Medicina Clinica最新文献_第10页

Rhupus syndrome: Description of 9 cases with special attention to the HLA-DR genotype. 红斑狼疮综合征：9 个病例的描述，特别关注 HLA-DR 基因型。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-07 DOI: 10.1016/j.medcli.2024.09.006

Andrés Pérez Hurtado, Isabel Martínez Cordellat, Roxana González Mazario, Elena Grau García, José Andrés Román Ivorra

{"title":"Rhupus syndrome: Description of 9 cases with special attention to the HLA-DR genotype.","authors":"Andrés Pérez Hurtado, Isabel Martínez Cordellat, Roxana González Mazario, Elena Grau García, José Andrés Román Ivorra","doi":"10.1016/j.medcli.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.006","url":null,"abstract":"<p><strong>Background and objectives: </strong>Rhupus is a very rare syndrome of overlapping rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), characterized by the presence of erosive polyarthritis associated with symptoms and signs of SLE and the presence of high specificity autoantibodies. The analysis of HLA-DR molecules would allow us to genetically characterize patients diagnosed with rhupus, being able to differentiate them from the HLA-DR profile of patients with RA and SLE.</p><p><strong>Materials and methods: </strong>Cross-sectional observational study of 9 patients diagnosed with rhupus in whom the HLA-DR genotype was genetically characterized.</p><p><strong>Results: </strong>Rhupus is usually more frequent in women with initial diagnosis of RA. The most frequent clinical manifestations are articular and, serologically, ANA, RF and anti-CCP positivity stand out. The most frequent HLA-DR were HLA-DR1, HLA-DR3, HLA-DR4, HLA-DR7 and HLA-DR13.</p><p><strong>Conclusions: </strong>A higher proportion of HLA-DR1 and DR9 was observed in patients with rhupus compared to RA and SLE, as well as a lower proportion of HLA-DR2, DR6 and DR8, which would help the early characterization of these patients prior to the overlap diagnosis.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher mortality risk from lung and hematological neoplasms in patients with rheumatoid arthritis: An observational study from the Spanish National Registry. 类风湿性关节炎患者死于肺部和血液肿瘤的风险更高：西班牙国家登记处的一项观察性研究。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-06 DOI: 10.1016/j.medcli.2024.09.007

Jorge Esteban-Sampedro, Víctor Moreno-Torres, Mario Martín-Portugués

{"title":"Higher mortality risk from lung and hematological neoplasms in patients with rheumatoid arthritis: An observational study from the Spanish National Registry.","authors":"Jorge Esteban-Sampedro, Víctor Moreno-Torres, Mario Martín-Portugués","doi":"10.1016/j.medcli.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.007","url":null,"abstract":"<p><strong>Objective: </strong>Evaluating the impact of solid organ neoplasms (SON) and hematological neoplasms (HN) on mortality among RA patients in a nationwide study.</p><p><strong>Methods: </strong>A retrospective, observational comparison of SON and HN-related deaths in RA patients and the general Spanish population was conducted (Spanish Hospital Discharge Database). Binary logistic regression analyzed the impact of RA on mortality risk from each neoplasm.</p><p><strong>Results: </strong>From 2016 to 2019, 139,531 neoplasm-related deaths were recorded, including 813 (0.6%) from RA patients. Patients with RA presented a lower mortality rate from SON (85.1% vs 91.2%, OR 0.99), mainly due to colorectal carcinoma (8% vs 10.6%, OR 0.67) and hepatocarcinoma (1% vs 2.7%, OR 0.44), but higher lung neoplasms risk (20.2% vs 18.6%, OR 1.31). HN-related deaths were also more prevalent in RA patients (14.9% vs 8.8%, OR 1.73), especially B and T/NK non-Hodgkin's lymphoma (6% vs 2.8%, OR 2.12) and myeloid leukemia (4.4% vs 2.3%, OR 1.92).</p><p><strong>Conclusion: </strong>RA patients might have a higher mortality risk from lung and hematologic neoplasms. Reducing immunosuppressive burden and developing early-detection programs should be primary goals in this population.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thromboprophylaxis in medical patients with and without cancer. 癌症内科病人和非癌症内科病人的血栓预防。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-06 DOI: 10.1016/j.medcli.2024.09.010

Juan J López-Núñez, Adrián Steinherr

引用次数: 0

Pancreatic abscess due to Salmonella: A case study. 沙门氏菌引起的胰腺脓肿：病例研究。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-04 DOI: 10.1016/j.medcli.2024.08.011

Verónica Vallejo Herrera, Carmen Morales Puerta, María José Vallejo Herrera

引用次数: 0

Importance of genetic study in primary hyperoxaluria type1. Case report. 原发性高草酸尿症 1 型遗传研究的重要性。病例报告。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-03 DOI: 10.1016/j.medcli.2024.07.027

María Molina-Zayas, María Del Mar Del Águila García, Rafael J Esteban de la Rosa

引用次数: 0

Hemophagocytic lymphohistiocytosis associated with Hodgkin lymphoma. 与霍奇金淋巴瘤相关的嗜血细胞淋巴组织细胞增多症。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-02 DOI: 10.1016/j.medcli.2024.08.007

