Microbiological research最新文献_第9页

Function analysis of RNase III in response to oxidative stress in Synechocystis sp. PCC 6803 胞囊藻（Synechocystis sp. pcc6803） RNase III响应氧化应激的功能分析。

IF 6.1 1区生物学

Microbiological research Pub Date : 2025-01-02 DOI: 10.1016/j.micres.2024.128045

Yihang Zhang , Xinyu Hu , Shanyu Wu , Tianyuan Zhang , Guidan Yang , Zhijie Li , Li Wang , Wenli Chen

{"title":"Function analysis of RNase III in response to oxidative stress in Synechocystis sp. PCC 6803","authors":"Yihang Zhang , Xinyu Hu , Shanyu Wu , Tianyuan Zhang , Guidan Yang , Zhijie Li , Li Wang , Wenli Chen","doi":"10.1016/j.micres.2024.128045","DOIUrl":"10.1016/j.micres.2024.128045","url":null,"abstract":"<div><div>RNase III, a ubiquitously distributed endonuclease, plays an important role in RNA processing and functions as a global regulator of gene expression. In this study, we explored the role of RNase III in mediating the oxidative stress response in <em>Synechocystis</em> sp. PCC 6803. Phenotypic analysis demonstrated that among the three RNase III-encoding genes (<em>slr0346</em>, <em>slr1646</em>, and <em>slr0954</em>), the deletional mutation of <em>slr0346</em> significantly impaired the growth of cyanobacteria on BG11 agar plates. However, this growth effect was not observed in liquid culture. In contrast, the deletion of <em>slr1646</em> and <em>slr0954</em> did not affect the growth of cyanobacteria under the tested conditions. However, under methyl viologen (MV)-induced oxidative stress, the <em>slr0346</em> deletion mutant exhibited a slower growth rate compared to the wild-type strain. Transcriptome analysis revealed that five pathways—nitrogen metabolism, ABC transporters, folate biosynthesis, ribosome biogenesis, and oxidative phosphorylation—were implicated in the oxidative stress response. The <em>slr0346</em> gene suppressed global gene expression, with a particular impact on genes associated with energy metabolism, protein synthesis, and transport. Furthermore, we identified Ssl3432 as an interacting protein that may participate in the oxidative stress response in coordination with Slr0346. Overall, the deletion of <em>slr0346</em> markedly weakened the ability of <em>Synechocystis</em> sp<em>.</em> PCC 6803 to respond to MV-induced oxidative stress. This study offers valuable insights into the oxidative stress response of <em>Synechocystis</em> sp<em>.</em> PCC 6803 and highlights the role of RNase III in adapting to environmental stress.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128045"},"PeriodicalIF":6.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging dietary polysaccharides and gut microbiome: How to achieve precision modulation for gut health promotion 桥接膳食多糖和肠道微生物群：如何实现肠道健康促进的精确调节。

IF 6.1 1区生物学

Microbiological research Pub Date : 2025-01-02 DOI: 10.1016/j.micres.2025.128046

Xihao Sun , Zhangming Pei , Hongchao Wang , Jianxin Zhao , Wei Chen , Wenwei Lu

{"title":"Bridging dietary polysaccharides and gut microbiome: How to achieve precision modulation for gut health promotion","authors":"Xihao Sun , Zhangming Pei , Hongchao Wang , Jianxin Zhao , Wei Chen , Wenwei Lu","doi":"10.1016/j.micres.2025.128046","DOIUrl":"10.1016/j.micres.2025.128046","url":null,"abstract":"<div><div>Dietary polysaccharides function not only as indispensable nutrients and energy sources for the host organism but also as critical substrates for the gut microbiota. Gut microorganisms possess the ability to selectively degrade and metabolize specific dietary polysaccharides, thus fostering their proliferation and yielding crucial bioactive metabolites that potentially influence host metabolic and immune pathways. Dysbiosis of the gut microbiota has been extensively documented to be closely linked with the onset and progression of various diseases; in this regard, the precision modulation strategy of the gut microbiome via dietary polysaccharides holds substantial potential to enhance human health. Here, we delve into the therapeutic potential of dietary polysaccharides for the precision modulation of specific gut microorganisms via dietary interventions, with particular emphasis on their implications for the prevention and management of metabolic and inflammatory disorders. Given the complexity of the human gut microbiome and the varying degrees to which different bacterial members utilize carbohydrates, we conduct an in-depth analysis of the differential utilization of dietary polysaccharides by key gut microbiome, with particular emphasis on the role of carbohydrate-active enzymes in these processes. Furthermore, we elucidate the pivotal role of carbohydrate utilization within microbial cross-feeding networks and its significance in maintaining gut homeostasis. In summary, this review investigates the precision modulation of gut microbiota through dietary polysaccharides, with the aim of establishing a theoretical foundation for the development of personalized nutritional interventions. These strategies hold substantial potential for enhancing human health and offer valuable opportunities for the prevention and treatment of microbiota-associated diseases.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128046"},"PeriodicalIF":6.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal dynamics of kiwifruit microbiome: A case study in a KVDS-affected orchard 猕猴桃微生物群落的季节动态：以受kvds影响的果园为例。

