Medicina Clinica最新文献_第5页

Fecal occult blood is associated with an increased risk of cerebral small vessel disease in elderly patients.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-28 DOI: 10.1016/j.medcli.2024.10.006

Cunsheng Wei, Xiaorong Yu, Yuan Chen, Junying Jiang, Meng Cao, Xuemei Chen

{"title":"Fecal occult blood is associated with an increased risk of cerebral small vessel disease in elderly patients.","authors":"Cunsheng Wei, Xiaorong Yu, Yuan Chen, Junying Jiang, Meng Cao, Xuemei Chen","doi":"10.1016/j.medcli.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.10.006","url":null,"abstract":"Background and purpose: Studies have shown that fecal occult blood is associated with an increased risk of ischemic stroke, but the relationship between fecal occult blood and cerebral small vessel disease (CSVD) remains largely unknown. This study aimed to identify predictors for CSVD, with fecal occult blood and its proxies as potential influencing factors in elderly patients.Method: Patients aged 65 years or older with various chronic diseases were enrolled. The presence of CSVD was evaluated by brain MRI results. Fecal occult blood was measured by fecal immunochemical test. Logistic regression analysis was used for the association between the presence of fecal occult blood and the risk of CSVD.Results: Logistic regression analysis indicated that a prevalence of positive fecal occult blood was related to CSVD (Model 1, adjusted OR=1.63, 95% CI: 1.15-2.29, P=0.006). We subsequently grouped all subjects as positive fecal occult blood (259, 16.48%) and negative fecal occult blood (1313, 83.52%), and logistic regression analysis indicated that a prevalence of CSVD was related to positive fecal occult blood (Model 2, adjusted OR=1.50, 95% CI: 1.08-2.08, P=0.015). In addition, the ratios of lacunes (67.18% vs. 53.85%, P<0.001) and enlarged perivascular spaces (43.63% vs. 34.42%, P=0.005) were higher in patients with positive fecal occult blood than in controls.Conclusions: The presence of fecal occult blood is probably related to the risk of CSVD in elderly patients and could be used as a screening tool for CSVD in elderly populations.","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung adenocarcinoma mimicking pulmonary miliary tuberculosis.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-28 DOI: 10.1016/j.medcli.2024.09.019

Ana María Vera-Carmona, Luis Gorospe Sarasúa, Marta González Sanz

引用次数: 0

Respiratory infection caused by Achromobacter xylosoxidans in an 80-year old patient.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-28 DOI: 10.1016/j.medcli.2024.09.031

Francisco Epelde

引用次数: 0

Ocular apraxia as the only diagnostic symptom of an occipito-parietal hematoma.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-28 DOI: 10.1016/j.medcli.2024.10.004

Carmen Teresa Sánchez Guillen, Alfonso Miranda Sánchez, Enrique Santo Bueso

引用次数: 0

Short stature in a patient with acid-labile subunit deficiency and type 1 diabetes mellitus.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-27 DOI: 10.1016/j.medcli.2024.09.021

Ángel López Montalbán, Víctor José Simón Frapolli, Álvaro Vidal Suárez

引用次数: 0

Coinfection with Mycobacterium avium and histoplasmosis in a patient with AIDS: A case report.

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-27 DOI: 10.1016/j.medcli.2024.09.024

Alejandro García García, Marco Andrés Rodríguez Astudillo, Beatriz Raboso Moreno

引用次数: 0

Importance of measurable residual disease in the outcome of adults with acute lymphoblastic leukemia after allogeneic stem cell transplantation: Long follow-up analysis from a single transplant center. 可测量残留疾病对异体干细胞移植后急性淋巴细胞白血病成人患者预后的重要性：来自单一移植中心的长期随访分析。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-26 DOI: 10.1016/j.medcli.2024.09.023

Irati Ormazabal Vélez, Arkaitz Galbete Jiménez, Miriam Sánchez-Escamilla, Ana Marcos-Jiménez, Elena Fernández-Ruiz, Jon Salmanton-García, Arancha Bermúdez Rodríguez, Ángela Figuera Álvarez

