Medicina ClinicaPub Date : 2024-12-09DOI: 10.1016/j.medcli.2024.10.020
Pablo Demelo-Rodríguez, Tatiana Pire-García, Sergio Moragón-Ledesma, Lucía Ordieres-Ortega, Francisco Galeano-Valle, Rubén Alonso-Beato
{"title":"Direct oral anticoagulants versus vitamin K antagonists in patients with thrombotic antiphospholipid syndrome: A prospective observational analysis.","authors":"Pablo Demelo-Rodríguez, Tatiana Pire-García, Sergio Moragón-Ledesma, Lucía Ordieres-Ortega, Francisco Galeano-Valle, Rubén Alonso-Beato","doi":"10.1016/j.medcli.2024.10.020","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.10.020","url":null,"abstract":"<p><strong>Background: </strong>The role of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE) in patients with antiphospholipid syndrome remains uncertain.</p><p><strong>Methods: </strong>We conducted a prospective observational study on APS patients with VTE treated with VKAs or DOACs in a tertiary hospital from 2010 to 2023. Clinical characteristics, recurrent arterial or VTE events, and hemorrhagic complications were analyzed over a one-year follow-up.</p><p><strong>Results: </strong>Fifty APS patients were included: 31 (62%) treated with VKAs and 19 (38%) with DOACs. Thrombotic recurrences occurred in 5 VKA patients (16.1%) and 3 DOAC patients (15.8%). Major bleeding occurred in 2 VKA patients (6.45%) and none in the DOAC group. There were no significant differences in thrombotic recurrence (OR 1.01; 95% CI: 0.19-5.46) or major bleeding (OR 1.09; 95% CI: 0.14-8.52) between groups.</p><p><strong>Conclusion: </strong>In APS patients with VTE, DOACs showed similar rates of recurrent thrombosis and major bleeding compared to VKAs. Future studies should therefore focus on the role of DOACs in APS patients with varying clinical and serological profiles.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-12-09DOI: 10.1016/j.medcli.2024.10.017
Antonio Rosales-Castillo, Antonio Bustos-Merlo, Joaquín Escobar Sevilla
{"title":"Experience and results of immediate care consultation in internal medicine.","authors":"Antonio Rosales-Castillo, Antonio Bustos-Merlo, Joaquín Escobar Sevilla","doi":"10.1016/j.medcli.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.10.017","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-12-09DOI: 10.1016/j.medcli.2024.11.003
Luis Castilla-Guerra, Antonio Gómez-Escobar, Estanislao Gutiérrez Sánchez, María Del Carmen Fernández-Moreno
{"title":"Usefulness of ocular ultrasound for monitoring acute retinal arterial ischemia.","authors":"Luis Castilla-Guerra, Antonio Gómez-Escobar, Estanislao Gutiérrez Sánchez, María Del Carmen Fernández-Moreno","doi":"10.1016/j.medcli.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.11.003","url":null,"abstract":"<p><strong>Introduction: </strong>The ocular ultrasound spot sign negatively predicts the success of thrombolytic treatment in retinal arterial occlusions. We evaluated the presence of the spot sign in these patients.</p><p><strong>Material and methods: </strong>Retrospective study of patients with acute central retinal artery occlusion (CRAO) or its branches (BRAO). An ocular ultrasound was performed to assess the presence of spot sign.</p><p><strong>Results: </strong>Twenty patients were included, 13 CRAO and 7 BRAO. Carotid stenosis was the most common etiology, in 50%, 7 CRAO and 3 BRAO. A spot sign was observed in 9 patients (45%), 7 CRAO and 2 BRAO. We did not observe significant differences between patients with CRAO and BRAO. Patients with the spot sign were significantly older: 73 (±9) vs. 66 (±6) years (p=0.028).</p><p><strong>Conclusions: </strong>Ocular ultrasound is very useful in the evaluation of patients with acute retinal ischemia. More than 50% of CRAOs and one in 4 with BRAOs have the spot sign and would not benefit from systemic thrombolysis.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-12-06DOI: 10.1016/j.medcli.2024.09.030
Shuo Wu, Meihong Ye, Chaoming Wang
{"title":"Adenocarcinoma of the renal pelvis and ureteral junction: A case report.","authors":"Shuo Wu, Meihong Ye, Chaoming Wang","doi":"10.1016/j.medcli.2024.09.030","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.030","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-12-03DOI: 10.1016/j.medcli.2024.09.026
Concepción Prados-Sánchez, Alberto Mangas-Moro
{"title":"Contamination by Mycobacterium lentiflavum in the bronchoscope washing water.","authors":"Concepción Prados-Sánchez, Alberto Mangas-Moro","doi":"10.1016/j.medcli.2024.09.026","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.09.026","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-12-02DOI: 10.1016/j.medcli.2024.10.012
Aurora Gil, Ricard Ferrer
{"title":"Value of albumin administration in intensive care.","authors":"Aurora Gil, Ricard Ferrer","doi":"10.1016/j.medcli.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.10.012","url":null,"abstract":"","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicina ClinicaPub Date : 2024-11-30DOI: 10.1016/j.medcli.2024.10.005
Santiago Roques, Pere Tudela, Eduard Clot, Sarah Dávila, Frank Abella, Josep Vega
{"title":"Impact of the improvement in the etiological diagnosis of community pneumonia.","authors":"Santiago Roques, Pere Tudela, Eduard Clot, Sarah Dávila, Frank Abella, Josep Vega","doi":"10.1016/j.medcli.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.10.005","url":null,"abstract":"<p><strong>Background and objective: </strong>Etiological diagnosis of community-acquired pneumonia (CAP) is only reached in 30-40% of cases, which frequently requires keeping empirical antibiotic regimens. The new nucleic acid amplification techniques (NAAT) in respiratory samples raise the possibility of improving this clinical practice. Our objective was to analyze TAANs contribution estimating both their costs and benefits.</p><p><strong>Patients and methods: </strong>The admitted CAPs were analyzed, in which, if the conventional diagnostic tests were negative, a NAAT was performed. If positive results was made, we assessed if antimicrobials were modified, a cost estimate, and isolation measures.</p><p><strong>Results: </strong>64 cases were documented. An etiological diagnosis was made in 65.6%: 10.9% were obtained by conventional techniques and the rest (54.7%) by TAAN. These tests' results led to antimicrobial regimen's modification in 88.9% of cases and isolations in 78.5% CONCLUSIONS: Compared to TAAN's economic cost, it is worth considering its contributions, such as antimicrobials' reduction, ecological pressure, and isolations' indications.</p>","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}