IF 6.1 1区生物学

Microbiological research Pub Date : 2025-01-01 DOI: 10.1016/j.micres.2024.128044

Antonella Cardacino, Silvia Turco, Giorgio Mariano Balestra

{"title":"Seasonal dynamics of kiwifruit microbiome: A case study in a KVDS-affected orchard","authors":"Antonella Cardacino, Silvia Turco, Giorgio Mariano Balestra","doi":"10.1016/j.micres.2024.128044","DOIUrl":"10.1016/j.micres.2024.128044","url":null,"abstract":"<div><div>Over the past decade, Italian kiwifruit orchards and overall production have faced a significant threat from Kiwifruit Vine Decline Syndrome (KVDS). Despite the insights gained from metagenomics studies into the microbial communities associated with the disease, unanswered questions still remain. In this study, the evolution of bacterial, fungal, and oomycetes communities in soil and root endosphere at three different time points during the vegetative season was investigated for the first time in a KVDS-affected orchard in the Lazio Region. The fungal and oomycetes genera previously associated with the syndrome, including <em>Fusarium, Ilyonectria, Thelonectria, Phytophthora, Pythium</em> and <em>Globisporangium</em>, were identified in both groups. In contrast, the characterization of bacterial communities revealed the first instance of the presence of the genus <em>Ralstonia</em> in soil and root samples. The microbiome composition shifts between KVDS-affected and asymptomatic plants were significant as evidenced by the results, particularly after a temperature increase. This temperature change coincided with the onset of severe disease symptoms and may indicate a key role in the progression of KVDS.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128044"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorghum rhizosphere bacteriome studies and generation of multistrain beneficial bacterial consortia 高粱根际细菌组研究及多菌种有益菌群的产生。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-27 DOI: 10.1016/j.micres.2024.128036

Chandan Kumar , Alfonso Esposito , Iris Bertani , Samson Musonerimana , Mulissa Jida Midekssa , Kassahun Tesfaye , Devin Coleman Derr , Lara Donaldson , Silvano Piazza , Cristina Bez , Vittorio Venturi

{"title":"Sorghum rhizosphere bacteriome studies and generation of multistrain beneficial bacterial consortia","authors":"Chandan Kumar , Alfonso Esposito , Iris Bertani , Samson Musonerimana , Mulissa Jida Midekssa , Kassahun Tesfaye , Devin Coleman Derr , Lara Donaldson , Silvano Piazza , Cristina Bez , Vittorio Venturi","doi":"10.1016/j.micres.2024.128036","DOIUrl":"10.1016/j.micres.2024.128036","url":null,"abstract":"<div><div>The plant rhizosphere microbiome plays a crucial role in plant growth and health. Within this microbiome, bacteria dominate, exhibiting traits that benefit plants, such as facilitating nutrient acquisition, fixing nitrogen, controlling pathogens, and promoting root growth. This study focuses on designing synthetic bacterial consortia using key bacterial strains which have been mapped and then isolated from the sorghum rhizosphere microbiome. A large set of samples of the rhizosphere bacteriome of <em>Sorghum bicolor</em> was generated and analyzed across various genotypes and geographical locations. We assessed the taxonomic composition and structure of the sorghum root-associated bacterial community identifying the most prevalent and keystone taxa. A set of 321 bacterial strains was then isolated, and three multi-strain consortia were designed making use of the bacteriome data generated using culture independent methodology. Subsequently, co-existence and plant-growth promoting ability of three bacterial consortia were tested both <em>in vitro</em> and <em>in planta</em>. Consortia 3 promoted plant growth in growth-chamber conditions while Consortia 1 and 2 performed better in field-plot experiments. Despite these differences, bacterial community profiling confirmed the colonization of the inoculated consortia in the sorghum rhizosphere without significant alterations to the overall bacterial community compared to the non inoculated ones. In summary, this study focused on a method, using root bacteriome data, to design and test bacterial consortia for plant beneficial effects with the aim of translating microbiome knowledge into applications.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128036"},"PeriodicalIF":6.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbial metabolites: The bridge connecting diet and atherosclerosis, and next-generation targets for dietary interventions 肠道微生物代谢物：连接饮食和动脉粥样硬化的桥梁，以及饮食干预的下一代目标。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-26 DOI: 10.1016/j.micres.2024.128037

