Metal-Based Drugs最新文献_第9页

Synthesis and biological activity of silyl- and germylsubstituted trifluroacetylfurans. 硅基和菌基取代三氟乙酰呋喃的合成及其生物活性。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.211

L Ignatovich, D Zarina, I Shestakova, S Germane, E Lukevics

引用次数: 12

Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis. 二聚体铜(II)双(邻乙酰氧基苯甲酸酯)对血小板-中性粒细胞粘附和血栓形成的抑制作用。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.103

Z Shen, L Wu, W Liu, J Liu, Z Chen

引用次数: 1

Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases. 噻二唑Schiff碱的抗菌Co（II）、Cu（II），Ni（II）和Zn（II）配合物。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.95

Z H Chohan, M F Jaffery, C T Supuran

引用次数: 30

Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways. MnTMPyP/KHSO在双链DNA中的鸟嘌呤氧化(5):至少三个独立的反应途径。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.47

A Lapi, G Pratviel, B Meunier

引用次数: 16

Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma. 口服钌复合物NAMI-A对CBA小鼠MCa乳腺癌的药理作用。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.1

S Zorzet, A Sorc, C Casarsa, M Cocchietto, G Sava

引用次数: 38

Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties. 席夫碱的过渡金属离子配合物。合成、表征及抗菌性能研究

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.137

Z H Chohan, A Munawar, C T Supuran

引用次数: 120

Novel Unsymmetrical Ru(III) and Mixed-valence Ru(III)/Ru(II) Dinuclear Compounds Related to the Antimetastatic Ru(III) Drug NAMI-A. 与抗转移Ru(III)药物NAMI-A相关的新型不对称Ru(III)和混价Ru(III)/Ru(II)双核化合物。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.9

B Serli, E Iengo, T Gianferrara, E Zangrando, E Alessio

{"title":"Novel Unsymmetrical Ru(III) and Mixed-valence Ru(III)/Ru(II) Dinuclear Compounds Related to the Antimetastatic Ru(III) Drug NAMI-A.","authors":"B Serli, E Iengo, T Gianferrara, E Zangrando, E Alessio","doi":"10.1155/MBD.2001.9","DOIUrl":"https://doi.org/10.1155/MBD.2001.9","url":null,"abstract":"In this paper we report the stepwise preparation and the characterization of new unsymmetrical monoanionic Ru(III) dinuclear compounds, [NH(4)][{trans-RuCl(4)(Me(2)SO-S)}(mu-L){mer-RuCl(3)(Me(2)SO-S)(Me(2)SO-O)}] (L = pyz (1), pym (2)). By a similar synthetic approach we also prepared new mixed-valence Ru(III)/Ru(II) dinuclear compounds of formula [NH(4)][{trans-RuCl(4)(Me(2)SO-S)}(mu-pyz){cis,cis,cis-RuCl(2)(Me(2)SO-S)(2)(CO)}] (L = pyrazine (pyz, 3), pyrimidine (pym, 4)). Moreover, we describe the chemical behavior of compounds 1-4 in physiological solution, also after complete reduction (with ascorbic acid) to the corresponding Ru(II)/Ru(II) species. Overall, the chemical behavior of 1 and 2 after reduction resembles that of the corresponding dianionic and neutral dinuclear species, [{trans-RuCl(3)(Me(2)SO-S)}(2)(mu-L)](2-)and [{mer-RuCl(3)(Me(2)SO-S)(Me(2)SO-O)}(2) (mu-L)]. On the other hand, the mixed-valence dinuclear compounds 3 and 4, owing to the great inertness of the cis,cis,cis-RuCl(2)(Me(2)SO-S)(2)(CO)(1/2mu-L) fragment, behave substantially like the mononuclear species [trans-RuCl(4)(Me(2)SO-S)(L)](-) in which the terminally bonded L ligand can be considered as bearing a bulky substituent on the other N atom.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Oligonucleotides modified with transplatin derivatives: fast and efficient metalloribozymes. 用移植衍生物修饰的寡核苷酸:快速高效的金属酶。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.39

R Dalbiès-Tran, M Leng, M Boudvillain

引用次数: 1

Essential metalloelement chelates facilitate repair of radiation injury. 必需金属元素螯合物促进辐射损伤的修复。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.215

J R Sorenson, L S Soderberg, L W Chang, R B Walker

{"title":"Essential metalloelement chelates facilitate repair of radiation injury.","authors":"J R Sorenson, L S Soderberg, L W Chang, R B Walker","doi":"10.1155/MBD.2001.215","DOIUrl":"https://doi.org/10.1155/MBD.2001.215","url":null,"abstract":"Treatment with essential metalloelement (Cu, Fe, Mn, and Zn) chelates or combinations of them before and/or after radiation injury is a useful approach to overcoming radiation injury. No other agents are known to increase survival when they are used to treat after irradiation, in a radiorecovery treatment paradigm. These chelates may be useful in facilitating de novo syntheses of essential metalloelement-dependent enzymes required to repair radiation injury. Reports of radioprotection, which involves treatment before irradiation, with calcium-channel blockers, acyl Melatonin homologs, and substituted anilines, which may serve as chelating agents after biochemical modification in vivo, as well as Curcumin, which is a chelating agent, have been included in this review. These inclusions are intended to suggest additional approaches to combination treatments that may be useful in facilitating radiation recovery. These approaches to radioprotection and radiorecovery offer promise in facilitating recovery from radiation-induced injury experienced by patients undergoing radiotherapy for neoplastic disease and by individuals who experience environmental, occupational, or accidental exposure to ultraviolet, x-ray, or gamma-ray radiation. Since there are no existing treatments of radiation-injury intended to facilitate tissue repair, studies of essential metalloelement chelates and combinations of them, as well as combinations of them with existing organic radioprotectants, seem worthwhile.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 4","pages":"215-34"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Construction of Ru(II) Polypyridyl Based Macrocycles: Synthesis, Characterization, Electrochemical, Li Binding, Antitumour and Anti-HIV properties. Ru(II)多吡啶基大环的构建:合成、表征、电化学、锂结合、抗肿瘤和抗hiv特性。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.113

L Mishra, R Sinha, P C Pandey

引用次数: 4