{"title":"Importance of measurable residual disease in the outcome of adults with acute lymphoblastic leukemia after allogeneic stem cell transplantation: Long follow-up analysis from a single transplant center.","authors":"Irati Ormazabal Vélez, Arkaitz Galbete Jiménez, Miriam Sánchez-Escamilla, Ana Marcos-Jiménez, Elena Fernández-Ruiz, Jon Salmanton-García, Arancha Bermúdez Rodríguez, Ángela Figuera Álvarez","doi":"10.1016/j.medcli.2024.09.023","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.023","url":null,"abstract":"Introduction: In this retrospective study, with prolonged follow-up, we analyze the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adult acute lymphoblastic leukemia (ALL) and the impact of pre-transplantation measurable residual disease (pre-HSCT MRD).Methods: Detection of MRD was performed by multiparametric flow cytometry (MFC) for Philadelphia chromosome-negative ALL (Ph-neg ALL) and by classic genetic tests for Ph-pos ALL.Results: Among 46 patients in first complete remission (CR1) who had available MRD data, 1- and 3-year cumulative incidences of relapse (CIR) for patients with positive and negative MRD were 47.1% and 52.9% vs. 3.4% and 6.9%, respectively (p<0.001). Disease free survival (DFS) at 1 and 3 years was 82.8% (95% CI 70.1-97.7) and 79.3% (95% CI 65.9-95.5) in the negative MRD group and 35.3% (95% CI 18.5-67.2) and 29.4% (95% CI 14.1-61.4) in the positive MRD group (p<0.001). With a median follow up of 29 months in the entire cohort and 177.6 months (14.8 years) in survivors, 1- and 3-year overall survival (OS) for the pre-HSCT negative MRD group was 82.8% (95% CI 70.1-97.7) and 79.2% (95% CI 65.6-95.5), respectively, compared to 64.7% (95% CI 45.5-91.9) and 41.2% (95% CI 23.3-72.7) in the positive MRD group (p=0.001). In a multivariate model, positive pre-HSCT MRD is associated with increased CIR and poorer DFS and OS.Conclusion: These results support that pre-HSCT MRD should be eradicated to improve survival of adult ALL patients who undergo allo-HSCT.","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous gastric embolization for obesity: A prospective mid-term outcomes study. 经皮胃栓塞治疗肥胖症：前瞻性中期疗效研究。

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-26 DOI: 10.1016/j.medcli.2024.09.028

Carlos Ivan Soledispa Suárez, Robert Alarcón Cedeño, Luis Mariano de la Torre Fonseca, Stephanie Susana Alberca Bonilla, Fabiola Loor Cedeño, Mayra Elizabeth Briones Fajardo, Pablo Juan-Salvadores

{"title":"Percutaneous gastric embolization for obesity: A prospective mid-term outcomes study.","authors":"Carlos Ivan Soledispa Suárez, Robert Alarcón Cedeño, Luis Mariano de la Torre Fonseca, Stephanie Susana Alberca Bonilla, Fabiola Loor Cedeño, Mayra Elizabeth Briones Fajardo, Pablo Juan-Salvadores","doi":"10.1016/j.medcli.2024.09.028","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.028","url":null,"abstract":"Introduction: Obesity represents one of the most pressing public health challenges that needs to be solved globally, with serious health implications. Despite primary prevention efforts the prevalence of obesity continues to increase. Percutaneous gastric embolisation (PGE) has emerged as a promising technique in the management of this disease.Material and methods: Prospective longitudinal cohort study including 15 patients diagnosed with grade III obesity, admitted to the Haemodynamics Service of the Cardiovascular Health Institute during the year 2022.Results: The 86.7% of the PGEs were successful. Treated patients experienced significant weight loss when comparing baseline weight (101.2±23.0, SE=5.9) with weight at 6 months after the interventional procedure (91.5±19.8, SE=5.1) t(14)=5.3, P<.001, d=0.45, especially males (106.7±18.4, P=.01). No major vascular complications, gastric ulcer or ischaemia, or abdominal symptoms were documented in any of the patients included in the study. Only 6 patients (40%) presented with epigastralgia, 9 (60%) with nausea and 3 (20%) with vomiting.Conclusions: Percutaneous gastric embolisation is an effective and safe procedure to reduce BMI with a high success rate, well tolerated by obese patients, without major complications, whose results are maintained over time.","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to comments on "Is the sustainability of exposure to non-ionizing electromagnetic radiation possible?" 对关于 "非电离电磁辐射暴露的可持续性可能吗？"的评论的答复

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-25 DOI: 10.1016/j.medcli.2024.09.013

Irene Calvente, María Isabel Núñez

引用次数: 0

Allergic bronchopulmonary aspergillosis: A treatable trait to consider in chronic obstructive pulmonary disease? 过敏性支气管肺曲霉菌病：慢性阻塞性肺病中需要考虑的一种可治疗性状？

IF 2.6 4区医学

Medicina Clinica Pub Date : 2024-11-25 DOI: 10.1016/j.medcli.2024.09.015

Miguel Jiménez-Gómez, Ismael García-Moguel, Rocío Magdalena Díaz-Campos

引用次数: 0