Liyin Zhang, Yao Yin, Si Jin

引用次数: 0

Assessing the risk of TB progression: Advances in blood-based biomarker research 评估结核病进展风险：基于血液的生物标志物研究进展。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-26 DOI: 10.1016/j.micres.2024.128038

Zhaodong Li , Yunlong Hu , Fa Zou , Wei Gao , SiWan Feng , Guanghuan Chen , Jing Yang , Wenfei Wang , Chenyan Shi , Yi Cai , Guofang Deng , Xinchun Chen

{"title":"Assessing the risk of TB progression: Advances in blood-based biomarker research","authors":"Zhaodong Li , Yunlong Hu , Fa Zou , Wei Gao , SiWan Feng , Guanghuan Chen , Jing Yang , Wenfei Wang , Chenyan Shi , Yi Cai , Guofang Deng , Xinchun Chen","doi":"10.1016/j.micres.2024.128038","DOIUrl":"10.1016/j.micres.2024.128038","url":null,"abstract":"<div><div>This review addresses the significant advancements in the identification of blood-based prognostic biomarkers for tuberculosis (TB), highlighting the importance of early detection to prevent disease progression. The manuscript discusses various biomarker categories, including transcriptomic, proteomic, metabolomic, immune cell-based, cytokine-based, and antibody response-based markers, emphasizing their potential in predicting TB incidence. Despite promising results, practical application is hindered by high costs, technical complexities, and the need for extensive validation across diverse populations. Transcriptomic biomarkers, such as the Risk16 signature, show high sensitivity and specificity, while proteomic and metabolic markers provide insights into protein-level changes and biochemical alterations linked to TB. Immune cell and cytokine markers offer real-time data on the body's response to infection. The manuscript also explores the role of single-nucleotide polymorphisms in TB susceptibility and the challenges of implementing novel RNA signatures as point-of-care tests in low-resource settings. The review concludes that, while significant progress has been made, further research and development are necessary to refine these biomarkers, improve their practical application, and achieve the World Health Organization's TB elimination goals.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128038"},"PeriodicalIF":6.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Klebsiella pneumoniae ST258 impairs intracellular elastase mobilization and persists within human neutrophils

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-26 DOI: 10.1016/j.micres.2024.128035

Federico Birnberg-Weiss , Joselyn E. Castro , Jose R. Pittaluga , Luis A. Castillo , Daiana Martire-Greco , Federico Fuentes , Fabiana Bigi , Sonia A. Gómez , Verónica I. Landoni , Gabriela C. Fernández

