Microbiological research最新文献

{"title":"Akkermansia muciniphila inhibits jejunal lipid absorption and regulates jejunal core bacteria","authors":"Qiming Ma ,&nbsp;Xincheng Zhou ,&nbsp;Weikang Su ,&nbsp;Qingyu Wang ,&nbsp;Guoxing Yu ,&nbsp;Weihua Tao ,&nbsp;Zhiyong Dong ,&nbsp;Cunchuan Wang ,&nbsp;Chi-Ming Wong ,&nbsp;Tiemin Liu ,&nbsp;Shiqi Jia","doi":"10.1016/j.micres.2025.128053","DOIUrl":"10.1016/j.micres.2025.128053","url":null,"abstract":"<div><div>Insufficiency of <em>Akkermansia muciniphila</em> (Akk) has been implicated in the pathogenesis of metabolic diseases, and administration or restoration of Akk has ameliorated these disorders. Recently, Pasteurized Akk (PA-Akk) has been approved as a functional food. However, the impact of Akk on lipid absorption in the proximal intestine, which is directly exposed to orally administered Akk, remains largely unexplored. In this study, we orally administered Akk and PA-Akk to mice and investigated the subsequent lipid absorption. Long-term administration of Akk resulted in reduced lipid deposits in the liver and adipocytes, along with improved glucose metabolism. This was primarily attributed to a reduction in lipid absorption by epithelial cells in the proximal jejunum. Mechanistically, Akk activated AMP-activated protein kinase (AMPK) and directly inhibit lipids absorption in both mouse and human jejunal epithelial cells. Furthermore, we demonstrated that Akk treatment, but not PA-Akk treatment, promotes the abundance of genera that are highly abundant in the normal jejunum and belong to the phylum Firmicutes. Thus, our study concludes that oral administration of Akk provides beneficial effects on metabolism, partially through inhibiting jejunal lipid absorption and promoting the abundance of core jejunal microbes.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"293 ","pages":"Article 128053"},"PeriodicalIF":6.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome succession on the pomegranate phylloplane during bacterial blight dysbiosis: Functional implications for blight suppression","authors":"Vinod Chouhan ,&nbsp;Sunil Thalor ,&nbsp;K. Charishma ,&nbsp;Mohammed Javed ,&nbsp;Shanu Kumar ,&nbsp;Jyotsana Sharma ,&nbsp;Vibuthi Munjal ,&nbsp;Aundy Kumar","doi":"10.1016/j.micres.2025.128050","DOIUrl":"10.1016/j.micres.2025.128050","url":null,"abstract":"<div><div>Bacterial blight of pomegranate caused by <em>Xanthomonas axonopodis</em> pv. <em>punicae</em> poses significant challenges to sustainable cultivation, necessitating eco-friendly management strategies, and this study explores the role of the phylloplane microbiome in disease suppression through metabarcoding, traditional microbiology, and antibacterial screening of microbial candidates. Here, we mapped the phylloplane microbiome of pomegranate cultivar 'Bhagwa' during bacterial blight development using metabarcoding sequencing (2443,834 reads), traditional microbiological methods (nutrient-rich and minimal media), and scanning electron microscopy. We observed shifts in microbial diversity, with <em>Xanthomonas</em> typically released through stomata as the blight progressed from water-soaked early lesion to advanced necrotic lesion. The Shannon diversity index peaked at 2.6 in early necrotic stages but dropped to 2.1 in advanced blight. Proteobacteria and Firmicutes were the dominant phyla, with significant compositional changes between disease stages. <em>Bacillus</em> species were prevalent throughout, peaking in both early and severe lesions. <em>Pantoea</em> and <em>Curtobacterium</em> increased during severe blight, while <em>Exiguobacterium</em> thrived on the abaxial surface. A core microbiome, including <em>Pantoea</em>, <em>Enterobacter</em>, and <em>Pseudomonas</em>, remained consistent across stages. Antibacterial screening of 116 bacterial candidates, dominated by <em>Pantoea</em> (32), <em>Bacillus</em> (18), and <em>Pseudomonas</em> (11), revealed multipronged activities against <em>X. axonopodis</em> pv. <em>punicae</em>. <em>Bacillus amyloliquefaciens</em> P2–1 and <em>Pantoea dispersa</em> Pg-Slp-6 suppressed the pathogen through secreted metabolites, while <em>Pantoea dispersa</em> Pg-Slp-6, <em>Pseudomonas oryzihabitans</em> Pg<em>-</em>Slp-82, and <em>Pantoea dispersa</em> Pg-slp-117 exhibited volatile-mediated suppression. Among these, <em>Bacillus amyloliquefaciens</em> P2–1 and <em>Pantoea dispersa</em> Pg-slp-6 showed 55 % and 42 % blight suppression, respectively, highlighting their potential as biocontrol agents.