia del ejercicio terapéutico en la sintomatología asociada al trasplante de progenitores hematopoyéticos","authors":"Antonio Chamorro Comesaña ,&nbsp;Noa Piñeiro Fernández ,&nbsp;Patricia Rodríguez Fernández ,&nbsp;Natalia Fente García ,&nbsp;Francisco Xosé Román Losada ,&nbsp;Ma del Carmen Quintela González ,&nbsp;Agustín Nieto Vázquez ,&nbsp;Ana Santamaría López ,&nbsp;Judith Vázquez Álvarez ,&nbsp;María del Carmen Albo López ,&nbsp;Angela Prieto","doi":"10.1016/j.medcli.2025.107137","DOIUrl":"10.1016/j.medcli.2025.107137","url":null,"abstract":"<div><div>Hematopoietic stem cell transplantation (HSCT) is a therapy used for the treatment of numerous pathologies, mainly oncohematological ones it is associated with the appearance of toxicities that can delay the patient's recovery.</div></div><div><h3>Objective</h3><div>To observe the effect of a therapeutic exercise (TE) program produces on the symptoms reported by patients undergoing HSCT 3 months after the transplant.</div></div><div><h3>Patients and methods</h3><div>Observational study in patients who underwent HSCT at the Álvaro Cunqueiro Hospital in Vigo between September 2020 and August 2021, with pre-admission assessment and 3 months post-transplant, using Edmonton Symptom Assessment System (ESAS) test. During their hospitalization, the patients followed the ET program based on the HSCT exercise guidelines from the Spanish Group for Transplantation and Cellular Therapy (GETH-TC).</div></div><div><h3>Results</h3><div>A total of 34 patients participated, and improvements were observed in fatigue, drowsiness, shortness of breath, mood, nervousness and feeling of well-being.</div></div><div><h3>Conclusions</h3><div>A therapeutic exercise program is safe, and may help reduce common symptoms in transplant patients. Exercise must be adapted to the specific situation of the patient throughout the transplant process.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 6","pages":"Article 107137"},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Réplica a la carta al editor de Fernández-Fernández et al. titulada «Efectividad de alirocumab y evolocumab (PCSK9i) en el tratamiento de la hipercolesterolemia» en relación con el artículo publicado por Bosch et al. (Medicina Clínica 2024;163:317-322)","authors":"Montserrat Bosch ,&nbsp;Elena Ballarín ,&nbsp;Immaculada Danés","doi":"10.1016/j.medcli.2025.107148","DOIUrl":"10.1016/j.medcli.2025.107148","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 5","pages":"Article 107148"},"PeriodicalIF":2.1,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presencia de síntomas y calidad de vida 3 años tras el COVID-19: evolución de los resultados de la encuesta C19-YRS en un hospital terciario español","authors":"Blanca Ayuso García ,&nbsp;Antía Pérez López ,&nbsp;Yoana Besteiro Balado ,&nbsp;Eva Romay Lema ,&nbsp;Álvaro Marchán-López ,&nbsp;Ramón Rabuñal Rey","doi":"10.1016/j.medcli.2025.107138","DOIUrl":"10.1016/j.medcli.2025.107138","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-COVID syndrome can hinder the quality of life of patients. This study aims at describing this syndrome and its natural history.</div></div><div><h3>Methods</h3><div>Prospective study including 443 inpatient and outpatient survivors of COVID-19 acquired between March and May 2020. Patients with dementia, nursing home residents, and those rejecting participation were excluded. Symptoms were assessed 10 and 36 months after the infection using the C19-YRS questionnaire. The prevalence and severity of symptoms, as well as risk factors for symptom persistence were investigated.</div></div><div><h3>Results</h3><div>At 10 months 62.3% of patients reported at least one symptom, down to 54.9% at 36 months. Fatigue (37.2%), dyspnea at exertion (33.4%), and anxiety (33.4%) were the most prevalent symptoms, all of which showed improvement at follow up. Domain-specific impairment was the strongest risk factor for symptom persistence. Most patients reported a similar health status (69.4%) and quality of life (71.4%) compared with their pre-infection condition.</div></div><div><h3>Conclusions</h3><div>Although frequent, post-COVID-19 symptoms improve over time, while quality of life remains stable compared to patients baseline status.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 5","pages":"Article 107138"},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical approval and conduct of registered non-pharmacological non-commercial completed Spanish trials: A systematic review of published reports","authors":"Rafael Dal-Ré ,&nbsp;Elena García-Méndez ,&nbsp;Ignacio Mahillo-Fernández","doi":"10.1016/j.medcli.2025.107159","DOIUrl":"10.1016/j.medcli.2025.107159","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 6","pages":"Article 107159"},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tratamiento de la obesidad después de la cirugía bariátrica con análogos del receptor de GLP-1: evidencia en vida real","authors":"Camila Milad ,&nbsp;Sergio Logwin ,&nbsp;Nerea Antón ,&nbsp;Amanda Jiménez ,&nbsp;Lilliam Flores ,&nbsp;Ainitze Ibarzábal ,&nbsp;Violeta Moizé ,&nbsp;Adriana Pané ,&nbsp;Josep Vidal ,&nbsp;Ana de Hollanda","doi":"10.1016/j.medcli.2025.107153","DOIUrl":"10.1016/j.medcli.2025.107153","url":null,"abstract":"<div><h3>Introduction</h3><div>Approximately 25–30% of patients undergoing bariatric surgery (BS) experience weight regain or suboptimal weight loss. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a therapeutic option in these cases.</div></div><div><h3>Aim</h3><div>To evaluate the effectiveness of GLP-1 RAs in managing weight regain and suboptimal weight response after BS in a real-world setting.</div></div><div><h3>Materials and Methods</h3><div>Retrospective study of BS patients treated with GLP-1 RAs due to weight regain or suboptimal weight response.</div></div><div><h3>Results</h3><div>A total of 953 patients underwent BS between 2015 and 2020; 122 initiated treatment with GLP-1 RAs. The cohort was composed 78% women, with a mean age of 50.4<!--> <!-->±<!--> <!-->10.6 years and a baseline BMI of 44.7<!--> <!-->±<!--> <!-->6.3<!--> <!-->kg/m². At the start of treatment, 41.9<!--> <!-->±<!--> <!-->20.5 months post-BS, the mean weight loss was 18.6<!--> <!-->±<!--> <!-->10%; 52% had lost &lt;<!--> <!-->20% of their initial weight and 82% had regained &gt;<!--> <!-->20% of the weight lost. 35% received liraglutide (LIRA) (1.8<!--> <!-->±<!--> <!-->0.5<!--> <!-->mg/day) and 65% semaglutide (SEMA) (1.0<!--> <!-->±<!--> <!-->0.8<!--> <!-->mg/week), with a mean treatment duration of 19.3<!--> <!-->±<!--> <!-->17.3 months. Maximum weight loss was 4.7<!--> <!-->±<!--> <!-->4.8% with LIRA vs. 8.3<!--> <!-->±<!--> <!-->5.9% with SEMA (p<!--> <!-->=<!--> <!-->0.01). Total weight loss (BS<!--> <!-->+<!--> <!-->GLP-1 RA) was 21.6<!--> <!-->±<!--> <!-->9.2% with LIRA vs. 25.6<!--> <!-->±<!--> <!-->10.5% with SEMA. The proportion of patients with a suboptimal weight response after BS<!--> <!-->+<!--> <!-->pharmacotherapy (&lt;<!--> <!-->20%) significantly decreased (from 52% to 31%).</div></div><div><h3>Conclusions</h3><div>SEMA led to greater weight reduction than LIRA, positioning it as a more effective option for managing post-BS weight regain.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 4","pages":"Article 107153"},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thrombolytic therapy in mortality of elderly patients with cancer and massive pulmonary embolism","authors":"Sefa Tatar,&nbsp;Yunus Emre Yavuz,&nbsp;Hakan Akilli","doi":"10.1016/j.medcli.2025.107144","DOIUrl":"10.1016/j.medcli.2025.107144","url":null,"abstract":"<div><h3>Introduction</h3><div>Massive pulmonary embolism (MPE) is associated with high mortality, particularly in cancer patients aged 65 years and older. Thrombolytic therapy (TT) is a life-saving intervention in pulmonary embolism, yet its efficacy and safety in this vulnerable population remain uncertain. This study aimed to evaluate the impact of thrombolytic therapy on mortality in elderly cancer patients diagnosed with MPE.</div></div><div><h3>Materials and methods</h3><div>This retrospective study included 90 patients aged<!--> <!-->≥<!--> <!-->65 years diagnosed with MPE. Patients were categorized based on malignancy status and administration of TT. Clinical, laboratory, and echocardiographic parameters were compared. One-month all-cause mortality was recorded for each patient.</div></div><div><h3>Results</h3><div>Patients with malignancy exhibited higher mortality rates compared to non-malignant cases (63.3% vs. 46.7%, <em>p</em> <!-->=<!--> <!-->0.1), though bleeding rates were similar between the two groups. Among cancer patients, the administration of TT did not significantly affect mortality (60% vs. 65%, <em>p</em> <!-->=<!--> <!-->0.7). Right ventricular function, assessed by RV systolic motion and TAPSE, was more severely impaired in cancer patients, and TT did not lead to significant improvement in these parameters.</div></div><div><h3>Conclusion</h3><div>Thrombolytic therapy in elderly cancer patients with massive pulmonary embolism does not significantly reduce 1-month mortality. However, it does not increase bleeding complications, suggesting that it may be a viable option for selected patients. The similar mortality rates between thrombolytic therapy and non-thrombolytic therapy groups highlight the complex interplay between malignancy, coagulation, and cardiovascular risk. These findings emphasize the need for individualized risk assessment and treatment decisions.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 6","pages":"Article 107144"},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}