{"title":"Klebsiella pneumoniae ST258 impairs intracellular elastase mobilization and persists within human neutrophils","authors":"Federico Birnberg-Weiss , Joselyn E. Castro , Jose R. Pittaluga , Luis A. Castillo , Daiana Martire-Greco , Federico Fuentes , Fabiana Bigi , Sonia A. Gómez , Verónica I. Landoni , Gabriela C. Fernández","doi":"10.1016/j.micres.2024.128035","DOIUrl":"10.1016/j.micres.2024.128035","url":null,"abstract":"<div><div><em>Klebsiella pneumoniae</em> (Kp) strains of sequence type (ST) 258 producing <em>K. pneumoniae</em>-carbapenemase (KPC) are a major cause of hospital-associated outbreaks and the main contributors of carbapenemase spreading. Here, we deepen into the mechanisms behind the inhibition of neutrophil bactericidal functions mediated by a clinical isolate of Kp ST258 KPC, Kp from now on. We found that NETs formation induced by different stimuli (PMA, ionomycin, <em>Staphylococcus aureus</em>) was significantly reduced in the presence of Kp. We revealed that Kp affects actin polymerization which correlates with impaired mobilization of elastase from azurophilic granules to the nucleus and reduced elastase mobilization towards phagosomes that contain bacteria. In line with these results, Kp survived within neutrophils for 3 h post-challenge without compromising neutrophil viability. We also found that different Kp clinical isolates inhibited NETs formation and actin polymerization. These results describe a strategy of evasion used by Kp to subvert PMN-mediating both intra and extracellular mechanisms of killing, representing a clear advantage for the survival and spreading of this multidrug-resistant bacteria.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128035"},"PeriodicalIF":6.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143101082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Actinobacillus pleuropneumoniae apxIV operon encodes an antibacterial toxin-immunity pair 胸膜肺炎放线杆菌apxIV操纵子编码抗菌毒素免疫对。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-26 DOI: 10.1016/j.micres.2024.128043

Eva Slivenecka, David Jurnecka, Jana Holubova, Ondrej Stanek, Ludmila Brazdilova, Monika Cizkova, Ladislav Bumba

{"title":"The Actinobacillus pleuropneumoniae apxIV operon encodes an antibacterial toxin-immunity pair","authors":"Eva Slivenecka, David Jurnecka, Jana Holubova, Ondrej Stanek, Ludmila Brazdilova, Monika Cizkova, Ladislav Bumba","doi":"10.1016/j.micres.2024.128043","DOIUrl":"10.1016/j.micres.2024.128043","url":null,"abstract":"<div><div>The ApxIVA protein belongs to a distinct class of a “clip and link” activity of Repeat-in-ToXin (RTX) exoproteins. Along with the three other pore-forming RTX toxins (ApxI, ApxII and ApxIII), ApxIVA serves as a major virulence factor of <em>Actinobacillus pleuropneumoniae</em>, the causative agent of porcine pneumonia. The gene encoding ApxIVA is located on a bicistronic operon downstream of the <em>orf1</em> gene and is expressed exclusively under <em>in vivo</em> conditions. Both ApxIVA and ORF1 are essential for full virulence of <em>A. pleuropneumoniae</em>, but the molecular mechanisms by which they contribute to the pathogenicity are not yet understood. Here, we provide a comprehensive structural and functional analysis of ApxIVA and ORF1 proteins. Our findings reveal that the N-terminal segment of ApxIVA shares structural similarity with colicin M (ColM)-like bacteriocins and exhibits an antimicrobial activity. The ORF1 protein resembles the colicin M immunity protein (Cmi) and, like Cmi, is exported to the periplasm through its N-terminal signal peptide. Additionally, ORF1 can protect bacterial cells from the antimicrobial activity of ApxIVA, suggesting that ORF1 and ApxIVA function as an antibacterial toxin-immunity pair. Moreover, we demonstrate that fetal bovine serum could elicit ApxIVA and ORF1 production under <em>in vitro</em> conditions. These findings highlight the coordinated action of various RTX determinants, where the fine-tuned spatiotemporal production of ApxIVA may enhance the fitness of <em>A. pleuropneumoniae,</em> facilitating its invasion to a resident microbial community on the surface of airway mucosa.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128043"},"PeriodicalIF":6.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperate bacteriophage SapYZUs7 alters Staphylococcus aureus fitness balance by regulating expression of phage resistance, virulence and antimicrobial resistance gene 温带噬菌体SapYZUs7通过调控噬菌体耐药性、毒力和耐药基因的表达改变金黄色葡萄球菌的适应性平衡。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-26 DOI: 10.1016/j.micres.2024.128040

Wenyuan Zhou , Yajie Li , Yuhong Wu , Weicheng Hu , Wenjuan Li , Aiping Deng , Yeling Han , Guoqiang Zhu , Zhenquan Yang