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"293 ","pages":"Article 128050"},"PeriodicalIF":6.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain diversity and host specificity of the gut symbiont Gilliamella in Apis mellifera, Apis cerana and Bombus terrestris","authors":"Nihong Zhou ,&nbsp;Qiulan Zheng ,&nbsp;Yao Liu ,&nbsp;Zhichu Huang ,&nbsp;Ye Feng ,&nbsp;Yanping Chen ,&nbsp;Fuliang Hu ,&nbsp;Huoqing Zheng","doi":"10.1016/j.micres.2025.128048","DOIUrl":"10.1016/j.micres.2025.128048","url":null,"abstract":"<div><div>Social bees, with their specialized gut microbiota and societal transmission between individuals, provide an ideal model for studying host-gut microbiota interactions. While the functional disparities arising from strain-level diversity of gut symbionts and their effects on host health have been studied in <em>Apis mellifera</em> and bumblebees, studies focusing on host-specific investigations of individual strains across different honeybee hosts remain relatively unexplored. In this study, the complete genomic sequences of 17 strains of <em>Gilliamella</em> from <em>A. mellifera</em>, <em>Apis cerana</em> and <em>Bombus terrestris</em> were analyzed. The analysis revealed that the strains of <em>A. mellifera</em> display a more expansive genomic and functional content compared to the strains of <em>A. cerana</em> and <em>B. terrestris</em>. Phylogenetic analysis showed a deep divergence among the <em>Gilliamella</em> strains from different hosts. Additionally, biochemistry tests and antibiotic susceptibility tests revealed that gut strains from <em>A. mellifera</em> exhibited a more extensive pathway for carbohydrate metabolism and a greater resistance to antibiotics than gut strains from <em>A. cerana</em> and <em>B. terrestris</em>. Strains from <em>A. mellifera</em> and <em>A. cerana</em> showed higher colonization efficiency and competitive ability whithin their respective host species, indicating a higher degree of host-specific adaptation of local gut microbiota. In addition, colonization by <em>A. mellifera</em>-derived strain triggers a stronger transcriptional response in the host than <em>A. cerana</em>-derived strain. The variation in the number of differentially expressed genes and the involvement of distinct signaling pathways across these two host species suggest species-specific adaptations to <em>Gilliamella</em> strains. These findings suggest that despite occupying similar niches in the bee gut, strain-level variations can influence microbial functions, and their impact on host physiological functions may vary across different strains.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"293 ","pages":"Article 128048"},"PeriodicalIF":6.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of two novel tmexCD-toprJ subtypes mediating tigecycline resistance in the megaplasmids from Pseudomonas putida","authors":"Chengzhen Wang ,&nbsp;Xun Gao ,&nbsp;Xiaoyu Zhang ,&nbsp;Chao Yue ,&nbsp;Luchao Lv ,&nbsp;Litao Lu ,&nbsp;Jian-Hua Liu","doi":"10.1016/j.micres.2025.128051","DOIUrl":"10.1016/j.micres.2025.128051","url":null,"abstract":"<div><div>The widespread antimicrobial resistance (AMR) problem poses a serious health threat, leaving few drug choices, including tigecycline, to treat multidrug resistance pathogens. However, a plasmid-borne tigecycline resistance gene cluster, <em>tmexCD1-toprJ1</em>, emerged and conferred tigecycline resistance. In this study, we identified two novel subtypes, <em>tmexCD2.3-toprJ2.3</em> and <em>tmexCD2.4-toprJ1b</em>, obtained from three chicken-origin <em>Pseudomonas putida</em> isolates. Two types of megaplasmids were found as the vital vehicle of these <em>tmexCD-toprJ</em> variants. Phylogenetic and genomic analysis indicated the two variants were mainly distributed in <em>Pseudomonas</em> and acted as an evolved intermediated state precursor of <em>tmexCD2-toprJ2</em>. Further gene cloning assay revealed both the expression of <em>tmexCD2.3-toprJ2.3</em> and <em>tmexCD2.4-toprJ1b</em> could confer multiple antimicrobial resistance, mediating 8- to 16-fold increase of tigecycline MIC. Importantly, two key nucleotide differences in promoter region influence the promoter activity between P_{<em>tmexC2.3</em>} and P_{<em>tmexC2.4</em>}, while the downregulation effect of TNfxB on the transcriptional expression level of <em>tmexCD2.3-toprJ2.3</em> and <em>tmexCD2.4-toprJ1b</em> were observed. The emergency of two novel <em>tmexCD-toprJ</em> variants necessitates preventive measures to curb their spread and highlights concerns about more emerging <em>tmexCD-toprJ</em> variants.