Rita González Resina, Mar Herrero Gutiérrez, Bárbara Menéndez Jándula

引用次数: 0

Scorpion fish sting. 蝎子鱼刺

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-01 DOI: 10.1016/j.medcli.2024.08.014

Miguel Mansilla-Polo, Daniel Martín-Torregrosa, Sara Becerril-Andrés

引用次数: 0

Trends in mortality in Spain, with a special focus on respiratory-related conditions in the midst of the COVID-19 pandemic. 西班牙的死亡率趋势，特别关注 COVID-19 大流行期间与呼吸系统有关的疾病。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-10-29 DOI: 10.1016/j.medcli.2024.08.004

Adrián Peláez, Joan B Soriano, María Rodrigo-García, José L Peñalvo, Julio Ancochea, Esteve Fernández

{"title":"Trends in mortality in Spain, with a special focus on respiratory-related conditions in the midst of the COVID-19 pandemic.","authors":"Adrián Peláez, Joan B Soriano, María Rodrigo-García, José L Peñalvo, Julio Ancochea, Esteve Fernández","doi":"10.1016/j.medcli.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.08.004","url":null,"abstract":"<p><strong>Background and objective: </strong>The COVID-19 pandemic significantly increased the global burden of respiratory morbidity and mortality. In Spain, 2020 saw a 68.5% surge in deaths from respiratory diseases compared to 2019, largely due to COVID-19. This study aims to describe respiratory disease mortality in Spain from 2019 to 2022, focusing on the intersection of COVID-19, pre-existing respiratory conditions, and specific health determinants.</p><p><strong>Materials and methods: </strong>We analyzed mortality data from the Spanish National Institute of Statistics (INE), covering 102 causes of death, including tuberculosis, COVID-19, and lung cancer as respiratory-related conditions. The analysis considered absolute death counts and proportions by sex, age, and region, along with percentage changes in proportional mortality. Logistic regression models were used to identify factors potentially associated with COVID-19 and respiratory-specific mortality.</p><p><strong>Results: </strong>In 2022, Spain reported 98,128 deaths from respiratory diseases, accounting for 21.1% of all deaths and ranking as the second leading cause of death after cardiovascular diseases. Although deaths due to COVID-19 decreased in 2021 and 2022, there was a notable rise in other respiratory causes, indicating a lasting post-pandemic impact. Factors linked to higher mortality included male gender, older age, being divorced, and residing in urban areas, with significant regional variability.</p><p><strong>Conclusions: </strong>Despite overall mortality returning to pre-pandemic levels, this study highlights a significant increase in respiratory disease deaths in Spain in 2022 compared to 2019.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Síndrome de hiperaflujo: una causa de insuficiencia cardíaca reversible en hemodiálisis 高流量动静脉瘘：血液透析中可逆性心力衰竭的病因。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-10-25 DOI: 10.1016/j.medcli.2024.04.016

引用次数: 0

Anti-factor H autoantibodies in patients with lupus nephritis 狼疮性肾炎患者体内的抗因子 H 自身抗体。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-10-25 DOI: 10.1016/j.medcli.2024.05.019

Galya Mihaylova , Vasil Vasilev , Mariya Kosturkova , Mariana Petkova , Maria Radanova

{"title":"Anti-factor H autoantibodies in patients with lupus nephritis","authors":"Galya Mihaylova , Vasil Vasilev , Mariya Kosturkova , Mariana Petkova , Maria Radanova","doi":"10.1016/j.medcli.2024.05.019","DOIUrl":"10.1016/j.medcli.2024.05.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are also observed in C3 glomerulopathies. The frequency and relevance of anti-FH in LN are poorly studied.</div></div><div><h3>Aim</h3><div>The aim of our investigation was to screen for the presence of anti-FH and FHR1 gene deletion in a cohort of LN patients and to evaluate their association with LN activity.</div></div><div><h3>Method</h3><div>ELISA test and Western blot for detection of anti-FH and FHR1 deletion were used, respectively. Patients’ clinical and laboratory parameters regarding anti-FH role were processed by statistical analysis.</div></div><div><h3>Results</h3><div>Anti-FH were found at low level in a small number of LN patients – 11.7% (7/60) and were not associated with deletion of FHR1. Anti-FH did not correlate with ANA titers, anti-dsDNA, C3/C4 hypocomplementemia, eGFR, proteinuria, or active urinary sediment in LN patients. A weak correlation was found between anti-FH and anti-C3 levels. Anti-FH were linked with endocapillary proliferation and histological activity index. Four anti-FH positive patients had severe to moderate LN as per the BILAG renal score.</div></div><div><h3>Conclusions</h3><div>Anti-FH autoantibodies are an accessory finding in LN and are more likely to manifest during the active phase of the disease. Due to their low frequency and plasma levels, they do not seem suitable for routine laboratory investigation in patients with LN.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"163 8","pages":"Pages 375-382"},"PeriodicalIF":2.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0