{"title":"Temperate bacteriophage SapYZUs7 alters Staphylococcus aureus fitness balance by regulating expression of phage resistance, virulence and antimicrobial resistance gene","authors":"Wenyuan Zhou , Yajie Li , Yuhong Wu , Weicheng Hu , Wenjuan Li , Aiping Deng , Yeling Han , Guoqiang Zhu , Zhenquan Yang","doi":"10.1016/j.micres.2024.128040","DOIUrl":"10.1016/j.micres.2024.128040","url":null,"abstract":"<div><div>Temperate bacteriophages are crucial for maintaining the pathogenicity and fitness of <em>S. aureus</em>, which also show promise as a biocontrol agent for <em>S. aureus</em>. However, the fitness benefit and cost of lysogeny by <em>S. aureus</em> temperate phages and their underlying mechanisms remain unexplored. In this study, phage resistance, virulence, antimicrobial resistance (AMR), transcriptome, and metabolome of phage SapYZUs7 lysogenic and non-lysogenic <em>S. aureus</em> strains were compared. Whole-genome analysis revealed that SapYZUs7 harbouring <em>smaII</em> associated with a single-protein MazF-like antiphage system could be integrated into the genome of <em>S. aureus</em> isolates. Notably, lysogenic <em>S. aureus</em> exhibited higher phage resistance, a lower growth rate, and inhibited metabolic activity compared to the parental strains, indicating interference of phage reproduction by <em>smaII</em>. Moreover, prophages carrying <em>smaII</em> are widely distributed across <em>S. aureus</em> and harboured other virulence factor (VF) and AMR genes. Besides, the SapYZUs7-integration increased phagocytosis resistance but decreased adhesion, biofilm formation, and AMR. The combined use of SapYZUs7 and antibiotics exhibited a better bactericidal effect than SapYZUs7 or the antibiotics alone. Consistently, integrated omics analysis suggested that SapYZUs7-lysogeny downregulated multiple VF and AMR genes. Our analysis suggests that <em>Sma</em>II drives mutualistic phage-host interactions through lysogenic conversion. The fitness cost of SapYZUs7-integration is the downregulated expression of VF and AMR genes, serving as an alternative candidate as a biocontrol agent for methicillin-resistant <em>S</em>. <em>aureus</em> and multidrug-resistant <em>S</em>. <em>aureus</em>.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128040"},"PeriodicalIF":6.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth in non-tuberculous mycobacteria: clever challengers to the immune system 非结核分枝杆菌的隐身性：免疫系统的聪明挑战者。

IF 6.1 1区生物学

Microbiological research Pub Date : 2024-12-25 DOI: 10.1016/j.micres.2024.128039

Zhenghao Wang , Xiurong Sun , Yuli Lin , Yurong Fu , Zhengjun Yi

{"title":"Stealth in non-tuberculous mycobacteria: clever challengers to the immune system","authors":"Zhenghao Wang , Xiurong Sun , Yuli Lin , Yurong Fu , Zhengjun Yi","doi":"10.1016/j.micres.2024.128039","DOIUrl":"10.1016/j.micres.2024.128039","url":null,"abstract":"<div><div><em>Non-tuberculous Mycobacteria (</em>NTM<em>)</em> are found extensively in various environments, yet most are non-pathogenic. Only a limited number of these organisms can cause various infections, including those affecting the lungs, skin, and central nervous system, particularly when the host's autoimmune function is compromised. Among these, Non-tuberculous Mycobacteria Pulmonary Diseases (NTM-PD) are the most prevalent. Currently, there is a lack of effective treatments and preventive measures for NTM infections. This article aims to deepen the comprehension of the pathogenic mechanisms linked to NTM and to formulate new intervention strategies by synthesizing current research and detailing the different tactics used by NTM to avoid elimination by the host's immune response. These intricate mechanisms not only affect the innate immune response but also successfully oppose the adaptive immune response, establishing persistent infections within the host. This includes effects on the functions of macrophages, neutrophils, dendritic cells, and T lymphocytes, as well as modulation of cytokine production. The article particularly emphasizes the survival strategies of NTM within macrophages, such as inhibiting phagosome maturation and acidification, resisting intracellular killing mechanisms, and interfering with autophagy and cell death pathways. This review aims to deepen the understanding of NTM's immune evasion mechanisms, thereby facilitating efforts to inhibit its proliferation and spread within the host, ultimately providing new methods and strategies for NTM-related treatments.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128039"},"PeriodicalIF":6.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0