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128051"},"PeriodicalIF":6.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid emergence, transmission, and evolution of KPC and NDM coproducing carbapenem-resistant Klebsiella pneumoniae","authors":"Jiayang Li ,&nbsp;Wenqi Wu ,&nbsp;Hao Wu ,&nbsp;Jinjian Huang ,&nbsp;Ze Li ,&nbsp;Jiajie Wang ,&nbsp;Zhitao Zhou ,&nbsp;Meilin Wu ,&nbsp;Xiuwen Wu ,&nbsp;Yun Zhao ,&nbsp;Jianan Ren","doi":"10.1016/j.micres.2025.128049","DOIUrl":"10.1016/j.micres.2025.128049","url":null,"abstract":"<div><div>Due to the limited treatment options, the widespread of carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) has become a serious clinical challenge. The emergence of <em>Klebsiella pneumoniae</em> carbapenemase (KPC) and New Delhi metallo-β-lactamase (NDM) coproducing CRKP (KPC-NDM-CRKP) further aggravates this issue. In this study, we identified 15 KPC-2-NDM-5-CRKPs as being responsible for an outbreak that involved 10 patients from October 2020 to May 2021. The outbreak was sustained by ST11-KL47-OL101 KPC-2-NDM-5-CRKPs, which exhibited non-susceptible to all antimicrobials available in mainland China. Of these strains, we characterized a conjugative hybrid plasmid co-harboring <em>bla</em>_KPC-2 and <em>bla</em>_NDM-5 with high stability. Plasmid comparison and phylogenetic analysis were performed to investigate the origin of the hybrid plasmid and its fusion mechanism. It was speculated that the hybrid plasmid might originate from <em>Klebsiella pneumoniae subsp. pneumoniae</em> strain kpn-hnqyy plasmids unnamed1 (encoding NDM-5) and unnamed2 (encoding KPC-2). The fusion of these two plasmids was presumably mediated by IS<em>26</em>. Global genomic surveillance raised an alarm about the increased prevalence of KPC-NDM-CRKPs. Phylogenetic evaluation was carried out with a total of 327 KPC-NDM-CRKP genomes to provide a global perspective on such strains, and potential transmission events in other global regions were also observed during the COVID-19 period. The outbreak of such strains in the real world and the co-transfer of <em>bla</em>_KPC and <em>bla</em>_NDM would exacerbate the dispersal of KPC-NDM-CRKPs, which poses a severe threat to public health.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"293 ","pages":"Article 128049"},"PeriodicalIF":6.1,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function analysis of RNase III in response to oxidative stress in Synechocystis sp. PCC 6803","authors":"Yihang Zhang ,&nbsp;Xinyu Hu ,&nbsp;Shanyu Wu ,&nbsp;Tianyuan Zhang ,&nbsp;Guidan Yang ,&nbsp;Zhijie Li ,&nbsp;Li Wang ,&nbsp;Wenli Chen","doi":"10.1016/j.micres.2024.128045","DOIUrl":"10.1016/j.micres.2024.128045","url":null,"abstract":"<div><div>RNase III, a ubiquitously distributed endonuclease, plays an important role in RNA processing and functions as a global regulator of gene expression. In this study, we explored the role of RNase III in mediating the oxidative stress response in <em>Synechocystis</em> sp. PCC 6803. Phenotypic analysis demonstrated that among the three RNase III-encoding genes (<em>slr0346</em>, <em>slr1646</em>, and <em>slr0954</em>), the deletional mutation of <em>slr0346</em> significantly impaired the growth of cyanobacteria on BG11 agar plates. However, this growth effect was not observed in liquid culture. In contrast, the deletion of <em>slr1646</em> and <em>slr0954</em> did not affect the growth of cyanobacteria under the tested conditions. However, under methyl viologen (MV)-induced oxidative stress, the <em>slr0346</em> deletion mutant exhibited a slower growth rate compared to the wild-type strain. Transcriptome analysis revealed that five pathways—nitrogen metabolism, ABC transporters, folate biosynthesis, ribosome biogenesis, and oxidative phosphorylation—were implicated in the oxidative stress response. The <em>slr0346</em> gene suppressed global gene expression, with a particular impact on genes associated with energy metabolism, protein synthesis, and transport. Furthermore, we identified Ssl3432 as an interacting protein that may participate in the oxidative stress response in coordination with Slr0346. Overall, the deletion of <em>slr0346</em> markedly weakened the ability of <em>Synechocystis</em> sp<em>.