Iago Pinal-Fernández , José César Milisenda , Albert Selva-O’Callaghan
{"title":"Fascitis eosinofílica","authors":"Iago Pinal-Fernández , José César Milisenda , Albert Selva-O’Callaghan","doi":"10.1016/j.medcli.2025.107066","DOIUrl":null,"url":null,"abstract":"<div><div>Eosinophilic fasciitis is a rare scleroderma-like syndrome of unknown cause. It is characterized by painful induration and progressive thickening of the muscular fascia and subcutaneous tissue of the limbs and trunk. The most common laboratory findings include peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate. The diagnosis is confirmed through a full-thickness wedge biopsy of the affected skin, revealing inflammation and thickening of the deep fascia.</div><div>The differential diagnosis includes scleroderma, morphea, myofasciitis in graft-versus-host disease, and epidemic fasciitis syndromes caused by toxins, such as eosinophilia-myalgia syndrome and toxic oil syndrome. Although the diagnosis is based on clinical, laboratory, and histological findings, no universal diagnostic criteria exist. Glucocorticoids are the standard treatment, although some patients may improve spontaneously.</div></div>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":"165 4","pages":"Article 107066"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Clinica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0025775325002945","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Eosinophilic fasciitis is a rare scleroderma-like syndrome of unknown cause. It is characterized by painful induration and progressive thickening of the muscular fascia and subcutaneous tissue of the limbs and trunk. The most common laboratory findings include peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate. The diagnosis is confirmed through a full-thickness wedge biopsy of the affected skin, revealing inflammation and thickening of the deep fascia.
The differential diagnosis includes scleroderma, morphea, myofasciitis in graft-versus-host disease, and epidemic fasciitis syndromes caused by toxins, such as eosinophilia-myalgia syndrome and toxic oil syndrome. Although the diagnosis is based on clinical, laboratory, and histological findings, no universal diagnostic criteria exist. Glucocorticoids are the standard treatment, although some patients may improve spontaneously.
期刊介绍:
Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.