</em> PCC 6803 to respond to MV-induced oxidative stress. This study offers valuable insights into the oxidative stress response of <em>Synechocystis</em> sp<em>.</em> PCC 6803 and highlights the role of RNase III in adapting to environmental stress.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128045"},"PeriodicalIF":6.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging dietary polysaccharides and gut microbiome: How to achieve precision modulation for gut health promotion","authors":"Xihao Sun ,&nbsp;Zhangming Pei ,&nbsp;Hongchao Wang ,&nbsp;Jianxin Zhao ,&nbsp;Wei Chen ,&nbsp;Wenwei Lu","doi":"10.1016/j.micres.2025.128046","DOIUrl":"10.1016/j.micres.2025.128046","url":null,"abstract":"<div><div>Dietary polysaccharides function not only as indispensable nutrients and energy sources for the host organism but also as critical substrates for the gut microbiota. Gut microorganisms possess the ability to selectively degrade and metabolize specific dietary polysaccharides, thus fostering their proliferation and yielding crucial bioactive metabolites that potentially influence host metabolic and immune pathways. Dysbiosis of the gut microbiota has been extensively documented to be closely linked with the onset and progression of various diseases; in this regard, the precision modulation strategy of the gut microbiome via dietary polysaccharides holds substantial potential to enhance human health. Here, we delve into the therapeutic potential of dietary polysaccharides for the precision modulation of specific gut microorganisms via dietary interventions, with particular emphasis on their implications for the prevention and management of metabolic and inflammatory disorders. Given the complexity of the human gut microbiome and the varying degrees to which different bacterial members utilize carbohydrates, we conduct an in-depth analysis of the differential utilization of dietary polysaccharides by key gut microbiome, with particular emphasis on the role of carbohydrate-active enzymes in these processes. Furthermore, we elucidate the pivotal role of carbohydrate utilization within microbial cross-feeding networks and its significance in maintaining gut homeostasis. In summary, this review investigates the precision modulation of gut microbiota through dietary polysaccharides, with the aim of establishing a theoretical foundation for the development of personalized nutritional interventions. These strategies hold substantial potential for enhancing human health and offer valuable opportunities for the prevention and treatment of microbiota-associated diseases.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128046"},"PeriodicalIF":6.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal dynamics of kiwifruit microbiome: A case study in a KVDS-affected orchard","authors":"Antonella Cardacino,&nbsp;Silvia Turco,&nbsp;Giorgio Mariano Balestra","doi":"10.1016/j.micres.2024.128044","DOIUrl":"10.1016/j.micres.2024.128044","url":null,"abstract":"<div><div>Over the past decade, Italian kiwifruit orchards and overall production have faced a significant threat from Kiwifruit Vine Decline Syndrome (KVDS). Despite the insights gained from metagenomics studies into the microbial communities associated with the disease, unanswered questions still remain. In this study, the evolution of bacterial, fungal, and oomycetes communities in soil and root endosphere at three different time points during the vegetative season was investigated for the first time in a KVDS-affected orchard in the Lazio Region. The fungal and oomycetes genera previously associated with the syndrome, including <em>Fusarium, Ilyonectria, Thelonectria, Phytophthora, Pythium</em> and <em>Globisporangium</em>, were identified in both groups. In contrast, the characterization of bacterial communities revealed the first instance of the presence of the genus <em>Ralstonia</em> in soil and root samples. The microbiome composition shifts between KVDS-affected and asymptomatic plants were significant as evidenced by the results, particularly after a temperature increase. This temperature change coincided with the onset of severe disease symptoms and may indicate a key role in the progression of KVDS.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128044"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorghum rhizosphere bacteriome studies and generation of multistrain beneficial bacterial consortia","authors":"Chandan Kumar ,&nbsp;Alfonso Esposito ,&nbsp;Iris Bertani ,&nbsp;Samson Musonerimana ,&nbsp;Mulissa Jida Midekssa ,&nbsp;Kassahun Tesfaye ,&nbsp;Devin Coleman Derr ,&nbsp;Lara Donaldson ,&nbsp;Silvano Piazza ,&nbsp;Cristina Bez ,&nbsp;Vittorio Venturi","doi":"10.1016/j.micres.2024.128036","DOIUrl":"10.1016/j.micres.2024.128036","url":null,"abstract":"<div><div>The plant rhizosphere microbiome plays a crucial role in plant growth and health. Within this microbiome, bacteria dominate, exhibiting traits that benefit plants, such as facilitating nutrient acquisition, fixing nitrogen, controlling pathogens, and promoting root growth. This study focuses on designing synthetic bacterial consortia using key bacterial strains which have been mapped and then isolated from the sorghum rhizosphere microbiome. A large set of samples of the rhizosphere bacteriome of <em>Sorghum bicolor</em> was generated and analyzed across various genotypes and geographical locations. We assessed the taxonomic composition and structure of the sorghum root-associated bacterial community identifying the most prevalent and keystone taxa. A set of 321 bacterial strains was then isolated, and three multi-strain consortia were designed making use of the bacteriome data generated using culture independent methodology. Subsequently, co-existence and plant-growth promoting ability of three bacterial consortia were tested both <em>in vitro</em> and <em>in planta</em>. Consortia 3 promoted plant growth in growth-chamber conditions while Consortia 1 and 2 performed better in field-plot experiments. Despite these differences, bacterial community profiling confirmed the colonization of the inoculated consortia in the sorghum rhizosphere without significant alterations to the overall bacterial community compared to the non inoculated ones. In summary, this study focused on a method, using root bacteriome data, to design and test bacterial consortia for plant beneficial effects with the aim of translating microbiome knowledge into applications.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128036"},"PeriodicalIF":6.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbial metabolites: The bridge connecting diet and atherosclerosis, and next-generation targets for dietary interventions","authors":"Liyin Zhang,&nbsp;Yao Yin,&nbsp;Si Jin","doi":"10.1016/j.micres.2024.128037","DOIUrl":"10.1016/j.micres.2024.128037","url":null,"abstract":"<div><div>Mounting evidence indicates that gut microbial metabolites are central hubs linking the gut microbiota to atherosclerosis (AS). Gut microbiota enriched with pathobiont bacteria responsible for producing metabolites like trimethylamine N-oxide and phenylacetylglutamine are related to an increased risk of cardiovascular events. Furthermore, gut microbiota enriched with bacteria responsible for producing short-chain fatty acids, indole, and its derivatives, such as indole-3-propionic acid, have demonstrated AS-protective effects. This study described AS-related gut microbial composition and how microbial metabolites affect AS. Summary findings revealed gut microbiota and their metabolites-targeted diets could benefit AS treatment. In conclusion, dietary interventions centered on the gut microbiota represent a promising strategy for AS treatment, and understanding diet-microbiota interactions could potentially be devoted to developing novel anti-AS therapies.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"292 ","pages":"Article 128037"},"PeriodicalIF":6.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}